Personal information

prion, protein aggregation, neurodegenerative diseases, protein biophysics, spectroscopy, protein biochemistry, phase separation

Activities

Employment (1)

Federal University of Rio de Janeiro: Rio de Janeiro, RJ, BR

2006-08-08 to present | Associate Professor (Pharmaceutical Biotechnology, Faculty of Pharmacy)
Employment
Source: Self-asserted source
Yraima Cordeiro

Education and qualifications (1)

Federal University of Rio de Janeiro: Rio de Janeiro, RJ, BR

2001-05 to 2005-02 | PhD (Medical Biochemistry Institute)
Education
Source: Self-asserted source
Yraima Cordeiro

Professional activities (3)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior: Brasilia, Distrito Federal, BR

2024-10-03 | "BASES ESTRUTURAIS E TERMODINÂMICAS PARA A CONVERSÃO CONFORMACIONAIS DA PROTEÍNA DO PRION E POSSÍVEIS IMPLICAÇÕES SOBRE A PATOGENIA." (Prêmio Capes de Tese - 2006 Edition - Honorable Mention - CIÊNCIAS BIOLÓGICAS II - Author)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior: Brasilia, Distrito Federal, BR

2024-10-03 | ESTUDOS IN VITRO E IN VIVO DE CONVERSÃO E AGREGAÇÃO DA PROTEÍNA PRION: EFEITO DE ÁCIDOS NUCLEICOS E A PROPOSTA DE UM MODELO DE AGREGAÇÃO AMILOIDE (Prêmio Capes de Tese - 2017 Edition - Honorable Mention - FARMÁCIA - Advisor)
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CAPES

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior: Brasilia, Distrito Federal, BR

2024-10-03 | PHASE TRANSITIONS OF THE PRION PROTEIN: COPPER IONS AND NUCLEIC ACIDS MODULATION OF BIOMOLECULAR CONDENSATES AND AGGREGATES FORMATION (Prêmio Capes de Tese - 2024 Edition - Honorable Mention - FARMÁCIA - Advisor)
Distinction
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CAPES

Works (50 of 65)

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Page 1 of 2

Zinc ions trigger the prion protein liquid-liquid phase separation

Biochemical and Biophysical Research Communications
2025-03 | Journal article
Contributors: Mariana Juliani do Amaral; Letícia Soares de Oliveira; Yraima Cordeiro
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Crossref

Understanding the mechanisms of green tea EGCG against amyloid β oligomer neurotoxicity through computational studies

RSC Advances
2024 | Journal article
Contributors: Priscila Baltazar Gonçalves; Yraima Cordeiro; Ana Carolina Rennó Sodero
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Crossref

How oxidized EGCG remodels α-synuclein fibrils into non-toxic aggregates: insights from computational simulations

Physical Chemistry Chemical Physics
2023 | Journal article
Contributors: Priscila Baltazar Gonçalves; Fernando L. Palhano; Yraima Cordeiro; Ana Carolina Rennó Sodero
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Crossref

Copper drives prion protein phase separation and modulates aggregation

Science Advances
2023-11-03 | Journal article
Contributors: Mariana Juliani do Amaral; Satabdee Mohapatra; Aline Ribeiro Passos; Taiana Sousa Lopes da Silva; Renato Sampaio Carvalho; Marcius da Silva Almeida; Anderson Sá Pinheiro; Susanne Wegmann; Yraima Cordeiro
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Crossref

(Dys)functional insights into nucleic acids and RNA-binding proteins modulation of the prion protein and α-synuclein phase separation

Biophysical Reviews
2023-08 | Journal article
Contributors: Yraima Cordeiro; Maria Heloisa O. Freire; Adalgisa Felippe Wiecikowski; Mariana Juliani do Amaral
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Crossref

Phase separation of the mammalian prion protein: Physiological and pathological perspectives

Journal of Neurochemistry
2023-07 | Journal article
Contributors: Mariana J. do Amaral; Maria Heloisa O. Freire; Marcius S. Almeida; Anderson S. Pinheiro; Yraima Cordeiro
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Crossref

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Chemical Reviews
2023-07-26 | Journal article
Contributors: Jerson L. Silva; Debora Foguel; Vitor F. Ferreira; Tuane C. R. G. Vieira; Mayra A. Marques; Giulia D. S. Ferretti; Tiago F. Outeiro; Yraima Cordeiro; Guilherme A. P. de Oliveira
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Crossref

