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Employment (1)

Georgia State University: Atlanta, GA, US

2014-01-01 to present | Research Scientist I (Chemistry)
Employment
Source: Self-asserted source
Ananya Paul

Education and qualifications (1)

Indian Institute of Science: Bangalore, Karnataka, IN

2005-08-01 to 2011-02-19 | Ph. D. (Organic Chemistry)
Education
Source: Self-asserted source
Ananya Paul

Works (38)

Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence

ACS Chemical Biology
2025-02-21 | Journal article
DOI: 10.1021/acschembio.4c00800
Contributors: Ananya Paul; J. Ross Terrell; Abdelbasset A. Farahat; Edwin N. Ogbonna; Arvind Kumar; David W. Boykin; Stephen Neidle; W. David Wilson
Source: check_circle
Crossref

Conserved Sequences from Dengue Virus Genomes Form Stable G-Quadruplexes

ACS Infectious Diseases
2025-01-10 | Journal article
DOI: 10.1021/acsinfecdis.4c00615
Contributors: Jessica L. Siemer; Thao T. Le; Ananya Paul; David. W. Boykin; Margo A. Brinton; W. David Wilson; Markus W. Germann
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Crossref

Single GC base pair recognition by a heterocyclic diamidine: structures, affinities, and dynamics

RSC Advances
2024 | Journal article
DOI: 10.1039/D4RA05957C
Contributors: Edwin N. Ogbonna; J Ross Terrell; Ananya Paul; Abdelbasset A. Farahat; Gregory M. K. Poon; David W. Boykin; W. David Wilson
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Crossref

Structure of an RNA G-quadruplex from the West Nile virus genome

Nature Communications
2024-06-26 | Journal article
DOI: 10.1038/s41467-024-49761-5
Part of ISSN: 2041-1723
Contributors: J. Ross Terrell; Thao Le; Ananya Paul; Margo Brinton; W. David Wilson; Gregory Poon; Markus W. Germann; Jessica L. Siemer
Source: Self-asserted source
Ananya Paul

X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences

ACS Bio & Med Chem Au
2023-08-16 | Journal article
DOI: 10.1021/acsbiomedchemau.3c00002
Contributors: Edwin N. Ogbonna; Ananya Paul; Abdelbasset A. Farahat; J. Ross Terrell; Ekaterina Mineva; Victor Ogbonna; David W Boykin; W. David Wilson
Source: check_circle
Crossref

Binding to the DNA Minor Groove by Heterocyclic Dications: from AT Specific to GC Recognition Compounds

Current Protocols
2023-04 | Journal article
DOI: 10.1002/cpz1.729
Part of ISSN: 2691-1299
Part of ISSN: 2691-1299
Contributors: Ananya Paul; Rupesh Nanjunda; W. David Wilson
Source: Self-asserted source
Ananya Paul

Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity

European Journal of Medicinal Chemistry
2023-04 | Journal article
DOI: 10.1016/j.ejmech.2023.115287
Part of ISSN: 0223-5234
Contributors: Abdelbasset Farahat; Arvind Kumar; Tanja Wenzler; Reto Brun; Ananya Paul; Pu Guo; W. David Wilson; David W. Boykin
Source: Self-asserted source
Ananya Paul

Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines

Bioorganic & Medicinal Chemistry
2022-08 | Journal article
DOI: 10.1016/j.bmc.2022.116861
Part of ISSN: 0968-0896
Contributors: Edwin N. Ogbonna; Ananya Paul; J. Ross Terrell; Ziyuan Fang; Cen Chen; Gregory M.K. Poon; David W Boykin; W. David Wilson
Source: Self-asserted source
Ananya Paul

Thermodynamic Factors That Drive Sequence-Specific DNA Binding of Designed, Synthetic Minor Groove Binding Agents

Life
2022-05-04 | Journal article
DOI: 10.3390/life12050681
Contributors: Ananya Paul; Abdelbasset A. Farahat; David W. Boykin; W. David Wilson
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove

Chemical Science
2021 | Journal article
DOI: 10.1039/D1SC04720E
Contributors: Pu Guo; Abdelbasset A. Farahat; Ananya Paul; David W. Boykin; W. David Wilson
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Crossref

New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: Synthesis, in vitro and in vivo biological evaluation, and molecular modelling studies

European Journal of Medicinal Chemistry
2021-10 | Journal article
DOI: 10.1016/j.ejmech.2021.113625
Part of ISSN: 0223-5234
Source: Self-asserted source
Ananya Paul

Extending the σ-Hole Motif for Sequence-Specific Recognition of the DNA Minor Groove

Biochemistry
2020-05-12 | Journal article
DOI: 10.1021/acs.biochem.0c00090
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Ananya Paul

Small Sequence‐Sensitive Compounds for Specific Recognition of the G⋅C Base Pair in DNA Minor Groove

Chemistry – A European Journal
2020-04-06 | Journal article
DOI: 10.1002/chem.201904396
Part of ISSN: 0947-6539
Part of ISSN: 1521-3765
Source: Self-asserted source
Ananya Paul

Biosensor-Surface Plasmon Resonance: Label-Free Method for Investigation of Small Molecule-Quadruplex Nucleic Acid Interactions

Methods in Molecular Biology
2019 | Book chapter
DOI: 10.1007/978-1-4939-9666-7_4
Part of ISBN: 9781493996650
Part of ISBN: 9781493996667
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Ananya Paul

Second Generation G-Quadruplex Stabilizing Trimethine Cyanines

Bioconjugate Chemistry
2019-10-16 | Journal article
DOI: 10.1021/acs.bioconjchem.9b00571
Part of ISSN: 1043-1802
Part of ISSN: 1520-4812
Source: Self-asserted source
Ananya Paul

A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

Molecules
2019-03 | Journal article | Author
DOI: 10.3390/molecules24050946
Contributors: Ananya Paul; PU GUO; David W. Boykin; W David Wilson
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

Journal of Medicinal Chemistry
2019-02-14 | Journal article
DOI: 10.1021/acs.jmedchem.8b01448
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Ananya Paul

Compound Shape Effects in Minor Groove Binding Affinity and Specificity for Mixed Sequence DNA

Journal of the American Chemical Society
2018-11-07 | Journal article
DOI: 10.1021/jacs.8b08152
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
Ananya Paul

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity

European Journal of Medicinal Chemistry
2018-01 | Journal article
DOI: 10.1016/j.ejmech.2017.10.056
Part of ISSN: 0223-5234
Source: Self-asserted source
Ananya Paul

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

Chemical Communications
2017 | Journal article
DOI: 10.1039/C7CC06246J
Contributors: Pu Guo; Ananya Paul; Arvind Kumar; Narinder K. Harika; Siming Wang; Abdelbasset A. Farahat; David W. Boykin; W. David Wilson
Source: check_circle
Crossref

Systematic synthetic and biophysical development of mixed sequence DNA binding agents

Organic & Biomolecular Chemistry
2017 | Journal article
DOI: 10.1039/c6ob02390h
Part of ISSN: 1477-0520
Part of ISSN: 1477-0539
Source: Self-asserted source
Ananya Paul

Pharmacological inhibition of the transcription factor PU.1 in leukemia

Journal of Clinical Investigation
2017-10-30 | Journal article
DOI: 10.1172/jci92504
Part of ISSN: 0021-9738
Part of ISSN: 1558-8238
Source: Self-asserted source
Ananya Paul

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

European Journal of Medicinal Chemistry
2017-03 | Journal article
DOI: 10.1016/j.ejmech.2017.01.037
Part of ISSN: 0223-5234
Source: Self-asserted source
Ananya Paul

YM155 inhibits topoisomerase function

Anti-Cancer Drugs
2017-02 | Journal article
DOI: 10.1097/cad.0000000000000441
Part of ISSN: 0959-4973
Source: Self-asserted source
Ananya Paul

The Thiophene “Sigma-Hole” as a Concept for Preorganized, Specific Recognition of G⋅C Base Pairs in the DNA Minor Groove

