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Bioinformatics, Computational Biology, Genomics, Biostatistics, Cancer Research

Activities

Employment (3)

Medical University of Innsbruck: Innsbruck, AT

2010-04-01 to present | Assistant Professor (Biocenter, Institute of Bioinformatics)
Employment
Source: Self-asserted source
Hubert Hackl

Graz University of Technology: Graz, AT

2007-07-01 to 2010-03-31 | Assistant Professor (Institute for Genomics and Bioinformatics)
Employment
Source: Self-asserted source
Hubert Hackl

The Institute for Genomics Research (TIGR) now J Craig Venter Institute: Rockville, MD, US

2000-06 to 2001-05 | Visiting Scientist
Employment
Source: Self-asserted source
Hubert Hackl

Education and qualifications (2)

Graz University of Technology: Graz, AT

Dr. (Institute for Genomics and Bioinformatics)
Education
Source: Self-asserted source
Hubert Hackl

Medical University of Innsbruck: Innsbruck, AT

2017 | Venia Docendi in Bioinformatics (Habilitation)
Qualification
Source: Self-asserted source
Hubert Hackl

Funding (3)

PhD program MYCOS Antimycotic Resistance - Approach from a One Health Perspective (Immunomodulation by intratumoral mycobiome)

2024 to 2027 | Grant
MUI (Innsbruck, AT)
Source: Self-asserted source
Hubert Hackl

MicroRNAs as predictive biomarker for COVID-19 (Co-PI)

2021-07 to 2022-12 | Grant
Austrian Science Fund (Vienna, AT)
GRANT_NUMBER:

P 34783-B

Source: Self-asserted source
Hubert Hackl

Connection of DNA damage and repair with the immunome in high grade serous ovarian cancer

2020-02 to 2022-01 | Grant
Austrian National Bank (OeNB) (Vienna, AT)
GRANT_NUMBER:

#18279

Source: Self-asserted source
Hubert Hackl

Works (50 of 160)

Items per page:
Page 1 of 4

Machine learning to dissect perturbations in complex cellular systems

Computational and Structural Biotechnology Journal
2025 | Journal article
Contributors: Pablo Monfort-Lanzas; Katja Rungger; Leonie Madersbacher; Hubert Hackl
Source: check_circle
Crossref

Differences in immunogenicity of TP53-mutated cancers with low tumor mutational burden (TMB) A study on TP53mut endometrial-, ovarian- and triple-negative breast cancer

European Journal of Cancer
2025-03 | Journal article
Part of ISSN: 0959-8049
Contributors: Katharina Steger; Heidelinde Fiegl; Barin Feroz; Katharina Leitner; Christian Marth; Hubert Hackl; Alain G. Zeimet
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

Myrobalan Fruit Extracts Modulate Immunobiochemical Pathways In Vitro

Antioxidants
2025-03-17 | Journal article
Contributors: Stefanie Hofer; Marcel Jenny; Angela Klein; Kathrin Becker; Lucia Parráková; Florian Überall; Markus Ganzera; Dietmar Fuchs; Hubert Hackl; Pablo Monfort-Lanzas et al.
Source: check_circle
Crossref
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Surgical and oncologic outcomes for liver resections of cystic neuroendocrine tumor liver metastasis

European Journal of Surgical Oncology
2025-01 | Journal article
Contributors: Markus Ammann; Stella K. Adjei Antwi; Hallbera Gudmundsdottir; Hubert Hackl; Jonas Santol; Benedetto E. Guillot; Giulia Pappalettera; Cornelius A. Thiels; Susanne G. Warner; Mark J. Truty et al.
Source: check_circle
Crossref

Application of artificial intelligence in immuno-oncology

Reference Module in Biomedical Sciences
2024 | Book chapter
Part of ISBN: 9780128012383
Contributors: Pablo Monfort-Lanzas; Raphael Gronauer; Melanie Balaz; Gabriel Floriani; Hubert Hackl
Source: Self-asserted source
Hubert Hackl

Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols

Journal of Lipid Research
2024-12 | Journal article
Contributors: Johannes Breithofer; Dominik Bulfon; Nermeen Fawzy; Martin Tischitz; Clara Zitta; Lennart Hartig; Gernot F. Grabner; Anita Pirchheim; Hubert Hackl; Ulrike Taschler et al.
Source: check_circle
Crossref

Reply to: Comparison of the LiMAx test vs. the APRI+ALBI score – Incorrect comparison parameters lead to questionable results

European Journal of Surgical Oncology
2024-12 | Journal article
Contributors: Jonas Santol; Markus Ammann; Tim Reese; Felix Oldhafer; Yawen Dong; Moritz Schmelzle; Karl J. Oldhafer; Hubert Hackl; Thomas Gruenberger; Patrick Starlinger
Source: check_circle
Crossref

Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours.

