Palomares O (0000-0003-4516-0369)

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Biography

Biochemistry degree (2000). PhD under the guidance of Drs. Rodríguez and Villalba at Complutense University of Madrid (UCM) (2005): Purification and recombinant production of allergens from mustard seeds and olive pollen, contributing to implement the concept of component-resolved diagnosis of allergy. Assistant Professor at UCM (2006): Occupational allergies. Post-doctoral stay at the Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland under the guidance of Prof. Dr. med. Cezmi A. Akdis (2008): Role played by functional allergen-specific FOXP3+ Treg cells and pDCs in the induction of tolerance to allergens in vivo in human tonsils. Ramón y Cajal (RyC) Scholar Research Associate at the Dept of Biochemistry and Molecular Biology I at UCM as junior group leader(2012-continue): Biochemistry and function of dendritic cells in the context of inflammatory diseases to identify potential novel therapeutic targets for their treatments.

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Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

2012-01 to present | Ramón y Cajal Associate Researcher (Biochemistry and Molecular Biology)

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Palomares O

https://orcid.org/0000-0003-4516-0369

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Biography

Activities

Employment (1)

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

Education and qualifications (2)

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

Works (50 of 69)

Allergen‐Specific Immunotherapy and Trained Immunity

The Direct and Indirect Role of IgE on Airway Epithelium in Asthma

European Respiratory Society Research Seminar on Preventing Pediatric Asthma

Nutritional and environmental exposures in athletes: Implications on the epithelial barrier function

Trained immunity–based vaccines for infections and allergic diseases

Ligelizumab impairs IgE‐binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN‐α production and FOXP3+ Treg generation

Tonsillar transcriptional profiles in atopic and non‐atopic subjects

Regulatory T cells and immunoglobulin E: A new therapeutic link for autoimmunity?

Nasal Symptoms in Asthmatic Patients under Treatment with Anti-IL-5 Monoclonal Antibodies. A Real-Life Cohort Study

COVID‐19 vaccination in patients receiving allergen immunotherapy (AIT) or biologicals—EAACI recommendations

Effects of non‐steroidal anti‐inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID‐19

The cannabinoid WIN55212‐2 suppresses effector T‐cell responses and promotes regulatory T cells in human tonsils

Allergoid‐mannan conjugates imprint tolerogenic features in human macrophages

Allergoid-mannan conjugates reprogram monocytes into tolerogenic DCs via epigenetic and metabolic rewiring

EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID‐19 vaccines

The cannabinoid WIN55212‐2 restores rhinovirus‐induced epithelial barrier disruption

Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I

Biologicals in allergic diseases and asthma: Toward personalized medicine and precision health: Highlights of the 3rd EAACI Master Class on Biologicals, San Lorenzo de El Escorial, Madrid, 2019

Alum impairs tolerogenic properties induced by allergoid‐mannan conjugates inhibiting mTOR and metabolic reprogramming in human DCs

The lipid interaction capacity of Sin a 2 and Ara h 1, major mustard and peanut allergens of the cupin superfamily, endorses allergenicity.

New Biological Insights in the Immunomodulatory Effects of Mucosal Polybacterial Vaccines in Clinical Practice.

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1.

Structural studies of novel glycoconjugates from polymerized allergens (allergoids) and mannans as allergy vaccines.

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.

An Enzymatically Active β-1,3-Glucanase from Ash Pollen with Allergenic Properties: A Particular Member in the Oleaceae Family.

EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders.

The allergenic structure of the thaumatin-like protein Ole e 13 is degraded by processing of raw olive fruits.

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β.

The contribution of biotechnology toward progress in diagnosis, management, and treatment of allergic diseases.

Detailed characterization of Act d 12 and Act d 13 from kiwi seeds: implication in IgE cross-reactivity with peanut and tree nuts.

Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine.

Act d 12 and Act d 13: two novel, masked, relevant allergens in kiwifruit seeds.

Distinct regulation of tonsillar immune response in virus infection.

The expression of cannabinoid receptor 1 is significantly increased in atopic patients.

The role of regulatory T cells in IgE-mediated food allergy.

Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood.

The 11S globulin Sin a 2 from yellow mustard seeds shows IgE cross-reactivity with homologous counterparts from tree nuts and peanut.

Chemical probes for the recognition of cannabinoid receptors in native systems.

Analysis of the structural and immunological stability of 2S albumin, nonspecific lipid transfer protein, and profilin allergens from mustard seeds.

TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection.

Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance.

Improvement of mustard (Sinapis alba) allergy diagnosis and management by linking clinical features and component-resolved approaches.

Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases.

nsLTP and profilin are allergens in mustard seeds: cloning, sequencing and recombinant production of Sin a 3 and Sin a 4.

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells.

Disulfide bond structure and domain organization of yeast beta(1,3)-glucanosyltransferases involved in cell wall biogenesis.

Occupational allergy in a researcher due to Ole e 9, an allergenic 1,3-beta-glucanase from olive pollen.

Solution structure of the C-terminal domain of Ole e 9, a major allergen of olive pollen.

Olive pollen recombinant allergens: value in diagnosis and immunotherapy.

Allergy to turnip seeds in a bird fancier.