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Helmholtz-Institut für Pharmazeutische Forschung Saarland: Saarbrücken, Saarland, DE

2009-08-01 to present | Researcher (Drug Design and Optimization)
Employment
Source: Self-asserted source
Jörg Haupenthal

Works (50 of 57)

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Page 1 of 2

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

Chemical Science
2024 | Journal article
Contributors: Olga Metelkina; Jelena Konstantinović; Andreas Klein; Roya Shafiei; Mario Fares; Alaa Alhayek; Samir Yahiaoui; Walid A. M. Elgaher; Jörg Haupenthal; Alexander Titz et al.
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Expression and characterization of pantothenate energy‐coupling factor transporters as an anti‐infective drug target

Protein Science
2024-11 | Journal article
Contributors: Atanaz Shams; Spyridon Bousis; Eleonora Diamanti; Walid A. M. Elgaher; Lucie Zeimetz; Jörg Haupenthal; Dirk J. Slotboom; Anna K. H. Hirsch
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Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy‐coupling factor transporters (ECFTs)

Archiv der Pharmazie
2024-09 | Journal article
Contributors: Jörg Haupenthal; Muhammad Rafehi; Andreas M. Kany; Anne Lespine; Katja Stefan; Anna K. H. Hirsch; Sven Marcel Stefan
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Development and evaluation of 2,4‐disubstituted‐5‐aryl pyrimidine derivatives as antibacterial agents

Archiv der Pharmazie
2024-04 | Journal article
Contributors: Hend Khalifa; Sari Rasheed; Jörg Haupenthal; Jennifer Herrmann; Yasmine M. Mandour; Ashraf H. Abadi; Matthias Engel; Rolf Müller; Anna K. H. Hirsch; Mohammad Abdel‐Halim et al.
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Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

Angewandte Chemie
2024-01-22 | Journal article
Contributors: Anastasiia M. Afanasenko; Xianyuan Wu; Alessandra De Santi; Walid A. M. Elgaher; Andreas M. Kany; Roya Shafiei; Marie‐Sophie Schulze; Thomas F. Schulz; Jörg Haupenthal; Anna K. H. Hirsch et al.
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Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

Angewandte Chemie International Edition
2024-01-22 | Journal article
Contributors: Anastasiia M. Afanasenko; Xianyuan Wu; Alessandra De Santi; Walid A. M. Elgaher; Andreas M. Kany; Roya Shafiei; Marie‐Sophie Schulze; Thomas F. Schulz; Jörg Haupenthal; Anna K. H. Hirsch et al.
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The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB

Antibiotics
2022-08-04 | Journal article
Contributors: Virgyl Camberlein; Gwenaëlle Jézéquel; Jörg Haupenthal; Anna K. H. Hirsch
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Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors

Angewandte Chemie International Edition
2022-01-26 | Journal article
Contributors: Cansu Kaya; Isabell Walter; Samir Yahiaoui; Asfandyar Sikandar; Alaa Alhayek; Jelena Konstantinović; Andreas M. Kany; Jörg Haupenthal; Jesko Köhnke; Rolf W. Hartmann et al.
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Substratinspirierte Fragment‐Fusion und ‐Erweiterung führt zu wirksamen LasB‐Inhibitoren

Angewandte Chemie
2022-01-26 | Journal article
Contributors: Cansu Kaya; Isabell Walter; Samir Yahiaoui; Asfandyar Sikandar; Alaa Alhayek; Jelena Konstantinović; Andreas M. Kany; Jörg Haupenthal; Jesko Köhnke; Rolf W. Hartmann et al.
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Assessment of the rules related to gaining activity against Gram-negative bacteria

RSC Medicinal Chemistry
2021 | Journal article
Contributors: Henni-Karoliina Ropponen; Eleonora Diamanti; Alexandra Siemens; Boris Illarionov; Jörg Haupenthal; Markus Fischer; Matthias Rottmann; Matthias Witschel; Anna K. H. Hirsch
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N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

RSC Medicinal Chemistry
2021 | Journal article
Contributors: Samir Yahiaoui; Katrin Voos; Jörg Haupenthal; Thomas A. Wichelhaus; Denia Frank; Lilia Weizel; Marco Rotter; Steffen Brunst; Jan S. Kramer; Ewgenij Proschak et al.
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Crossref

Front Cover: Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)

ChemMedChem
2021-04-20 | Journal article
Contributors: Katrin Voos; Esther Schönauer; Alaa Alhayek; Jörg Haupenthal; Anastasia Andreas; Rolf Müller; Rolf W. Hartmann; Hans Brandstetter; Anna K. H. Hirsch; Christian Ducho
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Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)

