Personal information

Keywords

Lipid mediator, GPCR, Inflammation

Countries

United States, Japan

Activities

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Funding (3)

Unraveling Mast Cell Protective EP3 Receptor Signaling in Allergic Inflammation

2025-01 to 2025-12 | Award
Goldberg Family Foundation (WA, WA, US)
Source: Self-asserted source
Jun Nagai

Cysteinyl Leukotriene Feedforward Signaling Between Mast Cells and Platelets in Allergic Inflammation

2023-07-01 to 2025-06-30 | Grant
American Lung Association (Chicago, US)
GRANT_NUMBER:

1051652
Source: check_circle
ProposalCentral

Nucleotide releasing profiles in allergic inflammatory diseases

2021-07-01 to 2023-06-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.9733896
GRANT_NUMBER: R21AI156068
Source: Self-asserted source
Jun Nagai via DimensionsWizard

Works (34)

Mast cells control lung type 2 inflammation via prostaglandin E<sub>2</sub>-driven soluble ST2.

Immunity
2024-05-30 | Journal article
DOI: 10.1016/j.immuni.2024.05.003
PMID: 38821053
Contributors: Kinan Alhallak; Nagai J; Zaleski K; Marshall S; Salloum T; Derakhshan T; Hayashi H; Feng C; Kratchmarov R; Lai J et al.
Source: Self-asserted source
Jun Nagai

Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease

The Journal of Immunology
2023-12-15 | Journal article
DOI: 10.4049/jimmunol.2300102
Contributors: Dinah Foer; Taneem Amin; Jun Nagai; Yumi Tani; Chunli Feng; Tao Liu; Dawn C Newcomb; Juying Lai; Hiroaki Hayashi; William E Snyder et al.
Source: check_circle
Crossref

Multistep IgE Mast Cell Desensitization Is a Dose- and Time-Dependent Process Partially Regulated by SHIP-1.

Journal of immunology (Baltimore, Md. : 1950)
2023-03-01 | Journal article | Author
DOI: 10.4049/jimmunol.2100485
PMID: 36881903
PMC: PMC9986054
Contributors: Ather Adnan; Acharya S; Leila A. Alenazy; Vecillas, Leticia De Las; Pedro Giavina-Bianchi; Matthieu Picard; Calbache-Gil L; Romero-Pinedo S; Abadía-Molina A. C.; William G. Kerr et al.
Source: Self-asserted source
Jun Nagai

Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation

The Journal of Immunology
2022-12-15 | Journal article
DOI: 10.4049/jimmunol.2200452
Contributors: Jun Nagai; Junrui Lin; Joshua A Boyce
Source: check_circle
Crossref

Nucleoside Triphosphate Hydrolases Assay in Toxoplasm gondii and Neospora caninum for High-Throughput Screening using a Robot Arm.

Journal of visualized experiments : JoVE
2022-07-22 | Journal article
DOI: 10.3791/62874
PMID: 35938815
Contributors: Kurata R; Harada M; Nagai J; Cui X; Isagawa T; Semba H; Yoshida Y; Takeda N; Maemura K; Yonezawa T
Source: Self-asserted source
Jun Nagai

Editorial: Targeting the Chemoattractant System in Inflammation.

Frontiers in pharmacology
2021-08-16 | Journal article
DOI: 10.3389/fphar.2021.744290
PMID: 34483948
PMC: PMC8415622
Contributors: Tadashi Hosoya; Cordelia D; Michael BD; Miyabe C; Nagai J; Murooka TT; Miyabe Y
Source: Self-asserted source
Jun Nagai

Secreted PLA<sub>2</sub>-III is a possible therapeutic target to treat neuropathic pain.

Biochemical and biophysical research communications
2021-07-05 | Journal article
DOI: 10.1016/j.bbrc.2021.06.058
PMID: 34237486
Contributors: Tanaka K; Dozono N; Hiroyuki Neyama; Nagai J; Tsukahara R; Kazuki Nagayasu; Kaneko S; Hiroshi Ueda
Source: Self-asserted source
Jun Nagai

Establishment of Novel Protein Interaction Assays between Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence Energy Transfer.

International journal of molecular sciences
2021-02-26 | Journal article
DOI: 10.3390/ijms22052323
PMID: 33652591
PMC: PMC7956749
Contributors: Harada M; Nagai J; Kurata R; Cui X; Isagawa T; Semba H; 0000-0003-1658-3119; Takeda N; Koji Maemura; Yonezawa T
Source: Self-asserted source
Jun Nagai

Leukotriene D<sub>4</sub> paradoxically limits LTC<sub>4</sub>-driven platelet activation and lung immunopathology.

