Personal information

GPCR, signal transduction, tethered agonist, second messenger assay, structure/function

Activities

Works (33)

The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development

Communications Biology
2024-01-16 | Journal article
Contributors: Juliane Röthe; Robert Kraft; Albert Ricken; Isabell Kaczmarek; Madlen Matz-Soja; Karsten Winter; André Nguyen Dietzsch; Julia Buchold; Marie-Gabrielle Ludwig; Ines Liebscher et al.
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Crossref

G Protein-Coupled Receptors in Cell Signaling Transduction

International Journal of Molecular Sciences
2023-12-25 | Journal article
Contributors: Sandra Beer-Hammer; Ines Liebscher
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Crossref
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Preferred source (of 2)‎

Intramolecular activity regulation of adhesion GPCRs in light of recent structural and evolutionary information

Pharmacological Research
2023-11 | Journal article
Contributors: Gunnar Kleinau; Amal Hassan Ali; Franziska Wiechert; Michal Szczepek; Andrea Schmidt; Christian M.T. Spahn; Ines Liebscher; Torsten Schöneberg; Patrick Scheerer
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Crossref

Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6

Cells
2023-06 | Journal article | Author
Contributors: Caroline Wilde; Paulomi Mehta Chaudhry; Rong Luo; Kay-Uwe Simon; Xianhua Piao; Ines Liebscher
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Multidisciplinary Digital Publishing Institute
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Preferred source (of 2)‎

A guide to adhesion GPCR research

The FEBS Journal
2022-12 | Journal article
Contributors: Ines Liebscher; Orkun Cevheroğlu; Cheng‐Chih Hsiao; André F. Maia; Hannes Schihada; Nicole Scholz; Mark Soave; Katja Spiess; Katarina Trajković; Mickey Kosloff et al.
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Crossref

Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies

Signal Transduction and Targeted Therapy
2022-07-09 | Journal article
Contributors: Ines Liebscher; Torsten Schöneberg; Doreen Thor
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Crossref

Translating the force—mechano-sensing GPCRs

American Journal of Physiology-Cell Physiology
2022-06-01 | Journal article
Contributors: Caroline Wilde; Jakob Mitgau; Tomáš Suchý; Torsten Schöneberg; Ines Liebscher
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Crossref

Affinity Proteomics Identifies Interaction Partners and Defines Novel Insights into the Function of the Adhesion GPCR VLGR1/ADGRV1

Molecules
2022-05 | Journal article | Author
Contributors: Barbara Knapp; Jens Roedig; Heiko Roedig; Jacek Krzysko; Nicola Horn; Baran E. Güler; Deva Krupakar Kusuluri; Adem Yildirim; Karsten Boldt; Marius Ueffing et al.
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Multidisciplinary Digital Publishing Institute

Hepatic Hedgehog Signaling Participates in the Crosstalk between Liver and Adipose Tissue in Mice by Regulating FGF21

Cells
2022-05 | Journal article | Author
Contributors: Fritzi Ott; Christiane Körner; Kim Werner; Martin Gericke; Ines Liebscher; Donald Lobsien; silvia radrezza; Andrej Shevchenko; Ute Hofmann; Jürgen Kratzsch et al.
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Multidisciplinary Digital Publishing Institute
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Preferred source (of 2)‎

The relevance of adhesion G protein-coupled receptors in metabolic functions

Biological Chemistry
2022-01-27 | Journal article
Contributors: Isabell Kaczmarek; Tomáš Suchý; Simone Prömel; Torsten Schöneberg; Ines Liebscher; Doreen Thor
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Crossref

The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator

2021-09-13 | Preprint
Contributors: Jakob Mitgau; Julius Franke; Camilla Schinner; Gabriele Stephan; Sandra Berndt; Dimitris G. Placantonakis; Hermann Kalwa; Volker Spindler; Caroline Wilde; Ines Liebscher
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Crossref

New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation

International Journal of Molecular Sciences
2021-06 | Journal article | Author
Contributors: Sandra Berndt; Ines Liebscher
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling

Journal of Biological Chemistry
2021-01 | Journal article
Contributors: Joshua D. Frenster; Gabriele Stephan; Niklas Ravn-Boess; Devin Bready; Jordan Wilcox; Bjoern Kieslich; Caroline Wilde; Norbert Sträter; Giselle R. Wiggin; Ines Liebscher et al.
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Crossref

Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches

Pharmacological Reviews
2021-01 | Journal article
Contributors: Torsten Schöneberg; Ines Liebscher; Paul Insel
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Crossref

