Personal information

Verified email domains

Activities

Funding (5)

Verbundprojekt NeuStaRT: Neue innovative Strategien zur Radiosensitivierung von Medulloblastomen, Teilprojekt B

2024-04-01 to 2028-03-31 | Grant
Federal Ministry of Education and Research (Bonn, DE)
GRANT_NUMBER: 02NUK090B
Source: Self-asserted source
Johann Matschke via DimensionsWizard

GRK 2762:  Heterogeneity, plasticity & dynamics in cancer cell, tumor and normal tissue responses to cancer radiotherapy

2022-01-01 to present | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
GRANT_NUMBER: 450917483
Source: Self-asserted source
Johann Matschke via DimensionsWizard

Verbundprojekt METABOLiST: Einfluss veränderter Stoffwechselwege auf die therapeutische Strahlenantwort von Tumoren, Teilprojekt B

2021-01-01 to 2023-12-31 | Grant
Federal Ministry of Education and Research (Bonn, DE)
GRANT_NUMBER: 02NUK061B
Source: Self-asserted source
Johann Matschke via DimensionsWizard

Metabolic induction of DNA repair defects for improving the outcome of radiotherapy.

2020-01-01 to present | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
GRANT_NUMBER: 442358541
Source: Self-asserted source
Johann Matschke via DimensionsWizard

International NETwork for training and innovations in THErapeutic RADiation

2019-09-01 to 2023-12-31 | Grant
European Commission (Brussels, BE)
GRANT_NUMBER: 860245
Source: Self-asserted source
Johann Matschke via DimensionsWizard

Works (39)

MetaboDynamics

Institute of Cell Biology (Cancer Research)
2025-01 | Research tool
Contributors:
Source: Self-asserted source
Johann Matschke

Targeting hypoxia-inducible factor-1 in a hypoxidative stress model of age-related macular degeneration protects RPE cells from cell death and metabolic dysregulation

2024-09-17 | Preprint
Contributors: Yoshiyuki Henning; Annika Schubert; Maria Lobo Barbosa da Silva; Tabea Ambrock; Orbel Terosian; Anna Malyshkina; Claudia Padberg; Safa Larafa; Johann Matschke; Joachim Fandrey
Source: check_circle
Crossref

Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS

Cells
2024-06-07 | Journal article
Contributors: Hilal Cihankaya; Verian Bader; Konstanze F. Winklhofer; Matthias Vorgerd; Johann Matschke; Sarah Stahlke; Carsten Theiss; Veronika Matschke
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells

Cell Death Discovery
2024-01-15 | Journal article
Contributors: Kexu Xiang; Mikhail Kunin; Safa Larafa; Maike Busch; Nicole Dünker; Verena Jendrossek; Johann Matschke
Source: check_circle
Crossref

Defects in DNA Damage Response Reinforce Proton Beam Specific Radiosensitivity of Cancer Cells

Strahlentherapie und Onkologie
2023 | Journal article
Contributors: Hessenow, Razan; Behrends, Carina; Lin, Xixi; Mladenov, Emil; Matschke, Johann; Soni, Aashish; Stuschke, Martin; Iliakis, George; Jendrossek, Verena; Timmermann, Beate
Source: check_circle
Web of Science Researcher Profile Sync

The importance of antioxidant-associated mitochondrial transport systems as targets for overcoming hypoxia-mediated radioresistance of cancer cells

Strahlentherapie und Onkologie
2023 | Journal article
Contributors: Hlouschek, Julian; Ritter, Violetta; Hansel, Christine; Wirsdoerfer, Florian; Klein, Diana; Jendrossek, Verena; Matschke, Johann
Source: check_circle
Web of Science Researcher Profile Sync

Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia

Cell Death Discovery
2023-10-25 | Journal article
Contributors: Yoshiyuki Henning; Katrin Willbrand; Safa Larafa; Gesa Weißenberg; Veronika Matschke; Carsten Theiss; Gina-Eva Görtz; Johann Matschke
Source: check_circle
Crossref

α-Ketoglutarate Supplementation and NAD+ Modulation Enhance Metabolic Rewiring and Radiosensitization in SLC25A1 Inhibited Cancer Cells

2023-07-21 | Preprint
Contributors: Johann Matschke; Kexu Xiang; Mikhail Kunin; Safa Larafa; Maike Busch; Nicole Duenker; Verena Jendrossek
Source: check_circle
Crossref

The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition

Biological Chemistry
2023-03-28 | Journal article | Author
Part of ISSN: 1431-6730
Part of ISSN: 1437-4315
Contributors: Maurice Dellin; Ina Rohrbeck; Purva Asrani; Julian A. Schreiber; Nadine Ritter; Frank Glorius; Bernhard Wünsch; Thomas Budde; Louisa Temme; Timo Strünker et al.
Source: Self-asserted source
Johann Matschke

