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Scopus Author ID: 24335898600

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Employment (4)

Oxford University: Oxford, GB

2024-03-01 to present | Head of Biology (Oxford Drug Discovery Institute)
Employment
Source: Self-asserted source
Emma Murphy

University of Oxford: Oxford, Oxfordshire, GB

2015-10-01 to 2024-02-29 | Assay Development and Screening Team Leader (Oxford Drug Discovery Institute)
Employment
Source: Self-asserted source
Emma Murphy

University of Colorado Denver: Denver, CO, US

2010-09-15 to 2015-09-15 | Senior Postdoctoral Researcher (Pharmacology)
Employment
Source: Self-asserted source
Emma Murphy

University College London: London, London, GB

2008-09-01 to 2010-09-01 | Postdoctoral Researcher (Biochemistry)
Employment
Source: Self-asserted source
Emma Murphy

Education and qualifications (1)

University of Leicester: Leicester, Leicestershire, GB

2005-09-01 to 2008-09-01 | PhD (Chemistry)
Education
Source: Self-asserted source
Emma Murphy

Works (26)

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor

Journal of Proteome Research
2025 | Journal article
DOI: 10.1021/acs.jproteome.4c00618
EID:

2-s2.0-85215864745

Part of ISSN: 15353907 15353893
Contributors: O’Brien, D.P.; Jones, H.B.; Shi, Y.; Guenther, F.; Vendrell, I.; Viner, R.; Brennan, P.E.; Mead, E.; Zarganes-Tzitzikas, T.; Davis, J.B. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms

2025-02 | Preprint
DOI: 10.1101/2025.02.03.636341
PPR: PPR975364
Contributors: Williamson MG; Heon-Roberts R; Franks SNJ; Mock E; Jones HBL; Britti E; Malpartida A; Bassal M; Lavelle M; Connor J et al.
Source: Self-asserted source
Emma Murphy via Europe PubMed Central

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor

2024-07 | Preprint
DOI: 10.1101/2024.07.20.604388
PPR: PPR884791
Contributors: O’Brien DP; Jones HB; Shi Y; Guenther F; Vendrell I; Viner R; Brennan PE; Mead E; Zarganes-Tzitzikas T; Davis JB et al.
Source: Self-asserted source
Emma Murphy via Europe PubMed Central
grade
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Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.

Structure (London, England : 1993)
2024-02 | Journal article
DOI: 10.1016/j.str.2024.01.005
PMID: 38309262
Contributors: Bradshaw WJ; Kennedy EC; Moreira T; Smith LA; Chalk R; Katis VL; Benesch JLP; Brennan PE; Murphy EJ; Gileadi O
Source: Self-asserted source
Emma Murphy via Europe PubMed Central
grade
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Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

bioRxiv
2023 | Other
DOI: 10.1101/2023.07.31.551266
EID:

2-s2.0-85168504149

Part of ISSN: 26928205
Contributors: Bradshaw, W.J.; Kennedy, E.C.; Moreira, T.; Smith, L.A.; Chalk, R.; Katis, V.L.; Benesch, J.L.P.; Brennan, P.E.; Murphy, E.J.; Gileadi, O.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

Molecular and Cellular Proteomics
2023 | Journal article
DOI: 10.1016/j.mcpro.2023.100609
EID:

2-s2.0-85168378040

Part of ISSN: 15359484 15359476
Contributors: O'Brien, D.P.; Jones, H.B.L.; Guenther, F.; Murphy, E.J.; England, K.S.; Vendrell, I.; Anderson, M.; Brennan, P.E.; Davis, J.B.; Pinto-Fernández, A. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

bioRxiv
2022 | Other
DOI: 10.1101/2022.09.13.507798
EID:

2-s2.0-85143252520

Part of ISSN: 26928205
Contributors: O’Brien, D.P.; Jones, H.B.L.; Guenther, F.; Murphy, E.J.; England, K.S.; Anderson, M.; Brennan, P.; Davis, J.B.; Pinto-Fernández, A.; Turnbull, A.P. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

bioRxiv
2020 | Other
DOI: 10.1101/2020.04.16.044206
EID:

2-s2.0-85098807333

Part of ISSN: 26928205
Contributors: Rusilowicz-Jones, E.; Jardine, J.; Kallinos, A.; Pinto-Fernandez, A.; Guenther, F.; Giurrandino, M.; Barone, F.G.; McCarron, K.; Burke, C.J.; Murad, A. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail

Scientific Reports
2020 | Journal article
DOI: 10.1038/s41598-020-60242-9
EID:

2-s2.0-85079759584

Part of ISSN: 20452322
Contributors: Wang, J.; Murphy, E.J.; Nix, J.C.; Jones, D.N.M.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

Life Science Alliance
2020 | Journal article
DOI: 10.26508/LSA.202000768
EID:

2-s2.0-85087679563

Part of ISSN: 25751077
Contributors: Rusilowicz-Jones, E.V.; Jardine, J.; Kallinos, A.; Pinto-Fernandez, A.; Guenther, F.; Giurrandino, M.; Barone, F.G.; McCarron, K.; Burke, C.J.; Murad, A. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6

Journal of Pharmacological and Toxicological Methods
2019 | Journal article
DOI: 10.1016/j.vascn.2018.11.003
EID:

2-s2.0-85057424266

Part of ISSN: 1873488X 10568719
Contributors: Priestley, R.S.; Cheung, J.; Murphy, E.J.; Ehebauer, M.T.; Davis, J.B.; Di Daniel, E.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid

Biomolecular NMR Assignments
2019 | Journal article
DOI: 10.1007/s12104-019-09875-0
EID:

2-s2.0-85060603180

Part of ISSN: 1874270X 18742718
Contributors: Jones, D.N.M.; Wang, J.; Murphy, E.J.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Correction to: Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid (Biomolecular NMR Assignments, (2019), 13, 1, (187-193), 10.1007/s12104-019-09875-0)

Biomolecular NMR Assignments
2019 | Journal article
DOI: 10.1007/s12104-019-09891-0
EID:

2-s2.0-85064347403

Part of ISSN: 1874270X 18742718
Contributors: Jones, D.N.M.; Wang, J.; Murphy, E.J.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier

Discovery of a PCAF Bromodomain Chemical Probe

Angewandte Chemie - International Edition
2017 | Journal article
DOI: 10.1002/anie.201610816
EID:

2-s2.0-85007227808

Part of ISSN: 15213773 14337851
Contributors: Moustakim, M.; Clark, P.G.K.; Trulli, L.; Fuentes de Arriba, A.L.; Ehebauer, M.T.; Chaikuad, A.; Murphy, E.J.; Mendez-Johnson, J.; Daniels, D.; Hou, C.-F.D. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase

Science
2014 | Journal article
DOI: 10.1126/science.1254398
EID:

2-s2.0-84904126318

Part of ISSN: 10959203 00368075
Contributors: Casadei, C.M.; Gumiero, A.; Metcalfe, C.L.; Murphy, E.J.; Basran, J.; Concilio, M.G.; Teixeira, S.C.M.; Schrader, T.E.; Fielding, A.J.; Ostermann, A. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae

Protein Science
2013 | Journal article
DOI: 10.1002/pro.2179
EID:

2-s2.0-84873051646

Part of ISSN: 09618368 1469896X
Contributors: Ziemba, B.P.; Murphy, E.J.; Edlin, H.T.; Jones, D.N.M.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Interactions of anopheles gambiae odorant-binding proteins with a human-derived repellent: Implications for the mode of action of N,N-diethyl-3-methylbenzamide (DEET)

Journal of Biological Chemistry
2013 | Journal article
DOI: 10.1074/jbc.M112.436386
EID:

2-s2.0-84873646229

Part of ISSN: 00219258 1083351X
Contributors: Murphy, E.J.; Booth, J.C.; Davrazou, F.; Port, A.M.; Jones, D.N.M.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Crystal structure of guaiacol and phenol bound to a heme peroxidase

