Personal information

Emails & domains

Verified email domains

Other IDs

Scopus Author ID: 7004689267
ResearcherID: F-2604-2015
Loop profile: 390811
ResearcherID: F-2604-2015

Activities

Collapse all

Employment (5)

Universidad Autonoma de Madrid Centro de Biología Molecular Severo Ochoa: Madrid, Madrid, ES

2018 to present | Científico Titular (CSIC)
Employment
Source: Self-asserted source
Margarita Sáiz

Universidad Autonoma de Madrid Centro de Biología Molecular Severo Ochoa: Madrid, Madrid, ES

2001 to 2005 | researcher (Ramón y Cajal Program) (CSIC)
Employment
Source: Self-asserted source
Margarita Sáiz

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria: Madrid, Madrid, ES

1997 to 2005 | Postdoctoral researcher (CISA-INIA)
Employment
Source: Self-asserted source
Margarita Sáiz

Harvard University: MA, MA, US

1994 to 1997 | Postdoctoral fellow (Microbiology and Molecular Genetics, Harvard Medical School)
Employment
Source: Self-asserted source
Margarita Sáiz

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria: Madrid, Madrid, ES

1989 to 1994 | PhD student
Employment
Source: Self-asserted source
Margarita Sáiz

Education and qualifications (2)

Universidad Complutense de Madrid: Madrid, Madrid, ES

1994 | Doctorado (Microbiología)
Qualification
Source: Self-asserted source
Margarita Sáiz

Universidad Complutense de Madrid: Madrid, Madrid, ES

1983 to 1988 | Biología
Education
Source: Self-asserted source
Margarita Sáiz

Professional activities (1)

Agencia Estatal Consejo Superior de Investigaciones Científicas: Madrid, Madrid, ES

Membership
Source: Self-asserted source
Margarita Sáiz

Works (47)

The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity

Structure
2025 | Journal article
DOI: 10.1016/J.STR.2024.10.025
WOSUID: WOS:001402082600001
Contributors: Marquez-Monino, Maria Angeles; Santiveri, Clara M.; de Leon, Patricia; Camero, Sergio; Campos-Olivas, Ramon; Jimenez, M. Angeles; Saiz, Margarita; Gonzalez, Beatriz; Perez-Canadillas, Jose Manuel
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases

Cellular and Molecular Life Sciences
2024-12 | Journal article
DOI: 10.1007/s00018-024-05190-7
Contributors: Miguel Ángel Sanz; Miryam Polo; Miguel Rodríguez-Pulido; Ranjitha Huildore Bommanna; Margarita Sáiz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The differential effect of SARS-COV-2 NSP1 on mRNA translation and stability reveals new insights linking ribosome recruitment, codon usage and virus evolution

2024-06-17 | Preprint
DOI: 10.1101/2024.06.17.599344
Contributors: Juan José Berlanga; Tania Matamoros; Miguel Rodríguez Pulido; Margarita Sáiz; Mercedes Núñez Bayón; René Toribio; Iván Ventoso
Source: check_circle
Crossref

Inhibition of Human Coronaviruses by Combinations of Host-Targeted and Direct-Acting Antivirals

Antimicrobial Agents and Chemotherapy
2023-04-18 | Journal article
DOI: 10.1128/aac.01703-22
Part of ISSN: 0066-4804
Part of ISSN: 1098-6596
Contributors: Patricia de León; Rodrigo Cañas-Arranz; María José Bustos; Margarita Sáiz; Francisco Sobrino
Source: Self-asserted source
Margarita Sáiz
grade
Preferred source (of 2)‎

Non-coding RNAs derived from the foot-and-mouth disease virus genome trigger broad antiviral activity against coronaviruses

Frontiers in Immunology
2023-03-29 | Journal article
DOI: 10.3389/fimmu.2023.1166725
Part of ISSN: 1664-3224
Contributors: Miguel Rodríguez-Pulido; Eva Calvo-Pinilla; Miryam Polo; Juan-Carlos Saiz; Raúl Fernández-González; Eva Pericuesta; Alfonso Gutiérrez-Adán; Francisco Sobrino; Miguel A. Martín-Acebes; Margarita Sáiz
Source: Self-asserted source
Margarita Sáiz
grade
Preferred source (of 2)‎

Use of Foot-and-Mouth Disease Virus Non-coding Synthetic RNAs as Vaccine Adjuvants.