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

Clinical Cancer Research
2023-01-17 | Journal article | Author
Part of ISSN: 1078-0432
Part of ISSN: 1557-3265
Contributors: Sied; Vivien Ullrich; Pia Berger; Celia Dobersalske; Sarah Langer; Rauschenbach L; Daniel Trageser; Andreas Till; Franziska Lorbeer; Anja Wieland et al.
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 2)‎

ROS scavengers decrease gamma H2ax spots in motor neuronal nuclei of ALS model mice in vitro

Frontiers in Cellular Neuroscience
2022 | Journal article
Contributors: Junghans, Maya; John, Felix; Cihankaya, Hilal; Schliebs, Daniel; Winklhofer, Konstanze F.; Bader, Verian; Matschke, Johann; Theiss, Carsten; Matschke, Veronika
Source: check_circle
Web of Science Researcher Profile Sync

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction

Cell Death & Disease
2022-07-29 | Journal article
Contributors: Yoshiyuki Henning; Ursula Sarah Blind; Safa Larafa; Johann Matschke; Joachim Fandrey
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity

Cell Death & Disease
2022-07-22 | Journal article
Contributors: Kexu Xiang; Christian Kalthoff; Corinna Münch; Verena Jendrossek; Johann Matschke
Source: check_circle
Crossref

Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation

Frontiers in Oncology
2022-07-08 | Journal article
Part of ISSN: 2234-943X
Source: Self-asserted source
Johann Matschke

Ensuring fuels for DNA repair - analysis of irradiated cancer cells reveals mitochondrial shutdown

Strahlentherapie und Onkologie
2021 | Journal article
Contributors: Krysztofiak, A.; Szymonomicz, K.; Hlouschek, J.; Xiang, K.; Waterkamp, C.; Larafa, S.; Goetting, I.; Vega-Rubin-de-Celis, S.; Theiss, C.; Matschke, V. et al.
Source: check_circle
Web of Science Researcher Profile Sync

Inhibition of the citrate carrier SLC25A1 affects repair of radiation-induced DNA damage, increases radiosensitivity, and enhances lethality of IR in combination with DNA repair defects or DSB inhibitors

Clinical Cancer Research
2021 | Journal article
Contributors: Kalthoff, Christian; Xiang, Kexu; Muench, Corinna; Hlouschek, Julian; Jendrossek, Verena; Matschke, Johann
Source: check_circle
Web of Science Researcher Profile Sync

Modeling common aspects of the metabolic response of cancer cells to ionizing radiation

Cancer Research
2021 | Journal article
Contributors: Krysztofiak, Adam; Szymonowicz, Klaudia A.; Hlouschek, Julian; Waterkamp, Christoph; Xiang, Kexu; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
Source: check_circle
Web of Science Researcher Profile Sync

The citrate carrier SLC25A1 acts as master regulator of metabolic reprogramming and offers an innovative strategy for metabolic induction of HRness and synthetic lethality approaches with radiotherapy

Strahlentherapie und Onkologie
2021 | Journal article
Contributors: Xiang, K.; Kalthoff, C.; Muench, C.; Hlouschek, J.; Jendrossek, V.; Matschke, J.
Source: check_circle
Web of Science Researcher Profile Sync

Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown

iScience
2021-11-19 | Journal article
Part of ISSN: 2589-0042
Source: Self-asserted source
Johann Matschke

Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion

Cells
2021-11-05 | Journal article
Contributors: Christine Hansel; Julian Hlouschek; Kexu Xiang; Margarita Melnikova; Juergen Thomale; Thomas Helleday; Verena Jendrossek; Johann Matschke
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?

Biochemical Society Transactions
2021-06-30 | Journal article
Part of ISSN: 0300-5127
Part of ISSN: 1470-8752
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 2)‎

Increased ROS‐Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis

Oxidative Medicine and Cellular Longevity
2021-01 | Journal article
Contributors: Jan Stein; Bernd Walkenfort; Hilal Cihankaya; Mike Hasenberg; Verian Bader; Konstanze F. Winklhofer; Pascal Röderer; Johann Matschke; Carsten Theiss; Veronika Matschke et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Inhibition of the mitochondrial citrate carrier SLC25A1 induces a DNA repair defect and increases cancer cell radiosensitivity

Strahlentherapie und Onkologie
2020 | Journal article
Contributors: Kalthoff, C.; Hlouschek, J.; Koska, B.; Vuellings, M.; Timmermann, B.; Jendrossek, V; Matschke, J.
Source: check_circle
Web of Science Researcher Profile Sync

