Personal information

Systems Toxicology, Systems Biology, Proteomics, Respiratory Disease, Cancer, Ophthamology
Switzerland

Activities

Employment (4)

Roche (Switzerland): Basel, CH

2023-03 to present | Computational Biologist (pRED/Ophthalmology)
Employment
Source: Self-asserted source
Bjoern Titz

Philip Morris Products SA: Neuchatel, CH

2020-11 to 2023-02 | Manager Proteomics & Lipidomics (Biomarkers & Biosensors)
Employment
Source: Self-asserted source
Bjoern Titz

Philip Morris International Research and Development Campus Neuchâtel: Neuchatel, NE, CH

2013 to 2020-11 | Scientist, Computational Biology (Systems Toxicology)
Employment
Source: Self-asserted source
Bjoern Titz

UCLA Life Sciences: Los Angeles, CA, US

2013 to 2013 | Staff Scientist (Molecular Pharmacology)
Employment
Source: Self-asserted source
Bjoern Titz

Education and qualifications (3)

UCLA Life Sciences: Los Angeles, CA, US

2006 to 2012 | Postdoc (Molecular Pharmacology)
Education
Source: Self-asserted source
Bjoern Titz

Karlsruher Institut für Technologie: Karlsruhe, Baden-Württemberg, DE

2003 to 2006 | PhD, Biology / Genetics (Institute of Toxicology and Genetics)
Education
Source: Self-asserted source
Bjoern Titz

Christian Albrechts Universität zu Kiel: Kiel, Schleswig-Holstein, DE

1998 to 2003 | Diplom (M.Sc.), Biochemistry and Molecular Biology
Education
Source: Self-asserted source
Bjoern Titz

Works (50 of 69)

Items per page:
Page 1 of 2

Blood and urine multi-omics analysis of the impact of e-vaping, smoking, and cessation: from exposome to molecular responses.

Scientific reports
2024-02-21 | Journal article
Contributors: Poussin C; Titz B; Xiang Y; Baglia L; Berg R; Bornand D; Choukrallah MA; Curran T; Dijon S; Dossin E et al.
Source: Self-asserted source
Bjoern Titz

Correlation of Aqueous, Vitreous, and Serum Protein Levels in Patients With Retinal Diseases.

Translational vision science & technology
2023-11-01 | Journal article
Contributors: Wilson S; Siebourg-Polster J; Titz B; Jiang Z; Bartolo F; Lavergne V; Gayán J; Garweg JG; Fauser S; Dieckmann A
Source: Self-asserted source
Bjoern Titz

Acclimation strategies of the green alga Chlorella vulgaris to different light regimes revealed by physiological and comparative proteomic analyses.

Journal of experimental botany
2023-08-01 | Journal article
Contributors: Cecchin M; Simicevic J; Chaput L; Hernandez Gil M; Girolomoni L; Stefano CAZZANIGA; Remacle C; Hoeng J; Nikolai V. Ivanov; Titz B et al.
Source: Self-asserted source
Bjoern Titz

Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids.

Toxicology mechanisms and methods
2022-12-19 | Journal article
Contributors: Nury C; Merg C; Eb-Levadoux Y; Bovard D; Porchet M; Maranzano F; Loncarevic I; Tavalaei S; Lize E; Demenescu RL et al.
Source: Self-asserted source
Bjoern Titz

Shotgun Lipidomics of Rodent Tissues.

Journal of visualized experiments : JoVE
2022-11-18 | Journal article
Contributors: Lavrynenko O; Dijon S; Titz B; Ivanov NV
Source: Self-asserted source
Bjoern Titz

Systems biology reveals anatabine to be an NRF2 activator.

Frontiers in pharmacology
2022-11-16 | Journal article
Contributors: Messinis DE; Poussin C; Diogo A.R.S. Latino; Eb-Levadoux Y; Dulize R; Peric D; Guedj E; Titz B; Ivanov NV; Peitsch MC et al.
Source: Self-asserted source
Bjoern Titz

Deconvolution of Systemic Pharmacokinetics Predicts Inhaled Aerosol Dosimetry of Nicotine.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2022-11-03 | Journal article
Contributors: Aditya R. Kolli; Calvino-Martin F; Arkadiusz K. Kuczaj; Wong ET; Titz B; Xiang Y; Lebrun S; Schlage WK; Vanscheeuwijck P; Hoeng J
Source: Self-asserted source
Bjoern Titz

Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System

Bioengineering
2022-09 | Journal article | Author
Contributors: Gabriele Specioso; David Bovard; Filippo Zanetti; Fabio Maranzano; Céline Merg; Antonin Sandoz; Bjoern Titz; Federico Dalcanale; Julia Hoeng; Kasper Renggli et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

Scientific Reports
2020-03-02 | Journal article
Contributors: Giuseppe Lo Sasso; Blaine W. Phillips; Alain Sewer; James N. D. Battey; Athanasios Kondylis; Marja Talikka; Bjoern Titz; Emmanuel Guedj; Dariusz Peric; David Bornand et al.
Source: check_circle
Crossref

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

Archives of Toxicology
2019-11-07 | Journal article
Contributors: Anita R. Iskandar; Filippo Zanetti; Diego Marescotti; Bjorn Titz; Alain Sewer; Athanasios Kondylis; Patrice Leroy; Vincenzo Belcastro; Laura Ortega Torres; Stefano Acali et al.
Source: check_circle
Crossref

A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes

Food and Chemical Toxicology
2019-04 | Journal article
Contributors: Blaine Phillips; Justyna Szostak; Bjoern Titz; Walter K. Schlage; Emmanuel Guedj; Patrice Leroy; Gregory Vuillaume; Florian Martin; Ansgar Buettner; Ashraf Elamin et al.
Source: check_circle
Crossref

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures

Food and Chemical Toxicology
2019-03 | Journal article
Contributors: Filippo Zanetti; Alain Sewer; Bjoern Titz; Walter K. Schlage; Anita R. Iskandar; Athanasios Kondylis; Patrice Leroy; Emmanuel Guedj; Keyur Trivedi; Ashraf Elamin et al.
Source: check_circle
Crossref

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

International Journal of Molecular Sciences
2018-09 | Journal article | Author
Contributors: Bjoern Titz; Raffaella Maria Gadaleta; Giuseppe Lo Sasso; Ashraf Elamin; Kim Ekroos; Nikolai V. Ivanov; Manuel Peitsch; Julia Hoeng
Source: check_circle
Multidisciplinary Digital Publishing Institute

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology

Food and Chemical Toxicology
2018-06 | Journal article
Contributors: Blaine W. Phillips; Walter K. Schlage; Bjoern Titz; Ulrike Kogel; Davide Sciuscio; Florian Martin; Patrice Leroy; Gregory Vuillaume; Subash Krishnan; Tom Lee et al.
Source: check_circle
Crossref

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment

Food and Chemical Toxicology
2018-05 | Journal article
Contributors: Bjoern Titz; Ulrike Kogel; Florian Martin; Walter K. Schlage; Yang Xiang; Catherine Nury; Sophie Dijon; Karine Baumer; Dariusz Peric; David Bornand et al.
Source: check_circle
Crossref

Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract

Toxicology Research
2017 | Journal article
Contributors: A. R. Iskandar; B. Titz; A. Sewer; P. Leroy; T. Schneider; F. Zanetti; C. Mathis; A. Elamin; S. Frentzel; W. K. Schlage et al.
Source: check_circle
Crossref

Toxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints [LIVER DATA]

2017 | Dataset
OTHER-ID:

PXD005958

Source: check_circle
EMBL-EBI

Toxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints [LUNG DATA]

2017 | Dataset
OTHER-ID:

PXD005959

Source: check_circle
EMBL-EBI

Toxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints [RNE DATA]

2017 | Dataset
OTHER-ID:

PXD006894

Source: check_circle
EMBL-EBI

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints

Food and Chemical Toxicology
2017-11 | Journal article
Contributors: Blaine Phillips; Bjoern Titz; Ulrike Kogel; Danilal Sharma; Patrice Leroy; Yang Xiang; Grégory Vuillaume; Stefan Lebrun; Davide Sciuscio; Jenny Ho et al.
Source: check_circle
Crossref

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study

Food and Chemical Toxicology
2017-03 | Journal article
Contributors: Filippo Zanetti; Bjoern Titz; Alain Sewer; Giuseppe Lo Sasso; Elena Scotti; Walter K. Schlage; Carole Mathis; Patrice Leroy; Shoaib Majeed; Laura Ortega Torres et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Systems toxicological assessment of the mentholated Tobacco Heating System 2.2 aerosol revealed reduced cellular and molecular exposure effects compared with cigarette smoke

Toxicology Letters
2016-10 | Journal article
Contributors: U. Kogel; B. Titz; W.K. Schlage; C. Nury; F. Martin; A. Oviedo; S. Lebrun; A. Elamin; E. Guedj; K. Trivedi et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