Nature
2024-12-11 | Journal article | Author
Contributors: Ignacio Melero; de Miguel Luken M; de Velasco G; Elena GARRALDA; Martín-Liberal J; Joerger M; Alonso G; Goebeler ME; Martin Schuler; König D et al.
Source: Self-asserted source
Hubert Hackl

Inhibition of the Sterol Regulatory Element Binding Protein SREBF-1 Overcomes Docetaxel Resistance in Advanced Prostate Cancer

The American Journal of Pathology
2024-11 | Journal article
Contributors: Maximilian P. Brandt; Olesya Vakhrusheva; Hubert Hackl; Tamas Daher; Katrin Tagscherer; Wilfried Roth; Igor Tsaur; Florian Handle; Andrea Eigentler; Zoran Culig et al.
Source: check_circle
Crossref

Integrated immunogenomic analyses of high-grade serous ovarian cancer reveal vulnerability to combination immunotherapy.

Frontiers in immunology
2024-11-28 | Journal article
Contributors: Gronauer R; Madersbacher L; Monfort-Lanzas P; Floriani G; Sprung S; Zeimet AG; Marth C; Fiegl H; Hackl H
Source: Self-asserted source
Hubert Hackl

Soluble PD-L1 shows no association to relapse and overall survival in early stage non-small cell lung cancer (NSCLC)

Lung Cancer
2024-10 | Journal article
Part of ISSN: 0169-5002
Contributors: F.O. Mildner; Martina Sykora; H. Hackl; A. Amann; B. Zelger; S. Sprung; M.L. Buch; Fabienne Isabelle Nocera; Patrizia Moser; Herbert Maier et al.
Source: Self-asserted source
Hubert Hackl

Transcriptomic signatures during normothermic liver machine perfusion correspond with graft quality and predict the early graft function

eBioMedicine
2024-10 | Journal article
Contributors: Theresa Hautz; Hubert Hackl; Hendrik Gottschling; Raphael Gronauer; Julia Hofmann; Stefan Salcher; Bettina Zelger; Rupert Oberhuber; Benno Cardini; Annemarie Weissenbacher et al.
Source: check_circle
Crossref

SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy

International Journal of Molecular Sciences
2024-10-04 | Journal article
Contributors: Ulrike Resch; Hubert Hackl; David Pereyra; Jonas Santol; Laura Brunnthaler; Joel Probst; Anna Sofie Jankoschek; Monika Aiad; Hendrik Nolte; Marcus Krueger et al.
Source: check_circle
Crossref
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SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy

2024-08-30 | Preprint
Contributors: Ulrike Resch; Hubert Hackl; David Pereyra; Jonas Santol; Laura Brunnthaler; Joel Probst; Anna Sofie Jankoschek; Monika Aiad; Hendrik Nolte; Marcus Krueger et al.
Source: check_circle
Crossref
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Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model

Cardiovascular Diabetology
2024-08-14 | Journal article
Part of ISSN: 1475-2840
Contributors: Melina Amor; Malena Diaz; Valentina Bianco; Monika Svecla; Birgit Schwarz; Silvia Rainer; Anita Pirchheim; Laszlo Schooltink; Suravi Mukherjee; Gernot F. Grabner et al.
Source: Self-asserted source
Hubert Hackl

Association of immune evasion in myeloid sarcomas with disease manifestation and patients’ survival

Frontiers in Immunology
2024-08-07 | Journal article
Part of ISSN: 1664-3224
Contributors: Marcus Bauer; Astrid Monecke; Hubert Hackl; Andreas Wilfer; Nadja Jaekel; Hendrik Bläker; Haifa Kathrin Al-Ali; Barbara Seliger; Claudia Wickenhauser
Source: Self-asserted source
Hubert Hackl

Tumoral programmed cell death 1 (PD1) expression in endometrial carcinoma is a prognostic marker for patient outcome

International Journal of Gynecologic Cancer
2024-07-05 | Journal article
Part of ISSN: 1525-1438
Contributors: Barin Feroz; Teresa L. Pan; Katharina Leitner; Christoph Ebner; Katharina Steger; Wanja Kildal; Gunnar Kristensen; Alain Gustave Zeimet; Hubert Hackl; Heidi Fiegl et al.
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