Oncometabolites and the response to radiotherapy

Radiation Oncology
2020-12 | Journal article
Contributors: Kexu Xiang; Verena Jendrossek; Johann Matschke
Source: check_circle
Crossref
grade
Preferred source (of 4)‎

A New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance

International Journal of Molecular Sciences
2020-11-13 | Journal article
Contributors: Isabell Götting; Verena Jendrossek; Johann Matschke
Source: check_circle
Crossref
grade
Preferred source (of 4)‎

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining

Cells
2020-04 | Journal article | Author
Contributors: Klaudia Szymonowicz; Adam Krysztofiak; Jansje van der Linden; Ajvar Kern; Simon Deycmar; Dr. Sebastian Oeck; Anthony Squire; Benjamin Koska; Julian Hlouschek; Melanie Vüllings et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E inhibition in melanoma

2019-03 | Journal article
Part of ISSN: 0959-8049
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 2)‎

Oxidative stress: the lowest common denominator of multiple diseases

2019-02 | Journal article
Part of ISSN: 1673-5374
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 2)‎

Combined inhibition of GSH levels and sanitization of dNTPs is effective in eradicating cancer cells exposed to acute hypoxia or chronic cycling severe hypoxia

Strahlentherapie und Onkologie
2018 | Journal article
Contributors: Hansel, C.; Hlouschek, J.; Helleday, T.; Jendrossek, V.; Matschke, J.
Source: check_circle
Web of Science Researcher Profile Sync

Targeting of antioxidant-associated mitochondrial transport systems overcomes chronic-cycling hypoxia-induced radioresistance

Oncology Research and Treatment
2018 | Journal article
Contributors: Hlouschek, J.; Hansel, C.; Riffkin, H.; Jendrossek, V.; Matschke, J.
Source: check_circle
Web of Science Researcher Profile Sync

Targeting of the mitochondrial citrate carrier (SLC25A1) lowers antioxidant defense systems and increases radiosensitivity of hypoxic cancer cells

Strahlentherapie und Onkologie
2018 | Journal article
Contributors: Hlouschek, J.; Hansel, C.; Jendrossek, V; Matschke, J.
Source: check_circle
Web of Science Researcher Profile Sync

Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia

Cancer Letters
2018-12 | Journal article
Contributors: Julian Hlouschek; Violetta Ritter; Florian Wirsdörfer; Diana Klein; Verena Jendrossek; Johann Matschke
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

2018-05-25 | Journal article
Part of ISSN: 2234-943X
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 2)‎

Inhibition of anti-apoptotic Bcl-2 proteins by ABT-263 sensitizes hypoxic cancer cells to ionizing radiation

European Journal of Cancer
2016 | Journal article
Contributors: Ritter, V.; Rudner, J.; Matschke, J.; Jendrossek, V.
Source: check_circle
Web of Science Researcher Profile Sync

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels

2016-12-21 | Journal article
EID:

2-s2.0-85008674842

Part of ISSN: 14219778 10158987
Part of ISSN: 1015-8987
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 3)‎

Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia

2016-06 | Journal article
Part of ISSN: 1748-717X
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 3)‎

Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia

2016-03-28 | Journal article
Part of ISSN: 1523-0864
Part of ISSN: 1557-7716
Source: Self-asserted source
Johann Matschke
grade
Preferred source (of 2)‎

Senescence-like responses in irradiated melanoma cells

JDDG: Journal der Deutschen Dermatologischen Gesellschaft
2015 | Journal article
Contributors: Shannan, B.; Matschke, J.; Hoewner, A.; Jendrossek, V.; Schadendorf, D.; Roesch, A.
Source: check_circle
Web of Science Researcher Profile Sync

Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death

European Journal of Cancer
2014 | Journal article
Contributors: Matschke, J.; Riffkin, H.; Handrick, R.; Klein-Hitpass, L.; Jendrossek, V.
Source: check_circle
Web of Science Researcher Profile Sync

Peer review (66 reviews for 18 publications/grants)

Review activity for Advanced science. (8)
Review activity for Cancer chemotherapy and pharmacology. (1)
Review activity for Cancers. (2)
Review activity for Cell death and differentiation. (1)
Review activity for Cell death and disease. (2)
Review activity for Cellular signalling. (2)
Review activity for International journal of molecular sciences. (7)
Review activity for International journal of radiation biology. (3)
Review activity for iScience. (4)
Review activity for Journal for immunotherapy of cancer. (1)
Review activity for Lung cancer. (1)
Review activity for Metabolites. (1)
Review activity for PloS one. (2)
Review activity for Radiation oncology. (8)
Review activity for Radiotherapy and oncology. (1)
Review activity for Stem cells translational medicine. (2)
Review activity for Strahlentherapie und Onkologie. (18)
Review activity for Translational cancer research. (2)