Methods in molecular biology (Clifton, N.J.)
2022-01-01 | Journal article
DOI: 10.1007/978-1-0716-2168-4_7
PMID: 35118619
Contributors: Miguel Rodriguez Pulido; Polo M; Borrego B; Sáiz M
Source: Self-asserted source
Margarita Sáiz
grade
Preferred source (of 2)‎

Cover Image

WIREs RNA
2021-07 | Journal article
DOI: 10.1002/wrna.1677
Contributors: Margarita Saiz; Encarnacion Martinez‐Salas
Source: check_circle
Crossref

Uncovering targets of the Leader protease: Linking RNA‐mediated pathways and antiviral defense

WIREs RNA
2021-07 | Journal article
DOI: 10.1002/wrna.1645
Contributors: Margarita Saiz; Encarnacion Martinez‐Salas
Source: check_circle
Crossref

MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response

Cell Death & Disease
2020-09-02 | Journal article
DOI: 10.1038/s41419-020-02931-x
Contributors: Miguel Rodríguez Pulido; Encarnación Martínez-Salas; Francisco Sobrino; Margarita Sáiz
Source: check_circle
Crossref

A Wide-Ranging Antiviral Response in Wild Boar Cells Is Triggered by Non-coding Synthetic RNAs From the Foot-and-Mouth Disease Virus Genome.

Frontiers in veterinary science
2020-08-04 | Journal article
DOI: 10.3389/fvets.2020.00495
PMID: 32850149
Source: Self-asserted source
Margarita Sáiz

A bivalent B‐cell epitope dendrimer peptide can confer long‐lasting immunity in swine against foot‐and‐mouth disease

Transboundary and Emerging Diseases
2020-07-12 | Journal article
DOI: 10.1111/tbed.13497
Contributors: Rodrigo Cañas‐Arranz; Mar Forner; Sira Defaus; Miguel Rodríguez‐Pulido; Patricia León; Elisa Torres; María J. Bustos; Belén Borrego; Margarita Sáiz; Esther Blanco et al.
Source: check_circle
Crossref

Synthetic RNA derived from the foot-and-mouth disease virus genome elicits antiviral responses in bovine and porcine cells through IRF3 activation

Veterinary Microbiology
2018-07 | Journal article
DOI: 10.1016/j.vetmic.2018.05.015
Contributors: Miguel Rodríguez Pulido; Laura del Amo; Francisco Sobrino; Margarita Sáiz
Source: check_circle
Crossref

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

PLOS Pathogens
2018-06-29 | Journal article
DOI: 10.1371/journal.ppat.1007135
Contributors: Miguel Rodríguez Pulido; Bert L. Semler; María Teresa Sánchez-Aparicio; Encarnación Martínez-Salas; Adolfo García-Sastre; Francisco Sobrino; Margarita Sáiz
Source: check_circle
Crossref

[Importance of enteroviruses in neuropaediatrics: from polioviruses to other enteroviruses].

