Personal information

Websites & social links

Linkedinn
Research Gate

Other IDs

SciProfiles: 1885637
ResearcherID: W-4977-2019

Keywords

Cancer, Signal Transduction, Drug Discovery, Oxidative Stress, Spatial Multi-Omics, Multi-Omics, Biochemistry, Bioinformatics, Immunology, Biomarker, Cancer Microenvironment, Immunometabolism

Countries

United States

Biography

Currently, Dr. Ain is working as a postdoctoral scholar at the Department of Pathology, University of California, San Francisco, USA. Where she is spatially characterizing the tumor microenvironment using NanoString's GeoMax Digital Spatial Profiling (DSP) Technology. In addition, she developed a human esophageal organoid model and optimized an organotypic air-liquid interface (ALI) model system and genetically modifying them through CRISPR-CAS technology.

As a part of CRUK-GC-Stroming Cancer Team at the University of California, San Francisco, she utilized single-cell RNA sequencing (scRNA-seq) and gene expression analysis to determine the effects of chronic and acute bile acid (BA) exposure on the transcriptional reprogramming of fibroblasts, leading to the production of pro-inflammatory cytokines.

Dr. Ain has been served as an Assistant Professor of Biochemistry/Pharmaceutical Chemistry at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy Hamdard University, Karachi, Pakistan and as a Visiting Assistant Professor of Molecular Biology/Genetics at the Department of Physical Therapy, Faculty of Health & Medicine, Hamdard University, Karachi, Pakistan.

Dr. Ain received a Ph. D. in Molecular Medicine from Dr. Panjwni Center for Molecular Medicine & Drug Research, International Center for Chemical & Biological Sciences, University of Karachi, Pakistan in Collaboration with Department of Dermatology & Allergic Disease University of Ulm Germany.

Dr. Ain Ph.D. research was focus on the investigation of the role of deregulated oxidative stress and kinase dependent signal transduction pathways and their related genes involved in the multiple types of cancers initiation and progression with the goal of discovery and development of new anticancer therapeutics.

She also has a background in neurological, metabolic and cardiovascular diseases, most particularly understanding the molecular pathways of Parkinson’s, Type-II diabetes and cardiovascular diseases, she worked for the identification of new therapeutic targets, biomarkers, and development of relative therapeutics.

Activities

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Employment (5)

University of California, San Francisco: San Francisco, California, US

2022-02-01 to 2026-01-01 | Postdoctoral Scholar (Pathology)
Employment
Source: Self-asserted source
QURAT UL AIN

Hamdard University: Karachi, Sindh, PK

2021-11-01 to 2022-01-30 | Visiting Assistant Professor (Department of Physical Therapy, Faculty of Health & Medicine)
Employment
Source: Self-asserted source
QURAT UL AIN

Hamdard University Faculty of Pharmacy: Karachi, Sindh, PK

2020-01-26 to 2022-01-03 | Assistant Professor (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
Employment
Source: Self-asserted source
QURAT UL AIN

International Center for Chemical and Biological Sciences: Karachi, PK

2009-03-01 to 2010-04-30 | Research Officer (Neurosciences Laboratory, Dr. Panjwni Center for Molecular Medicine and Drug Research)
Employment
Source: Self-asserted source
QURAT UL AIN

International Center for Chemical and Biological Sciences: Karachi, Sindh, PK

2008-04-01 to 2009-03-30 | Research Officer (Molecular and Cardiovascular Pharmacology Laboratory, Dr. Panjwni Center for Molecular Medicine and Drug Research)
Employment
Source: Self-asserted source
QURAT UL AIN

Education and qualifications (4)

International Center for Chemical and Biological Sciences: Karachi, Sindh, PK

2016-03-10 to 2019-04-18 | Ph. D. (Dr. Panjwni Center for Molecular Medicine and Drug Research)
Education
Source: Self-asserted source
QURAT UL AIN

University of Ulm: Ulm, Baden-Württemberg, DE

2017-04-04 to 2017-10-30 | Collaborative Ph.D. Student (Department of Dermatology and Allergic Diseases)
Qualification
Source: Self-asserted source
QURAT UL AIN

