Personal information

Emails & domains

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Websites & social links

Research Lab Website

Other IDs

ResearcherID: E-3772-2016
Scopus Author ID: 8673209400

Keywords

Vascular cognitive impairment and dementia (VCID), Alzheimer's disease, microglia biology, aging, mass spectrometry imaging

Countries

Canada

Activities

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Employment (1)

Western: London, CA

Employment
Source: Self-asserted source
Shawn Whitehead

Funding (26)

Interrogating ganglioside regulation of neuroinflammation in Alzheimer's Disease

2023-05-01 to 2026-04-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.13557575
GRANT_NUMBER: 13557575
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Complementary mass spectrometry based detection of gangliosides and other lipids in the brain

2022-04-01 to 2023-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.13592424
GRANT_NUMBER: 13592424
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Health Research Training to Address Vascular Contributions to Cognitive Decline: the Vascular Training (VAST) Platform

2022-01-01 to 2027-12-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.12850741
GRANT_NUMBER: 12850741
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Evaluating the relationship between age-dependent white matter microglia activation and post-stroke cognitive impairment

2021-10-01 to 2026-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9881009
GRANT_NUMBER: 9881009
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Dementia and hearing loss: Using preclinical models to uncover the mechanisms that accelerate cognitive decline in aging and Alzheimer's disease

2021-05-01 to 2022-08-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.10026960
GRANT_NUMBER: 10026960
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Complementary mass spectrometry based detection of gangliosides and other lipids in the brain

2021-04-01 to 2022-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.13005272
GRANT_NUMBER: 13005272
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Selective Brain Hypothermia via Intranasal Cooling to Limit Brain Injury Post Cardiac Arrest

2020-04-01 to 2024-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9047937
GRANT_NUMBER: 9047937
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

The early molecular events setting up acute brain injury

2020-04-01 to 2022-03-31 | Grant
Social Sciences and Humanities Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9974049
GRANT_NUMBER: 9974049
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Complementary mass spectrometry based detection of gangliosides and other lipids in the brain

2020-04-01 to 2021-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9871842
GRANT_NUMBER: 9871842
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Identifying early white matter changes within the brain that predict cognitive decline and Alzheimer's disease using novel blood-based microparticle screening.

2019-09-01 to 2022-08-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.8579844
GRANT_NUMBER: 8579844
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Complementary mass spectrometry based detection of gangliosides and other lipids in the brain

2019-04-01 to 2021-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9447596
GRANT_NUMBER: 9447596
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Selective Brain Hypothermia via Intranasal Cooling to Limit Brain Injury Post Cardiac Arrest

2018-10-01 to 2019-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.7644279
GRANT_NUMBER: 7644279
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Sex-based protection from systemic vasculopathy with chronic stress and depressive symptoms.

2018-04-01 to 2021-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.7633116
GRANT_NUMBER: 7633116
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Complementary mass spectrometry based detection of gangliosides within the brain

2018-04-01 to 2019-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.8651777
GRANT_NUMBER: 8651777
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Desorption Electrospray Ionization (DESI) for Mass Spectrometry Based Imaging

2016-04-01 to 2017-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.6972770
GRANT_NUMBER: 6972770
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Molecular Imaging of Lipids in Rodent Models Brain Co-Morbidities

2015-08-06 to 2020-08-05 | Grant
Ministry of Colleges and Universities (Toronto, CA)
URL: https://app.dimensions.ai/details/grant/grant.7441267
GRANT_NUMBER:

RI-34213
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

A nano-UPLC system for the Q-Exactive mass spectrometer

2015-04-01 to 2016-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.5536085
GRANT_NUMBER: 5536085
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Molecular imaging of lipids in rodent models brain co-morbidities

2015-03-24 to present | Grant
Canada Foundation for Innovation (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.6764057
GRANT_NUMBER:

CFI5237
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Canadian Consortium on Neurodegeneration in Aging - Full Proposal

2014-04-01 to 2019-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.8969505
GRANT_NUMBER: 8969505
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Novel Molecular Imaging Platform to Elucidate the Role of Membrane Lipids in Neurodegeneration

2013-10-15 to 2018-10-14 | Grant
Ministry of Colleges and Universities (Toronto, CA)
URL: https://app.dimensions.ai/details/grant/grant.3928816
GRANT_NUMBER:

31734
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Post-Stroke Brain Deterioration: Role of Abeta and Neuroinflammation

2013-04-01 to 2018-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.6805771
GRANT_NUMBER: 6805771
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Imaging Membrane Lipids During Neurodegeneration

2012-04-01 to 2018-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.2955857
GRANT_NUMBER: 2955857
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

CIHR Team in Vascular Cognitive Impairment: Animal Models of Co-morbidity

2009-10-01 to 2014-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.7617928
GRANT_NUMBER: 7617928
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Vascular Cognitive Impairment (VCI): Animal Models of Comorbidity. Project Type: Infrastructure Proposal.

