Personal information

Drug discovery, medicinal chemistry, chemistry, pharmaceuticals

Activities

Employment (3)

Atavistik Bio: Cambridge, MA, US

2021-09 to present | Vice President, Head of Chemistry
Employment
Source: Self-asserted source
Maria-Jesus Blanco

Sage Therapeutics: Cambridge, MA, US

2017-01 to 2021-09 | Senior Director, Head of Chemistry
Employment
Source: Self-asserted source
Maria-Jesus Blanco

Eli Lilly and Company: Indianapolis, IN, US

2000 to 2017-01 | Director
Employment
Source: Self-asserted source
Maria-Jesus Blanco

Education and qualifications (3)

Université de Strasbourg Institut universitaire Louis Pasteur: Strasbourg, FR

1998-08 to 1999-12 (Laboratoire de Chimie Organo-Minérale)
Education
Source: Self-asserted source
Maria-Jesus Blanco

Massachusetts Institute of Technology: Cambridge, MA, US

1997 to 1998 | Postdoc (Department of Chemistry)
Education
Source: Self-asserted source
Maria-Jesus Blanco

Universidade de Santiago de Compostela: Santiago de Compostela, ES

1992-09 to 1997-02 | PhD
Education
Source: Self-asserted source
Maria-Jesus Blanco

Professional activities (7)

American Association of Pharmaceutical Scientists: Arlington, VA, US

2021 to present | Regular
Membership
Source: Self-asserted source
Maria-Jesus Blanco

American Association For The Advancement of Science: Washington D.C., District of Columbia, US

2019-01-01 to present | Member (Pharmaceutical Division)
Service
Source: Self-asserted source
Maria-Jesus Blanco

American Chemical Society: Washington, DC, US

1997 to present | Industrial alternate councilor (ACS MEDI Division; ACS ORG Division; Committee on Science (ComSci))
Membership
Source: Self-asserted source
Maria-Jesus Blanco

American Chemical Society: Washington, DC, US

2021 | ACS Fellow
Distinction
Source: Self-asserted source
Maria-Jesus Blanco

American Chemical Society: Washington, DC, US

2019 to 2020 | ACS Medicinal Chemistry Letters Guest Editor
Invited position
Source: Self-asserted source
Maria-Jesus Blanco

Women & Hi Tech: Indianapolis, US

2016 | Leading Light Award on Outstanding Achievement in STEM
Distinction
Source: Self-asserted source
Maria-Jesus Blanco

University of Santiago de Compostela: Santiago de Compostela, ES

1996 | Premio Extraordinario de Licenciatura
Distinction
Source: Self-asserted source
Maria-Jesus Blanco

Works (50 of 100)

Items per page:
Page 1 of 2

Allostery Illuminated: Harnessing AI and Machine Learning for Drug Discovery

ACS Medicinal Chemistry Letters
2024-09-12 | Journal article
Contributors: Maria-Jesus Blanco; Melissa J. Buskes; Rajiv G. Govindaraj; Jonathan J. Ipsaro; Joann E. Prescott-Roy; Anil K. Padyana
Source: check_circle
Crossref

Empowering Voices: Inspiring Women in Medicinal Chemistry

ACS Medicinal Chemistry Letters
2024-04-11 | Journal article
Contributors: Maria-Jesus Blanco; Joanne J. Bronson; Erin F. DiMauro; Carolyn Dzierba; MariJean Eggen; Amanda L. Garner; Gunda Georg; Jeanine Giarolla; Nicole C. Goodwin; Melissa C. Grenier-Davies et al.
Source: check_circle
Crossref

Empowering Voices: Inspiring Women in Medicinal Chemistry

Journal of Medicinal Chemistry
2024-03-28 | Journal article
Contributors: Maria-Jesus Blanco; Joanne J. Bronson; Erin F. DiMauro; Carolyn Dzierba; MariJean Eggen; Amanda L. Garner; Gunda Georg; Jeanine Giarolla; Nicole C. Goodwin; Melissa C. Grenier-Davies et al.
Source: check_circle
Crossref

Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations

ACS Medicinal Chemistry Letters
2023-06-08 | Journal article
Contributors: Maria-Jesus Blanco; Amanda Bryant-Friedrich; Gunda Georg; Amjad Ali; Paul L. Ornstein; Lori Ferrins; Paul C. Trippier
Source: check_circle
Crossref

Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations

Journal of Medicinal Chemistry
2023-06-08 | Journal article
Contributors: Maria-Jesus Blanco; Amanda Bryant-Friedrich; Gunda Georg; Amjad Ali; Paul L. Ornstein; Lori Ferrins; Paul C. Trippier
Source: check_circle
Crossref

Accelerating Drug Discovery: Synthesis of Complex Chemotypes via Multicomponent Reactions

ACS Medicinal Chemistry Letters
2023-04-13 | Journal article
Contributors: Melissa J. Buskes; Aaron Coffin; Dawn M. Troast; Rachel Stein; Maria-Jesus Blanco
Source: check_circle
Crossref

Collaboration and knowledge integration for successful brain therapeutics – lessons learned from the pandemic

Disease Models & Mechanisms
2022-12-01 | Journal article
Contributors: Maria Isabel Loza; Julija Hmeljak; Chas Bountra; James E. Audia; Sohini Chowdhury; Shannon Weiman; Kalpana Merchant; Maria-Jesus Blanco
Source: check_circle
Crossref

Advancing New Chemical Modalities into Clinical Studies

ACS Medicinal Chemistry Letters
2022-11-10 | Journal article
Contributors: Maria-Jesus Blanco; Kevin M. Gardinier; Mark N. Namchuk
Source: check_circle
Crossref

SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment

Journal of Medicinal Chemistry
2022-07-14 | Journal article
Contributors: Matthew D. Hill; Maria-Jesus Blanco; Francesco G. Salituro; Zhu Bai; Jacob T. Beckley; Michael A. Ackley; Jing Dai; James J. Doherty; Boyd L. Harrison; Ethan C. Hoffmann et al.
Source: check_circle
Crossref

Medicinal Chemistry in Portugal and Spain: A Strong Iberian Alliance

ACS Medicinal Chemistry Letters
2022-06-09 | Journal article
Contributors: Maria João Matos; Maria-Jesus Blanco
Source: check_circle
Crossref

Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders

RSC Medicinal Chemistry
2021 | Journal article
Contributors: Silke Miller; Maria-Jesus Blanco
Source: check_circle
Crossref

Medicinal Chemistry in Portugal and Spain: A Strong Iberian Alliance — Call for Papers

ACS Medicinal Chemistry Letters
2021-05-13 | Journal article
Contributors: Maria João Matos; Maria-Jesus Blanco
Source: check_circle
Crossref

Impact of Allosteric Modulation in Drug Discovery: Innovation in Emerging Chemical Modalities

ACS Medicinal Chemistry Letters
2020-10-08 | Journal article
Contributors: Bingsong Han; Francesco G. Salituro; Maria-Jesus Blanco
Source: check_circle
Crossref

Impact of Cross-Coupling Reactions in Drug Discovery and Development

Molecules
2020-07-31 | Journal article
Contributors: Melissa J. Buskes; Maria-Jesus Blanco
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Mentoring Matters in Drug Discovery

ACS Medicinal Chemistry Letters
2020-03-12 | Journal article
Contributors: Maria-Jesus Blanco; James E. Audia
Source: check_circle
Crossref

New Chemical Modalities and Strategic Thinking in Early Drug Discovery

ACS Medicinal Chemistry Letters
2020-03-12 | Journal article
Contributors: Maria-Jesus Blanco; Kevin M. Gardinier
Source: check_circle
Crossref

Women in Medicinal Chemistry Special Issue

ACS Medicinal Chemistry Letters
2020-03-12 | Journal article
Contributors: Maria-Jesus Blanco; Donna M. Huryn
Source: check_circle
Crossref

Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases

Journal of Medicinal Chemistry
2019-07-11 | Journal article
Contributors: Quinn Coughlin; Allen T. Hopper; Maria-Jesus Blanco; Vijaya Tirunagaru; Albert J. Robichaud; Dario Doller
Source: check_circle
Crossref

Preparation of steroid compounds for treating CNS disorders

2019-06-27 | Patent
Source: Self-asserted source
Maria-Jesus Blanco

Preparation of steroid derivatives for treating CNS disorders

2019-06-27 | Patent
Source: Self-asserted source
Maria-Jesus Blanco

Women in Medicinal Chemistry Special Issue

ACS Medicinal Chemistry Letters
2019-06-13 | Journal article
Contributors: Maria-Jesus Blanco; Donna M. Huryn
Source: check_circle
Crossref