ChemMedChem
2021-04-20 | Journal article
Contributors: Katrin Voos; Esther Schönauer; Alaa Alhayek; Jörg Haupenthal; Anastasia Andreas; Rolf Müller; Rolf W. Hartmann; Hans Brandstetter; Anna K. H. Hirsch; Christian Ducho
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Crossref

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor

Biological Chemistry
2020 | Journal article
EID:

2-s2.0-85060377414

Part of ISSN: 14374315 14316730
Contributors: Empting, M.; Kamal, A.A.M.; Haupenthal, J.; Habib, M.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

Journal of Medicinal Chemistry
2020 | Journal article
EID:

2-s2.0-85089609352

Part of ISSN: 15204804 00222623
Contributors: Konstantinović, J.; Yahiaoui, S.; Alhayek, A.; Haupenthal, J.; Schönauer, E.; Andreas, A.; Kany, A.M.; Müller, R.; Koehnke, J.; Berger, F.K. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach

ChemMedChem
2020 | Journal article
EID:

2-s2.0-85082830036

Part of ISSN: 18607187 18607179
Contributors: Konstantinidou, M.; Magari, F.; Sutanto, F.; Haupenthal, J.; Jumde, V.R.; Ünver, M.Y.; Heine, A.; Camacho, C.J.; Hirsch, A.K.H.; Klebe, G. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Synthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (-)-Pentenomycin i

Synlett
2020 | Journal article
EID:

2-s2.0-85081540129

Part of ISSN: 14372096 09365214
Contributors: Zisopoulou, S.A.; Bousis, S.; Haupenthal, J.; Herrmann, J.; Müller, R.; Hirsch, A.K.H.; Komiotis, D.; Gallos, J.K.; Stathakis, C.I.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice

ACS Infectious Diseases
2020-10-09 | Journal article
Contributors: Jörg Haupenthal; Yannik Kautz; Walid A. M. Elgaher; Linda Pätzold; Teresa Röhrig; Matthias W. Laschke; Thomas Tschernig; Anna K. H. Hirsch; Vadim Molodtsov; Katsuhiko S. Murakami et al.
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From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

ACS Central Science
2019 | Journal article
EID:

2-s2.0-85076357887

Part of ISSN: 23747951 23747943
Contributors: Elangovan, S.; Afanasenko, A.; Haupenthal, J.; Sun, Z.; Liu, Y.; Hirsch, A.K.H.; Barta, K.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase

Journal of Steroid Biochemistry and Molecular Biology
2019 | Journal article
EID:

2-s2.0-85067333225

Part of ISSN: 18791220 09600760
Contributors: Akram, M.; Patt, M.; Kaserer, T.; Temml, V.; Waratchareeyakul, W.; Kratschmar, D.V.; Haupenthal, J.; Hartmann, R.W.; Odermatt, A.; Schuster, D.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Spray-drying of inhalable, multifunctional formulations for the treatment of biofilms formed in cystic fibrosis

Journal of Controlled Release
2019 | Journal article
EID:

2-s2.0-85074055692

Part of ISSN: 18734995 01683659
Contributors: Lababidi, N.; Ofosu Kissi, E.; Elgaher, W.A.M.; Sigal, V.; Haupenthal, J.; Schwarz, B.C.; Hirsch, A.K.H.; Rades, T.; Schneider, M.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Quorum Sensing Inhibitors as Pathoblockers for Pseudomonas aeruginosa Infections: A New Concept in Anti-Infective Drug Discovery

Topics in Medicinal Chemistry
2018 | Book chapter
EID:

2-s2.0-85049378098

Part of ISSN: 1862247X 18622461
Contributors: Kamal, A.A.M.; Maurer, C.K.; Allegretta, G.; Haupenthal, J.; Empting, M.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor

ACS Chemical Biology
2018-09-21 | Journal article
Contributors: Andreas M. Kany; Asfandyar Sikandar; Samir Yahiaoui; Jörg Haupenthal; Isabell Walter; Martin Empting; Jesko Köhnke; Rolf W. Hartmann
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In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics

ACS Infectious Diseases
2018-08-10 | Journal article
Contributors: Florian Graef; Robert Richter; Verena Fetz; Xabier Murgia; Chiara De Rossi; Nicole Schneider-Daum; Giuseppe Allegretta; Walid Elgaher; Jörg Haupenthal; Martin Empting et al.
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Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

ACS Infectious Diseases
2018-06-08 | Journal article
Contributors: Andreas M. Kany; Asfandyar Sikandar; Jörg Haupenthal; Samir Yahiaoui; Christine K. Maurer; Ewgenij Proschak; Jesko Köhnke; Rolf W. Hartmann
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Bacterial RNAP Inhibitors: Synthesis and Evaluation of Prodrugs of Aryl-ureidothiophene-carboxylic acids

