Personal information

United States

Activities

Employment (3)

Rockefeller University: New York, New York, US

2021-06-24 to present | Visiting Fellow (St Giles Laboratory of Human Genetics of Infectious Diseases)
Employment
Source: Self-asserted source
Rui Yang

NewYork–Presbyterian Hospital: New York, New York, US

2021-06-24 to present | Resident House Staff (Weil Cornell/Pediatrics)
Employment
Source: Self-asserted source
Rui Yang

Rockefeller University: New York, NY, US

2016-10-15 to 2021-06-23 | Postdoc (Human Genetics of Infectious Diseases)
Employment
Source: Self-asserted source
Rui Yang

Education and qualifications (2)

University of Vermont: Burlington, VT, US

2011-08-20 to 2016-10-01 (Department of Medicine/Immunobiology Program)
Education
Source: Self-asserted source
Rui Yang

Huazhong University of Science and Technology Tongji Medical College: Wuhan, Hubei, CN

2006-09-01 to 2011-07-01
Education
Source: Self-asserted source
Rui Yang

Funding (5)

Inherited T-BET deficiency in Mendelian Susceptibility to Mycobacterial Disease

2019-05 to 2020-08 | Grant
Immune Deficiency Foundation (Md., Md., US)
Source: Self-asserted source
Rui Yang

Molecular and cellular dissection of inherited T-bet deficiency in the pathogenesis of MSMD

2018-10 to 2019-10 | Grant
Rockefeller University Pilot Project by the Shapiro-Silverberg Fund (New York, US)
Source: Self-asserted source
Rui Yang

Molecular and cellular dissection of inherited BTN3A3

2018-07 to 2020-06 | Salary award
Stony Wold-Herbert Fund (NY, NY, US)
Source: Self-asserted source
Rui Yang

Molecular and cellular dissection of inherited BTN3A3 deficiency in the pathogenesis of human tuberculosis

2017-10 to 2018-10 | Grant
Rockefeller University Sackler Center for Biomedicine and Nutrition (NY, NY, US)
Source: Self-asserted source
Rui Yang

2015 Careers in Immunology Fellowship

2015-09 to 2016-09 | Award
American Association of Immunologists (MD, MD, US)
Source: Self-asserted source
Rui Yang

Works (43)

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals

OpenAlex
2024-03-12 | Other
Contributors: Jessica N. Peel; Rui Yang; tom le voyer; Adrian Gervais; Jeremie Rosain; Paul Bastard; Anish Behere; Axel Cederholm; Aaron Bodansky; Yoann Seeleuthner et al.
Source: check_circle
DataCite

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals

OpenAlex
2024-03-12 | Other
Contributors: Jessica N. Peel; Rui Yang; tom le voyer; Adrian Gervais; Jeremie Rosain; Paul Bastard; Anish Behere; Axel Cederholm; Aaron Bodansky; Yoann Seeleuthner et al.
Source: check_circle
DataCite

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria

OpenAlex
2023-11-01 | Other
Contributors: Jonathan Bohlen; Qinhua Zhou; Quentin Philippot; Masato Ogishi; Darawan Rinchai; Tea Nieminen; simin seyedpour; Nima Parvaneh; Nima Rezaei; Niloufar Yazdanpanah et al.
Source: check_circle
DataCite

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria

OpenAlex
2023-11-01 | Other
Contributors: Jonathan Bohlen; Qinhua Zhou; Quentin Philippot; Masato Ogishi; Darawan Rinchai; Tea Nieminen; simin seyedpour; Nima Parvaneh; Nima Rezaei; Niloufar Yazdanpanah et al.
Source: check_circle
DataCite

Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity

Current Opinion in Immunology
2023-04 | Journal article
Part of ISSN: 0952-7915
Contributors: Masato Ogishi; Rui Yang; Jérémie Rosain; Jacinta Bustamante; Jean-Laurent Casanova; Stéphanie Boisson-Dupuis
Source: Self-asserted source
Rui Yang

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Cell
2023-02 | Journal article
Part of ISSN: 0092-8674
Contributors: Jérémie Rosain; Anna-Lena Neehus; Jérémy Manry; Rui Yang; Jérémie Le Pen; Wassim Daher; Zhiyong Liu; Yi-Hao Chan; Natalia Tahuil; Özden Türel et al.
Source: Self-asserted source
Rui Yang

Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria

Science Immunology
2023-02-24 | Journal article | Author
Part of ISSN: 2470-9468
Contributors: Quentin Philippot; Masato Ogishi; Jonathan Bohlen; Julia Puchan; Arias AA; Tina Nguyen ; Marta Martín-Fernández; Clement Conil; Darawan Rinchai; Mana Momenilandi et al.
Source: Self-asserted source
Rui Yang

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

OpenAlex
2023-02-01 | Other
Contributors: Jeremie Rosain; Anna-Lena Neehus; Jeremy Manry; Rui Yang; Jérémie Le Pen; wassim DAHER; Zhiyong Liu; Yi-Hao Chan ; Natalia Tahuil; Ozden Turel et al.
Source: check_circle
DataCite