2009-02-01 to 2010-01-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.7624708
GRANT_NUMBER: 7624708
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

PGSB

2004-04-01 to 2005-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.2949883
GRANT_NUMBER: 2949883
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

PGSB

2003-04-01 to 2004-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.2893629
GRANT_NUMBER: 2893629
Source: Self-asserted source
Shawn Whitehead via DimensionsWizard

Works (50 of 95)

Items per page:
Page 1 of 2

Early elevations in arterial pressure: a contributor to rapid depressive symptom emergence in female Zucker rats with metabolic disease?

Journal of Applied Physiology
2024-11-01 | Journal article
DOI: 10.1152/japplphysiol.00586.2024
Contributors: Filip Konecny; Lujaina Kamar; Isabel Zimmerman; Shawn N. Whitehead; Daniel Goldman; Jefferson C. Frisbee
Source: check_circle
Crossref

Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury

Neural Regeneration Research
2024-10 | Journal article
DOI: 10.4103/1673-5374.391329
Contributors: Nikita Ollen-Bittle; Austyn D. Roseborough; Wenxuan Wang; Jeng-liang D. Wu; Shawn N. Whitehead
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Simple gangliosides co-localize with amyloid plaques and increase with age in a transgenic mouse model of Alzheimer’s disease

2024-10-07 | Preprint
DOI: 10.21203/rs.3.rs-5182325/v1
Contributors: Wenxuan Wang; Sarah J. Myers; Nikita Ollen-Bittle; Shawn N. Whitehead
Source: check_circle
Crossref

Using microglia-derived extracellular vesicles to capture diversity of microglial activation phenotypes following neurological injury

Neural Regeneration Research
2024-08 | Journal article
DOI: 10.4103/1673-5374.389632
Contributors: Austyn D. Roseborough; Nikita Ollen-Bittle; Shawn N. Whitehead
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White matter microglia morphological changes with aging in guinea pig offspring born growth restricted

2024-07-08 | Preprint
DOI: 10.1101/2024.07.04.602101
Contributors: Timothy B. Nunes; Karen L. Nygard; Marc C.J. Courchesne; Shawn N. Whitehead; Bryan S. Richardson; Timothy R.H. Regnault
Source: check_circle
Crossref

Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease

Acta Neuropathologica
2024-06 | Journal article
DOI: 10.1007/s00401-024-02759-1
Contributors: Nikita Ollen-Bittle; Shervin Pejhan; Stephen H. Pasternak; C. Dirk Keene; Qi Zhang; Shawn N. Whitehead
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Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease.

2024-02-27 | Preprint
DOI: 10.21203/rs.3.rs-3985371/v1
Contributors: Nikita Ollen-Bittle; Shervin Pejhan; Stephen H. Pasternak; C. Dirk Keene; Qi Zhang; Shawn N. Whitehead
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Thromboxane-induced cerebral microvascular rarefaction predicts depressive symptom emergence in metabolic disease

Journal of Applied Physiology
2024-01-01 | Journal article
DOI: 10.1152/japplphysiol.00410.2023
Contributors: Brayden D. Halvorson; Yuki Bao; Krishna K. Singh; Stephanie J. Frisbee; Vladimir Hachinski; Shawn N. Whitehead; C. W. James Melling; Paul D. Chantler; Daniel Goldman; Jefferson C. Frisbee
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Acute minocycline treatment inhibits microglia activation, reduces infarct volume, and has domain-specific effects on post-ischemic stroke cognition in rats

Behavioural Brain Research
2023 | Journal article
DOI: 10.1016/j.bbr.2023.114680
EID:

2-s2.0-85172127021

Part of ISSN: 18727549 01664328
Contributors: Myers, S.J.; Agapova, V.; Patel, S.V.; Hayes, S.H.; Sposato, L.A.; Allman, B.L.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier
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Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions

Neuropsychopharmacology
2023 | Journal article
DOI: 10.1038/s41386-022-01496-x
EID:

2-s2.0-85142289205

Part of ISSN: 1740634X 0893133X
Contributors: De Felice, M.; Chen, C.; Rodríguez-Ruiz, M.; Szkudlarek, H.J.; Lam, M.; Sert, S.; Whitehead, S.N.; Yeung, K.K.-C.; Rushlow, W.J.; Laviolette, S.R.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Assessment of executive function in a rodent model of Type 1 diabetes

Behavioural Brain Research
2023 | Journal article
DOI: 10.1016/j.bbr.2022.114130
EID:

2-s2.0-85139733767

Part of ISSN: 18727549 01664328
Contributors: Murphy, K.T.; Camenzuli, J.; Myers, S.J.; Whitehead, S.N.; Rajakumar, N.; Melling, C.W.J.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction

Neurobiology of Disease
2023 | Journal article
DOI: 10.1016/j.nbd.2023.106001
EID:

2-s2.0-85146477645

Part of ISSN: 1095953X 09699961
Contributors: Roseborough, A.D.; Zhu, Y.; Zhao, L.; Laviolette, S.R.; Pasternak, S.H.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development

Research Square
2023 | Other
DOI: 10.21203/rs.3.rs-2818625/v1
EID:

2-s2.0-85167629135
Contributors: Renaud, S.J.; Jeyarajah, M.J.; Patterson, V.S.; Bhattad, G.J.; Zhao, L.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model

Journal of Neuroinflammation
2023 | Journal article
DOI: 10.1186/s12974-023-02708-x
EID:

2-s2.0-85147124198

Part of ISSN: 17422094
Contributors: Roseborough, A.D.; Myers, S.J.; Khazaee, R.; Zhu, Y.; Zhao, L.; Iorio, E.; Elahi, F.M.; Pasternak, S.H.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: A meta-analysis, systematic review, and recommendations for future study harmonization

Alzheimer's and Dementia
2023 | Journal article
DOI: 10.1002/alz.12642
EID:

2-s2.0-85126874224

Part of ISSN: 15525279 15525260
Contributors: Roseborough, A.D.; Saad, L.; Goodman, M.; Cipriano, L.E.; Hachinski, V.C.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Validating MALDI-IMS Feasibility in Ex Vivo Brain Slices

Journal of the American Society for Mass Spectrometry
2023-08-02 | Journal article
DOI: 10.1021/jasms.3c00152
Contributors: Nikita Ollen-Bittle; Chloe A. Lowry; Katherine E. Donovan; R. David Andrew; Shawn N. Whitehead
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Atrial cardiopathy and cognitive impairment

Frontiers in Aging Neuroscience
2022 | Journal article
DOI: 10.3389/fnagi.2022.914360
EID:

2-s2.0-85135465678

Part of ISSN: 16634365
Contributors: Myers, S.J.; Jiménez-Ruiz, A.; Sposato, L.A.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Brain health: Key to health, productivity, and well-being

Alzheimer's and Dementia
2022 | Journal article
DOI: 10.1002/alz.12478
EID:

2-s2.0-85116843275

Part of ISSN: 15525279 15525260
Contributors: Avan, A.; Hachinski, V.; Aamodt, A.-H.; Alessi, C.; Ali, S.; Alladi, S.; Andersen, R.; Anderson, K.K.; Avan, A.; Azarpazhooh, M.R. et al.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Developments in NEW triad research

Aging
2022 | Journal article
DOI: 10.18632/aging.204062
EID:

2-s2.0-85130863611

Part of ISSN: 19454589
Contributors: Whitehead, S.N.; Hachinski, V.; Levit, A.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition

GeroScience
2022 | Journal article
DOI: 10.1007/s11357-021-00461-8
EID:

2-s2.0-85116736700

Part of ISSN: 25092723 25092715
Contributors: Whitehead, S.N.; Bruno, A.; Burns, J.M.; Carmichael, S.T.; Csiszar, A.; Edwards, J.D.; Elahi, F.M.; Faraco, G.; Gould, D.B.; Gustafson, D.R. et al.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Mechanisms and Biomarker Potential of Extracellular Vesicles in Stroke

Biology
2022 | Journal article
DOI: 10.3390/biology11081231
EID:

2-s2.0-85137349370

Part of ISSN: 20797737
Contributors: Ollen-Bittle, N.; Roseborough, A.D.; Wang, W.; Wu, J.-L.D.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Microglial Inflammation and Cognitive Dysfunction in Comorbid Rat Models of Striatal Ischemic Stroke and Alzheimer's Disease: Effects of Antioxidant Catalase-SKL on Behavioral and Cellular Pathology

Neuroscience
2022 | Journal article
DOI: 10.1016/j.neuroscience.2022.01.026
EID:

2-s2.0-85124589638

Part of ISSN: 18737544 03064522
Contributors: MacKenzie, J.L.; Ivanova, N.; Nell, H.J.; Giordano, C.R.; Terlecky, S.R.; Agca, C.; Agca, Y.; Walton, P.A.; Whitehead, S.N.; Cechetto, D.F.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function

Frontiers in Neuroscience
2022 | Journal article
DOI: 10.3389/fnins.2022.1001686
EID:

2-s2.0-85140782783

Part of ISSN: 1662453X 16624548
Contributors: Patel, S.V.; DeCarlo, C.M.; Book, S.A.; Schormans, A.L.; Whitehead, S.N.; Allman, B.L.; Hayes, S.H.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model

Scientific Reports
2022 | Journal article
DOI: 10.1038/s41598-022-10208-w
EID:

2-s2.0-85128349049

Part of ISSN: 20452322
Contributors: Kowalewska, P.M.; Piazza, J.E.; Milkovich, S.L.; Sové, R.J.; Wang, L.; Whitehead, S.N.; Ellis, C.G.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Editorial Focus: White matter-associated microglia (WAMs) represent an important link between aging, white matter disease and microglial activity

GeroScience
2022-02 | Journal article
DOI: 10.1007/s11357-021-00435-w
Contributors: A. D. Roseborough; V. M. Jaremek; S. N. Whitehead
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Microvessel stenosis, enlarged perivascular spaces, and fibrinogen deposition are associated with ischemic periventricular white matter hyperintensities

Brain Pathology
2022-01 | Journal article
DOI: 10.1111/bpa.13017
Contributors: Austyn D. Roseborough; Berk Rasheed; Youngkyung Jung; Kevin Nishimura; William Pinsky; Kristopher D. Langdon; Robert Hammond; Stephen H. Pasternak; Ali R. Khan; Shawn N. Whitehead
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Brain Targeting and Toxicological Assessment of the Extracellular Vesicle-Packaged Antioxidant Catalase-SKL Following Intranasal Administration in Mice

Neurotoxicity Research
2021 | Journal article
DOI: 10.1007/s12640-021-00390-6
EID:

2-s2.0-85113122138

Part of ISSN: 14763524 10298428
Contributors: Hayes, S.H.; Liu, Q.; Selvakumaran, S.; Haney, M.J.; Batrakova, E.V.; Allman, B.L.; Walton, P.A.; Kiser, P.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

GABA<sub>B</sub> Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity and Filtering in the Cntnap2 Knock-Out Rat

Frontiers in Integrative Neuroscience
2021 | Journal article
DOI: 10.3389/fnint.2021.710593
EID:

2-s2.0-85114345381

Part of ISSN: 16625145
Contributors: Möhrle, D.; Wang, W.; Whitehead, S.N.; Schmid, S.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

Nature Neuroscience
2021 | Journal article
DOI: 10.1038/s41593-021-00801-z
EID:

2-s2.0-85101007107

Part of ISSN: 15461726 10976256
Contributors: Dong, Y.; D’Mello, C.; Pinsky, W.; Lozinski, B.M.; Kaushik, D.K.; Ghorbani, S.; Moezzi, D.; Brown, D.; Melo, F.C.; Zandee, S. et al.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors (BMC Neuroscience, (2008), 9, 1, (92), 10.1186/1471-2202-9-92)

BMC Neuroscience
2021 | Journal article
DOI: 10.1186/s12868-021-00644-1
EID:

2-s2.0-85107071839

Part of ISSN: 14712202
Contributors: Wislet-Gendebien, S.; Visanji, N.P.; Whitehead, S.N.; Marsilio, D.; Hou, W.; Figeys, D.; Fraser, P.E.; Bennett, S.A.L.; Tandon, A.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Precocious White Matter Inflammation and Behavioural Inflexibility Precede Learning and Memory Impairment in the TgAPP21 Rat Model of Alzheimer Disease

