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IntegriCulture Inc.
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Keywords

Cultivated meat, Food Tech, Cellular Agriculture

Countries

Japan

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Employment (1)

IntegriCulture Inc.: Fujisawa, Kanagawa, JP

Director (Production Development)
Employment
Source: Self-asserted source
Kazuhiro Kunimasa

Funding (5)

薬剤感受性及びオミクスデータを用いたミトコンドリア代謝脆弱性因子の同定と治療応用

2022-04-01 to 2025-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.12873576
GRANT_NUMBER: 22K07312
Source: Self-asserted source
Kazuhiro Kunimasa via DimensionsWizard

Molecular basis of oncogenic mutation-associated resistance to endoplasmic reticulum stresses and their applications to cancer chemotherapy

2018-04-01 to 2021-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.7534139
GRANT_NUMBER: 18K07309
Source: Self-asserted source
Kazuhiro Kunimasa via DimensionsWizard

Identification and characterization of mitochondrial regulators modulating the unfolded protein response

2013-04-01 to 2016-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.6117937
GRANT_NUMBER: 25430120
Source: Self-asserted source
Kazuhiro Kunimasa via DimensionsWizard

A comprehensive search for antiangiogenic food factors and molecular biological analysis of their mode of inhibition

2009-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.6014734
GRANT_NUMBER: 21500782
Source: Self-asserted source
Kazuhiro Kunimasa via DimensionsWizard

Cancer Preventive Effects of Resveratrol Oligomer-Rich Food Factors with an Antiangiogenic Activity

2009-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.6022994
GRANT_NUMBER: 21700773
Source: Self-asserted source
Kazuhiro Kunimasa via DimensionsWizard

Works (26)

Environmental Impacts of Producing Culture Medium Consisting of Serum-free, Food and Complex Ingredients for Cultivated Meat

2024-09-10 | Preprint
DOI: 10.1101/2024.09.05.611339
Contributors: Natsufumi Takenaka; Kimiko Hong Mitsui; Kazuhiro Kunimasa; Kotaro Kawajiri; Chihiro Kayo; Naoki Yoshikawa
Source: check_circle
Crossref

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation.

Scientific reports
2022-07-07 | Journal article
DOI: 10.1038/s41598-022-15673-x
PMID: 35798783
PMC: PMC9262966
Contributors: Kunimasa K; Ikeda-Ishikawa C; Tani Y; Tsukahara S; Sakurai J; Okamoto Y; Koido M; Dan S; Akihiro Tomida
Source: Self-asserted source
Kazuhiro Kunimasa

GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.

Molecular pharmacology
2020-10-08 | Journal article
DOI: 10.1124/molpharm.120.000070
PMID: 33033108
Contributors: Kato Y; Kunimasa K; Takahashi M; Harada A; Nagasawa I; Osawa M; Sugimoto Y; Akihiro Tomida
Source: Self-asserted source
Kazuhiro Kunimasa

Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy.

iScience
2020-03-31 | Journal article
DOI: 10.1016/j.isci.2020.101028
PMID: 32283529
PMC: PMC7155235
Contributors: Nagasawa I; Koido M; Tani Y; Tsukahara S; Kunimasa K; Akihiro Tomida
Source: Self-asserted source
Kazuhiro Kunimasa

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.

Biochemical and biophysical research communications
2018-09-11 | Journal article
DOI: 10.1016/j.bbrc.2018.09.032
PMID: 30217442
Contributors: Kato Y; Kunimasa K; Sugimoto Y; Akihiro Tomida
Source: Self-asserted source
Kazuhiro Kunimasa

BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.

Biochemical and biophysical research communications
2016-12-10 | Journal article
DOI: 10.1016/j.bbrc.2016.12.062
PMID: 27965097
Contributors: Nagasawa I; Kunimasa K; Tsukahara S; Akihiro Tomida
Source: Self-asserted source
Kazuhiro Kunimasa

Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo.

