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Other IDs

SciProfiles: 2515661
Scopus Author ID: 54380563400

Keywords

nAChRs, epilepsy, Obesity, Semaglutide, GLP-1 Receptor, GPCRs, Hypothalamus, neurons, Stem Cells

Countries

United Kingdom, United States

Activities

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Employment (1)

University of Cambridge: Cambridge, UK, GB

2022-01-17 to present | Research associate
Employment
Source: Self-asserted source
Simone Mazzaferro

Works (16)

Structural bases for stoichiometry‐selective calcium potentiation of a neuronal nicotinic receptor

British Journal of Pharmacology
2024-07 | Journal article
DOI: 10.1111/bph.16321
Contributors: Simone Mazzaferro; Guipeun Kang; Kathiresan Natarajan; Ryan E. Hibbs; Steven M. Sine
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Crossref

GLP1R agonists activate human POMC neurons

2024-04 | Preprint
DOI: 10.1101/2024.04.02.587825
PPR: PPR831564
Contributors: Mazzaferro S; Chen HC; Cahn O; Yang A; Shepilov D; Chen J; Alcaino C; Macarelli V; Mali I; Gribble F et al.
Source: Self-asserted source
Simone Mazzaferro via Europe PubMed Central

An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis

EMBO Reports
2023-12-20 | Journal article
DOI: 10.1038/s44319-023-00016-2
Contributors: Sara KM Jörgensen; Alena Karnošová; Simone Mazzaferro; Oliver Rowley; Hsiao-Jou Cortina Chen; Sarah J Robbins; Sarah Christofides; Florian T Merkle; Lenka Maletínská; David Petrik
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Crossref

Genetic Variant in Nicotinic Receptor α4-Subunit Causes Sleep-Related Hyperkinetic Epilepsy via Increased Channel Opening

International Journal of Molecular Sciences
2022-10-12 | Journal article
DOI: 10.3390/ijms232012124
Part of ISSN: 1422-0067
Contributors: Simone Mazzaferro
Source: Self-asserted source
Simone Mazzaferro

Stoichiometry‐selective modulation of α4β2 nicotinic ACh receptors by divalent cations

British Journal of Pharmacology
2022-04 | Journal article
DOI: 10.1111/bph.15723
Contributors: Simone Mazzaferro; John R. Strikwerda; Steven M. Sine
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Crossref
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NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor

Cellular and Molecular Life Sciences
2021-02-16 | Journal article
DOI: 10.1007/s00018-020-03592-x
Contributors: Simone Mazzaferro; Sara T. Whiteman; Constanza Alcaino; Arthur Beyder; Steven M. Sine
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Crossref
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Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors.

Neuropharmacology
2019-06-01 | Journal article
DOI: 10.1016/j.neuropharm.2019.05.037
PMID: 31163179
Source: Self-asserted source
Simone Mazzaferro
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Potentiation of a neuronal nicotinic receptor via pseudo-agonist site.

Cellular and molecular life sciences : CMLS
2019-01-01 | Journal article
DOI: 10.1007/s00018-018-2993-7
PMID: 30600358
Source: Self-asserted source
Simone Mazzaferro
grade
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The fifth subunit of the (α4β2)2 β2 nicotinic acetylcholine receptor modulates maximal ACh responses.

2017-06 | Journal article
DOI: 10.1111/bph.13905
PMID: 28600847
Contributors: New K; Del Villar SG; Mazzaferro S; Alcaino C; Bermudez I
Source: Self-asserted source
Simone Mazzaferro via Europe PubMed Central
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α4β2 Nicotinic Acetylcholine Receptors

Journal of Biological Chemistry
2017-02 | Journal article
DOI: 10.1074/jbc.M116.764183
Contributors: Simone Mazzaferro; Isabel Bermudez; Steven M. Sine
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Crossref
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Role of the Cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors

Journal of Biological Chemistry
2016-11 | Journal article
DOI: 10.1074/jbc.m116.751206
Contributors: Constanza Alcaino; Maria Musgaard; Teresa Minguez; Simone Mazzaferro; Manuel Faundez; Patricio Iturriaga-Vasquez; Philip C Biggin; Isabel Bermudez
Source: Self-asserted source
Simone Mazzaferro via Crossref Metadata Search
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Non-equivalent ligand selectivity of agonist sites in (α4β2)2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy.

2014-08 | Journal article
DOI: 10.1074/jbc.m114.555136
PMID: 24936069
PMC: PMC4118137
Contributors: Mazzaferro S; Gasparri F; New K; Alcaino C; Faundez M; Iturriaga Vasquez P; Vijayan R; Biggin PC; Bermudez I
Source: Self-asserted source
Simone Mazzaferro via Europe PubMed Central
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The additional ACh binding site at the α4(+)/α4(-) interface of the (α4β2)2α4 nicotinic ACh receptor contributes to desensitization.

2013-09 | Journal article
DOI: 10.1111/bph.12268
PMID: 23742319
PMC: PMC3834755
Contributors: Benallegue N; Mazzaferro S; Alcaino C; Bermudez I
Source: Self-asserted source
Simone Mazzaferro via Europe PubMed Central
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Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery.

2012-11 | Journal article
DOI: 10.4155/fmc.12.172
PMID: 23190109
Contributors: Mantione E; Micheloni S; Alcaino C; New K; Mazzaferro S; Bermudez I
Source: Self-asserted source
Simone Mazzaferro via Europe PubMed Central
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Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity.

2011-09 | Journal article
DOI: 10.1074/jbc.m111.262014
PMID: 21757735
PMC: PMC3162463
Contributors: Mazzaferro S; Benallegue N; Carbone A; Gasparri F; Vijayan R; Biggin PC; Moroni M; Bermudez I
Source: Self-asserted source
Simone Mazzaferro via Europe PubMed Central
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Differentiation, Transcriptomic Profiling, and Calcium Imaging of Human Hypothalamic Neurons

Current Protocols
Journal article
DOI: 10.1002/cpz1.786
Source: Self-asserted source
Simone Mazzaferro via Crossref Metadata Search
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