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Technische Universität Dresden profile page

Other IDs

ResearcherID: B-2822-2017
Scopus Author ID: 7005187370
Scopus author ID: 7005187370
Researcher ID: ABB-8277-2021

Keywords

Cytoplasm - Phase Separation - Protein quality control - Protein aggregation

Countries

Germany

Activities

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Employment (4)

Technische Universität Dresden: Dresden, Sachsen, DE

2018-11-01 to present | Professor (BIOTEC)
Employment
Source: Self-asserted source
Simon Alberti

Technische Universität Dresden: N/A, DE

2018-11-01 to present | Member (Clusters of Excellence PoL: Physics of Life)
Employment
Source: check_circle
FIS TU Dresden

Technische Universität Dresden: N/A, DE

2018-11-01 to present | Academic Staff (Chair of Cellular Biochemistry)
Employment
Source: check_circle
FIS TU Dresden

Max Planck Institute of Molecular Cell Biology and Genetics: Dresden, DE

2010 to 2018-10-31 | Senior Group Leader
Employment
Source: Self-asserted source
Simon Alberti

Education and qualifications (3)

Whitehead Institute for Biomedical Research: Cambridge, MA, US

2005 to 2010 | Postdoc
Qualification
Source: Self-asserted source
Simon Alberti

University of Bonn: Bonn, DE

2000 to 2004 | PhD
Education
Source: Self-asserted source
Simon Alberti

University of Bochum: Bochum, DE

1993 to 2000 | Diploma (Biology)
Education
Source: Self-asserted source
Simon Alberti

Works (50 of 138)

Items per page:
Page 1 of 3

G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability

Molecular cell
2025-02-06 | Journal article | Author
DOI: 10.1016/j.molcel.2024.11.039
SOURCE-WORK-ID:

e3591817-b3d3-493c-8994-f05b9647b1d9

PMID: 39729994
EID:

2-s2.0-85216570955
Contributors: Irmela R E A Trussina; Andreas Hartmann; Christine Desroches Altamirano; Janani Natarajan; Charlotte M Fischer; Marta Aleksejczuk; Hannes Ausserwöger; Tuomas P J Knowles; Michael Schlierf; Titus M Franzmann et al.
Source: check_circle
FIS TU Dresden

Molecular determinants of condensate composition

Molecular Cell
2025-01-16 | Review | Author
DOI: 10.1016/j.molcel.2024.12.021
SOURCE-WORK-ID:

dd4228c8-8d43-401b-a394-31c199e335b8

EID:

2-s2.0-85214344959
Contributors: Alex S. Holehouse; Simon Alberti
Source: check_circle
FIS TU Dresden

Surviving the heat

Trends in Biochemical Sciences
2025-01-02 | Review | Author
DOI: 10.1016/j.tibs.2024.09.008
SOURCE-WORK-ID:

f301fa60-d584-49ce-adc5-ce582731c79f

EID:

2-s2.0-85207323772
Contributors: Christine Desroches Altamirano; Simon Alberti
Source: check_circle
FIS TU Dresden

Optical characterization of molecular interaction strength in protein condensates

Molecular Biology of the Cell
2024-12-01 | Journal article | Author
DOI: 10.1091/mbc.E24-03-0128
SOURCE-WORK-ID:

b0e6a6f0-d2d5-4d04-a487-d3f7f32157c2

EID:

2-s2.0-85211665904

PMID: 39535884
Contributors: Timon Andreas Beck; Lize-Mari van der Linden; Wade M Borcherds; Kyoohyun Kim; Raimund Schlüßler; Paul Müller; Titus Marcellus Franzmann; Conrad Möckel; Ruchi Yashavantgiri Goswami; Mark Leaver et al.
Source: check_circle
FIS TU Dresden

Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system

Communications biology
2024-10-08 | Journal article | Author
DOI: 10.1038/s42003-024-06974-0
SOURCE-WORK-ID:

daeabc45-2b5c-4f03-9f59-eaedb2b8222d

PMID: 39379572
EID:

2-s2.0-85205994447
Contributors: Shanshan Xu; Maria E Gierisch; Enrica Barchi; Ina Poser; Simon Alberti; Florian A Salomons; Nico P Dantuma
Source: check_circle
FIS TU Dresden