HMGB1-Mediated Cell Death—A Crucial Element in Post-Hepatectomy Liver Failure

International Journal of Molecular Sciences
2024-06 | Journal article | Author
Contributors: Laura Brunnthaler; Thomas Hammond; David Pereyra; Jonas Santol; Joel Probst; Valerie Laferl; Ulrike Resch; Monika Aiad; Anna Sofie Janoschek; Thomas Gruenberger et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

ExonSurfer: a web-tool to design primers at exon–exon junctions

BMC Genomics
2024-06-12 | Journal article
Part of ISSN: 1471-2164
Contributors: Pablo Monfort-Lanzas; Elena Cristina Rusu; Lucia Parrakova; Cornelia A. Karg; Dorina-Elina Kernbichler; Dietmar Rieder; Peter Lackner; Hubert Hackl; Johanna M. Gostner
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

ASO Visual Abstract: Neuroendocrine Tumors of Unknown Primary in the Setting of Cytoreductive Hepatectomy

Annals of Surgical Oncology
2024-05-29 | Journal article
Part of ISSN: 1534-4681
Contributors: Markus Ammann; Hallbera Gudmundsdottir; Hubert Hackl; Stella K. Adjei Antwi; Jonas Santol; Elizabeth B. Habermann; Cornelius A. Thiels; Susanne G. Warner; Mark J. Truty; Michael L. Kendrick et al.
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

CD8+ T-cell Differentiation and Dysfunction Inform Treatment Response in Acute Myeloid Leukemia

Blood Journal
2024-05-22 | Journal article
Contributors: Francesco Mazziotta; Luca Biavati; Joseph Cataquiz Rimando; Sergio Rutella; Nicholas Borcherding; Sonali Parbhoo; Rupkatha Mukhopadhyay; Hanna A. Knaus; Peter Valent; Hubert Hackl et al.
Source: check_circle
Crossref

Neuroendocrine Tumors of Unknown Primary in the Setting of Cytoreductive Hepatectomy

Annals of Surgical Oncology
2024-05-08 | Journal article
Part of ISSN: 1534-4681
Contributors: Markus Ammann; Hallbera Gudmundsdottir; Hubert Hackl; Stella K. Adjei Antwi; Jonas Santol; Elizabeth B. Habermann; Cornelius A. Thiels; Susanne G. Warner; Mark J. Truty; Michael L. Kendrick et al.
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

Neutralizing GDF-15 can overcome anti-PD-(L)1 resistance in late-stage cancer

2024-03-07 | Preprint | Author
Contributors: Ignacio Melero; María de Miguel Luken; Guillermo de Velasco; Elena GARRALDA; Juan Martin Liberal; Markus Joerger; Guzman Alonso; Maria-Elizabeth Goebeler; Martin Schuler; David König et al.
Source: Self-asserted source
Hubert Hackl

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Oncogene
2024-01-19 | Journal article
Contributors: Andrea Eigentler; Florian Handle; Silvia Schanung; Antonia Degen; Hubert Hackl; Holger H. H. Erb; Georgios Fotakis; Julia Hoefer; Christian Ploner; Karin Jöhrer et al.
Source: check_circle
Crossref

Integrated immunogenomic analyses of high-grade serous ovarian cancer reveal vulnerability to combination immunotherapy

2024-01-10 | Preprint
Contributors: Raphael Gronauer; Leonie Madersbacher; Pablo Monfort-Lanzas; Gabriel Floriani; Susanne Sprung; Alain Gustave Zeimet; Christian Marth; Heidelinde Fiegl; Hubert Hackl
Source: check_circle
Crossref
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Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC.

Oncoimmunology
2023-11-28 | Journal article | Author
Contributors: Koeck S; Amann A; Kern J; Zwierzina M; Lorenz E; Sopper S; Zwierzina H; Mildner F; Sykora M; Sprung S et al.
Source: Self-asserted source
Hubert Hackl

An APRI+ALBI Based Multivariable Model as Preoperative Predictor for Posthepatectomy Liver Failure.