Revista de neurologia
2017 | Journal article
WOSUID:

MEDLINE:28524217
Contributors: Cabrerizo, M; Grupo Para El Estudio de Las Infecciones Por Enterovirus Y Parechovirus, Grupo Para El Estudio de Las Infecciones Por Enterovirus Y Parechovirus
Source: Self-asserted source
Margarita Sáiz via ResearcherID

Combined administration of synthetic RNA and a conventional vaccine improves immune responses and protection against foot-and-mouth disease virus in swine

Antiviral Research
2017-06 | Journal article
DOI: 10.1016/j.antiviral.2017.03.009
Contributors: Belén Borrego; Esther Blanco; Miguel Rodríguez Pulido; Francisco Mateos; Gema Lorenzo; Sabrina Cardillo; Eliana Smitsaart; Francisco Sobrino; Margarita Sáiz
Source: check_circle
Crossref

Molecular Mechanisms of Foot-and-Mouth Disease Virus Targeting the Host Antiviral Response

Frontiers in Cellular and Infection Microbiology
2017-06-13 | Journal article
DOI: 10.3389/fcimb.2017.00252
Source: Self-asserted source
Margarita Sáiz

Synthetic RNAs mimicking structural domains in the foot-and-mouth disease virus genome elicit a broad innate immune response in porcine cells triggered by RIG-I and TLR activation

Viruses
2015 | Journal article
DOI: 10.3390/v7072807
Source: Self-asserted source
Margarita Sáiz

Design and validation of a real-time RT-PCR for the simultaneous detection of enteroviruses and parechoviruses in clinical samples

Journal of Virological Methods
2014 | Journal article
DOI: 10.1016/j.jviromet.2014.08.008
EID:

2-s2.0-84906816611
Contributors: Cabrerizo, M.; Calvo, C.; Rabella, N.; Muñoz-Almagro, C.; del Amo, E.; Pérez-Ruiz, M.; Sanbonmatsu-Gámez, S.; Moreno-Docón, A.; Otero, A.; Trallero, G. et al.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Protection against Rift Valley fever virus infection in mice upon administration of interferon-inducing RNA transcripts from the FMDV genome

Antiviral Research
2014 | Journal article
DOI: 10.1016/j.antiviral.2014.06.010
EID:

2-s2.0-84904318544
Contributors: Lorenzo, G.; Rodríguez-Pulido, M.; López-Gil, E.; Sobrino, F.; Borrego, B.; Sáiz, M.; Brun, A.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Delivery of synthetic RNA can enhance the immunogenicity of vaccines against foot-and-mouth disease virus (FMDV) in mice

Vaccine
2013 | Journal article
DOI: 10.1016/j.vaccine.2013.07.008
EID:

2-s2.0-84882848322
Contributors: Borrego, B.; Rodríguez-Pulido, M.; Mateos, F.; de la Losa, N.; Sobrino, F.; Sáiz, M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Modulation of foot-and-mouth disease virus pH threshold for uncoating correlates with differential sensitivity to inhibition of cellular Rab GTPases and decreases infectivity in vivo

Journal of General Virology
2012 | Journal article
DOI: 10.1099/vir.0.045419-0
EID:

2-s2.0-84867559832
Contributors: Vázquez-Calvo, Á.; Caridi, F.; Rodriguez-Pulido, M.; Borrego, B.; Sáiz, M.; Sobrino, F.; Martín-Acebes, M.A.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Protection against West Nile Virus Infection in Mice after Inoculation with Type I Interferon-Inducing RNA Transcripts

PLoS ONE
2012 | Journal article
DOI: 10.1371/journal.pone.0049494
EID:

2-s2.0-84869104406
Contributors: Rodríguez-Pulido, M.; Martín-Acebes, M.A.; Escribano-Romero, E.; Blázquez, A.-B.; Sobrino, F.; Borrego, B.; Sáiz, M.; Saiz, J.-C.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Inoculation of newborn mice with non-coding regions of foot-and-mouth disease virus RNA can induce a rapid, solid and wide-range protection against viral infection

Antiviral Research
2011 | Journal article
DOI: 10.1016/j.antiviral.2011.10.005
EID:

2-s2.0-84858730304
Contributors: Rodríguez-Pulido, M.; Sobrino, F.; Borrego, B.; Sáiz, M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

RNA structural domains in noncoding regions of the foot-and-mouth disease virus genome trigger innate immunity in porcine cells and mice

Journal of Virology
2011 | Journal article
DOI: 10.1128/JVI.00599-11
EID:

2-s2.0-80052077030
Contributors: Rodríguez-Pulido, M.; Borrego, B.; Sobrino, F.; Sáiz, M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

RNA immunization can protect mice against foot-and-mouth disease virus

Antiviral Research
2010 | Journal article
DOI: 10.1016/j.antiviral.2009.12.005
EID:

2-s2.0-76949094913
Contributors: Pulido, M.R.; Sobrino, F.; Borrego, B.; Sáiz, M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Attenuated foot-and-mouth disease virus RNA carrying a deletion in the 3′ noncoding region can elicit immunity in swine

Journal of Virology
2009 | Journal article
DOI: 10.1128/JVI.01836-08
EID:

2-s2.0-64049103834
Contributors: Pulido, M.R.; Sobrino, F.; Borrego, B.; Sáiz, M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context

Journal of General Virology
2008 | Journal article
DOI: 10.1099/vir.0.2008/003194-0
EID:

2-s2.0-54449091825
Contributors: Gutiérrez-Rivas, M.; Pulido, M.R.; Baranowski, E.; Sobrino, F.; Sáiz, M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins

Virology
2007 | Journal article
DOI: 10.1016/j.virol.2007.03.013
EID:

2-s2.0-34249899152
Contributors: Rodríguez Pulido, M.; Serrano, P.; Sáiz, M.; Martínez-Salas, E.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

The 3′ end of the foot-and-mouth disease virus genome establishes two distinct long-range RNA-RNA interactions with the 5′ and region

Journal of General Virology
2006 | Journal article
DOI: 10.1099/vir.0.82059-0
EID:

2-s2.0-33749069918
Contributors: Serrano, P.; Pulido Rodriguez, M.; Sáiz, M.; Martínez-Salas, E.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Evidence that the fully assembled caspsid of Leishmania RNA virus 1-4 possesses catalytically active endoribonuclease activity

Experimental and Molecular Medicine
2004 | Journal article
EID:

2-s2.0-2442656777
Contributors: Ro, Y.T.; Kim, E.J.; Lee, H.I.; Saiz, M.; Carrion Jr., R.; Patterson, J.L.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Detection of foot-and-mouth disease virus from culture and clinical samples by reverse transcription-PCR coupled to restriction enzyme and sequence analysis

Veterinary Research
2003 | Journal article
EID:

2-s2.0-0037283484
Contributors: Sáiz, M.; De La Morena, D.B.; Blanco, E.; Núñez, J.I.; Fernández, R.; Sánchez-Vizcaíno, J.M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Recovery of infectious foot-and-mouth disease virus from suckling mice after direct inoculation with in vitro-transcribed RNA

Journal of Virology
2003 | Journal article
DOI: 10.1128/JVI.77.20.11290-11295.2003
EID:

2-s2.0-0141676531
Contributors: Baranowski, E.; Molina, N.; Núñez, J.I.; Sobrino, F.; Sáiz, M.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Foot-and-mouth disease virus: Biology and prospects for disease control

Microbes and Infection
2002 | Journal article
DOI: 10.1016/S1286-4579(02)01644-1
EID:

2-s2.0-0036753658
Contributors: Sáiz, M.; Núñez, J.I.; Jimenez-Clavero, M.A.; Baranowski, E.; Sobrino, F.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

IRES-driven translation is stimulated separately by the FMDV 3′-NCR and poly(A) sequences

Nucleic Acids Research
2002 | Journal article
EID:

2-s2.0-0037109209
Contributors: López De Quinto, S.; Sáiz, M.; De La Morena, D.; Sobrino, F.; Martínez-Salas, E.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Deletion or substitution of the aphthovirus 3′ NCR abrogates infectivity and virus replication

Journal of General Virology
2001 | Journal article
EID:

2-s2.0-0035170571
Contributors: Sáiz, M.; Gómez, S.; Martínez-Salas, E.; Sobrino, F.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Foot-and-mouth disease virus: A long known virus, but a current threat