Protocol to reconstitute translationally arrested heat shock mRNPs and condensates in vitro

STAR Protocols
2024-09-20 | Journal article | Author
DOI: 10.1016/j.xpro.2024.103275
SOURCE-WORK-ID:

19ecf6ff-0af1-49f8-a002-270bbbec5f8d

PMID: 39172644
EID:

2-s2.0-85205084117
Contributors: Christine Desroches Altamirano; Simon Alberti
Source: check_circle
FIS TU Dresden

Single-molecule digital sizing of proteins in solution

Nature Communications
2024-09-04 | Journal article | Author
DOI: 10.1038/s41467-024-50825-9
SOURCE-WORK-ID:

dbbc15a8-0b71-4742-ae41-610fc7df4daa

EID:

2-s2.0-85203298782

PMID: 39231922
Contributors: Georg Krainer; Raphael PB Jacquat; Matthias M Schneider; Timothy J Welsh; Jieyuan Fan; Quentin AE Peter; Ewa A Andrzejewska; Kadi L Saar; Therese W Herling; Titus Marcellus Franzmann et al.
Source: check_circle
FIS TU Dresden

Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation

2024-05 | Preprint | Author
DOI: 10.1101/2024.05.23.595321
SOURCE-WORK-ID:

8a47dfe4-fa99-4260-b750-d2152c527ef9
Contributors: Hannes Ausserwoeger; Rob M Sutton; Tomas Snerideris; Charlotte M Fischer; Daoyuan Qian; Ella de Csilléry; Kadi L Saar; Alan Z Bialek; Marc Oeller; Georg Krainer et al.
Source: check_circle
FIS TU Dresden

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

2024-05-24 | Preprint | Author
DOI: 10.1101/2024.01.23.576837
SOURCE-WORK-ID:

be60ef5a-2077-4ed6-800a-3c9ce4b107f3

PMID: 38328053
Contributors: Xiao Yan; David Kuster; Priyesh Mohanty; Jik Nijssen; Karina Pombo-García; Azamat Rizuan; Titus Marcellus Franzmann; Aleksandra Sergeeva; Patricia M Passos; Leah George et al.
Source: check_circle
FIS TU Dresden

eIF4F is a thermo-sensing regulatory node in the translational heat shock response

Molecular cell
2024-05-02 | Journal article | Author
DOI: 10.1016/j.molcel.2024.02.038
SOURCE-WORK-ID:

965c7eb9-808b-4220-98d9-5e052d56f0d4

EID:

2-s2.0-85190416286

PMID: 38547866
Contributors: Christine Desroches Altamirano; Moo Koo Kang; Mareike A. Jordan; Tom Borianne; Irem Dilmen; Maren Gnädig; Alexander von Appen; Alf Honigmann; Titus M. Franzmann; Simon Alberti
Source: check_circle
FIS TU Dresden

PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Cell
2024-02-15 | Journal article | Author
DOI: 10.1016/j.cell.2024.01.015
SOURCE-WORK-ID:

3e11902c-b9f3-46e0-b899-ccb085915edc

PMID: 38320550
EID:

2-s2.0-85185346177
Contributors: Nagaraja Chappidi; Thomas Quail; Simon Doll; Laura T Vogel; Radoslav Aleksandrov; Suren Felekyan; Ralf Kühnemuth; Stoyno Stoynov; Claus A M Seidel; Jan Brugués et al.
Source: check_circle
FIS TU Dresden

Biomolecular condensates in kidney physiology and disease

Nature Reviews. Nephrology
2023-12 | Review | Author
DOI: 10.1038/s41581-023-00767-0
SOURCE-WORK-ID:

6508ae3e-66a0-49b8-86b7-b7aa42c1125a

EID:

2-s2.0-85172672224

PMID: 37752323
Contributors: Guoming Gao; Emily S. Sumrall; Sethuramasundaram Pitchiaya; Markus Bitzer; Simon Alberti; Nils G. Walter
Source: check_circle
FIS TU Dresden

Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process

Journal of the American Chemical Society
2023-07-19 | Journal article | Author
DOI: 10.1021/jacs.3c02022
SOURCE-WORK-ID:

77e6accb-4867-4670-a754-56f444ec4a0c

EID:

2-s2.0-85164681384

PMID: 37411010
Contributors: Dhawal Choudhary; Laura Mediani; Mario J. Avellaneda; Sveinn Bjarnason; Simon Alberti; Edgar E. Boczek; Pétur O. Heidarsson; Alessandro Mossa; Serena Carra; Sander J. Tans et al.
Source: check_circle
FIS TU Dresden

A shared fate for nuclear and cytosolic inclusions

Nature cell biology
2023-05 | Annotation | Author
DOI: 10.1038/s41556-023-01121-z
SOURCE-WORK-ID:

5f73a495-bc9d-47df-b124-3f3329e25739

EID:

2-s2.0-85153336094

PMID: 37081163
Contributors: Simon Alberti; Serena Carra
Source: check_circle
FIS TU Dresden

Direct digital sensing of protein biomarkers in solution

Nature communications
2023-02-06 | Journal article | Author
DOI: 10.1038/s41467-023-35792-x
SOURCE-WORK-ID:

fd324bd4-df6d-404c-ba55-d14cc40a3ce8

PMID: 36746944
EID:

2-s2.0-85147461210
Contributors: Georg Krainer; Kadi L Saar; William E Arter; Timothy J Welsh; Magdalena A Czekalska; Raphaël P B Jacquat; Quentin Peter; Walther C Traberg; Arvind Pujari; Akhila K Jayaram et al.
Source: check_circle
FIS TU Dresden

Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment

EMBO Journal
2022-12-27 | Journal article | Author
DOI: 10.15252/embj.2022111802
SOURCE-WORK-ID:

1d5ee6c4-28d5-4d92-aa94-c7c63a377849

EID:

2-s2.0-85144907561

PMID: 36574355
Contributors: Shanshan Xu; Maria E. Gierisch; Anna Katharina Schellhaus; Ina Poser; Simon Alberti; Florian A. Salomons; Nico P. Dantuma
Source: check_circle
FIS TU Dresden

Biomolecular condensate phase diagrams with a combinatorial microdroplet platform

Nature communications
2022-12-21 | Journal article | Author
DOI: 10.1038/s41467-022-35265-7
SOURCE-WORK-ID:

fad6ae50-690f-48dc-be21-b0c22113dff6

EID:

2-s2.0-85144492623

PMID: 36543777
Contributors: William E. Arter; Runzhang Qi; Nadia A. Erkamp; Georg Krainer; Kieran Didi; Timothy J. Welsh; Julia Acker; Jonathan Nixon-Abell; Seema Qamar; Jordina Guillén-Boixet et al.
Source: check_circle
FIS TU Dresden

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

Molecular cell
2022-10-06 | Journal article | Author
DOI: 10.1016/j.molcel.2022.08.031
SOURCE-WORK-ID:

37795d23-d823-447a-ad2b-f210efd57e2a

EID:

2-s2.0-85139011734

PMID: 36150385
WOSUID:

000898432000004
Contributors: Shovamayee Maharana; Stefanie Kretschmer; Susan Hunger; Xiao Yan; David Kuster; Sofia Traikov; Thomas Zillinger; Marc Gentzel; Shobha Elangovan; Padmanava Dasgupta et al.
Source: check_circle
FIS TU Dresden

CAPRIN1P512L causes aberrant protein aggregation and associates with early-onset ataxia

Cellular and Molecular Life Sciences
2022-09-22 | Journal article | Author
DOI: 10.1007/s00018-022-04544-3
SOURCE-WORK-ID:

ebb55803-3bbb-48b1-bc9c-7101f845a5bb

EID:

2-s2.0-85138460283

PMID: 36136249
Contributors: Andrea Delle Vedove; Janani Natarajan; Ginevra Zanni; Matthias Eckenweiler; Anixa Muiños-Bühl; Markus Storbeck; Jordina Guillén Boixet; Sabina Barresi; Simone Pizzi; Irmgard Hölker et al.
Source: check_circle
FIS TU Dresden

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions

Proceedings of the National Academy of Sciences of the United States of America : PNAS
2022-07-12 | Journal article | Author
DOI: 10.1073/pnas.2202222119
SOURCE-WORK-ID:

f659c865-9c00-4280-8387-3da4962fa3ba

EID:

2-s2.0-85133289528

PMID: 35787038
Contributors: Mrityunjoy Kar; Furqan Dar; Timothy J. Welsh; Laura T. Vogel; Ralf Kühnemuth; Anupa Majumdar; Georg Krainer; Titus M. Franzmann; Simon Alberti; Claus A.M. Seidel et al.
Source: check_circle
FIS TU Dresden

Correlative all-optical quantification of mass density and mechanics of sub-cellular compartments with fluorescence specificity

eLife
2022-01-10 | Journal article | Author
DOI: 10.7554/eLife.68490
SOURCE-WORK-ID:

b5f2e651-7751-48b2-ad48-f48be2fabf52

EID:

2-s2.0-85123678303

PMID: 35001870
WOSUID:

000758043100001
Contributors: Raimund Schlüßler; Kyoohyun Kim; Martin Nötzel; Anna Taubenberger; Shada Abuhattum; Timon Beck; Paul Müller; Shovamayee Maharana; Gheorghe Cojoc; Salvatore Girardo et al.
Source: check_circle
FIS TU Dresden

Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates

Nano letters
2022-01-10 | Journal article | Author
DOI: 10.1021/acs.nanolett.1c03138
SOURCE-WORK-ID:

e23cbf99-79c0-4bd4-b8a6-8f8a1554a3d8

PMID: 35001622
EID:

2-s2.0-85123385700

WOSUID:

000745242500001
Contributors: Timothy J Welsh; Georg Krainer; Jorge R Espinosa; Jerelle A Joseph; Akshay Sridhar; Marcus Jahnel; William E Arter; Kadi L Saar; Simon Alberti; Rosana Collepardo-Guevara et al.
Source: check_circle
FIS TU Dresden

Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy

Cancers
2021-11-01 | Journal article | Author
DOI: 10.3390/cancers13215549
SOURCE-WORK-ID:

8b44b823-682c-4e58-b637-f4ca2176b0b3

EID:

2-s2.0-85118508656
Contributors: Vaibhav Mahajan; Timon Beck; Paulina Gregorczyk; André Ruland; Simon Alberti; Jochen Guck; Carsten Werner; Raimund Schlüßler; Anna Taubenberger
Source: check_circle
FIS TU Dresden

Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila development.

Developmental cell
2021-10-12 | Journal article
DOI: 10.1016/j.devcel.2021.09.021
PMID: 34655524
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.

The Journal of biological chemistry
2021-09-24 | Journal article
DOI: 10.1016/j.jbc.2021.101050
PMID: 34571008
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain.

eLife
2021-09-06 | Journal article
DOI: 10.7554/elife.69377
PMID: 34487489
PMC: PMC8510580
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Ubiquitin protein helps cells to recover from stress.

Nature
2021-09-01 | Journal article
DOI: 10.1038/d41586-021-02197-z
PMID: 34400837
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Reciprocal regulation of cellular mechanics and metabolism (vol 3, pg 456, 2021)

Nature metabolism
2021-06 | Journal article | Author
DOI: 10.1038/s42255-021-00423-6
SOURCE-WORK-ID:

aae527a8-b21b-4cbe-b79d-8e9111fd05ea

WOSUID:

000660578600001

EID:

2-s2.0-85107592146
Contributors: Tom M. J. Evers; Liam J. Holt; Simon Alberti; Alireza Mashaghi
Source: check_circle
FIS TU Dresden

Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.

Cell death & disease
2021-05-06 | Journal article
DOI: 10.1038/s41419-021-03737-1
PMID: 33958580
PMC: PMC8102500
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Reciprocal regulation of cellular mechanics and metabolism.

Nature metabolism
2021-04-19 | Journal article
DOI: 10.1038/s42255-021-00384-w
PMID: 33875882
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling.

EMBO reports
2021-03-19 | Journal article
DOI: 10.15252/embr.202051740
PMID: 33738926
PMC: PMC8097338
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Protein products of nonstop mRNA disrupt nucleolar homeostasis.

Cell stress & chaperones
2021-02-22 | Journal article
DOI: 10.1007/s12192-021-01200-w
PMID: 33619693
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.