FEBS Journal
2012 | Journal article
DOI: 10.1111/j.1742-4658.2011.08425.x
EID:

2-s2.0-84860216256

Part of ISSN: 1742464X 17424658
Contributors: Murphy, E.J.; Metcalfe, C.L.; Nnamchi, C.; Moody, P.C.E.; Raven, E.L.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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G6PC3 mutations are associated with a major defect of glycosylation: A novel mechanism for neutrophil dysfunction

Glycobiology
2011 | Journal article
DOI: 10.1093/glycob/cwr023
EID:

2-s2.0-79958838942

Part of ISSN: 09596658 14602423
Contributors: Hayee, B.; Antonopoulos, A.; Murphy, E.J.; Rahman, F.Z.; Sewell, G.; Smith, B.N.; McCartney, S.; Furman, M.; Hall, G.; Bloom, S.L. et al.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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New insights into the mechanism of odorant detection by the malaria-transmitting mosquito Anopheles gambiae

Journal of Biological Chemistry
2011 | Journal article
DOI: 10.1074/jbc.M111.274712
EID:

2-s2.0-80053199724

Part of ISSN: 00219258 1083351X
Contributors: Davrazou, F.; Dong, E.; Murphy, E.J.; Johnson, H.T.; Jones, D.N.M.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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An analysis of substrate binding interactions in the heme peroxidase enzymes: A structural perspective

Archives of Biochemistry and Biophysics
2010 | Journal article
DOI: 10.1016/j.abb.2010.02.015
EID:

2-s2.0-77954310525

Part of ISSN: 00039861 10960384
Contributors: Gumiero, A.; Murphy, E.J.; Metcalfe, C.L.; Moody, P.C.E.; Raven, E.L.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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CO binding and ligand discrimination in human myeloperoxidase

Biochemistry
2010 | Journal article
DOI: 10.1021/bi9021507
EID:

2-s2.0-77949375446

Part of ISSN: 00062960 15204995
Contributors: Murphy, E.J.; Maréchal, A.; Segal, A.W.; Rich, P.R.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1

Bioorganic and Medicinal Chemistry
2009 | Journal article
DOI: 10.1016/j.bmc.2009.06.070
EID:

2-s2.0-68149141339

Part of ISSN: 09680896
Contributors: Aubry, C.; Wilson, A.J.; Emmerson, D.; Murphy, E.; Chan, Y.Y.; Dickens, M.P.; García, M.D.; Jenkins, P.R.; Mahale, S.; Chaudhuri, B.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Peroxide-dependent formation of a covalent link between Trp51 and the heme in cytochrome c peroxidase

Biochemistry
2009 | Journal article
DOI: 10.1021/bi802210g
EID:

2-s2.0-65449164281

Part of ISSN: 00062960
Contributors: Pipirou, Z.; Guallar, V.; Basran, J.; Metcalfe, C.L.; Murphy, E.J.; Bottrill, A.R.; Mistry, S.C.; Raven, E.L.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
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Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase

Biochemistry
2008 | Journal article
DOI: 10.1021/bi801480r
EID:

2-s2.0-58849088119

Part of ISSN: 00062960 15204995
Contributors: Murphy, E.J.; Metcalfe, C.L.; Basran, J.; Moody, P.C.E.; Raven, E.L.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
Preferred source (of 2)‎

The tuberculosis prodrug isoniazid bound to activating peroxidases

Journal of Biological Chemistry
2008 | Journal article
DOI: 10.1074/jbc.M707412200
EID:

2-s2.0-44449089084

Part of ISSN: 00219258 1083351X
Contributors: Metcalfe, C.; Macdonald, I.K.; Murphy, E.J.; Brown, K.A.; Raven, E.L.; Moody, P.C.E.
Source: Self-asserted source
Emma Murphy via Scopus - Elsevier
grade
Preferred source (of 2)‎
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