Evaluating the feasibility of Cas9 overexpression in 3T3-L1 cells for generation of genetic knock-out adipocyte cell lines

Adipocyte
2021-01-01 | Journal article
Contributors: Tomás Suchý; Isabell Kaczmarek; Tomislav Maricic; Christian Zieschang; Torsten Schöneberg; Doreen Thor; Ines Liebscher
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Crossref

Activation of Adhesion G Protein-coupled Receptors

Journal of Biological Chemistry
2017-03 | Journal article
Contributors: Lilian M. Demberg; Jana Winkler; Caroline Wilde; Kay-Uwe Simon; Julia Schön; Sven Rothemund; Torsten Schöneberg; Simone Prömel; Ines Liebscher
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Crossref

Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133)

BMC Genomics
2016-12 | Journal article
Contributors: Liane Fischer; Caroline Wilde; Torsten Schöneberg; Ines Liebscher
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Crossref

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

2015 | Journal article
Contributors: Hamann J; Aust G; Araç D; Engel FB; Formstone C; Fredriksson R; Hall RA; Harty BL; Kirchhoff C; Knapp B et al.
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist.

2015-10 | Journal article
Contributors: Wilde C; Fischer L; Lede V; Kirchberger J; Rothemund S; Schöneberg T; Liebscher I
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms.

2015-09 | Journal article
Contributors: Monk KR; Hamann J; Langenhan T; Nijmeijer S; Schöneberg T; Liebscher I
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

How to wake a giant.

2015-09 | Journal article
Contributors: Liebscher I; Monk KR; Schöneberg T
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2.

2015-08 | Journal article
Contributors: Demberg LM; Rothemund S; Schöneberg T; Liebscher I
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation.

2015-06 | Journal article
Contributors: Schöneberg T; Liebscher I; Luo R; Monk KR; Piao X
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211.

2015-02 | Journal article
Contributors: Petersen SC; Luo R; Liebscher I; Giera S; Jeong SJ; Mogha A; Ghidinelli M; Feltri ML; Schöneberg T; Piao X et al.
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133.

2014-12 | Journal article
Contributors: Liebscher I; Schön J; Petersen SC; Fischer L; Auerbach N; Demberg LM; Mogha A; Cöster M; Simon KU; Rothemund S et al.
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.

2014-12 | Journal article
Contributors: Liebscher I; Ackley B; Araç D; Ariestanti DM; Aust G; Bae BI; Bista BR; Bridges JP; Duman JG; Engel FB et al.
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Combined newborn screening for familial hemophagocytic lymphohistiocytosis and severe T- and B-cell immunodeficiencies.

2014-07 | Journal article
Contributors: Borte S; Meeths M; Liebscher I; Krist K; Nordenskjöld M; Hammarström L; von Döbeln U; Henter JI; Bryceson YT
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation.

2013-11 | Journal article
Contributors: Mogha A; Benesh AE; Patra C; Engel FB; Schöneberg T; Liebscher I; Monk KR
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Progress in demystification of adhesion G protein-coupled receptors.

2013-08 | Journal article
Contributors: Liebscher I; Schöneberg T; Prömel S
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Dissecting signaling and functions of adhesion G protein-coupled receptors.

2012-12 | Journal article
Contributors: Araç D; Aust G; Calebiro D; Engel FB; Formstone C; Goffinet A; Hamann J; Kittel RJ; Liebscher I; Lin HH et al.
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

The ligand specificity of the G-protein-coupled receptor GPR34.

2012-05 | Journal article
Contributors: Ritscher L; Engemaier E; Stäubert C; Liebscher I; Schmidt P; Hermsdorf T; Römpler H; Schulz A; Schöneberg T
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Altered immune response in mice deficient for the G protein-coupled receptor GPR34.

2011-01 | Journal article
Contributors: Liebscher I; Müller U; Teupser D; Engemaier E; Engel KM; Ritscher L; Thor D; Sangkuhl K; Ricken A; Wurm A et al.
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Structural and functional evolution of the P2Y(12)-like receptor group.

2007-09 | Journal article
Contributors: Schöneberg T; Hermsdorf T; Engemaier E; Engel K; Liebscher I; Thor D; Zierau K; Römpler H; Schulz A
Source: Self-asserted source
Ines Liebscher via Europe PubMed Central

Peer review (8 reviews for 6 publications/grants)

Review activity for Advanced science. (1)
Review activity for Cellular and molecular life sciences (1)
Review activity for Communications biology. (1)
Review activity for Nature (3)
Review activity for Nature communications (1)
Review activity for Nature metabolism. (1)