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

OpenAlex
2023-02-01 | Other
Contributors: Jeremie Rosain; Anna-Lena Neehus; Jeremy Manry; Rui Yang; Jérémie Le Pen; wassim DAHER; Zhiyong Liu; Yi-Hao Chan ; Natalia Tahuil; Ozden Turel et al.
Source: check_circle
DataCite

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

Journal of Experimental Medicine
2023-01-02 | Journal article | Author
Part of ISSN: 0022-1007
Part of ISSN: 1540-9538
Contributors: Masato Ogishi; Rui Yang; Rémy Rodriguez; Dominic P Golec; Emmanuel Martin; Quentin Philippot; Jonathan Bohlen; Simon Pelham; Arias AA; taushif khan et al.
Source: Self-asserted source
Rui Yang

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

OpenAlex
2022-11-03 | Other
Contributors: Masato Ogishi; Rui Yang; Rémy Rodriguez; Dominic P Golec; Emmanuel Martin; Quentin Philippot; Jonathan Bohlen; Simon Pelham; Arias AA; taushif khan et al.
Source: check_circle
DataCite

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

OpenAlex
2022-11-03 | Other
Contributors: Masato Ogishi; Rui Yang; Rémy Rodriguez; Dominic P Golec; Emmanuel Martin; Quentin Philippot; Jonathan Bohlen; Simon Pelham; Arias AA; taushif khan et al.
Source: check_circle
DataCite
grade
Preferred source (of 2)‎

Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency

Journal of Experimental Medicine
2022-10-03 | Journal article | Author
Part of ISSN: 0022-1007
Part of ISSN: 1540-9538
Contributors: Masato Ogishi; Arias AA; Rui Yang; JI EUN HAN; Peng Zhang; Darawan Rinchai; Joshua Halpern; Jeanette Mulwa; Narelle Keating; maya chrabieh et al.
Source: Self-asserted source
Rui Yang

Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency

OpenAlex
2022-09-12 | Other
Contributors: Masato Ogishi; Arias AA; Rui Yang; JI EUN HAN; Peng Zhang; Darawan Rinchai; Joshua Halpern; Jeanette Mulwa; Narelle Keating; maya chrabieh et al.
Source: check_circle
DataCite

Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency

OpenAlex
2022-09-12 | Other
Contributors: Masato Ogishi; Arias AA; Rui Yang; JI EUN HAN; Peng Zhang; Darawan Rinchai; Joshua Halpern; Jeanette Mulwa; Narelle Keating; maya chrabieh et al.
Source: check_circle
DataCite

Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

Nature Communications
2022-07-27 | Journal article
Part of ISSN: 2041-1723
Contributors: Carys Anne Croft; 0000-0002-0698-8561; Solenne Marie; Jean-Marc Doisne; Laura Surace; Rui Yang; Anne Puel; Jacinta Bustamante; Jean-Laurent Casanova; James P. Di Santo
Source: Self-asserted source
Rui Yang

Human T-bet governs the generation of a distinct subset of CD11c <sup>high</sup> CD21 <sup>low</sup> B cells

Science Immunology
2022-07-22 | Journal article | Author
Part of ISSN: 2470-9468
Contributors: Rui Yang; Danielle; Katherine Jackson; Masato Ogishi; IBTIHAL BENHSAIEN; Likun Du; Xiaofei Ye; Jing Han; Jeremie Rosain; Jessica N. Peel et al.
Source: Self-asserted source
Rui Yang

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin

Science
2022-06-17 | Journal article | Author
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Contributors: András Spaan; Anna-Lena Neehus; Emmanuel LAPLANTINE; Frederik Staels; Masato Ogishi; Yoann Seeleuthner; Franck Rapaport; Keenan A. Lacey; Erika Van Nieuwenhove; Maya Chrabieh et al.
Source: Self-asserted source
Rui Yang

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

Proceedings of the National Academy of Sciences of the United States of America
2022-05-16 | Journal article | Author
Contributors: Manry J; Paul Bastard; Gervais A; Le Voyer T; Jeremie Rosain; Philippot Q; Eleftherios Michailidis; Hoffmann HH; Eto S; Marina Garcia-Prat et al.
Source: Self-asserted source
Rui Yang

Human genetic and immunological determinants of critical COVID-19 pneumonia.

Nature
2022-01-28 | Journal article
Contributors: Qian Zhang; Bastard P; COVID Human Genetic Effort; Aurélie Cobat; Jean-Laurent Casanova
Source: Self-asserted source
Rui Yang

IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca<sup>2+</sup>through the noncanonical STAT3 pathway

Proceedings of the National Academy of Sciences
2021-09-14 | Journal article | Author
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Felipe Valença-Pereira; Qian Fang; Isabelle J. Marié; Emily Giddings; Karen A. Fortner; Rui Yang; Alejandro V. Villarino; Yina H. Huang; David A. Frank; Haitao Wen et al.
Source: Self-asserted source
Rui Yang

Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents

Journal of Clinical Investigation
2021-09-01 | Journal article | Author
Part of ISSN: 1558-8238
Contributors: Romain Lévy; David Langlais; Vivien Béziat; Franck Rapaport; Geetha Rao; Tomi Lazarov; Mathieu Bourgey; Yu J. Zhou; Coralie Briand; Kunihiko Moriya et al.
Source: Self-asserted source
Rui Yang

Autoantibodies neutralizing type I IFNs are present in <b>~</b>4% of uninfected individuals over 70 years old and account for <b>~</b>20% of COVID-19 deaths.