Cancer medicine
2015-09-26 | Journal article
DOI: 10.1002/cam4.520
PMID: 26408414
PMC: PMC4674003
Contributors: Narayanan NK; Kunimasa K; Yamori Y; Mori M; Mori H; Nakamura K; Miller G; Manne U; Amit K. Tiwari; Narayanan B
Source: Self-asserted source
Kazuhiro Kunimasa

Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation.

Cancer science
2015-05-25 | Journal article
DOI: 10.1111/cas.12682
PMID: 25911996
PMC: PMC4520644
Contributors: Mashima T; Ushijima M; Matsuura M; Tsukahara S; Kunimasa K; Furuno A; Saito S; Kitamura M; Soma-Nagae T; Hiroyuki Seimiya et al.
Source: Self-asserted source
Kazuhiro Kunimasa

FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway.

Cellular signalling
2013-05-22 | Journal article
DOI: 10.1016/j.cellsig.2013.05.008
PMID: 23707520
Contributors: Ryoji Eguchi; Kubo S; Ohta T; Kunimasa K; Okada M; Tamaki H; Kaji K; Wakabayashi I; Fujimori Y; Ogawa H
Source: Self-asserted source
Kazuhiro Kunimasa

Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals.

Evidence-based complementary and alternative medicine : eCAM
2013-04-24 | Journal article
DOI: 10.1155/2013/826245
PMID: 23710238
PMC: PMC3655572
Contributors: Tsuchiya I; Hosoya T; Ushida M; Kunimasa K; Ohta T; Kumazawa S
Source: Self-asserted source
Kazuhiro Kunimasa

Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis.

Molecular nutrition & food research
2011-09-21 | Journal article
DOI: 10.1002/mnfr.201100098
PMID: 21936049
Contributors: Kunimasa K; Ohta T; Tani H; Kato E; Eguchi R; Kaji K; Ikeda K; Mori H; Mori M; Tatefuji T et al.
Source: Self-asserted source
Kazuhiro Kunimasa

Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model.

International journal of oncology
2010-11-01 | Journal article
DOI: 10.3892/ijo_00000780
PMID: 20878076
Contributors: Ryoji Eguchi; Fujimori Y; Ohta T; Kunimasa K; Nakano T
Source: Self-asserted source
Kazuhiro Kunimasa

High susceptibility of obese hypertensive SHRSP.Z-Lepr(fa) /IzmDmcr rats to lipid deposition in the mesenteric artery.

Clinical and experimental pharmacology & physiology
2010-11-01 | Journal article
DOI: 10.1111/j.1440-1681.2010.05440.x
PMID: 20726991
Contributors: Kunimasa K; Yoshitomi H; Miura C; Mori H; Tsuchikura S; Ikeda K; Gao M; Yamori Y; Mori M
Source: Self-asserted source
Kazuhiro Kunimasa

Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo.

Cancer science
2010-11-01 | Journal article
DOI: 10.1111/j.1349-7006.2010.01668.x
PMID: 20670297
Contributors: Kunimasa K; Ikekita M; Sato M; Ohta T; Yamori Y; Ikeda M; Kuranuki S; Oikawa T
Source: Self-asserted source
Kazuhiro Kunimasa

Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/2.

Evidence-based complementary and alternative medicine : eCAM
2010-10-31 | Journal article
DOI: 10.1093/ecam/nep024
PMID: 19351710
PMC: PMC3137750
Contributors: Kunimasa K; Ahn MR; Kobayashi T; Eguchi R; Kumazawa S; Fujimori Y; Nakano T; Nakayama T; Kaji K; Ohta T
Source: Self-asserted source
Kazuhiro Kunimasa

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies.

Journal of biomedical science
2010-08-24 | Journal article
DOI: 10.1186/1423-0127-17-s1-s6
PMID: 20804626
PMC: PMC2994368
Contributors: Yamori Y; Taguchi T; Hamada A; Kunimasa K; Mori H; Mori M
Source: Self-asserted source
Kazuhiro Kunimasa

Taurine's health influence on Japanese high school girls.