Nature communications
2021-02-17 | Journal article
DOI: 10.1038/s41467-021-21181-9
PMID: 33597515
PMC: PMC7889641
Source: Self-asserted source
Simon Alberti

Reentrant Liquid Condensate Phase of Proteins is Stabilized by Hydrophobic and Non-Ionic interactions

Biophysical journal
2021-02-12 | Other | Author
SOURCE-WORK-ID:

0221dd4c-55ff-47df-a572-a60083a0182b

WOSUID:

000629601400133
Contributors: Georg Krainer; Timothy J. Welsh; Jerelle A. Joseph; Peter St George-Hyslop; Anthony A. Hyman; Rosana Collepardo-Guevara; Simon Alberti; Tuomas P. J. Knowles
Source: check_circle
FIS TU Dresden

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing.

Nature reviews. Molecular cell biology
2021-01-28 | Journal article
DOI: 10.1038/s41580-020-00326-6
PMID: 33510441
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.

Autophagy
2021-01-01 | Journal article
DOI: 10.1080/15548627.2020.1797280
PMID: 33634751
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Protein phase separation and its role in tumorigenesis.

eLife
2020-11-03 | Journal article
DOI: 10.7554/elife.60264
PMID: 33138914
PMC: PMC7609067
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

The plant response to heat requires phase separation

Nature
2020-09-10 | Journal issue or edition | Author
SOURCE-WORK-ID:

a9a93483-c935-41bc-a684-ede703b56e06

WOSUID:

000566733500004

EID:

2-s2.0-85090508656
Contributors: Simon Alberti
Source: check_circle
FIS TU Dresden

The plant response to heat requires phase separation.

Nature
2020-09-01 | Journal article
DOI: 10.1038/d41586-020-02442-x
PMID: 32848237
Source: Self-asserted source
Simon Alberti

BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes.

Cell stress & chaperones
2020-07-21 | Journal article
DOI: 10.1007/s12192-020-01141-w
PMID: 32696179
PMC: PMC7591658
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.

Nature nanotechnology
2020-07-13 | Journal article
DOI: 10.1038/s41565-020-0731-4
PMID: 32661370
PMC: PMC7116851
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells.

Biology open
2020-07-08 | Journal article
DOI: 10.1242/bio.046391
PMID: 32554487
PMC: PMC7358136
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.

Molecular cell
2020-06-09 | Journal article
DOI: 10.1016/j.molcel.2020.05.017
PMID: 32521226
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production.

Cell
2020-04-30 | Journal article
DOI: 10.1016/j.cell.2020.04.009
PMID: 32359423
PMC: PMC7237889
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Reorganization of budding yeast cytoplasm upon energy depletion.

Molecular biology of the cell
2020-04-15 | Journal article
DOI: 10.1091/mbc.e20-02-0125
PMID: 32293990
PMC: PMC7353153
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.

Cell
2020-04-01 | Journal article
DOI: 10.1016/j.cell.2020.03.049
PMID: 32302572
PMC: PMC7181197
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo

Nature Communications
2019-12 | Journal article
DOI: 10.1038/s41467-019-10554-w
Part of ISSN: 2041-1723
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Liquid–Liquid Phase Separation in Disease

Annual Review of Genetics
2019-11-25 | Journal article
DOI: 10.1146/annurev-genet-112618-043527
Part of ISSN: 0066-4197
Part of ISSN: 1545-2948
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

MOLECULAR & CELLULAR ONCOLOGY
2019-11-02 | Journal article | Author
DOI: 10.1080/23723556.2019.1652519
SOURCE-WORK-ID:

53348982-08ad-4696-b6f3-8b692c655cf3

WOSUID:

000490592200001

EID:

2-s2.0-85071297645
Contributors: L. Mediani; J. Guillen-Boixet; Simon Alberti; S. Carra
Source: check_circle
FIS TU Dresden

Nucleolus: A Liquid Droplet Compartment for Misbehaving Proteins

Current Biology
2019-10 | Journal article
DOI: 10.1016/j.cub.2019.08.013
Part of ISSN: 0960-9822
Source: Self-asserted source
Simon Alberti
grade
Preferred source (of 2)‎
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