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Employment (4)

Universitätsklinikum Hamburg-Eppendorf: Hamburg, Hamburg, DE

2010-01-01 to present | Director (ZMNH Institute of Molecular Neurogenetics)
Employment
Source: Self-asserted source
Matthias Kneussel

Universitätsklinikum Hamburg-Eppendorf: Hamburg, Hamburg, DE

2002-08-01 to 2009-12-31 | group leader (Research Group Protein Trafficking and Synapse Formation)
Employment
Source: Self-asserted source
Matthias Kneussel

MPI for Brain Research Frankfurt/Main: Frankfurt, DE

1999-10-01 to 2002-07-31 | group leader (Dept. of Neurochemistry, Neurotransmitter Receptor Group)
Employment
Source: Self-asserted source
Matthias Kneussel

MPI for Brain Research Frankfurt/Main: Frankfurt, DE

1997-10-01 to 1999-09-30 | Postdoc (Dept. of Neurochemistry)
Employment
Source: Self-asserted source
Matthias Kneussel

Education and qualifications (5)

University of Hamburg: Hamburg, DE

2005 to present | Habilitation in Molecular Biology and Genetics (Biology)
Qualification
Source: Self-asserted source
Matthias Kneussel

Goethe University Frankfurt: Frankfurt am Main, Hessen, DE

2004 to present | Habilitation (Biological Sciences - Biochemistry)
Qualification
Source: Self-asserted source
Matthias Kneussel

Technical University of Darmstadt: Darmstadt, DE

1997-07 to present | Dr. rer. nat (Biological Sciences - Biochemistry)
Qualification
Source: Self-asserted source
Matthias Kneussel

University College London: London, London, GB

1994-01-01 to 1997-07-31 | PhD student (Division of Biosciences)
Education
Source: Self-asserted source
Matthias Kneussel

Technical University of Darmstadt: Darmstadt, DE

1987-10-01 to 1992-12-31 | Diploma (Biology)
Education
Source: Self-asserted source
Matthias Kneussel

Professional activities (3)

Zentrum für Molekulare Neurobiologie Hamburg: Hamburg, Hamburg, DE

2017 to present | Scientific Director
Invited position
Source: Self-asserted source
Matthias Kneussel

Neurowissenschaftliche Gesellschaft: Berlin, Berlin, DE

2015 to present | Executive Committee member
Invited position
Source: Self-asserted source
Matthias Kneussel

Journal Frontiers of Molecular Neurosciences: Lausanne, CH

2009 to present | Review editor (Open Access Publisher and Open Science Platform)
Invited position
Source: Self-asserted source
Matthias Kneussel

Funding (1)

FOR 2419

2016-01 to 2021-12 | Grant
Deutsche Forschungsgemeinschaft (Bonn, Germany, DE)
GRANT_NUMBER:

KN 556/11

Source: Self-asserted source
Matthias Kneussel

Works (50 of 99)

Items per page:
Page 1 of 2

Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

2025-01-30 | Preprint
Contributors: Ana C Costa; Blanca R Murillo; Rita Bessa; Ricardo Ribeiro; Tiago Ferreira da Silva; Patrícia Porfírio-Rodrigues; Gabriel G Martins; Pedro Brites; Matthias Kneussel; Thomas Misgeld et al.
Source: check_circle
Crossref

Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

2025-01-30 | Preprint
Contributors: Ana C Costa; Blanca R Murillo; Rita Bessa; Ricardo Ribeiro; Tiago Ferreira da Silva; Patrícia Porfírio-Rodrigues; Gabriel G Martins; Pedro Brites; Matthias Kneussel; Thomas Misgeld et al.
Source: check_circle
Crossref

Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants

Proceedings of the National Academy of Sciences
2024-12-17 | Journal article
Contributors: Liana Mkrtchyan; Harutyun Sahakyan; Jodene Eldstrom; Tatev Karapetyan; Astghik Abrahamyan; Karen Nazaryan; Jürgen R. Schwarz; Matthias Kneussel; David Fedida; Vitya Vardanyan
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Crossref

Neurobeachin regulates receptor downscaling at GABAergic inhibitory synapses in a protein kinase A-dependent manner

Communications Biology
2024-12-12 | Journal article
Contributors: Felix P. Lützenkirchen; Yipeng Zhu; Hans M. Maric; Dominik S. Boeck; Kira V. Gromova; Matthias Kneussel
Source: check_circle
Crossref

Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

2024-11-29 | Preprint
Contributors: Ana C Costa; Blanca R Murillo; Rita Bessa; Ricardo Ribeiro; Tiago Ferreira da Silva; Patrícia Porfírio-Rodrigues; Gabriel G Martins; Pedro Brites; Matthias Kneussel; Thomas Misgeld et al.
Source: check_circle
Crossref

Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes

The EMBO Journal
2024-11-29 | Journal article
Contributors: Daniel Ten Martin; Nicolas Jardin; Juliette Vougny; François Giudicelli; Laïla Gasmi; Naomi Berbée; Véronique Henriot; Laura Lebrun; Cécile Haumaître; Matthias Kneussel et al.
Source: check_circle
Crossref

Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

2024-10-14 | Preprint
Contributors: Ana C. Costa; Blanca R. Murillo; Rita Bessa; Ricardo Ribeiro; Tiago Ferreira da Silva; Patrícia Porfírio-Rodrigues; Gabriel G. Martins; Pedro Brites; Matthias Kneussel; Thomas Misgeld et al.
Source: check_circle
Crossref

Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go–related gene) K + channel subunits

Science Advances
2024-10-04 | Journal article
Contributors: Jürgen R. Schwarz; Sandra Freitag; Yvonne Pechmann; Irm Hermans-Borgmeyer; Wolfgang Wagner; Sönke Hornig; Matthias Kneussel
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Crossref

Tspan15 depletion in mice affects social investigation and aggressive behavior

2024-05-16 | Preprint
Contributors: Daniele Stajano; Sandra Freitag; Paul Saftig; Kira V Gromova; Matthias Kneussel
Source: check_circle
Crossref

Polyglutamylation of microtubules drives neuronal remodeling

2024-03-12 | Preprint
Contributors: Antoneta Gavoci; Anxhela Zhiti; Michaela Rusková; Maria M. Magiera; Mengzhe Wang; Karin A. Ziegler; Torben Johann Hausrat; Stefan Engelhardt; Matthias Kneussel; Martin Balastik et al.
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Crossref

Tetraspanin 15 depletion impairs extracellular vesicle docking at target neurons

Journal of Extracellular Biology
2023-09 | Journal article
Contributors: Daniele Stajano; Franco L. Lombino; Michaela Schweizer; Markus Glatzel; Paul Saftig; Kira V. Gromova; Matthias Kneussel
Source: check_circle
Crossref

Mechanism of external K+ sensitivity of KCNQ1 channels

Journal of General Physiology
2023-05-01 | Journal article
Contributors: Astghik Abrahamyan; Jodene Eldstrom; Harutyun Sahakyan; Nare Karagulyan; Liana Mkrtchyan; Tatev Karapetyan; Ernest Sargsyan; Matthias Kneussel; Karen Nazaryan; Jürgen R. Schwarz et al.
Source: check_circle
Crossref

Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport

Cellular and Molecular Life Sciences
2022-11 | Journal article
Contributors: Jennifer Radwitz; Torben J. Hausrat; Frank F. Heisler; Philipp C. Janiesch; Yvonne Pechmann; Michael Rübhausen; Matthias Kneussel
Source: check_circle
Crossref

ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning

Nature Communications
2022-10-26 | Journal article
Contributors: Paul J. Lamothe-Molina; Andreas Franzelin; Lennart Beck; Dong Li; Lea Auksutat; Tim Fieblinger; Laura Laprell; Joachim Alhbeck; Christine E. Gee; Matthias Kneussel et al.
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Crossref

Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice

Nature Communications
2022-07-20 | Journal article
Contributors: Torben Johann Hausrat; Philipp C. Janiesch; Petra Breiden; David Lutz; Sabine Hoffmeister-Ullerich; Irm Hermans-Borgmeyer; Antonio Virgilio Failla; Matthias Kneussel
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Crossref

Katanin is involved in Microtubule Polymerization into Dendritic Spines and regulates Synaptic Plasticity

2022-05-05 | Preprint
Contributors: Franco L. Lombino; Jürgen R. Schwarz; Yvonne Pechmann; Michaela Schweizer; Markus Glatzel; Christine E. Gee; Kira V. Gromova; Matthias Kneussel
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Crossref

KIF21B binds Myosin Va for Spine Entry and regulates Actin Dynamics to control Homeostatic Synaptic Downscaling

2022-05-04 | Preprint
Contributors: Kira V. Gromova; Edda Thies; Céline D. Dürst; Daniele Stajano; Michaela Schweizer; Marina Mikhaylova; Christine E. Gee; Matthias Kneussel
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Crossref

Tubulin glutamylation is key to axon guidance via selective tuning of microtubule-severing enzymes

2022-01-20 | Preprint
Contributors: Daniel Ten Martin; Nicolas Jardin; Juliette Vougny; François Giudicelli; Laïla Gasmi; Véronique Henriot; Laura Lebrun; Cécile Haumaître; Matthias Kneussel; Xavier Nicol et al.
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Crossref

Dynein and muskelin control myosin VI delivery towards the neuronal nucleus

iScience
2021-05 | Journal article
Contributors: Matthias Kneussel; Noelia Sánchez-Rodríguez; Michaela Mischak; Frank F. Heisler
Source: check_circle
Crossref

Alpha‐ and beta‐tubulin isotypes are differentially expressed during brain development

Developmental Neurobiology
2021-04 | Journal article
Contributors: Torben J. Hausrat; Jennifer Radwitz; Franco L. Lombino; Petra Breiden; Matthias Kneussel
Source: check_circle
Crossref

Cover Image

Developmental Neurobiology
2021-04 | Journal article
Contributors: Torben J. Hausrat; Jennifer Radwitz; Franco L. Lombino; Petra Breiden; Matthias Kneussel
Source: check_circle
Crossref