ChemistrySelect
2017 | Journal article
EID:

2-s2.0-85041825704

Part of ISSN: 23656549
Contributors: Ruthenbeck, A.; Elgaher, W.A.M.; Haupenthal, J.; Hartmann, R.W.; Meier, C.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials

ChemMedChem
2017 | Journal article
EID:

2-s2.0-85030845367

Part of ISSN: 18607187 18607179
Contributors: Brengel, C.; Thomann, A.; Schifrin, A.; Allegretta, G.; Kamal, A.A.M.; Haupenthal, J.; Schnorr, I.; Cho, S.H.; Franzblau, S.G.; Empting, M. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone

Journal of Steroid Biochemistry and Molecular Biology
2017 | Journal article
EID:

2-s2.0-85029600473

Part of ISSN: 18791220 09600760
Contributors: de Mello Martins, A.G.G.; Allegretta, G.; Unteregger, G.; Haupenthal, J.; Eberhard, J.; Hoffmann, M.; van der Zee, J.A.; Junker, K.; Stöckle, M.; Müller, R. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Pharmacophore modeling and in Silico/in Vitro screening for human cytochrome P450 11B1 and cytochrome P450 11B2 inhibitors

Frontiers in Chemistry
2017 | Journal article
EID:

2-s2.0-85041658731

Part of ISSN: 22962646
Contributors: Akram, M.; Waratchareeyakul, W.; Haupenthal, J.; Hartmann, R.W.; Schuster, D.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

Journal of the American Chemical Society
2017-09-13 | Journal article
Contributors: Esther Schönauer; Andreas M. Kany; Jörg Haupenthal; Kristina Hüsecken; Isabel J. Hoppe; Katrin Voos; Samir Yahiaoui; Brigitta Elsässer; Christian Ducho; Hans Brandstetter et al.
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Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84982140601

Part of ISSN: 15204804 00222623
Contributors: Elgaher, W.A.M.; Sharma, K.K.; Haupenthal, J.; Saladini, F.; Pires, M.; Real, E.; Mély, Y.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors

Bioorganic and Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84956792745

Part of ISSN: 14643391 09680896
Contributors: Aggarwal, S.; Mahapatra, M.K.; Kumar, R.; Bhardwaj, T.R.; Hartmann, R.W.; Haupenthal, J.; Kumar, M.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Synthesis, biological evaluation and in silico studies of novel 5-aza-bhomo- 3,5-secosteroids as potential 5α-reductase inhibitors

Letters in Drug Design and Discovery
2016 | Journal article
EID:

2-s2.0-84992188388

Part of ISSN: 1875628X 15701808
Contributors: Kumar, R.; Chauhan, P.; Malla, P.; Mahapatra, M.K.; Hartmann, R.W.; Haupenthal, J.; Kumar, M.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections

Pharmaceutical Research
2015 | Journal article
EID:

2-s2.0-84946480032

Part of ISSN: 1573904X 07248741
Contributors: Dimer, F.; De Souza Carvalho-Wodarz, C.; Haupenthal, J.; Hartmann, R.; Lehr, C.-M.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

European Journal of Medicinal Chemistry
2014 | Journal article
EID:

2-s2.0-84896877636

Part of ISSN: 02235234 17683254
Contributors: Hinsberger, S.; De Jong, J.C.; Groh, M.; Haupenthal, J.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Binding mode characterization of novel RNA polymerase inhibitors using a combined biochemical and NMR approach

ACS Chemical Biology
2014 | Journal article
EID:

2-s2.0-84908562097

Part of ISSN: 15548937 15548929
Contributors: Fruth, M.; Plaza, A.; Hinsberger, S.; Sahner, J.H.; Haupenthal, J.; Bischoff, M.; Jansen, R.; Müller, R.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Expanding the scaffold for bacterial RNA polymerase inhibitors: Design, synthesis and structure-activity relationships of ureido-heterocyclic-carboxylic acids

RSC Advances
2014 | Journal article
EID:

2-s2.0-84890291502

Part of ISSN: 20462069
Contributors: Elgaher, W.A.M.; Fruth, M.; Groh, M.; Haupenthal, J.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent

Antimicrobial Agents and Chemotherapy
2014 | Journal article
EID:

2-s2.0-84903130018

Part of ISSN: 10986596 00664804
Contributors: Zhu, W.; Haupenthal, J.; Groh, M.; Fountain, M.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Surface plasmon resonance - More than a screening technology: Insights in the binding mode of σ<sup>70</sup>:Core RNAP inhibitors