Building upon Nature’s Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles

Methods in Molecular Biology
2019-05-28 | Book chapter
Part of ISBN: 9781493995035
Part of ISBN: 9781493995042
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Maria-Jesus Blanco

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility

Journal of Medicinal Chemistry
2018 | Journal article
Part of ISSN: 0022-2623
Contributors: Matthew R. Naylor; Andrew M. Ly; Mason J. Handford; Daniel P. Ramos; Cameron R. Pye; Akihiro Furukawa; Victoria G. Klein; Ryan P. Noland; Quinn Edmondson; Alexandra C. Turmon et al.
Source: Self-asserted source
Maria-Jesus Blanco via Crossref Metadata Search

Developing SAGE-324 for the treatment of epileptiform disorders

American Epilepsy Society Annual Meeting
2018-12-01 | Conference abstract
Source: Self-asserted source
Maria-Jesus Blanco

Discovery and Clinical Development of SAGE-217: A Next Generation Neuroactive Steroid Positive Allosteric Modulator of the GABAA Receptor

ACS SHANGHAI MEDICINAL CHEMISTRY CONFERENCE
2018-10-27 | Conference paper
Source: Self-asserted source
Maria-Jesus Blanco

Breakthroughs in neuroactive steroid drug discovery

Bioorganic & Medicinal Chemistry Letters
2018-01 | Journal article
Contributors: Maria-Jesus Blanco; Daniel La; Quinn Coughlin; Caitlin A. Newman; Andrew M. Griffin; Boyd L. Harrison; Francesco G. Salituro
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

C17, c20, and c21 substituted neuroactive steroids and their methods of use

2018-01-18 | Patent
PAT:

PCT Int. Appl. (2018), WO 2018013613

Source: Self-asserted source
Maria-Jesus Blanco

C7, c12, and c16 substituted neuroactive steroids and their methods of use

2018-01-18 | Patent
PAT:

PCT Int. Appl. (2018), WO 2018013615

Source: Self-asserted source
Maria-Jesus Blanco

Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache

Bioorganic and Medicinal Chemistry Letters
2017 | Journal article
EID:

2-s2.0-85006932876

Contributors: Blanco, M.-J.; Benesh, D.R.; Knobelsdorf, J.A.; Khilevich, A.; Cortez, G.S.; Mokube, F.; Aicher, T.D.; Groendyke, T.M.; Marmsater, F.P.; Tang, T.P. et al.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor

Journal of Medicinal Chemistry
2017-09-28 | Journal article
Contributors: Gabriel Martinez Botella; Francesco G. Salituro; Boyd L. Harrison; Richard T. Beresis; Zhu Bai; Maria-Jesus Blanco; Gabriel M. Belfort; Jing Dai; Carlos M. Loya; Michael A. Ackley et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Diversity of thought in science: How to leverage the best talent in a global chemistry enterprise

American Chemical Society
2017-08-20 | Conference abstract
Source: Self-asserted source
Maria-Jesus Blanco

Analgesic and anti‐inflammatory properties of novel, selective, and potent EP4 receptor antagonists

Pharmacology Research & Perspectives
2017-06 | Journal article
Contributors: Srinivasan Chandrasekhar; Xiao‐Peng Yu; Anita K. Harvey; Jennifer L. Oskins; Chaohua Lin; Xushan Wang; Maria‐Jesus Blanco; Matthew J. Fisher; Steven L. Kuklish; Matthew A. Schiffler et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets

Current Opinion in Chemical Biology
2017-06 | Journal article
Contributors: Matthew R Naylor; Andrew T Bockus; Maria-Jesus Blanco; R Scott Lokey
Source: Self-asserted source
Maria-Jesus Blanco via Crossref Metadata Search
grade
Preferred source (of 2)‎

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-85007099137

Contributors: Chappell, M.D.; Li, R.; Smith, S.C.; Dressman, B.A.; Tromiczak, E.G.; Tripp, A.E.; Blanco, M.-J.; Vetman, T.; Quimby, S.J.; Matt, J. et al.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
EID:

2-s2.0-84979198210

Contributors: Blanco, M.-J.; Vetman, T.; Chandrasekhar, S.; Fisher, M.J.; Harvey, A.; Chambers, M.; Lin, C.; Mudra, D.; Oskins, J.; Wang, X.-S. et al.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Discovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonists

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
EID:

2-s2.0-84949531718

Contributors: Blanco, M.-J.; Vetman, T.; Chandrasekhar, S.; Fisher, M.J.; Harvey, A.; Mudra, D.; Wang, X.-S.; Yu, X.-P.; Schiffler, M.A.; Warshawsky, A.M.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
EID:

2-s2.0-84962142216

Contributors: Blanco, M.-J.; Vetman, T.; Chandrasekhar, S.; Fisher, M.J.; Harvey, A.; Kuklish, S.L.; Chambers, M.; Lin, C.; Mudra, D.; Oskins, J. et al.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
EID:

2-s2.0-84996477144

Contributors: Dressman, B.A.; Tromiczak, E.G.; Chappell, M.D.; Tripp, A.E.; Quimby, S.J.; Vetman, T.; Fivush, A.M.; Matt, J.; Jaramillo, C.; Li, R. et al.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides

ACS Medicinal Chemistry Letters
2016 | Journal article
EID:

2-s2.0-84982189633

Contributors: Schwochert, J.; Lao, Y.; Pye, C.R.; Naylor, M.R.; Desai, P.V.; Gonzalez Valcarcel, I.C.; Barrett, J.A.; Sawada, G.; Blanco, M.-J.; Lokey, R.S.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Composés d'acide diméthylbenzöıque

2016-10 | Patent
Source: Self-asserted source
Maria-Jesus Blanco

Amide-to-ester substitutions modify the permeability and ADME properties of natural and synthetic cyclic peptides

252nd ACS National Meeting & Exposition, Philadelphia, PA, United States, August 21-25, 2016,
2016-08-21 | Conference paper
Source: Self-asserted source
Maria-Jesus Blanco

Property assessment of medium size molecules: Connecting drug-like properties from in vitro to in vivo

252nd ACS National Meeting & Exposition, Philadelphia, PA, United States, August 21-25, 2016
2016-08-21 | Conference paper
Source: Self-asserted source
Maria-Jesus Blanco

Technologies for assessing target engagement and their applications in drug discovery

252nd ACS National Meeting & Exposition, Philadelphia, PA, United States, August 21-25, 2016
2016-08-21 | Conference paper
Source: Self-asserted source
Maria-Jesus Blanco

SAR expansion and drug-like in-silico property assessment of novel quinoline and naphthalene EP4 antagonists

251st ACS National Meeting & Exposition, San Diego, CA, United States, March 13-17, 2016
2016-03-13 | Conference paper
Source: Self-asserted source
Maria-Jesus Blanco

Synthesis, SAR, and pharmacological characterization of novel potent and selective EP4 antagonists triaryl scaffold

251st ACS National Meeting & Exposition, San Diego, CA, United States, March 13-17, 2016
2016-03-13 | Conference paper
Source: Self-asserted source
Maria-Jesus Blanco

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT<inf>1F</inf>receptor agonists: Evolution from bicyclic to monocyclic cores

Bioorganic and Medicinal Chemistry Letters
2015 | Journal article
EID:

2-s2.0-84945479110

Contributors: Zhang, D.; Blanco, M.-J.; Ying, B.-P.; Kohlman, D.; Liang, S.X.; Victor, F.; Chen, Q.; Krushinski, J.; Filla, S.A.; Hudziak, K.J. et al.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

Target Engagement in Lead Generation

Bioorganic and Medicinal Chemistry Letters
2015 | Journal article
EID:

2-s2.0-84922714658

Contributors: Durham, T.B.; Blanco, M.-J.
Source: Self-asserted source
Maria-Jesus Blanco via Scopus - Elsevier

ChemInform Abstract: Target Engagement in Lead Generation

ChemInform
2015-03 | Journal article
Part of ISSN: 0931-7597
Contributors: Timothy B. Durham; Maria-Jesus Blanco
Source: Self-asserted source
Maria-Jesus Blanco via Crossref Metadata Search

Dimethyl-benzoic acid compounds

2015-01 | Patent
Source: Self-asserted source
Maria-Jesus Blanco

Discovery of novel 3-thiomethyl bicyclo [3, 1, 0] hexane analogs as highly potent and selective antagonists of metabotropic 2/3 receptors for the treatment of depression

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
2014 | Conference paper
Source: Self-asserted source
Maria-Jesus Blanco
Items per page:
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Peer review (24 reviews for 2 publications/grants)

Review activity for ACS medicinal chemistry letters. (10)
Review activity for Journal of medicinal chemistry. (14)