International Center for Chemical and Biological Sciences: Karachi, Sindh, PK

2010-10-01 to 2016-10-31 | M.Phil (Dr. Panjwni Center for Molecular Medicine &Drug Research)
Education
Source: Self-asserted source
QURAT UL AIN

University of Karachi : Karachi, Sindh, PK

1999-11-03 to 2007-06-28 | Bachelors/ B. Pharmacy ( Faculty of Pharmacy)
Education
Source: Self-asserted source
QURAT UL AIN

Professional activities (11)

American Association for Cancer Research: Philadelphia, Philadelphia, US

2023-04 to present
Membership
Source: Self-asserted source
QURAT UL AIN

PLOS ONE.: San Francisco, California, US

2022-03-12 to present | Reviewer
Service
Source: Self-asserted source
QURAT UL AIN

Journal of the Chemical Society of Pakistan: Karachi, Sindh, PK

2020-09-20 to present
Service
Source: Self-asserted source
QURAT UL AIN

University of Karachi International Center for Chemical and Biological Sciences: Karachi, Sindh, PK

2019-11 to present | Invited speaker (7th International Symposium Cum Training Course on Molecular Medicine and Drug Research organized by Dr. Panjwni Center for Molecular Medicine and Drug Research.)
Invited position
Source: Self-asserted source
QURAT UL AIN

University of Ulm: Ulm, Baden Wuttemberg, DE

2016-09-21 to present | Invited Speaker to delivered presentation (Department of Dermatology and Allergic Diseases)
Invited position
Source: Self-asserted source
QURAT UL AIN

National Technical University of Athens: Athens, Attiki, GR

2016-09-04 to present | Invited Speaker (7th International Conference on Oxidative Stress in Skin Medicine and Biology organized by School of Pharmacy, Div. of Pharmaceutical Technology, Panepistimiopolis, 157 71, Athens,)
Invited position
Source: Self-asserted source
QURAT UL AIN

Society of Free Radical Research Europe: Valencia, Valencia, ES

2016-12-19 to 2031-12-31 | Individual
Membership
Source: Self-asserted source
QURAT UL AIN

International Union of Biochemistry and Molecular Biology: Calgary, AB, CA

2017-05-31 to 2031-12-19 | Individual
Membership
Source: Self-asserted source
QURAT UL AIN

International Union of Biochemistry and Molecular Biology: Calgary, AB, CA

2018-07-19 to 2029-09-17 | Reviewer (Journal of IUBMB Life)
Service
Source: Self-asserted source
QURAT UL AIN

Elsevier Ltd: London, London, GB

2019-01-21 to 2028-12-22 | Reviewer (Journal of Bioorganic Chemistry)
Service
Source: Self-asserted source
QURAT UL AIN

International Union of Biochemistry and Molecular Biology: Calgary, AB, CA

2018-06-16 to 2028-10-19 | Reviewer (Bio Factors Journal)
Service
Source: Self-asserted source
QURAT UL AIN

Funding (12)

Modulation of Melanoma Cell Proliferation and Spreading by Novel Small Molecular Weight Antioxidants

2018-06 to 2018-06 | Award
SFRR-Europe and OCC (Berlin, DE)
Source: Self-asserted source
QURAT UL AIN

DFG Research Grant

2017-08 to 2017-08 | Grant
Deutsche Forschungsgemeinschaft ( Ulm, Baden-Württemberg, DE)
Source: Self-asserted source
QURAT UL AIN

Modulation of Melanoma Cell Proliferation by Small Molecular Weight Antioxidants

2017-04 to 2017-07 | Grant
International Union of Biochemistry and Molecular Biology (Melbourne, Victoria, AU)
Source: Self-asserted source
QURAT UL AIN

Antioxidant and Cytotoxic Activities of New Classes of Synthetic Compounds

2016-09 to 2016-09 | Award
Pakistan Science Foundation (Islamabad, Punjab, PK)
Source: Self-asserted source
QURAT UL AIN