Copper drives prion protein phase separation and modulates aggregation

2023-02-16 | Preprint
Contributors: Mariana Juliani do Amaral; Aline Ribeiro Passos; Satabdee Mohapatra; Taiana Sousa Lopes da Silva; Renato Sampaio Carvalho; Marcius da Silva Almeida; Anderson de Sá Pinheiro; Susanne Wegmann; Yraima Cordeiro
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Crossref

Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation

Current Opinion in Structural Biology
2022-04 | Journal article
Contributors: Jerson L. Silva; Tuane C. Vieira; Yraima Cordeiro; Guilherme A.P. de Oliveira
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Crossref

Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo

Molecular Therapy
2021-09 | Journal article
Contributors: Katrina Albert; Diana P. Raymundo; Anne Panhelainen; Ave Eesmaa; Liana Shvachiy; Gabriela R. Araújo; Piotr Chmielarz; Xu Yan; Aastha Singh; Yraima Cordeiro et al.
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Crossref

Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases

Biomolecules
2021-05-20 | Journal article
Contributors: Priscila Baltazar Gonçalves; Ana Carolina Rennó Sodero; Yraima Cordeiro
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Crossref
grade
Preferred source (of 2)‎

RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction

Scientific Reports
2019-08-27 | Journal article
Contributors: Petar Stefanov Kovachev; Mariana P. B. Gomes; Yraima Cordeiro; Natália C. Ferreira; Leticia P. Felix Valadão; Lucas M. Ascari; Luciana P. Rangel; Jerson L. Silva; Suparna Sanyal
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Crossref

Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells

Bioorganic Chemistry
2018-10 | Journal article
Contributors: Veronica D. da Silva; Bruna M. de Faria; Eduardo Colombo; Lucas Ascari; Gabriella P.A. Freitas; Leonã S. Flores; Yraima Cordeiro; Luciana Romão; Camilla D. Buarque
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Crossref

Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain

Journal of Biological Chemistry
2017-06 | Journal article
Contributors: Petar Stefanov Kovachev; Debapriya Banerjee; Luciana Pereira Rangel; Jonny Eriksson; Murilo M. Pedrote; Mafalda Maria D.C. Martins-Dinis; Katarina Edwards; Yraima Cordeiro; Jerson L. Silva; Suparna Sanyal
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Crossref

Unraveling Prion Protein Interactions with Aptamers and Other PrP-Binding Nucleic Acids

International Journal of Molecular Sciences
2017-05 | Journal article
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Virtual drug screening for prion diseases: A valuable step?

EBioMedicine
2016-06 | Journal article
Contributors: Yraima Cordeiro
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Crossref

Conformational dissection of Thermomyces lanuginosus lipase in solution

Biophysical Chemistry
2014-01 | Journal article
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Crossref

The effect of temperature on protein refolding at high pressure: Enhanced green fluorescent protein as a model

Process Biochemistry
2014-01 | Journal article
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Crossref

A Comprehensive Study on the Activity and Deactivation of Immobilized Lecitase Ultra in Esterifications of Food Waste Streams to Monoacylglycerols

Chemsuschem
2013 | Journal article
DOI:

10.1002/cssc.201300026

Part of ISSN:

1864-5631

Contributors: Alves de Souza, Rodrigo Octavio M.; Cordeiro, Yraima; Flores, Marcella C.; Goncalves, Karen M.; Junior, Ivaldo I.; Leal, Ivana C. R.; Luque, Rafael; Sutili, Felipe K.; de Mariz e Miranda, Leandro Soter
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

An analysis of the factors that affect the dissociation of inclusion bodies and the refolding of endostatin under high pressure

Process Biochemistry
2013 | Journal article
DOI:

10.1016/j.procbio.2012.12.017

Part of ISSN:

1359-5113

Contributors: Chura-Chambi, R. M.; Cordeiro, Y.; Lemke, L. S.; Malavasi, N. V.; Morganti, L.; Rodrigues, D.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Continuous flow valorization of fatty acid waste using silica-immobilized lipases

Green Chemistry
2013 | Journal article
DOI:

10.1039/c2gc36674f

Part of ISSN:

1463-9262

Contributors: Cordeiro, Yraima; Goncalves, Karen M.; Itabaiana, Ivaldo, Jr.; Leal, Ivana C. R.; Leite, Selma G. F.; Luque, Rafael; Miranda, Leandro S. M.; Ojeda, Manuel; Sutili, Felipe K.; de Souza, Rodrigo O. M. A.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Insights into the Intramolecular Coupling between the N- and C-Domains of Troponin C Derived from High-Pressure, Fluorescence, Nuclear Magnetic Resonance, and Small-Angle X-ray Scattering Studies

Biochemistry
2013 | Journal article
DOI:

10.1021/bi301139d

Part of ISSN:

0006-2960

Contributors: Cordeiro, Yraima; Foguel, Debora; Marques, Mayra de A.; Rocha, Cristiane B.; Silva, Jerson L.; Sorenson, Martha M.; Suarez, Marisa C.; de Oliveira, Guilherme A. P.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Allosteric function and dysfunction of the prion protein

Cellular and Molecular Life Sciences
2012 | Journal article
DOI:

10.1007/s00018-011-0847-7

Contributors: Cordeiro, Yraima; Lima, Luis Mauricio T. R.; Linden, Rafael
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Heparin binding increases murine prion protein stability

Prion
2012 | Journal article
Contributors: Cordeiro, Yraima; Gomes, Mariana; Silva, Jerson; Vieira, Tuane
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Moniliophthora perniciosa Necrosis- and Ethylene-Inducing Protein 2 (MpNep2) as a Metastable Dimer in Solution: Structural and Functional Implications

Plos One
2012 | Journal article
DOI:

10.1371/journal.pone.0045620

Contributors: Almeida, Fabio C.; Camillo, Luciana R.; Cascardo, Julio; Cordeiro, Yraima; Dias, Cristiano V.; Ferretti, Giulia D. S.; Pereira, Elen G.; Silva, Jerson L.; Souza, Theo L. F.; Valente, Ana Paula et al.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils IMPLICATIONS FOR CANCER

Journal of Biological Chemistry
2012 | Journal article
DOI:

10.1074/jbc.M112.340638

Contributors: Bom, Ana P. D. Ano; Braga, Carolina A.; Cepeda, Ana O. T.; Cordeiro, Yraima; Costa, Danielly C. F.; De Moura Gallo, Claudia V.; Gava, Lisandra M.; Ramos, Carlos H. I.; Rangel, Luciana P.; Sanches, Daniel et al.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Nonspecific Prion Protein-Nucleic Acid Interactions Lead to Different Aggregates and Cytotoxic Species

Biochemistry
2012 | Journal article
DOI:

10.1021/bi300440e

Contributors: Braga, Carolina A. C. A.; Cordeiro, Yraima; Ferreira, Priscila S.; Gomes, Mariana P. B.; Kraineva, Julia; Macedo, Bruno; Millen, Thiago A.; Silva, Jerson L.; Winter, Roland
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Parkinson's disease: evaluating the effects of possible anti-parkinsonian compounds on alpha-synuclein aggregation and neurotoxicity

Febs Journal
2012 | Journal article
Contributors: Braga, C.; Cordeiro, Y.; Foguel, D.; Freitas, M.; Khattar, E.; Romao, L.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

The role of RNA in mammalian prion protein conversion

Wiley Interdisciplinary Reviews-Rna
2012 | Journal article
DOI:

10.1002/wrna.118

Contributors: Cordeiro, Yraima; Gomes, Mariana P. B.; Silva, Jerson L.; Vieira, Tuane C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors (vol 43, pg 60, 2011)

International Journal of Biochemistry & Cell Biology
2011 | Journal article
DOI:

10.1016/j.biocel.2011.01.009

Contributors: Ano Bom, Ana P. D.; Cordeiro, Yraima; DeMoura-Gallo, Claudia V.; Levy, Claudia B.; Portari, Elisabeth A.; Silva, Jerson L.; Stumbo, Ana C.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion

Methods
2011 | Journal article
DOI:

10.1016/j.ymeth.2010.12.002

Contributors: Cordeiro, Yraima; Gomes, Mariana P. B.; Rangel, Luciana P.; Scapin, Sandra M. N.; Silva, Jerson L.; Vieira, Tuane C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