Annals of surgery
2023-10-20 | Journal article
Contributors: Santol J; Kim S; Gregory LA; Baumgartner R; Murtha-Lemekhova A; Birgin E; Gloor S; Braunwarth E; Ammann M; Starlinger J et al.
Source: Self-asserted source
Hubert Hackl

Age-Dependent Surface Receptor Expression Patterns in Immature Versus Mature Platelets in Mouse Models of Regenerative Thrombocytopenia

Cells
2023-10-08 | Journal article
Contributors: Anita Pirabe; Sabine Frühwirth; Laura Brunnthaler; Hubert Hackl; Anna Schmuckenschlager; Waltraud C. Schrottmaier; Alice Assinger
Source: check_circle
Crossref

Intravesical BCG in bladder cancer induces innate immune responses against SARS-CoV-2

Frontiers in Immunology
2023-07 | Journal article
Part of ISSN: 1664-3224
Contributors: Renate Pichler; Gabriel Diem; Hubert Hackl; Jiří Koutník; Laura S. Mertens; David D`Andrea; Benjamin Pradere; Francesco Soria; Andrea Mari; Ekaterina Laukhtina et al.
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment.

Nature communications
2023-07-20 | Journal article | Author
Contributors: Markus Haake; Haack B; Schäfer T; Harter PN; Mattavelli G; Eiring P; Vashist N; Wedekink F; Genssler S; Fischer B et al.
Source: Self-asserted source
Hubert Hackl

Transcriptomic landscapes of effective and failed liver regeneration in humans

JHEP Reports
2023-04 | Journal article
Contributors: Patrick Starlinger; Laura Brunnthaler; Chantal McCabe; David Pereyra; Jonas Santol; Jessica Steadman; Matthias Hackl; Susanna Skalicky; Hubert Hackl; Raphael Gronauer et al.
Source: check_circle
Crossref

Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification.

Circulation
2023-04-04 | Journal article | Author
Contributors: Can Gollmann-Tepeköylü; Michael Graber; Jakob Hirsch; Mair S; Naschberger A; Leo Poelzl; Leo Pölzl; Nägele F; Kirchmair E; Gerald Degenhart et al.
Source: Self-asserted source
Hubert Hackl

An angiogenic tumor phenotype predicts poor prognosis in ovarian cancer.

Gynecologic oncology
2023-02 | Journal article
Contributors: Wieser V; Tsibulak I; Reimer DU; Zeimet AG; Fiegl H; Hackl H; Marth C
Source: Self-asserted source
Hubert Hackl via Europe PubMed Central

Prediction and validation of murine MHC class I epitopes of the recombinant virus VSV-GP

Frontiers in Immunology
2023-01 | Journal article
Part of ISSN: 1664-3224
Contributors: Saskia V. Vijver; Sarah Danklmaier; Lisa Pipperger; Raphael Gronauer; Gabriel Floriani; Hubert Hackl; Krishna Das; Guido Wollmann
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

Hepatocellular carcinoma as predominant cancer subgroup accounting for sex differences in post-hepatectomy liver failure, morbidity and mortality

HPB
2022-09 | Journal article
Contributors: Gabriel De la Cruz Ku; Matthew Aizpuru; Hubert Hackl; Daniel S. Ubl; Elizabeth B. Habermann; Ron Pery; Michael Driedger; Alice Assinger; David M. Nagorney; Sean P. Cleary et al.
Source: check_circle
Crossref

MIO: microRNA target analysis system for immuno-oncology.

Bioinformatics (Oxford, England)
2022-07 | Journal article
Contributors: Monfort-Lanzas P; Gronauer R; Madersbacher L; Schatz C; Rieder D; Hackl H
Source: Self-asserted source
Hubert Hackl via Europe PubMed Central
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Platelets and Antiplatelet Medication in COVID-19-Related Thrombotic Complications

Frontiers in Cardiovascular Medicine
2022-01-24 | Journal article
Part of ISSN: 2297-055X
Source: Self-asserted source
Hubert Hackl

CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.

Journal for immunotherapy of cancer
2022-01-16 | Journal article
Source: Self-asserted source
Hubert Hackl

The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents

Cell Death & Disease
2021-12-13 | Journal article
Contributors: Gerlinde Karbon; Manuel D. Haschka; Hubert Hackl; Claudia Soratroi; Lourdes Rocamora-Reverte; Walther Parson; Heidelinde Fiegl; Andreas Villunger
Source: check_circle
Crossref

Adverse Outcome in COVID-19 Is Associated With an Aggravating Hypo-Responsive Platelet Phenotype.