Study of the Effects of Antioxidant on Oxidative Stress in Molecular and Cellular Models

2016-03 to 2016-08 | Grant
Prof. Dr. Salimuzzaman Siddiqui Scholarship (Karachi, Sindh, PK)
Source: Self-asserted source
QURAT UL AIN

Study of the Effect of Antioxidants on Oxidative Stress in Molecular and Cellular Models

2016-02 to 2016-04 | Salary award
H.E.J Research Institute of Chemistry (Karachi, Sindh, PK)
Source: Self-asserted source
QURAT UL AIN

Study of the Effects of Antioxidant on Oxidative Stress in Molecular and Cellular Models

2010-04 to 2014-03 | Grant
Higher Education Commission, Pakistan (Islamabad, Panjab, PK)
Source: Self-asserted source
QURAT UL AIN

Assessing effect of bile acid exposure on fibroblasts through single cell RNA sequencing (scRNA-seq) & gene expression analysis

Grant
Cancer Research UK (London, GB)
Source: Self-asserted source
QURAT UL AIN

Developing in vitro 3D Model Systems for Functional Studies Interrogating the Role of Chronic Bile Acid Exposure (Reflux) and Fibroblasts in the Progression Process

Grant
Cancer Research UK (London, GB)
Source: Self-asserted source
QURAT UL AIN

Development of a combined genomic & inflammatory driven Murine Model of Barrett’s Esophagus to determining contribution of neutrophils in metaplasia progression

Grant
Prevent Cancer Foundation (Alexandria, Virginia, US)
Source: Self-asserted source
QURAT UL AIN

Optimization & genetic modification of an organotypic air liquid interface (ALI) model system through CRISPER-CAS technology

Grant
Cancer Research UK (London, GB)
Source: Self-asserted source
QURAT UL AIN

Spatial transcriptomic & spatial proteomics characterization of the inflammatory landscape of formalin fixed paraffin embedded non dysplastic Barrett’s esophagus tissues through GeoMX Digital Spatial Profiling Technology

Grant
American Association For Cancer Research (Philadelphia, Pennsylvania, US)
Source: Self-asserted source
QURAT UL AIN

Works (25)

Refining definitions of Barrett’s oesophagus to improve clinical resource utilisation

Gut
2024-05 | Journal article
DOI: 10.1136/gutjnl-2023-331458
Contributors: Matthew D Stachler; Qurat Ul Ain
Source: check_circle
Crossref

Abstract 6853: Spatial proteomic and transcriptomic characterization of the inflammatory landscape of formalin fixed paraffin embedded Barrett’s esophagus tissues

Cancer Research
2024-03-22 | Journal article
DOI: 10.1158/1538-7445.am2024-6853
Part of ISSN: 1538-7445
Contributors: Qurat ul Ain; Nicola Frei; Amir M. Khoshiwal; Pim Stougie; Robert Odze; Sophie Camilleri-Broet; Lorenzo Ferri; Lucas C. Duits; Jacques Bergman; Matthew D. Stachler
Source: Self-asserted source
QURAT UL AIN

Feasibility Study Utilizing NanoString’s Digital Spatial Profiling (DSP) Technology for Characterizing the Immune Microenvironment in Barrett’s Esophagus Formalin-Fixed Paraffin-Embedded Tissues

Cancers
2023-12-18 | Journal article
DOI: 10.3390/cancers15245895
Contributors: Qurat-ul-Ain; Nicola F. Frei; Amir M. Khoshiwal; Pim Stougie; Robert Odze; Sophie Camilleri-Broet; Lorenzo Ferri; Lucas C. Duits; Jacques Bergman; Matthew D. Stachler
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Benzophenone Semicarbazones as Potential alpha-glucosidase and Prolyl Endopeptidase Inhibitor: In-vitro free radical scavenging, enzyme inhibition, mechanistic, and molecular docking studies