Journal of biomedical science
2010-08-24 | Journal article
DOI: 10.1186/1423-0127-17-s1-s47
PMID: 20804624
PMC: PMC2994398
Contributors: Ishikawa M; Arai S; Takano M; Hamada A; Kunimasa K; Mori M
Source: Self-asserted source
Kazuhiro Kunimasa

Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC.

The Journal of nutrition
2009-11-04 | Journal article
DOI: 10.3945/jn.109.112359
PMID: 19889811
Contributors: Kunimasa K; Kobayashi T; Kaji K; Ohta T
Source: Self-asserted source
Kazuhiro Kunimasa

Correlation between antiangiogenic activity and antioxidant activity of various components from propolis.

Molecular nutrition & food research
2009-05-01 | Journal article
DOI: 10.1002/mnfr.200800021
PMID: 19065585
Contributors: Ahn MR; Kunimasa K; Kumazawa S; Nakayama T; Kaji K; Uto Y; Hori H; Nagasawa H; Ohta T
Source: Self-asserted source
Kazuhiro Kunimasa

Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.

Phytotherapy research : PTR
2009-03-01 | Journal article
DOI: 10.1002/ptr.2658
PMID: 19003952
Contributors: Messerli SM; Ahn MR; Kunimasa K; Yanagihara M; Tatefuji T; Hashimoto K; Mautner V; Uto Y; Hori H; Kumazawa S et al.
Source: Self-asserted source
Kazuhiro Kunimasa

Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion.

Bioorganic & medicinal chemistry letters
2009-02-07 | Journal article
DOI: 10.1016/j.bmcl.2009.02.002
PMID: 19268587
Contributors: Kunimasa K; Kuranuki S; Matsuura N; Iwasaki N; Ikeda M; Ito A; Sashida Y; Mimaki Y; Yano M; Sato M et al.
Source: Self-asserted source
Kazuhiro Kunimasa

Propolis suppresses tumor angiogenesis by inducing apoptosis in tube-forming endothelial cells.

Bioscience, biotechnology, and biochemistry
2008-09-07 | Journal article
DOI: 10.1271/bbb.80169
PMID: 18776674
Contributors: Ohta T; Kunimasa K; Kobayashi T; Sakamoto M; Kaji K
Source: Self-asserted source
Kazuhiro Kunimasa

Indole-3-carbinol suppresses tumor-induced angiogenesis by inhibiting tube formation and inducing apoptosis.

Bioscience, biotechnology, and biochemistry
2008-08-07 | Journal article
DOI: 10.1271/bbb.80292
PMID: 18685185
Contributors: Kunimasa K; Kobayashi T; Sugiyama S; Kaji K; Ohta T
Source: Self-asserted source
Kazuhiro Kunimasa
grade
Preferred source (of 2)‎

Proteomic analysis of hypoxia-induced tube breakdown of an in vitro capillary model composed of HUVECs: potential role of p38-regulated reduction of HSP27.

Proteomics
2008-07-01 | Journal article
DOI: 10.1002/pmic.200800055
PMID: 18655027
Contributors: Ryoji Eguchi; Naitou H; Kunimasa K; Ayuzawa R; Fujimori Y; Ohashi N; Kaji K; Ohta T
Source: Self-asserted source
Kazuhiro Kunimasa

Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation.

Cancer letters
2007-03-06 | Journal article
DOI: 10.1016/j.canlet.2006.12.039
PMID: 17343983
Contributors: Ahn MR; Kunimasa K; Ohta T; Kumazawa S; Kamihira M; Kaji K; Uto Y; Hori H; Nagasawa H; Nakayama T
Source: Self-asserted source
Kazuhiro Kunimasa

Inhibition of in vivo angiogenesis by N-beta-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine.

European journal of pharmacology
2006-04-20 | Journal article
DOI: 10.1016/j.ejphar.2006.03.084
PMID: 16725138
Contributors: Nishikawa T; Akiyama N; Kunimasa K; Oikawa T; Ishizuka M; Tsujimoto M; Natori S
Source: Self-asserted source
Kazuhiro Kunimasa
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