Molecular Neurobiology
2021-10 | Journal article
DOI: 10.1007/s12035-021-02476-w
Contributors: Alexander Levit; Andrew Gibson; Olivia Hough; Youngkyung Jung; Yuksel Agca; Cansu Agca; Vladimir Hachinski; Brian L. Allman; Shawn N. Whitehead
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Imaging of Neurotransmitters and Small Molecules in Brain Tissues Using Laser Desorption/Ionization Mass Spectrometry Assisted with Zinc Oxide Nanoparticles

Journal of the American Society for Mass Spectrometry
2021-04-07 | Journal article
DOI: 10.1021/jasms.1c00021
Contributors: Chaochao Chen; Steven R. Laviolette; Shawn N. Whitehead; Justin B. Renaud; Ken K.-C. Yeung
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Regional Lipid Expression Abnormalities Identified Using MALDI IMS Correspond to MRI-Defined White Matter Hyperintensities within Post-mortem Human Brain Tissues

Analytical Chemistry
2021-02-02 | Journal article
DOI: 10.1021/acs.analchem.0c05017
Contributors: William Pinsky; Aaron Harris; Austyn D. Roseborough; Wenxuan Wang; Ali R. Khan; Kristina Jurcic; Ken K.-C. Yeung; Stephen H. Pasternak; Shawn N. Whitehead
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Danegaptide enhances astrocyte gap junctional coupling and reduces ischemic reperfusion brain injury in mice

Biomolecules
2020 | Journal article
DOI: 10.3390/biom10030353
EID:

2-s2.0-85081070173

Part of ISSN: 2218273X
Contributors: Freitas-Andrade, M.; Bechberger, J.; Wang, J.; Yeung, K.K.C.; Whitehead, S.N.; Hansen, R.S.; Naus, C.C.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Hypertension and Pathogenic hAPP Independently Induce White Matter Astrocytosis and Cognitive Impairment in the Rat

Frontiers in Aging Neuroscience
2020 | Journal article
DOI: 10.3389/fnagi.2020.00082
EID:

2-s2.0-85083969205

Part of ISSN: 16634365
Contributors: Levit, A.; Cheng, S.; Hough, O.; Liu, Q.; Agca, Y.; Agca, C.; Hachinski, V.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

The Analyst
2020 | Journal article
DOI: 10.1039/C9AN02270H
Contributors: W. X. Wang; S. N. Whitehead
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Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease

GeroScience
2020 | Journal article
DOI: 10.1007/s11357-020-00164-6
EID:

2-s2.0-85078823081

Part of ISSN: 25092723 25092715
Contributors: Levit, A.; Hachinski, V.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Post-mortem 7 Tesla MRI detection of white matter hyperintensities: A multidisciplinary voxel-wise comparison of imaging and histological correlates

NeuroImage: Clinical
2020 | Journal article
DOI: 10.1016/j.nicl.2020.102340
EID:

2-s2.0-85087919727

Part of ISSN: 22131582
Contributors: Roseborough, A.D.; Langdon, K.D.; Hammond, R.; Cipriano, L.E.; Pasternak, S.H.; Whitehead, S.N.; Khan, A.R.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging

GeroScience
2020 | Journal article
DOI: 10.1007/s11357-019-00141-8
EID:

2-s2.0-85076224917

Part of ISSN: 25092723 25092715
Contributors: Sorond, F.A.; Whitehead, S.; Arai, K.; Arnold, D.; Carmichael, S.T.; De Carli, C.; Duering, M.; Fornage, M.; Flores-Obando, R.E.; Graff-Radford, J. et al.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat

EJNMMI Research
2020 | Journal article
DOI: 10.1186/s13550-020-00699-x
EID:

2-s2.0-85091719686

Part of ISSN: 2191219X
Contributors: Al-Khishman, N.U.; Qi, Q.; Roseborough, A.D.; Levit, A.; Allman, B.L.; Anazodo, U.C.; Fox, M.S.; Whitehead, S.N.; Thiessen, J.D.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

White Matter Degeneration - A Treatable Target?