The systems toxicology challenge: Marker of exposure response identification in blood

Toxicology Letters
2016-10 | Journal article
Contributors: C. Poussin; V. Belcastro; S. Boué; F. Martin; A. Sewer; B. Titz; L. Cannesson; M.C. Peitsch; J. Hoeng
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Toxicological assessment of the mentholated Tobacco Heating System 2.2 – A modified risk tobacco product – In a 90-day inhalation study complemented with systems toxicology

Toxicology Letters
2016-10 | Journal article
Contributors: A. Oviedo; S. Lebrun; J. Ho; W.T. Tan; U. Kogel; P. Leroy; B. Titz; M. Martin; C. Nury; A. Elamin et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

International Journal of Molecular Sciences
2016-09 | Journal article
Contributors: Bjoern Titz; Karsta Luettich; Patrice Leroy; Stephanie Boue; Gregory Vuillaume; Terhi Vihervaara; Kim Ekroos; Florian Martin; Manuel Peitsch; Julia Hoeng
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma

Cell Discovery
2016-09-06 | Journal article
Contributors: Bjoern Titz; Anastasia Lomova; Allison Le; Willy Hugo; Xiangju Kong; Johanna ten Hoeve; Michael Friedman; Hubing Shi; Gatien Moriceau; Chunying Song et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer

Cell
2016-08 | Journal article
Contributors: Justin M. Drake; Evan O. Paull; Nicholas A. Graham; John K. Lee; Bryan A. Smith; Bjoern Titz; Tanya Stoyanova; Claire M. Faltermeier; Vladislav Uzunangelov; Daniel E. Carlin et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

2016-06 | Journal article
Contributors: Chen Z; Shojaee S; Buchner M; Geng H; Lee JW; Klemm L; Titz B; Graeber TG; Park E; Tan YX et al.
Source: Self-asserted source
Bjoern Titz via Europe PubMed Central

Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice

Journal of Proteomics
2016-06 | Journal article
Contributors: Ashraf Elamin; Bjoern Titz; Sophie Dijon; Celine Merg; Marcel Geertz; Thomas Schneider; Florian Martin; Walter K. Schlage; Stefan Frentzel; Fabio Talamo et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Systems Toxicology

Encyclopedia of Drug Metabolism and Interactions
2016-06 | Other
Contributors: Marja Talikka; Stephanie Boué; Stefan Frentzel; Ulrike Kogel; Nicolas Sierro; Bjorn Titz; Emilija Veljkovic; Julia Hoeng; Manuel C. Peitsch
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

CRAF R391W is a melanoma driver oncogene

Sci. Rep.
2016-06-08 | Journal article
Contributors: Mohammad Atefi; Bjoern Titz; Jennifer Tsoi; Earl Avramis; Allison Le; Charles Ng; Anastasia Lomova; Amanda Lassen; Michael Friedman; Bartosz Chmielowski et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/−Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

Toxicol. Sci.
2016-05 | Journal article
Contributors: Blaine Phillips; Emilija Veljkovic; Stéphanie Boué; Walter K. Schlage; Gregory Vuillaume; Florian Martin; Bjoern Titz; Patrice Leroy; Ansgar Buettner; Ashraf Elamin et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver inApoe−/−mice – a systems toxicology analysis

Inhalation Toxicology
2016-03 | Journal article
Contributors: Giuseppe Lo Sasso; Bjoern Titz; Catherine Nury; Stéphanie Boué; Blaine Phillips; Vincenzo Belcastro; Thomas Schneider; Sophie Dijon; Karine Baumer; Daruisz Peric et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

Sci. Data
2016-01-05 | Journal article
Contributors: Sam Ansari; Karine Baumer; Stéphanie Boué; Sophie Dijon; Remi Dulize; Kim Ekroos; Ashraf Elamin; Clement Foong; Emmanuel Guedj; Julia Hoeng et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product

Food and Chemical Toxicology
2015 | Journal article
EID:

2-s2.0-84927607692

Contributors: Phillips, B.; Veljkovic, E.; Peck, M.J.; Buettner, A.; Elamin, A.; Guedj, E.; Vuillaume, G.; Ivanov, N.V.; Martin, F.; Boué, S. et al.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier

Analysis of Proteomic Data for Toxicological Applications

Computational Systems Toxicology
2015 | Other
Contributors: Bjoern Titz; Thomas Schneider; Ashraf Elamin; Florian Martin; Sophie Dijon; Nikolai V. Ivanov; Julia Hoeng; Manuel C. Peitsch
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma

Molecular Cancer
2015 | Journal article
EID:

2-s2.0-84924275450

Contributors: Atefi, M.; Titz, B.; Avramis, E.; Ng, C.; Wong, D.J.L.; Lassen, A.; Cerniglia, M.; Escuin-Ordinas, H.; Foulad, D.; Comin-Anduix, B. et al.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier

Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1

PLoS ONE
2015 | Journal article
EID:

2-s2.0-84926467013

Contributors: Ting, P.Y.; Damoiseaux, R.; Titz, B.; Bradley, K.A.; Graeber, T.G.; Fernández-Vega, V.; Bannister, T.D.; Chase, P.; Nair, R.; Scampavia, L. et al.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
EID:

2-s2.0-84922311449

Contributors: Ploper, D.; Taelman, V.F.; Robert, L.; Perez, B.S.; Titz, B.; Chen, H.-W.; Graeber, T.G.; Von Euw, E.; Ribas, A.; De Robertis, E.M.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier

The systems toxicology challenge

Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics - BCB '15
2015 | Conference paper
Contributors: Nikolai V. Ivanov; Carine Poussin; Stéphanie Boué; Florian Martin; Alain Sewer; Bjoern Titz; Manuel C. Peitsch; Julia Hoeng
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe −/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

Toxicol. Sci.
2015-11 | Journal article
Contributors: Blaine Phillips; Emilija Veljkovic; Stéphanie Boué; Walter K. Schlage; Gregory Vuillaume; Florian Martin; Bjoern Titz; Patrice Leroy; Ansgar Buettner; Ashraf Elamin et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe −/− Mice—An Integrative Systems Toxicology Analysis

Toxicol. Sci.
2015-11 | Journal article
Contributors: Bjoern Titz; Stéphanie Boué; Blaine Phillips; Marja Talikka; Terhi Vihervaara; Thomas Schneider; Catherine Nury; Ashraf Elamin; Emmanuel Guedj; Michael J. Peck et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects

Journal of Proteomics
2015-10 | Journal article
Contributors: Bjoern Titz; Alain Sewer; Thomas Schneider; Ashraf Elamin; Florian Martin; Sophie Dijon; Karsta Luettich; Emmanuel Guedj; Gregory Vuillaume; Nikolai V. Ivanov et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

Nature
2015-03 | Journal article
Contributors: Zhengshan Chen; Seyedmehdi Shojaee; Maike Buchner; Huimin Geng; Jae Woong Lee; Lars Klemm; Björn Titz; Thomas G. Graeber; Eugene Park; Ying Xim Tan et al.
Source: Self-asserted source
Bjoern Titz via Crossref Metadata Search

Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma

Clinical Cancer Research
2014 | Journal article
EID:

2-s2.0-84903831602

Contributors: Atefi, M.; Avramis, E.; Lassen, A.; Wong, D.J.L.; Robert, L.; Foulad, D.; Cerniglia, M.; Titz, B.; Chodon, T.; Graeber, T.G. et al.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier
grade
Preferred source (of 2)‎

Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84896927130

Contributors: Zimman, A.; Titz, B.; Komisopoulou, E.; Biswas, S.; Graeber, T.G.; Podrez, E.A.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier

Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors

Molecular Cancer Research
2014 | Journal article
EID:

2-s2.0-84919341027

Contributors: Anderson, J.L.; Titz, B.; Akiyama, R.; Komisopoulou, E.; Park, A.; Tap, W.D.; Graeber, T.G.; Denny, C.T.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier
grade
Preferred source (of 2)‎

Proteomics for systems toxicology

Computational and Structural Biotechnology Journal
2014 | Journal article
EID:

2-s2.0-84924965409

Contributors: Titz, B.; Elamin, A.; Martin, F.; Schneider, T.; Dijon, S.; Ivanov, N.V.; Hoeng, J.; Peitsch, M.C.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier

BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

Nature Medicine
2013 | Journal article
EID:

2-s2.0-84882281048

Contributors: Swaminathan, S.; Huang, C.; Geng, H.; Chen, Z.; Harvey, R.; Kang, H.; Ng, C.; Titz, B.; Hurtz, C.; Sadiyah, M.F. et al.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
EID:

2-s2.0-84889677377

Contributors: Drake, J.M.; Graham, N.A.; Lee, J.K.; Stoyanova, T.; Faltermeier, C.M.; Sud, S.; Titz, B.; Huang, J.; Pienta, K.J.; Graeber, T.G. et al.
Source: Self-asserted source
Bjoern Titz via Scopus - Elsevier
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