Future Medicinal Chemistry
2014 | Journal article
EID:

2-s2.0-84908568253

Part of ISSN: 17568927 17568919
Contributors: Hüsecken, K.; Hinsberger, S.; Elgaher, W.A.M.; Haupenthal, J.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

A detective story in drug discovery: Elucidation of a screening artifact reveals polymeric carboxylic acids as potent inhibitors of RNA polymerase

Chemistry - A European Journal
2013 | Journal article
EID:

2-s2.0-84879190695

Part of ISSN: 09476539 15213765
Contributors: Zhu, W.; Groh, M.; Haupenthal, J.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Differential Stability of Cell-Free Circulating microRNAs: Implications for Their Utilization as Biomarkers

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84884471107

Part of ISSN: 19326203
Contributors: Köberle, V.; Pleli, T.; Schmithals, C.; Augusto Alonso, E.; Haupenthal, J.; Bönig, H.; Peveling-Oberhag, J.; Biondi, R.M.; Zeuzem, S.; Kronenberger, B. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Discovery of novel bacterial RNA polymerase inhibitors: Pharmacophore-based virtual screening and hit optimization

Journal of Medicinal Chemistry
2013 | Journal article
EID:

2-s2.0-84887872346

Part of ISSN: 00222623 15204804
Contributors: Hinsberger, S.; Hüsecken, K.; Groh, M.; Negri, M.; Haupenthal, J.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Novel small molecule inhibitors targeting the "switch region" of bacterial RNAP: Structure-based optimization of a virtual screening hit

European Journal of Medicinal Chemistry
2013 | Journal article
EID:

2-s2.0-84878150208

Part of ISSN: 17683254 02235234
Contributors: Sahner, J.H.; Groh, M.; Negri, M.; Haupenthal, J.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Peptide-based investigation of the escherichia coli RNA polymerase σ<sup>70</sup>:Core interface as target site

ACS Chemical Biology
2013 | Journal article
EID:

2-s2.0-84876566895

Part of ISSN: 15548929 15548937
Contributors: Hüsecken, K.; Negri, M.; Fruth, M.; Boettcher, S.; Hartmann, R.W.; Haupenthal, J.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Transferrin-coated gadolinium nanoparticles as MRI contrast agent

Molecular Imaging and Biology
2013 | Journal article
EID:

2-s2.0-84878506577

Part of ISSN: 18602002 15361632
Contributors: Korkusuz, H.; Ulbrich, K.; Welzel, K.; Koeberle, V.; Watcharin, W.; Bahr, U.; Chernikov, V.; Knobloch, T.; Petersen, S.; Huebner, F. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Contrast enhancement of the brain by folate-conjugated gadolinium- diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging

Molecular Imaging
2012 | Journal article
EID:

2-s2.0-84866851658

Part of ISSN: 15353508
Contributors: Korkusuz, H.; Ulbrich, K.; Bihrer, V.; Welzel, K.; Chernikov, V.; Knobloch, T.; Petersen, S.; Huebner, F.; Ackermann, H.; Gelperina, S. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Influence of DNA template choice on transcription and inhibition of Escherichia coli RNA polymerase

Antimicrobial Agents and Chemotherapy
2012 | Journal article
EID:

2-s2.0-84864386779

Part of ISSN: 00664804 10986596
Contributors: Haupenthal, J.; Hüsecken, K.; Negri, M.; Maurer, C.K.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels

Neoplasia (United States)
2012 | Journal article
EID:

2-s2.0-84861681511

Part of ISSN: 14765586 15228002
Contributors: Haupenthal, J.; Bihrer, V.; Korkusuz, H.; Kollmar, O.; Schmithals, C.; Kriener, S.; Engels, K.; Pleli, T.; Benz, A.; Canamero, M. et al.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach

European Journal of Medicinal Chemistry
2012 | Journal article
EID:

2-s2.0-84864413353

Part of ISSN: 02235234 17683254
Contributors: Aggarwal, S.; Thareja, S.; Bhardwaj, T.R.; Haupenthal, J.; Hartmann, R.W.; Kumar, M.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier

Optimization of the first selective steroid-11β-hydroxylase (CYP11B1) inhibitors for the treatment of cortisol dependent diseases

ACS Medicinal Chemistry Letters
2011 | Journal article
EID:

2-s2.0-80051710067

Part of ISSN: 19485875
Contributors: Hille, U.E.; Zimmer, C.; Haupenthal, J.; Hartmann, R.W.
Source: Self-asserted source
Jörg Haupenthal via Scopus - Elsevier
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Peer review (1 review for 1 publication/grant)

Review activity for ACS chemical biology. (1)