The Journal of allergy and clinical immunology
2020-12-04 | Journal article
DOI: 10.1016/j.jaci.2020.10.041
PMID: 33285161
PMC: PMC8175451
Contributors: Liu T; Barrett NA; Nagai J; Lai J; Feng C; Boyce JA
Source: Self-asserted source
Jun Nagai

Establishment of Novel High-Standard Chemiluminescent Assay for NTPase in Two Protozoans and Its High-Throughput Screening.

Marine drugs
2020-03-13 | Journal article
DOI: 10.3390/md18030161
PMID: 32183121
PMC: PMC7142789
Contributors: Harada M; Nagai J; Kurata R; Shimizu K; Cui X; Isagawa T; Semba H; Jun Ishihara; 0000-0003-1658-3119; Takeda N et al.
Source: Self-asserted source
Jun Nagai

Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening.

Marine drugs
2020-01-17 | Journal article
DOI: 10.3390/md18010060
PMID: 31963531
PMC: PMC7024245
Contributors: Kurata R; Shimizu K; Cui X; Harada M; Isagawa T; Semba H; Jun Ishihara; Yamada K; Nagai J; 0000-0003-1658-3119 et al.
Source: Self-asserted source
Jun Nagai

P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation.

The Journal of clinical investigation
2019-12-01 | Journal article
DOI: 10.1172/jci129761
PMID: 31638598
PMC: PMC6877315
Contributors: Nagai J; Barbara Balestrieri; Fanning LB; Kyin T; Haley Cirka; Lin J; Idzko M; Zech A; Edy Kim; Brennan PJ et al.
Source: Self-asserted source
Jun Nagai

Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis.

Arthritis research & therapy
2019-08-20 | Journal article
DOI: 10.1186/s13075-019-1973-0
PMID: 31429784
PMC: PMC6702724
Contributors: Miyabe C; Miyabe Y; Nagai J; Miura NN; Ohno N; Chun J; Tsuboi R; Hiroshi Ueda; Miyasaka M; Miyasaka N et al.
Source: Self-asserted source
Jun Nagai

Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins.

Current pharmaceutical biotechnology
2019-01-01 | Journal article
DOI: 10.2174/1389201020666190206203640
PMID: 30727885
Contributors: Kumagai A; Shimizu K; Kurata R; Cui X; Isagawa T; Harada M; Nagai J; Yoshida Y; Ozaki KI; Takeda N et al.
Source: Self-asserted source
Jun Nagai

Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain.

Pain
2018-11-01 | Journal article
DOI: 10.1097/j.pain.0000000000001316
PMID: 29939962
Contributors: Hiroshi Ueda; Hiroyuki Neyama; Nagai J; Matsushita Y; Tsukahara T; Tsukahara R
Source: Self-asserted source
Jun Nagai

Establishment of Novel Reporter Cells Stably Maintaining Transcription Factor-driven Human Secreted Alkaline Phosphatase Expression.

Current pharmaceutical biotechnology
2018-01-01 | Journal article
DOI: 10.2174/1389201019666180418093334
PMID: 29667554
Contributors: Kurata R; Kumagai A; Cui X; Harada M; Nagai J; Yoshida Y; Ozaki KI; Yoshimasa Tanaka; Yonezawa T
Source: Self-asserted source
Jun Nagai

High-Throughput Screening and Prediction Model Building for Novel Hemozoin Inhibitors Using Physicochemical Properties.

Antimicrobial agents and chemotherapy
2017-01-24 | Journal article
DOI: 10.1128/aac.01607-16
PMID: 27919903
PMC: PMC5278743
Contributors: Nguyen Tien Huy; Chi PL; Nagai J; Dang TN; Mbanefo EC; Ali Mahmoud Ahmed; Long NP; Le Thi Bich Thoa; Hung LP; Titouna A et al.
Source: Self-asserted source
Jun Nagai

Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation.

Scientific reports
2015-08-13 | Journal article
DOI: 10.1038/srep13343
PMID: 26268898
PMC: PMC4542628
Contributors: Omotuyi OI; Nagai J; Hiroshi Ueda
Source: Self-asserted source
Jun Nagai

Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice.

Molecular pain
2014-11-19 | Journal article
DOI: 10.1186/1744-8069-10-71
PMID: 25411045
PMC: PMC4246549
Contributors: Uchida H; Nagai J; Ueda H
Source: Self-asserted source
Jun Nagai

Interleukin-1β plays key roles in LPA-induced amplification of LPA production in neuropathic pain model.

Cellular and molecular neurobiology
2013-08-15 | Journal article
DOI: 10.1007/s10571-013-9970-3
PMID: 23949386
Contributors: Yano R; Ma L; Nagai J; Hiroshi Ueda
Source: Self-asserted source
Jun Nagai

Necessity of lysophosphatidic acid receptor 1 for development of arthritis.