Journal of the American Chemical Society
2011 | Journal article
DOI:

10.1021/ja106725p

Contributors: Almeida, Marcius S.; Cordeiro, Yraima; Gomes, Mariana P. B.; Reynaldo, Daniel P.; Silva, Jerson L.; Vieira, Tuane C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Hydrophilic cyclodextrin protected Pd nanoclusters: insights into their size control and host-guest behavior

Journal of Materials Chemistry
2011 | Journal article
DOI:

10.1039/c1jm11962a

Contributors: Aguiar, Lucia C. S.; Cordeiro, Yraima; Malta, Luiz Fernando B.; Michel, Ricardo C.; Senra, Jaqueline D.; Simao, Renata A.; Simas, Alessandro B. C.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

3D-reconstruction and overall topology of the dimeric mitochondrial ATP synthase of the colorless alga Polytomella sp

Biochimica Et Biophysica Acta-Bioenergetics
2010 | Journal article
DOI:

10.1016/j.bbabio.2010.04.113

Contributors: Cano-Estrada, Araceli; Cardol, Pierre; Cordeiro, Yraima; Foguel, Debora; Gonzalez-Halphen, Diego; Mignaco, Julio A.; Remacle, Claire; Vazquez-Acevedo, Miriam; Villavicencio-Queijeiro, Alexa; Wilkens, Stephan
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins

Accounts of Chemical Research
2010 | Journal article
DOI:

10.1021/ar900179t

Contributors: Bom, Paula Ano; Cordeiro, Yraima; Foguel, Debora; Freitas, Monica S.; Gomes, Mariana P. B.; Ishimaru, Daniella; Lima, Luis Mauricio T. R.; Silva, Jerson L.; Vieira, Tuane C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Prion Protein Interaction with Low Molecular Weight Heparin

Prion
2010 | Journal article
Contributors: Almeida, Marcius M. S.; Cordeiro, Yraima; Gomes, Mariana M. P. B.; Reynaldo, Daniel P.; Silva, Jerson L.; Vieira, Tuane C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

PrP interactions with nucleic acids and glycosaminoglycans in function and disease

Frontiers in Bioscience-Landmark
2010 | Journal article
DOI:

10.2741/3611

Contributors: Cordeiro, Yraima; Gomes, Mariana P. B.; Silva, Jerson L.; Vieira, Tuane C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Structural and Physiological Aspects of PrP Interaction with RNA Molecules

Prion
2010 | Journal article
Contributors: Almeida, M. S.; Cordeiro, Y.; Ferreira, P. S.; Gomes, M. P. B.; Rangel, L. P.; Silva, J. L.; Vieira, T. C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Subunit-subunit interactions and overall topology of the dimeric mitochondrial ATP synthase of Polytomella sp.

Biochimica Et Biophysica Acta-Bioenergetics
2010 | Journal article
DOI:

10.1016/j.bbabio.2010.02.024

Contributors: Cano-Estrada, Araceli; Cardol, Pierre; Cordeiro, Yraima; Figueroa-Martinez, Francisco; Foguel, Debora; Gonzalez-Halphen, Diego; Lapaille, Marie; Mignaco, Julio A.; Miranda-Astudillo, Hector; Remacle, Claire et al.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Synthesis and anti-prion activity evaluation of aminoquinoline analogues

European Journal of Medicinal Chemistry
2010 | Journal article
DOI:

10.1016/j.ejmech.2010.07.054

Contributors: Chaves, Juliana A. P.; Cordeiro, Yraima; Egan, Timothy J.; Hunter, Roger; Kaschula, Catherine H.; Macedo, Bruno; Silva, Jerson L.; van der Merwe, Johannes D.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

The p53 Core Domain Is a Molten Globule at Low pH FUNCTIONAL IMPLICATIONS OF A PARTIALLY UNFOLDED STRUCTURE

Journal of Biological Chemistry
2010 | Journal article
DOI:

10.1074/jbc.M109.075861

Contributors: Ano Bom, Ana Paula D.; Cordeiro, Yraima; Ferraz, Danielly; Freitas, Monica S.; Gomes, Andre M. O.; Moreira, Flavia S.; Sanches, Daniel; Silva, Jerson L.; Valente, Ana Paula
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Cognate DNA Stabilizes the Tumor Suppressor p53 and Prevents Misfolding and Aggregation