JAMA Neurology
2020 | Journal article
DOI: 10.1001/jamaneurol.2020.0814
EID:

2-s2.0-85084117350

Part of ISSN: 21686157 21686149
Contributors: Roseborough, A.; Hachinski, V.; Whitehead, S.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer's disease rat model

Journal of Neuroinflammation
2020 | Journal article
DOI: 10.1186/s12974-020-1698-7
EID:

2-s2.0-85078294801

Part of ISSN: 17422094
Contributors: Ivanova, N.; Liu, Q.; Agca, C.; Agca, Y.; Noble, E.G.; Whitehead, S.N.; Cechetto, D.F.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Ganglioside Detection from Formalin-Fixed Human Brain Tissue Utilizing MALDI Imaging Mass Spectrometry

Journal of the American Society for Mass Spectrometry
2020-03-04 | Journal article
DOI: 10.1021/jasms.9b00110
Contributors: Aaron Harris; A. Roseborough; Rahul Mor; Ken K.-C. Yeung; Shawn N. Whitehead
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Endothelium-dependent impairments to cerebral vascular reactivity with type 2 diabetes mellitus in the Goto-Kakizaki rat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology
2019 | Journal article
DOI: 10.1152/ajpregu.00088.2019
EID:

2-s2.0-85069236683

Part of ISSN: 15221490 03636119
Contributors: Halvorson, B.D.; Whitehead, S.N.; McGuire, J.J.; Wiseman, R.W.; Frisbee, J.C.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease

Brain, Behavior, and Immunity
2019 | Journal article
DOI: 10.1016/j.bbi.2019.02.013
EID:

2-s2.0-85061645359

Part of ISSN: 10902139 08891591
Contributors: Levit, A.; Regis, A.M.; Gibson, A.; Hough, O.H.; Maheshwari, S.; Agca, Y.; Agca, C.; Hachinski, V.; Allman, B.L.; Whitehead, S.N.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Lateralization of the control of cardiovascular autonomic function and left atrial injury after selective right and left insular stroke

International Journal of Cardiology
2019 | Journal article
DOI: 10.1016/j.ijcard.2019.08.003
EID:

2-s2.0-85072040465

Part of ISSN: 18741754 01675273
Contributors: Jaremek, V.M.; Whitehead, S.; Sposato, L.A.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Left atrial microvascular endothelial dysfunction, myocardial inflammation and fibrosis after selective insular cortex ischemic stroke

International Journal of Cardiology
2019 | Journal article
DOI: 10.1016/j.ijcard.2019.06.004
EID:

2-s2.0-85067036095

Part of ISSN: 18741754 01675273
Contributors: Balint, B.; Jaremek, V.; Thorburn, V.; Whitehead, S.N.; Sposato, L.A.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Preventing dementia by preventing stroke: The Berlin Manifesto

Alzheimer's and Dementia
2019 | Journal article
DOI: 10.1016/j.jalz.2019.06.001
EID:

2-s2.0-85069004242

Part of ISSN: 15525279 15525260
Contributors: Hachinski, V.; Einhäupl, K.; Ganten, D.; Alladi, S.; Brayne, C.; Stephan, B.C.M.; Sweeney, M.D.; Zlokovic, B.; Iturria-Medina, Y.; Iadecola, C. et al.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto

International Journal of Stroke
2019 | Journal article
DOI: 10.1177/1747493019871915
EID:

2-s2.0-85073992926

Part of ISSN: 17474949 17474930
Contributors: Hachinski, V.; Einhäupl, K.; Ganten, D.; Alladi, S.; Brayne, C.; Stephan, B.C.M.; Sweeney, M.D.; Zlokovic, B.; Iturria-Medina, Y.; Iadecola, C. et al.
Source: Self-asserted source
Shawn Whitehead via Scopus - Elsevier

Chloroquine Restores Ganglioside Homeostasis and Improves Pathological and Behavioral Outcomes Post-stroke in the Rat

Molecular Neurobiology
2019-05 | Journal article
DOI: 10.1007/s12035-018-1317-0
Contributors: Sarah Caughlin; Jeffrey Hepburn; Qingfan Liu; Lynn Wang; Ken K.-C. Yeung; David F. Cechetto; Shawn N. Whitehead
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Peer review (9 reviews for 5 publications/grants)

Review activity for ACS chemical neuroscience. (3)
Review activity for Analytical chemistry. (1)
Review activity for Chemické zvesti. (1)
Review activity for Journal of neuroinflammation (3)
Review activity for Journal of proteome research. (1)
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