Personal information

Medicinal Chemistry, Drug Design, Molecular modeling, Computer-aided drug design, Green Chemistry, Neurodegeneration, Cancer, Anti-microbials, Hit-to-Lead Optimization, Organic Chemistry, New method development
India

Biography

Amit Sharma did his Ph.D. in Medicinal Chemistry from Birla Institute of Technology and Sciences, Pilani (BITS Pilani), Pilani campus, Rajasthan, India in 2024. He completed his B. Pharmacy in 2017, from Dr. A.P.J Abdul Kalam Technical University, Lucknow. He completed his M.Pharm. in Pharmaceutical Chemistry from Birla Institute of Technology, Mesra (BIT Mesra), Mesra campus, Jharkhand, India, 2019. In Masters, he worked in the field of antimicrobial drug design and development under the supervision of Prof. Swastika Ganguly, Professor, Ex. Head, Department of Pharmaceutical Sciences, BIT, Mesra, Ranchi, India. He joined Ph.D. programme at BITS Pilani, Pilani Campus, under the supervision of Prof. Hemant R. Jadhav, Professor, Department of Pharmacy, BITS Pilani, Pilani Campus in the year 2019. His research interest includes the use of molecular modeling tools in the design of analogs, and synthetic medicinal chemistry for the treatment of neurodegeneration. He has published articles in peer-reviewed journals.

My expertise in medicinal chemistry science and technology empowers me to create new paradigms in pursuit of breakthrough treatments to enhance the lives of those affected by debilitating conditions.

Research Areas-

-Neurodegenerative disease (Exploration on BACE-1 and AChE)
- Antimicrobial drug discovery emphasis on AMR
-Drug design & discovery
- Synthetic medicinal chemistry (targeted small molecule synthesis using organic/green chemistry approach)
- Hit-to-Lead Optimization, Structure-activity relationship (SAR)
- New method development, Process Optimization
-Computer-aided drug design
-Expertise in molecular modeling: Molecular Docking (Glide) and Molecular Dynamics Simulation via Schrödinger (Desmond), Pharmacophore modeling/mapping, Homology Modeling, QSAR, SBDD/LBDD/Denovo, High throughput Virtual Screening, Site Map Analysis (binding site prediction), MMGBSA/MMPBSA Calculations, Molegro Virtual Docker (MVD), Pyrex, SeeSAR, Qik Prop, Swiss ADME, Protox, DruLiTo, OSIRIS Data Warrior, UCSF Chimera 1.10.2, Discovery Studio Visualizer, VMD 1.9.2, PyMOL 3.0, Autodock, and Autodock Vina MGL tools
- In-vitro studies: In-vitro culture of primary and secondary human and mouse cell lines and biological evaluation of various cells using techniques such as cytotoxicity, apoptosis, cellular uptake assay using multicolor flow cytometry, confocal, and fluorescence microscopy, and In-vitro enzyme inhibition assays.
- Track record of high-impact peer-reviewed scientific publications, awards, and fellowships.

Activities

Employment (1)

Birla Institute of Technology and Science, Pilani: Pilāni, IN

2019-07 to 2024-07 | Doctoral Research Scholar (Department of Pharmacy)
Employment
Source: Self-asserted source
Amit Sharma

Works (8)

Recent advancements in the therapeutic approaches for Alzheimer's disease treatment: current and future perspective

RSC Medicinal Chemistry
2025 | Journal article
Contributors: Amit Sharma; Santosh Rudrawar; Sandip B. Bharate; Hemant R. Jadhav
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Crossref
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Preferred source (of 2)‎

Unfolding the Potential of Pyrrole- and Indole-Based Allylidene Hydrazine Carboximidamides as Antimicrobial Agents

ACS Infectious Diseases
2025-01-13 | Journal article
Contributors: Amit Sharma; Sonali J. Jain; Prabhat Nath Jha; Santosh Rudrawar; Sandip B. Bharate; Hemant R. Jadhav
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Crossref

Design, synthesis, in silico, and in vitro evaluation of pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors

RSC Advances
2024 | Journal article
Contributors: Amit Sharma; Santosh Rudrawar; Ankita Sharma; Sandip B. Bharate; Hemant R. Jadhav
Source: check_circle
Crossref

Unveiling the potential of novel indol-3-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors: a combined in silico, synthesis and in vitro study

RSC Advances
2024 | Journal article
Contributors: Amit Sharma; Santosh Rudrawar; Ankita Sharma; Sandip B. Bharate; Hemant R. Jadhav
Source: check_circle
Crossref

A Comprehensive Review of Systemic Targeted Therapies in Cancer Treatment

Current Cancer Therapy Reviews
2024-09 | Journal article
Part of ISSN: 1573-3947
Contributors: Amit Sharma; Hemant R. Jadhav; Anubhav Rai; Naga Rajiv Lakkaniga; Harish C. Chandramoorthy; Hossam Mohammed Kamli; Mohammad Y. Alshahrani; Prasanna Rajagopalan
Source: Self-asserted source
Amit Sharma

Butadiene Sulfone-catalyzed Monobromination of Arenes with NBS as the Bromination Source: A Simple, Mild, Efficient, and Chemoselective Protocol

Letters in Organic Chemistry
2024-02 | Journal article
Part of ISSN: 1570-1786
Contributors: Amit Sharma; Santosh Rudrawar; 0000-0001-8719-5258
Source: Self-asserted source
Amit Sharma

Network pharmacology and molecular modelling study of <i>Enhydra fluctuans</i> for the prediction of the molecular mechanisms involved in the amelioration of nephrolithiasis

Journal of Biomolecular Structure and Dynamics
2023-12-29 | Journal article
Part of ISSN: 0739-1102
Part of ISSN: 1538-0254
Contributors: Bornika Chattaraj; Pukar Khanal; Arijit Nandi; Anwesha Das; Amit Sharma; Soumya Mitra; Yadu Nandan Dey
Source: Self-asserted source
Amit Sharma

Inhibitory activity of Enhydra fluctuans Lour. on calcium oxalate crystallisation through in silico and in vitro studies

Frontiers in Pharmacology
2023-01-20 | Journal article
Part of ISSN: 1663-9812
Contributors: Bornika Chattaraj; Arijit Nandi; Anwesha Das; Amit Sharma; Yadu Nandan Dey; Dharmendra Kumar; Mogana R
Source: Self-asserted source
Amit Sharma