Molecules
2023-12-10 | Preprint
DOI: 10.48550/ARXIV.2310.00947
Contributors: Qurat-ul-Ain Sidra Rafi; ; ; Arshia Arshia; Reaz Uddin; ; Khalid Mohammed Khan; M. Iqbal Choudhary; QURAT UL AIN
Source: Self-asserted source
QURAT UL AIN

Feasibility Study Utilizing NanoString’s Digital Spatial Profiling (DSP) Technology for Characterizing the Immune Microenvironment in Barrett’s Esophagus FFPE Tissues

2023-11-02 | Preprint
DOI: 10.1101/2023.11.02.565001
Contributors: Qurat-ul Ain; Nicola Frei; Amir M Khoshiwal; Pim Stougie; Robert Odze; Lorenzo Ferri; Lucas C Duits; Jacques Bergman; Matthew D Stachler
Source: Self-asserted source
QURAT UL AIN

Estimation of In-Vitro Free Radical Scavenging and Cytotoxic Activities of Thiocarbohydrazones Derivatives

2023-10-03 | Preprint
DOI: 10.48550/ARXIV.2310.00939
Contributors: ; Munira Taj Muhammad Khalid Mohammed Khan; M. Iqbal Choudhary
Source: Self-asserted source
QURAT UL AIN

1,1-Diphenyl-2-picrylhydrazyl and superoxide anion radical scavenging 1 activities of heterocyclic 2-oxo-1,2,3,4-tetrahydropyrimidines

2023-09-30 | Preprint
DOI: 10.48550/ARXIV.2310.10063
Contributors: Shahida Perveen; ; Sarosh Iqbal; Sheeba Wajid; Khalid Muhammad khan; Muhammad Iqbal Choudhary
Source: Self-asserted source
QURAT UL AIN

“IUBMB Wood Whelan Scholarship: A Prestigious Opportunity Worth Exploring”

IUBMB NEWS LETTER
2023-06-15 | Newspaper article
Contributors: QURAT UL AIN
Source: Self-asserted source
QURAT UL AIN

Dissecting Immune-Inflammatory Microenvironment in the Barrett’s Esophagus to Esophageal Adenocarcinoma Transition: A Nanostring GeoMx Pilot Study

“Think Tank on Advancing Gastroesophageal Cancer Research, Boston, Massachusetts, U.S.A
2022-11-05 | Lecture
Contributors: QURAT UL AIN
Source: Self-asserted source
QURAT UL AIN

3, 3′- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFRY1086 Phosphorylation

Molecules
2022-02-09 | Journal article | Author
DOI: 10.3390/molecules27041172
Part of ISSN: 1420-3049
Contributors: QURAT UL AIN; Abhijit Basu; M. Iqbal Choudhary; Karin Scharffetter-Kochanek
Source: Self-asserted source
QURAT UL AIN

“3, 5-DCPBC: A magic bullet for melanoma therapy.

Annual Virtual Meeting SFRR-E: Redox Biology in the 21st Century: A New Scientific Discipline
2021-06-18 | Lecture
OTHER-ID: https://www.sfrre2021belgrade.rs/wp-content/uploads/2021/06/2021_SFRRE_abstracts.pdf
Source: Self-asserted source
QURAT UL AIN

In Silico and In Vitro Analysis of a Novel Bis- coumarin Derivative Induced Anti -melanoma Effect: Suppression of the Phosphorylation of Epidermal Growth Factor Receptor (EGFR) and Proto-oncogene Cellular Sarcoma (c-SRC) Related Downstream Pathways”

Hünfeld 2021: Workshop on Computer Simulation and Theory of Macromolecules
2021-04-24 | Lecture
OTHER-ID: https://www.mpibpc.mpg.de/17764697/2021-Posters-Huenfeld-theory-Workshop_V5.pdf
Source: Self-asserted source
QURAT UL AIN

Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines

Cancer therapy & Oncology International Journal
2020-06-12 | Journal article
DOI: 10.19080/CTOIJ.2020.16.555940
Part of ARXIV: https://arxiv.org/ftp/arxiv/papers/2003/2003.04536.pdf
Source: Self-asserted source
QURAT UL AIN