Completion of neuronal remodeling prompts myelination along developing motor axon branches

Journal of Cell Biology
2021-04-05 | Journal article
Contributors: Mengzhe Wang; Tatjana Kleele; Yan Xiao; Gabriela Plucinska; Petros Avramopoulos; Stefan Engelhardt; Markus H. Schwab; Matthias Kneussel; Tim Czopka; Diane L. Sherman et al.
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Crossref

cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space

2020-08-31 | Preprint
Contributors: Paul J. Lamothe-Molina; Andreas Franzelin; Lennart Beck; Dong Li; Lea Auksutat; Tim Fieblinger; Laura Laprell; Joachim Alhbeck; Christine E. Gee; Matthias Kneussel et al.
Source: check_circle
Crossref

Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins

Neuron
2019-02 | Journal article
Part of ISSN: 0896-6273
Source: Self-asserted source
Matthias Kneussel

Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants

Human Mutation
2018-12 | Journal article
Part of ISSN: 1059-7794
Source: Self-asserted source
Matthias Kneussel

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

The EMBO Journal
2018-12-03 | Journal article
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Source: Self-asserted source
Matthias Kneussel

Clinical relevance of cytoskeleton associated proteins for ovarian cancer

Journal of Cancer Research and Clinical Oncology
2018-11 | Journal article
Part of ISSN: 0171-5216
Part of ISSN: 1432-1335
Source: Self-asserted source
Matthias Kneussel

Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

Neuron
2018-09 | Journal article
Part of ISSN: 0896-6273
Source: Self-asserted source
Matthias Kneussel

Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.

Cell reports
2018-05-01 | Journal article
Source: Self-asserted source
Matthias Kneussel

The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing

EMBO reports
2017-11 | Journal article
Part of ISSN: 1469-221X
Part of ISSN: 1469-3178
Part of ISSN: 1469-221X
Part of ISSN: 1469-3178
Source: Self-asserted source
Matthias Kneussel

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

Nature Chemical Biology
2017-02 | Journal article
Part of ISSN: 1552-4450
Part of ISSN: 1552-4469
Source: Self-asserted source
Matthias Kneussel

Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B.

Neuron
2016-11-03 | Journal article
Source: Self-asserted source
Matthias Kneussel

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

Neuron
2016-10 | Journal article
Part of ISSN: 0896-6273
Source: Self-asserted source
Matthias Kneussel

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.

Neuron
2016-10-20 | Journal article
Source: Self-asserted source
Matthias Kneussel

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory.

Cell reports
2016-04-21 | Journal article
Source: Self-asserted source
Matthias Kneussel

Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation

Trends in Neurosciences
2016-03 | Journal article
Part of ISSN: 0166-2236
Source: Self-asserted source
Matthias Kneussel

Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels

The Journal of Cell Biology
2015-11-09 | Journal article
Part of ISSN: 0021-9525
Part of ISSN: 1540-8140
Source: Self-asserted source
Matthias Kneussel

Structure–function–behavior relationship in estrogen-induced synaptic plasticity

Hormones and Behavior
2015-08 | Journal article
Part of ISSN: 0018-506X
Source: Self-asserted source
Matthias Kneussel

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion

Oncotarget
2015-07-30 | Journal article
Part of ISSN: 1949-2553
Source: Self-asserted source
Matthias Kneussel

Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.

Nature communications
2015-04-20 | Journal article
Source: Self-asserted source
Matthias Kneussel

GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites

European Journal of Cell Biology
2015-03 | Journal article
Part of ISSN: 0171-9335
Source: Self-asserted source
Matthias Kneussel
grade
Preferred source (of 3)‎

The LisH Motif of Muskelin Is Crucial for Oligomerization and Governs Intracellular Localization

Structure
2015-02 | Journal article
Part of ISSN: 0969-2126
Source: Self-asserted source
Matthias Kneussel

MmTX1 and MmTX2 from coral snake venom potently modulate GABAAreceptor activity

Proceedings of the National Academy of Sciences
2015-02-24 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Matthias Kneussel

Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7

Journal of Cell Science
2015-01-15 | Journal article
Part of ISSN: 0021-9533
Part of ISSN: 1477-9137
Source: Self-asserted source
Matthias Kneussel

Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin

Nature Communications
2014-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Matthias Kneussel

Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

Angewandte Chemie International Edition
2014-11-20 | Journal article
Part of ISSN: 1433-7851
Source: Self-asserted source
Matthias Kneussel

The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors

European Journal of Cell Biology
2014-08 | Journal article
Part of ISSN: 0171-9335
Source: Self-asserted source
Matthias Kneussel

SnapShot: Receptor Dynamics at Plastic Synapses

Cell
2014-06 | Journal article
Part of ISSN: 0092-8674
Source: Self-asserted source
Matthias Kneussel

Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.

Nature communications
2014-06-04 | Journal article
Source: Self-asserted source
Matthias Kneussel
grade
Preferred source (of 2)‎

GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites.

Proceedings of the National Academy of Sciences of the United States of America
2014-03-17 | Journal article
Source: Self-asserted source
Matthias Kneussel
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