Personal information

Websites & social links

https://publons.com/researcher/2255800/joao-luiz-silva-filho/

Other IDs

ResearcherID: I-5704-2016
Loop profile: 304703

Countries

United Kingdom, Switzerland, Brazil, Malawi, Panama, United States

Biography

As a dynamic scientist at University of Glasgow, I lead human immunology research projects investigating immune-based diseases, from infectious diseases caused by viruses and parasites, such as Zika, COVID-19, and malaria, to kidney acute disease, hypertension, and cancer. In my current work, I apply artificial intelligence to develop predictive models to assist clinical decision systems for patient stratification and tailored therapeutic plans, in a precise medicine approach, aimed to improve clinical outcomes of such diseases. My passion is to uncover novel insights and potential interventions for global health challenges, advancing human health and wellbeing.

• Goal-oriented scientist with expertise in immunology, data analysis, single-cell and spatial biology, cellular and molecular biology, machine learning and precision medicine, addressing projects using multidisciplinary and integrative strategies.
• My accomplishments are evidenced by my portfolio of 30+ published studies in recognised high-impact medical journals, as well as by the grants and awards, worth more than £1million, I secured from prestigious UK and international research funding agencies.
• Strong writing and communication skills, with proficiency in delivering comprehensive and informative presentations, which led to strategic collaborations and 10+ awards’ recognition.
• Outstanding analytical and project management skills, with a proven ability to think strategically and translate research gaps into learning and development strategies.
• Highly organized, objective, with excellent interpersonal skills, and solid know-how in mentoring to develop and accomplish career goals.
• Proficient in using various wet-lab techniques, from bulk to single-cell, and spatial biology approaches.
• Advanced proficiency in bioinformatics and statistical methodologies, coupled with creative application thereof.
• Highly skilled in R and Python programming languages, and in applying computational tools for big data analysis, integration, build of predictive models and visualization. The portfolio of my computational analysis pipelines are available on my GitHub page (github.com/joaolsf).

Activities

Collapse all

Employment (2)

University of Glasgow: Glasgow, Glasgow, GB

2019-05-31 to present | MRC Co-Investigator (Wellcome Center for Integrative Parasitology)
Employment
Source: Self-asserted source
João Luiz Silva-Filho

State University of Campinas: Campinas, Sao Paulo, BR

2016-10 to 2019-05 | Postdoctoral Researcher (Institute of Biology)
Employment
Source: Self-asserted source
João Luiz Silva-Filho

Education and qualifications (6)

University of Glasgow: Glasgow, Glasgow, GB

2019-05-28 to present | Research Associate (Wellcome Centre of Integrative Parasitology)
Education
Source: Self-asserted source
João Luiz Silva-Filho

State University of Campinas: Campinas, BR

2016-10-01 to 2019-05-27 | Postdoctoral Fellow (Dept. of Immunology and Microbiology)
Education
Source: Self-asserted source
João Luiz Silva-Filho

Federal University of Rio de Janeiro: Rio de Janeiro, BR

2012-02-01 to 2015-02-27 | PhD (Biophysics Institute - Dept of Physiology)
Education
Source: Self-asserted source
João Luiz Silva-Filho

Johns Hopkins University: Baltimore, MD, US

2012-05-01 to 2013-05-31 (Department of Molecular Microbiology and Immunology)
Education
Source: Self-asserted source
João Luiz Silva-Filho

Federal University of Rio de Janeiro: Rio de Janeiro, BR

2009-01-01 to 2011-12-01 | Masters in Science (Biophysics Institute - Dept of Physiology)
Education
Source: Self-asserted source
João Luiz Silva-Filho

Federal University of Rio de Janeiro: Rio de Janeiro, BR

2004-02-01 to 2007-12-20 | Bachelor in Pharmacology
Education
Source: Self-asserted source
João Luiz Silva-Filho

Professional activities (1)

Brazilian Society of Immunology: Sao Paulo, BR

2015-01-01 to present
Membership
Source: Self-asserted source
João Luiz Silva-Filho

Funding (8)

MRC FAPESP: Defining the role of the hematopoietic parasite reservoir in Plasmodium vivax infection and pathology

2022-05-31 to 2026-05-30 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.12930859
GRANT_NUMBER: MR/W018802/1
Source: Self-asserted source
João Luiz Silva-Filho via DimensionsWizard

Investigating COVID-19 co-infections at the single cell level: a postmortem study in the Brazilian Amazon.