Antioxidant Approach to Cancer Therapy: A Review of Evidence Based Clinical and Experimental Studies

arXiv/Evidence-Based Complementary and Alternative Medicine
2020-03-06 | Review
ARXIV: arXiv:2003.04538
Source: Self-asserted source
QURAT UL AIN

Metastatic melanoma-A review of current and future perspective

arXiv
2020-03-03 | Review
ARXIV: arXiv:2003.04537
Source: Self-asserted source
QURAT UL AIN

Discovery of a Novel Bis-Coumarin Derivative as an Emerging Anti-Melanoma Anti-Metastatic Agent

Free Radical Biology & Medicine
2019-08-26 | Conference abstract
Contributors: QURAT UL AIN
Source: Self-asserted source
QURAT UL AIN

Study of the Effect of Antioxidant on Oxidative Stress in Molecular and Cellular Models

2019-06-11 | Dissertation or Thesis
OTHER-ID: http://173.208.131.244:9060/xmlui/handle/123456789/4499
Source: Self-asserted source
QURAT UL AIN

Synthetic 4,4′-{(Arylmethylene)}<i>bis</i>(1<i>H</i>-pyrazol-5-ols): Efficient Radical Scavenger

Journal of Chemical Society of Pakistan
2018 | Journal article
WOSUID: WOS:000441473400019
Contributors: Qurat-ul-ain; Perveen, Shahida; Muhammad, Munira Taj; Yousuf, Sahar; Khan, Khalid Mohammed; Choudhary, M. Iqbal
Source: check_circle
Web of Science Researcher Profile Sync

New Small Molecular Weight Antioxidants and Pro-oxidants Control Melanoma Cell Proliferation and Spreading in vitro

2018-08-20 | Conference abstract
DOI: https://doi.org/10.1016/j.freeradbiomed.2018.05.050
Source: Self-asserted source
QURAT UL AIN
grade
Preferred source (of 3)‎

Effect of a Novel Bis-coumarin Derivative on Human Melanoma Cells: Regulation of Cell Survival, Proliferation, Migration and Kinases

2018-05-14 | Conference abstract
DOI: https://doi.org/10.1016/j.freeradbiomed.2018.04.252
Source: Self-asserted source
QURAT UL AIN
grade
Preferred source (of 3)‎

Novel Small Bioactive Compounds for the Control of Melanoma Cell Proliferation, and Migration

9th International Conference and Expo on Proteomics and Molecular Medicine
2017-11-15 | Conference abstract
DOI: DOI: 10.4172/0974-276X-C1-107
Source: Self-asserted source
QURAT UL AIN

Modulation of Melanoma Cell Proliferation and Spreading by novel Small Molecular Weight Antioxidants

OCC World Congress and Annual SFRR-E Conference 2017 Metabolic Stress and Redox Regulation
2017-06-23 | Conference abstract
DOI: https://doi.org/10.1016/j.freeradbiomed.2017.04.117.
Source: Self-asserted source
QURAT UL AIN

Synthesis, X-ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of A Series of Barbiturate Derivatives

Journal of Chemistry
2016-05-11 | Journal article
DOI: doi.org/10.1155/2016/8517243
Source: Self-asserted source
QURAT UL AIN
grade
Preferred source (of 4)‎

Role of Aromatase Inhibitors in Breast Cancer

, delivered at Dr. Panjwni Center for Molecular Medicine & Drug Research, International Center for Chemical & Biological Sciences, University of Karachi, Pakistan
2016-03-15 | Lecture
Contributors: QURAT UL AIN
Source: Self-asserted source
QURAT UL AIN

Pakistani scientist makes headway in treating cancers

The News International
2014-12-15 | Newsletter article
OTHER-ID: http://karachi.newspakistan.pk/?p=86078
Source: Self-asserted source
QURAT UL AIN

Peer review (4 reviews for 2 publications/grants)

Review activity for BioFactors. (2)
Review activity for PloS one. (2)
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