Arthritis and rheumatism
2013-08-01 | Journal article
DOI: 10.1002/art.37991
PMID: 23666827
Contributors: Miyabe Y; Miyabe C; Iwai Y; Takayasu A; Fukuda S; Yokoyama W; Nagai J; Jona M; Yasunori Tokuhara; Ryunosuke Ohkawa et al.
Source: Self-asserted source
Jun Nagai

An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model.

Molecular pain
2013-06-17 | Journal article
DOI: 10.1186/1744-8069-9-29
PMID: 23773289
PMC: PMC3691926
Contributors: Ma L; Nagai J; Chun J; Hiroshi Ueda
Source: Self-asserted source
Jun Nagai

Lysophosphatidic acid: chemical signature of neuropathic pain.

Biochimica et biophysica acta
2012-08-29 | Journal article
DOI: 10.1016/j.bbalip.2012.08.014
PMID: 22960381
Contributors: Ueda H; Hayato MATSUNAGA; Olaposi OI; Nagai J
Source: Self-asserted source
Jun Nagai

Single application of A2 NTX, a botulinum toxin A2 subunit, prevents chronic pain over long periods in both diabetic and spinal cord injury-induced neuropathic pain models.

Journal of pharmacological sciences
2012-06-28 | Journal article
DOI: 10.1254/jphs.12080sc
PMID: 22785019
Contributors: Ma L; Nagai J; Yuki Sekino; Goto Y; Nakahira S; Ueda H
Source: Self-asserted source
Jun Nagai

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants.

Molecular pain
2011-09-21 | Journal article
DOI: 10.1186/1744-8069-7-69
PMID: 21933442
PMC: PMC3184270
Contributors: Nishiyori M; Uchida H; Nagai J; Araki K; Takehiro MUKAE; Kishioka S; Hiroshi Ueda
Source: Self-asserted source
Jun Nagai

Pre-emptive morphine treatment abolishes nerve injury-induced lysophospholipid synthesis in mass spectrometrical analysis.

Journal of neurochemistry
2011-05-25 | Journal article
DOI: 10.1111/j.1471-4159.2011.07297.x
PMID: 21542849
Contributors: Nagai J; Ueda H
Source: Self-asserted source
Jun Nagai

Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain.

Molecular pain
2011-05-14 | Journal article
DOI: 10.1186/1744-8069-7-33
PMID: 21569544
PMC: PMC3113318
Contributors: Kakiuchi Y; Nagai J; Mari GOTOH; Harumi Hotta; Murofushi H; Ogawa T; Ueda H; Murakami-Murofushi K
Source: Self-asserted source
Jun Nagai

Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine.

Molecular pain
2010-11-09 | Journal article
DOI: 10.1186/1744-8069-6-78
PMID: 21062487
PMC: PMC2989310
Contributors: Nagai J; Uchida H; Matsushita Y; Yano R; Ueda M; Niwa M; Junken Aoki; Chun J; Ueda H
Source: Self-asserted source
Jun Nagai

Microglial activation mediates de novo lysophosphatidic acid production in a model of neuropathic pain.

Journal of neurochemistry
2010-09-06 | Journal article
DOI: 10.1111/j.1471-4159.2010.06955.x
PMID: 20722972
Contributors: Ma L; Nagai J; Ueda H
Source: Self-asserted source
Jun Nagai

Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.

Journal of neurochemistry
2010-05-01 | Journal article
DOI: 10.1111/j.1471-4159.2010.06664.x
PMID: 20420580
PMC: PMC2908211
Contributors: Xie W; Uchida H; Nagai J; Ueda M; Chun J; Ueda H
Source: Self-asserted source
Jun Nagai

Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia.

Neuroscience letters
2010-02-04 | Journal article
DOI: 10.1016/j.neulet.2010.01.080
PMID: 20138970
Contributors: Nishiyori M; Nagai J; Nakazawa T; Hiroshi Ueda
Source: Self-asserted source
Jun Nagai

Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain.

The Journal of pharmacology and experimental therapeutics
2010-02-01 | Journal article
DOI: 10.1124/jpet.109.164830
PMID: 20123931
Contributors: Ma L; Uchida H; Nagai J; Inoue M; Junken Aoki; Ueda H
Source: Self-asserted source
Jun Nagai

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.

Molecular pain
2009-11-13 | Journal article
DOI: 10.1186/1744-8069-5-64
PMID: 19912636
PMC: PMC2780384
Contributors: Ma L; Uchida H; Nagai J; Inoue M; Chun J; Junken Aoki; Ueda H
Source: Self-asserted source
Jun Nagai

Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task.

The Journal of pharmacology and experimental therapeutics
2007-01-05 | Journal article
DOI: 10.1124/jpet.106.115121
PMID: 17209168
Contributors: Nagai J; Kurokawa M; Hiroshi Takeshima; Kieffer BL; Hiroshi Ueda
Source: Self-asserted source
Jun Nagai

Peer review (1 review for 1 publication/grant)

Review activity for The journal of allergy and clinical immunology (1)
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