2020-10 to 2021-10 | Grant
Global Challenges Research Fund (Glasgow, Scotland, GB)
Source: Self-asserted source
João Luiz Silva-Filho

Host-Parasite Interactions in the Bone Marrow: A Key Role in Malaria Pathogenesis

2019-05 to 2020-05 | Award
Fundação de Amparo à Pesquisa do Estado de São Paulo (Sao Paulo, BR)
GRANT_NUMBER:

2019/01578-2
Source: Self-asserted source
João Luiz Silva-Filho

Papel do Gas6, ligante de receptores do tipo TAM, na patogênese da infecção pelo Zika Vírus em humanos

2018-10-01 to 2019-06-30 | Grant
São Paulo Research Foundation (São Paulo, BR)
URL: https://app.dimensions.ai/details/grant/grant.9104134
GRANT_NUMBER: 18/13866-0
Source: Self-asserted source
João Luiz Silva-Filho via DimensionsWizard

The role of Gas6, TAM receptor ligand, in Zika virus pathogenesis in humans

2018-10 to 2019-10 | Grant
São Paulo Research Foundation (São Paulo, BR) (Sao Paulo, BR)
GRANT_NUMBER:

2018/13866-0
Source: Self-asserted source
João Luiz Silva-Filho

Mechanism of action of Lipoxin in the Protection Against Experimental Cerebral Malaria

2017-10 to 2018-10 | Grant
Universidade Estadual de Campinas (Sao Paulo, BR)
GRANT_NUMBER:

519.292
Source: Self-asserted source
João Luiz Silva-Filho

Mechanism of action of Lipoxin in the Protection Against Experimental Cerebral Malaria

2016-10 to 2020-09 | Award
Fundação de Amparo à Pesquisa do Estado de São Paulo (Sao Paulo, BR)
GRANT_NUMBER:

2016/12855-9
Source: Self-asserted source
João Luiz Silva-Filho

The role of Angiotensin II in T-cell regulation in malaria immunopathogenesis

2012-05 to 2013-05 | Award
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Rio de Janeiro, BR)
Source: Self-asserted source
João Luiz Silva-Filho

Works (35)

Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population

Nature Medicine
2024-12 | Journal article
DOI: 10.1038/s41591-024-03354-3
Contributors: James Nyirenda; Olympia M. Hardy; João Da Silva Filho; Vanessa Herder; Charalampos Attipa; Charles Ndovi; Memory Siwombo; Takondwa Rex Namalima; Leticia Suwedi; Georgios Ilia et al.
Source: check_circle
Crossref

A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories

Science Translational Medicine
2024-09-11 | Journal article
DOI: 10.1126/scitranslmed.adk9149
Contributors: João Da Silva Filho; Vanessa Herder; Matthew P. Gibbins; Monique Freire dos Reis; Gisely Cardoso Melo; Michael J. Haley; Carla Cristina Judice; Fernando Fonseca Almeida Val; Mayla Borba; Tatyana Almeida Tavella et al.
Source: check_circle
Crossref

Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response

2023-11-17 | Preprint
DOI: 10.1101/2023.11.16.566964
Contributors: James Nyirenda; Olympia Hardy; João Da Silva Filho; Vanessa Herder; Charalampos Attipa; Charles Ndovi; Memory Siwombo; Takondwa Namalima; Leticia Suwedi; Watipenge Nyasulu et al.
Source: Self-asserted source
João Luiz Silva-Filho

Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies

2023-09-08 | Preprint
DOI: 10.1101/2023.09.08.23295024
Contributors: João Da Silva Filho; Vanessa Herder; Matthew P. Gibbins; Monique Freire dos Reis; Gisely Cardoso Melo; Michael J. Haley; Carla Cristina Judice; Fernando Fonseca Almeida Val; Mayla Borba; Tatyana Almeida Tavella et al.
Source: check_circle
Crossref

Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

eLife
2023-03-14 | Journal article
DOI: 10.7554/eLife.85140
Contributors: Abdirahman I Abdi; Fiona Achcar; Lauriane Sollelis; João Luiz Silva-Filho; Kioko Mwikali; Michelle Muthui; Shaban Mwangi; Hannah W Kimingi; Benedict Orindi; Cheryl Andisi Kivisi et al.
Source: check_circle
Crossref

Plasmodium falciparumadapts its investment into replicationversustransmission according to the host environment