Chemistry - A European Journal
2016-10-17 | Journal article
DOI: 10.1002/chem.201603422
Part of ISSN: 0947-6539
Source: Self-asserted source
Ananya Paul

Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition

Nucleic Acids Research
2016-06-02 | Journal article
DOI: 10.1093/nar/gkw353
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Ananya Paul

Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair

Bioorganic & Medicinal Chemistry Letters
2015-11 | Journal article
DOI: 10.1016/j.bmcl.2015.05.005
Part of ISSN: 0960-894X
Source: Self-asserted source
Ananya Paul

Understanding Mixed Sequence DNA Recognition by Novel Designed Compounds: The Kinetic and Thermodynamic Behavior of Azabenzimidazole Diamidines

Biochemistry
2015-01-20 | Journal article
DOI: 10.1021/bi500989r
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Ananya Paul

A Short DNA Sequence Confers Strong Bleomycin Binding to Hairpin DNAs

Journal of the American Chemical Society
2014-10-01 | Journal article
DOI: 10.1021/ja505733u
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
Ananya Paul

Kinetics and Structures on the Molecular Path to the Quadruplex Form of the Human Telomere

Journal of Molecular Biology
2014-04 | Journal article
DOI: 10.1016/j.jmb.2014.02.001
Part of ISSN: 0022-2836
Source: Self-asserted source
Ananya Paul

The Unusual Monomer Recognition of Guanine-Containing Mixed Sequence DNA by a Dithiophene Heterocyclic Diamidine

Biochemistry
2014-02-25 | Journal article
DOI: 10.1021/bi401582t
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Ananya Paul

Design and Synthesis of Heterocyclic Cations for Specific DNA Recognition: From AT-Rich to Mixed-Base-Pair DNA Sequences

The Journal of Organic Chemistry
2014-02-07 | Journal article
DOI: 10.1021/jo402599s
Part of ISSN: 0022-3263
Part of ISSN: 1520-6904
Source: Self-asserted source
Ananya Paul

Stabilization and Structural Alteration of the G-Quadruplex DNA Made from the Human Telomeric Repeat Mediated by Tröger’s Base Based Novel Benzimidazole Derivatives

Journal of Medicinal Chemistry
2012-09-13 | Journal article
DOI: 10.1021/jm300442r
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Ananya Paul

Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors

PLoS ONE
2012-06-21 | Journal article
DOI: 10.1371/journal.pone.0039467
Part of ISSN: 1932-6203
Source: Self-asserted source
Ananya Paul

Dimeric 1,3-Phenylene-bis(piperazinyl benzimidazole)s: Synthesis and Structure–Activity Investigations on their Binding with Human Telomeric G-Quadruplex DNA and Telomerase Inhibition Properties

Journal of Medicinal Chemistry
2012-04-12 | Journal article
DOI: 10.1021/jm200860b
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Ananya Paul

Symmetrical Bisbenzimidazoles with Benzenediyl Spacer: The Role of the Shape of the Ligand on the Stabilization and Structural Alterations in Telomeric G-Quadruplex DNA and Telomerase Inhibition

Bioconjugate Chemistry
2010-07-21 | Journal article
DOI: 10.1021/bc9003298
Part of ISSN: 1043-1802
Part of ISSN: 1520-4812
Source: Self-asserted source
Ananya Paul

Synthesis and Evaluation of a Novel Class of G-Quadruplex-Stabilizing Small Molecules Based on the 1,3-Phenylene-Bis(piperazinyl benzimidazole) System

Biochemistry
2009-11-17 | Journal article
DOI: 10.1021/bi9003815
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Ananya Paul
grade
Preferred source (of 2)‎

Design, Synthesis, and DNA Binding Properties of Photoisomerizable Azobenzene−Distamycin Conjugates: An Experimental and Computational Study

Bioconjugate Chemistry
2008-12-17 | Journal article
DOI: 10.1021/bc800130u
Part of ISSN: 1043-1802
Part of ISSN: 1520-4812
Source: Self-asserted source
Ananya Paul
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