Veterinary Research
2001 | Journal article
EID:

2-s2.0-0343371820
Contributors: Sobrino, F.; Sáiz, M.; Jiménez-Clavero, M.A.; Núñez, J.I.; Rosas, M.F.; Baranowski, E.; Ley, V.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Host cell proteins bind specifically to the capsid-cleaved 5' end of Leishmaniavirus RNA

Journal of Biochemistry
1999 | Journal article
EID:

2-s2.0-0032872802
Contributors: Saiz, M.; Ro, Y.-T.; Wirth, D.F.; Patterson, J.L.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Response to retreatment with interferon-α plus ribavirin in chronic hepatitis C patients is independent of the NS5A gene nucleotide sequence

American Journal of Gastroenterology
1999 | Journal article
DOI: 10.1016/S0002-9270(99)00437-2
EID:

2-s2.0-0033199147
Contributors: Ibarrola, N.; Moreno-Monteagudo, J.A.; Sáiz, M.; García-Monzón, C.; Sobrino, F.; García-Buey, L.; Lo Iacono, O.; Moreno-Otero, R.; Martínez-Salas, E.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Short report: Detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru

American Journal of Tropical Medicine and Hygiene
1998 | Journal article
EID:

2-s2.0-0031931513
Contributors: Saiz, M.; Llanos-Cuentas, A.; Echevarria, J.; Roncal, N.; Cruz, M.; Tupayachi Muniz, M.; Lucas, C.; Wirth, D.F.; Scheffter, S.; Magill, A.J. et al.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Incidence and characterization of bean common mosaic virus isolates in Spanish bean fields

Plant Disease
1995 | Journal article
EID:

2-s2.0-0029109006
Contributors: Saiz, M.; de Blas, C.; Carazo, G.; Fresno, J.; Romero, J.; Castro, S.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Broad spectrum detection of Cucumber mosaic virus (CMV) using the polymerase chain reaction

Journal of Phytopathology
1994 | Journal article
Source: Self-asserted source
Margarita Sáiz

Evolutionary relationships among bean common mosaic virus strains and closely related potyviruses

Virus Research
1994 | Journal article
DOI: 10.1016/0168-1702(94)90069-8
EID:

2-s2.0-0028097709
Contributors: Sáiz, M.; Dopazo, J.; Castro, S.; Romero, J.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Mycoplasmalike Organisms Associated with Vicia ervilia

Plant Disease
1994 | Journal article
Source: Self-asserted source
Margarita Sáiz

Serotype-specific detection of bean common mosaic potyvirus in bean leaf and seed tissue by enzymatic amplification

Journal of Virological Methods
1994 | Journal article
DOI: 10.1016/0166-0934(94)90171-6
EID:

2-s2.0-0028606129
Contributors: Sáiz, M.; Castro, S.; De Blas, C.; Romero, J.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

First report of bean yellow mosaic virus in Spain.

Plant Disease
1993 | Journal article
Source: Self-asserted source
Margarita Sáiz

Use of enzymatic cDNA amplification as a method of detection of bean yellow mosaic virus

Netherlands Journal of Plant Pathology
1993 | Journal article
DOI: 10.1007/BF01998477
EID:

2-s2.0-0010874260
Contributors: Castro, S.; Carazo, G.; Saiz, M.; Romero, J.; De Blas, C.
Source: Self-asserted source
Margarita Sáiz via Scopus - Elsevier

Virus diseases of chickpea in Spain

Plant Disease
1993 | Other
Source: Self-asserted source
Margarita Sáiz

Peer review (17 reviews for 7 publications/grants)

Review activity for BMC veterinary research (2)
Review activity for Journal of virology : (5)
Review activity for PLOS pathogens : (3)
Review activity for Transboundary and emerging diseases. (2)
Review activity for Vaccines. (1)
Review activity for Virologica Sinica. (2)
Review activity for Viruses. (2)
How many people are using ORCID?