2022-12-02 | Preprint
DOI: 10.1101/2022.11.29.518379
Contributors: Abdirahman I. Abdi; Fiona Achcar; Lauriane Sollelis; Joao Luiz Silva-Filho; Kioko Mwikali; Michelle Muthui; Shaban Mwangi; Hannah W. Kimingi; Benedict Orindi; Cheryl Andisi Kivisi et al.
Source: check_circle
Crossref

Editorial: Inflammatory Mechanisms of Hemolytic Diseases

Frontiers in Immunology
2022-01-12 | Journal article
DOI: 10.3389/fimmu.2021.834527
Part of ISSN: 1664-3224
Contributors: Renata Sesti-Costa; João Luiz Silva-Filho; Wilma Barcellini; Caroline Le Van Kim; Nicola Conran
Source: Self-asserted source
João Luiz Silva-Filho

Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice

Brain, Behavior, and Immunity
2021-10 | Journal article
DOI: 10.1016/j.bbi.2021.08.008
Part of ISSN: 0889-1591
Source: Self-asserted source
João Luiz Silva-Filho

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

eLife
2021-09-29 | Journal article
DOI: 10.7554/eLife.71351
Contributors: João L Silva-Filho; João CK Dos-Santos; Carla Judice; Dario Beraldi; Kannan Venugopal; Diogenes Lima; Helder I Nakaya; Erich V De Paula; Stefanie CP Lopes; Marcus VG Lacerda et al.
Source: check_circle
Crossref

A prenylated dsRNA sensor protects against severe COVID-19

Science
2021-09-28 | Journal article
DOI: 10.1126/science.abj3624
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Source: Self-asserted source
João Luiz Silva-Filho

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

MedRxiv
2021-03-20 | Preprint
DOI: 10.1101/2021.03.19.21253933
Source: Self-asserted source
João Luiz Silva-Filho

Malaria in pregnancy regulates P‐glycoprotein (P‐gp/ Abcb1a ) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac

Journal of Cellular and Molecular Medicine
2020-09 | Journal article
DOI: 10.1111/jcmm.15682
Part of ISSN: 1582-1838
Part of ISSN: 1582-4934
Source: Self-asserted source
João Luiz Silva-Filho

Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria

PLOS Neglected Tropical Diseases
2020-07-20 | Journal article
DOI: 10.1371/journal.pntd.0007656
Part of ISSN: 1935-2735
Source: Self-asserted source
João Luiz Silva-Filho

Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response

PLOS Neglected Tropical Diseases
2020-07-08 | Journal article
DOI: 10.1371/journal.pntd.0008471
Part of ISSN: 1935-2735
Source: Self-asserted source
João Luiz Silva-Filho

Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous

Trends in Parasitology
2020-05 | Journal article
DOI: 10.1016/j.pt.2020.03.002
Part of ISSN: 1471-4922
Source: Self-asserted source
João Luiz Silva-Filho

IL-4 Receptor α Chain Protects the Kidney Against Tubule-Interstitial Injury Induced by Albumin Overload

Frontiers in Physiology
2020-02-27 | Journal article
DOI: 10.3389/fphys.2020.00172
Part of ISSN: 1664-042X
Contributors: Diogo B. Peruchetti; João Luiz Silva-Filho; Rodrigo P. Silva-Aguiar; Douglas E. Teixeira; Christina M. Takiya; Mariana C. Souza; Maria das Graças Henriques; Ana Acacia S. Pinheiro; Celso Caruso-Neves
Source: Self-asserted source
João Luiz Silva-Filho

Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor

Scientific Reports
2019-12 | Journal article
DOI: 10.1038/s41598-019-47865-3
Part of ISSN: 2045-2322
Source: Self-asserted source
João Luiz Silva-Filho

Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway

PLOS ONE
2019-04-19 | Journal article
DOI: 10.1371/journal.pone.0215871
Part of ISSN: 1932-6203
Source: Self-asserted source
João Luiz Silva-Filho

Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2)

Malaria Journal
2018-12 | Journal article
DOI: 10.1186/s12936-018-2543-7
Part of ISSN: 1475-2875
Source: Self-asserted source
João Luiz Silva-Filho

Inhibition of hypoxia‐associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria

The FASEB Journal
2018-08 | Journal article
DOI: 10.1096/fj.201700844r
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
João Luiz Silva-Filho