Science immunology
2021-08-01 | Journal article
Contributors: Bastard P; Adrian Gervais; Le Voyer T; Rosain J; Philippot Q; Manry J; Eleftherios Michailidis; Hoffmann HH; Eto S; Marina Garcia-Prat et al.
Source: Self-asserted source
Rui Yang

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.

Nature medicine
2021-06-28 | Journal article
Source: Self-asserted source
Rui Yang

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency.

The Journal of experimental medicine
2021-06-23 | Journal article
Source: Self-asserted source
Rui Yang

Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.

Cell
2021-06-22 | Journal article
Source: Self-asserted source
Rui Yang

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine.

The Journal of experimental medicine
2021-04-01 | Journal article
Source: Self-asserted source
Rui Yang

Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease.

Proceedings of the National Academy of Sciences of the United States of America
2021-04-01 | Journal article
Source: Self-asserted source
Rui Yang

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.

Cell
2020-12-08 | Journal article
Source: Self-asserted source
Rui Yang

Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.

Med (New York, N.Y.)
2020-12-01 | Journal article
Source: Self-asserted source
Rui Yang

Multibatch Cytometry Data Integration for Optimal Immunophenotyping.

Journal of immunology (Baltimore, Md. : 1950)
2020-11-23 | Journal article
Source: Self-asserted source
Rui Yang

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19.

Science (New York, N.Y.)
2020-09-24 | Journal article
Source: Self-asserted source
Rui Yang

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

Science (New York, N.Y.)
2020-09-24 | Journal article
Source: Self-asserted source
Rui Yang

Inherited human IFN-γ deficiency underlies mycobacterial disease.

The Journal of clinical investigation
2020-03-12 | Journal article
Source: Self-asserted source
Rui Yang

Homozygosity for TYK2 P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry.

Proceedings of the National Academy of Sciences of the United States of America
2019-05-08 | Journal article
Source: Self-asserted source
Rui Yang

Mitochondrial Stat3, the Need for Design Thinking.

2016 | Journal article
Contributors: Yang R; Rincon M
Source: Self-asserted source
Rui Yang via Europe PubMed Central

IL-6 promotes the differentiation of a subset of naive CD8+T cells into IL-21–producing B helper CD8+T cells

The Journal of Experimental Medicine
2016-09 | Journal article
Contributors: Rui Yang; April R. Masters; Karen A. Fortner; Devin P. Champagne; Natalia Yanguas-Casás; Daniel J. Silberger; Casey T. Weaver; Laura Haynes; Mercedes Rincon
Source: Self-asserted source
Rui Yang via Crossref Metadata Search

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.

2016-06 | Journal article
Contributors: Champagne DP; Hatle KM; Fortner KA; D'Alessandro A; Thornton TM; Yang R; Torralba D; Tomás-Cortázar J; Jun YW; Ahn KH et al.
Source: Self-asserted source
Rui Yang via Europe PubMed Central

Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.

2015 | Journal article
Contributors: Yang R; Lirussi D; Thornton TM; Jelley-Gibbs DM; Diehl SA; Case LK; Madesh M; Taatjes DJ; Teuscher C; Haynes L et al.
Source: Self-asserted source
Rui Yang via Europe PubMed Central

Resveratrol pretreatment protects rat hearts from ischemia/reperfusion injury partly via a NALP3 inflammasome pathway.

2015 | Journal article
Contributors: Dong W; Yang R; Yang J; Yang J; Ding J; Wu H; Zhang J
Source: Self-asserted source
Rui Yang via Europe PubMed Central

RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways

Cell Physiol Biochem
2015-07 | Journal article
Contributors: Jun Yang; Xin Guo; Jian Yang; Jia-wang Ding; Song Li; Rui Yang; Zhi-xing Fan; Chao-jun Yang
Source: Self-asserted source
Rui Yang via Crossref Metadata Search

Expression of Toll-like Receptor 4 on Peripheral Blood Mononuclear Cells and Its Effects on Patients with Acute Myocardial Infarction Treated with Thrombolysis

Archives of Medical Research
2010-08 | Journal article
Contributors: Jun Yang; Lv-ying Jin; Jia-wang Ding; Yong-qin Zhou; Jian Yang; Rui-Yang; Li-li
Source: Self-asserted source
Rui Yang via Crossref Metadata Search

The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4

Mol Biol Rep
2010-02-04 | Journal article
Contributors: Jun Yang; Xiao-Dong Zhang; Jian Yang; Jia-Wang Ding; Zhao-Qi Liu; Shu-Guo Li; Rui Yang
Source: Self-asserted source
Rui Yang via Crossref Metadata Search

Peer review (2 reviews for 2 publications/grants)

Review activity for Human genetics. (1)
Review activity for Journal of clinical immunology. (1)