Frontiers in cardiovascular medicine
2021-12-10 | Journal article
Source: Self-asserted source
Hubert Hackl

Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

mBio
2021-10 | Journal article
Part of ISSN: 2150-7511
Contributors: Wilfried Posch; Marta Bermejo-Jambrina; Marion Steger; Christina Witting; Gabriel Diem; Paul Hörtnagl; Hubert Hackl; Cornelia Lass-Flörl; Lukas A. Huber; Teunis B. H. Geijtenbeek et al.
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

Early postoperative arterial lactate concentrations to stratify risk of post-hepatectomy liver failure

British Journal of Surgery
2021-10 | Journal article
Part of ISSN: 0007-1323
Contributors: Thomas Niederwieser; Eva Braunwarth; Bobby V M Dasari; Kamil Pufal; Peter Szatmary; Hubert Hackl; Clemens Haselmann; Catherine E Connolly; Benno Cardini; Dietmar Öfner et al.
Source: Self-asserted source
Hubert Hackl via Crossref Metadata Search

Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness

Leukemia
2021-10-29 | Journal article
Contributors: Alexander Michael Grandits; Chi Huu Nguyen; Angela Schlerka; Hubert Hackl; Heinz Sill; Julia Etzler; Elizabeth Heyes; Dagmar Stoiber; Florian Grebien; Gerwin Heller et al.
Source: check_circle
Crossref

Expression of MICA in Zero Hour Biopsies Predicts Graft Survival After Liver Transplantation

Frontiers in Immunology
2021-07-20 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Hubert Hackl

Circulating metabolites as a concept beyond tumor biology determining disease recurrence after resection of colorectal liver metastasis

HPB
2021-06 | Journal article
Part of ISSN: 1365-182X
Source: Self-asserted source
Hubert Hackl

Targeting the glucocorticoid receptor signature gene Mono Amine Oxidase-A enhances the efficacy of chemo- and anti-androgen therapy in advanced prostate cancer

Oncogene
2021-04-29 | Journal article
Contributors: Martin Puhr; Andrea Eigentler; Florian Handle; Hubert Hackl; Christian Ploner; Isabel Heidegger; Georg Schaefer; Maximilian P. Brandt; Julia Hoefer; Gabri Van der Pluijm et al.
Source: check_circle
Crossref

The Addition of C-Reactive Protein and von Willebrand Factor to MELD-Na Improves Prediction of Waitlist Mortality.

Hepatology (Baltimore, Md.)
2021-03-31 | Journal article
Source: Self-asserted source
Hubert Hackl

Initial Evidence of Distinguishable Bacterial and Fungal Dysbiosis in the Skin of Patients with Atopic Dermatitis or Netherton Syndrome

Journal of Investigative Dermatology
2021-01 | Journal article
Contributors: Verena Moosbrugger-Martinz; Hubert Hackl; Robert Gruber; Matthias Pilecky; Ludwig Knabl; Dorothea Orth-Höller; Sandrine Dubrac
Source: check_circle
Crossref

Combined APRI/ALBI score to predict mortality after hepatic resection

BJS Open
2021-01-08 | Journal article
Contributors: P Starlinger; D S Ubl; H Hackl; J Starlinger; D M Nagorney; R L Smoot; E B Habermann; S P Cleary
Source: check_circle
Crossref

The miR-34 family and its clinical significance in ovarian cancer

Journal of Cancer
2020 | Journal article
Part of ISSN: 1837-9664
Source: Self-asserted source
Hubert Hackl
Items per page:
Page 1 of 4

Peer review (59 reviews for 21 publications/grants)

Review activity for BMC genomics (17)
Review activity for Cancers. (5)
Review activity for Cells. (1)
Review activity for Communications biology. (1)
Review activity for Computational and Structural Biotechnology Journal (1)
Review activity for European journal of biochemistry. (6)
Review activity for FEBS letters. (2)
Review activity for Genome medicine. (1)
Review activity for Human vaccines & immunotherapeutics. (2)
Review activity for International journal of cancer. (1)
Review activity for International journal of molecular sciences. (2)
Review activity for Journal for immunotherapy of cancer. (3)
Review activity for Journal of personalized medicine. (1)
Review activity for Journal of the National Cancer Institute (1)
Review activity for Journal of the National Cancer Institute : (1)
Review activity for Journal of translational medicine. (1)
Review activity for NAR genomics and bioinformatics. (2)
Review activity for Nature communications (1)
Review activity for Nature immunology. (1)
Review activity for Oncoimmunology. (5)
Review activity for PLoS computational biology. (4)