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion

Frontiers in Molecular Biosciences
2018-07-18 | Journal article
DOI: 10.3389/fmolb.2018.00067
Part of ISSN: 2296-889X
Source: Self-asserted source
João Luiz Silva-Filho

Therapeutic effect of Lipoxin A 4  in malaria‐induced acute lung injury

Journal of Leukocyte Biology
2018-04 | Journal article
DOI: 10.1002/jlb.3a1016-435rrr
Part of ISSN: 0741-5400
Part of ISSN: 1938-3673
Source: Self-asserted source
João Luiz Silva-Filho

Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria

Frontiers in Cellular and Infection Microbiology
2017-02-16 | Journal article
DOI: 10.3389/fcimb.2017.00042
Part of ISSN: 2235-2988
Source: Self-asserted source
João Luiz Silva-Filho

Angiotensin II type-1 receptor (AT1R) regulates expansion, differentiation, and functional capacity of antigen-specific CD8+ T cells

Scientific Reports
2016-12 | Journal article
DOI: 10.1038/srep35997
Part of ISSN: 2045-2322
Source: Self-asserted source
João Luiz Silva-Filho

Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium Handling in the Kidney

PLOS ONE
2016-01-28 | Journal article
DOI: 10.1371/journal.pone.0147785
Part of ISSN: 1932-6203
Source: Self-asserted source
João Luiz Silva-Filho
grade
Preferred source (of 2)‎

New Concepts in Malaria Pathogenesis: The Role of the Renin-Angiotensin System

Frontiers in Cellular and Infection Microbiology
2016-01-07 | Journal article
DOI: 10.3389/fcimb.2015.00103
Part of ISSN: 2235-2988
Source: Self-asserted source
João Luiz Silva-Filho

Renin–angiotensin system contributes to naive T-cell migration in vivo

Archives of Biochemistry and Biophysics
2015-05 | Journal article
DOI: 10.1016/j.abb.2015.02.035
Part of ISSN: 0003-9861
Source: Self-asserted source
João Luiz Silva-Filho

5-Lypoxygenase Products Are Involved in Renal Tubulointerstitial Injury Induced by Albumin Overload in Proximal Tubules in Mice

PLoS ONE
2014-10-10 | Journal article
DOI: 10.1371/journal.pone.0107549
Part of ISSN: 1932-6203
Source: Self-asserted source
João Luiz Silva-Filho

IL-4: an important cytokine in determining the fate of T cells

Biophysical Reviews
2014-03 | Journal article
DOI: 10.1007/s12551-013-0133-z
Part of ISSN: 1867-2450
Part of ISSN: 1867-2469
Source: Self-asserted source
João Luiz Silva-Filho

Inhibitory Effects of Trypanosoma cruzi Sialoglycoproteins on CD4+ T Cells Are Associated with Increased Susceptibility to Infection

PLoS ONE
2013-10-28 | Journal article
DOI: 10.1371/journal.pone.0077568
Part of ISSN: 1932-6203
Source: Self-asserted source
João Luiz Silva-Filho

Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes

Microbes and Infection
2013-05 | Journal article
DOI: 10.1016/j.micinf.2013.02.003
Part of ISSN: 1286-4579
Source: Self-asserted source
João Luiz Silva-Filho

Sepsis-Surviving Mice Are More Susceptible to a Secondary Kidney Insult*

Critical Care Medicine
2013-04 | Journal article
DOI: 10.1097/ccm.0b013e3182746696
Part of ISSN: 0090-3493
Source: Self-asserted source
João Luiz Silva-Filho

Angiotensin II Is a New Component Involved in Splenic T Lymphocyte Responses during Plasmodium berghei ANKA Infection

PLoS ONE
2013-04-30 | Journal article
DOI: 10.1371/journal.pone.0062999
Part of ISSN: 1932-6203
Source: Self-asserted source
João Luiz Silva-Filho

AT1 receptor-mediated angiotensin II activation and chemotaxis of T lymphocytes

Molecular Immunology
2011-09 | Journal article
DOI: 10.1016/j.molimm.2011.05.008
Part of ISSN: 0161-5890
Source: Self-asserted source
João Luiz Silva-Filho

Impairment of the Plasmodium falciparum Erythrocytic Cycle Induced by Angiotensin Peptides

PLoS ONE
2011-02-18 | Journal article
DOI: 10.1371/journal.pone.0017174
Part of ISSN: 1932-6203
Source: Self-asserted source
João Luiz Silva-Filho
How many people are using ORCID?