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Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

Cancer Research
2025-03-03 | Journal article
DOI: 10.1158/0008-5472.CAN-24-0798
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Data from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.c.7700661
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S1 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523481
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S10 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523478
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S2 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523475
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S3 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523472
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S4 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523469
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S5 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523466
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S6 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523463
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S7 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523457
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S8 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523454
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Figure S9 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523451
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Table S1 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523448
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Table S2 from Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

2025-03-03 | Preprint
DOI: 10.1158/0008-5472.28523445
Contributors: Joan Jacob; Yasuaki Anami; Peyton C. High; Zhengdong Liang; Shraddha Subramanian; Sukhen C. Ghosh; Solmaz AghaAmiri; Cara Guernsey-Biddle; Ha Tran; Julie Rowe et al.
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Crossref

Data from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.c.6611316.v3
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Data from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.c.6611316
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S1 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035770
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S1 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035770.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S2 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035767.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S2 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035767
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S3 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035764
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S3 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035764.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S4 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035761
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S4 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035761.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S5 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035758
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S5 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035758.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S6 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035755.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S6 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035755
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Supplementary Tables S1-S3 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035752.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Supplementary Tables S1-S3 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

2024-09-16 | Preprint
DOI: 10.1158/1535-7163.27035752
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Data from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.c.6611316.v2
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S1 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758737
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S1 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758737.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S2 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758734
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S2 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758734.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S3 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758731
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S3 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758731.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S4 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758728
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S4 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758728.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S5 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758725
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Figure S5 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758725.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S6 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758722
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S6 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758722.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

Molecular Cancer Therapeutics
2023-05-04 | Journal article
DOI: 10.1158/1535-7163.MCT-22-0415
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Supplementary Tables S1-S3 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758719
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Supplementary Tables S1-S3 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-05-04 | Preprint
DOI: 10.1158/1535-7163.22758719.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Data from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-04-21 | Preprint
DOI: 10.1158/1535-7163.c.6611316.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
Source: check_circle
Crossref

Figure S1 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-04-21 | Preprint
DOI: 10.1158/1535-7163.22674504
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
Source: check_circle
Crossref

Figure S1 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-04-21 | Preprint
DOI: 10.1158/1535-7163.22674504.v1
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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Crossref

Figure S2 from Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells

2023-04-21 | Preprint
DOI: 10.1158/1535-7163.22674501
Contributors: Tressie A. Posey; Joan Jacob; Ashlyn Parkhurst; Shraddha Subramanian; Liezl E. Francisco; Zhengdong Liang; Kendra S. Carmon
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