Biochemistry
2009 | Journal article
DOI:

10.1021/bi9003028

Contributors: Ano Bom, Ana Paula D.; Cordeiro, Yraima; Ishimaru, Daniella; Lima, Luis Mauricio T. R.; Oyama, Marcos F. C.; Quesado, Pablo A.; Silva, Jerson L.; de Moura Gallo, Claudia V.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Effects of compressed fluids on the activity and structure of horseradish peroxidase

Journal of Supercritical Fluids
2009 | Journal article
DOI:

10.1016/j.supflu.2009.04.014

Contributors: Antunes, O. A. C.; Cardozo Filho, Lucio; Cordeiro, Yraima; Dariva, Claudio; Feihrmann, Andresa C.; Fricks, Alini T.; Oestreicher, Enrique G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Enhanced prion protein stability coupled to DNA recognition and milieu acidification

Biophysical Chemistry
2009 | Journal article
DOI:

10.1016/j.bpc.2008.12.011

Contributors: Cordeiro, Yraima; Lima, Luis Mauricio T. R.; Marques, Adriana F.; Silva, Jerson L.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1

Faseb Journal
2009 | Journal article
DOI:

10.1096/fj.09-138974

Contributors: Cordeiro, Yraima; Foguel, Debora; Lima, Luis Mauricio T. R.; Linden, Rafael; Lopes, Marilene H.; Romano, Sebastian A.; Silva, Jerson L.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Response to Radulescu and Brenig: Infectious nucleic acids in prion disease: halfway there

Trends in Biochemical Sciences
2009 | Journal article
DOI:

10.1016/j.tibs.2008.10.001

Contributors: Cordeiro, Yraima; Foguel, Debora; Lima, Luis Mauricio T. R.; Silva, Jerson L.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Intriguing nucleic-acid-binding features of mammalian prion protein

Trends in Biochemical Sciences
2008 | Journal article
DOI:

10.1016/j.tibs.2007.11.003

Contributors: Cordeiro, Yraima; Foguel, Debora; Lima, Luis Mauricio T. R.; Silva, Jerson L.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cells

Journal of Biological Chemistry
2008 | Journal article
DOI:

10.1074/jbc.M802102200

Contributors: Almeida, Marcius S.; Cordeiro, Yraima; Cunha E Silva, Narcisa L.; Ferreira, Priscila S.; Gomes, Mariana P. B.; Millen, Thiago A.; Silva, Jerson L.; Vieira, Tuane C. R. G.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

Recognition mechanism of D- and L-tryptophan enantiomers using 2-hydroxypropyl-alpha- or beta-cyclodextrins as chiral selectors

Tetrahedron-Asymmetry
2008 | Journal article
DOI:

10.1016/j.tetasy.2008.04.035

Contributors: Brum Malta, Luiz Fernando; Campos, Cora Cunha; Ceva Antunes, Octavio Augusto; Cordeiro, Yraima; Medeiros, Marta Eloisa; Tinoco, Luzineide Wanderley
Source: Self-asserted source
Yraima Cordeiro via ResearcherID

The peculiar interaction between mammalian prion protein and RNA

Prion
2008 | Journal article
Contributors: Cordeiro, Yraima; Gomes, Mariana P. B.; Silva, Jerson L.
Source: Self-asserted source
Yraima Cordeiro via ResearcherID
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Peer review (26 reviews for 18 publications/grants)

Review activity for ACS nano. (1)
Review activity for ACS omega. (1)
Review activity for Archives of biochemistry and biophysics. (1)
Review activity for Biochimica et biophysica acta (2)
Review activity for Biochimica et biophysica acta. (1)
Review activity for Biomacromolecules. (3)
Review activity for Biomolecules. (1)
Review activity for Bioorganic chemistry. (3)
Review activity for Biophysical reviews. (1)
Review activity for Chemistry. (1)
Review activity for Food chemistry. (1)
Review activity for iScience. (2)
Review activity for Journal of Molecular Biology. (1)
Review activity for Journal of the American Chemical Society. (1)
Review activity for Nature communications (2)
Review activity for Neurobiology of disease. (2)
Review activity for Neurochemical research. (1)
Review activity for The journal of physical chemistry letters. (1)