Personal information
Biography
Amit Sharma did his Ph.D. in Medicinal Chemistry from Birla Institute of Technology and Sciences, Pilani (BITS Pilani), Pilani campus, Rajasthan, India in 2024. He completed his B. Pharmacy in 2017, from Dr. A.P.J Abdul Kalam Technical University, Lucknow. He completed his M.Pharm. in Pharmaceutical Chemistry from Birla Institute of Technology, Mesra (BIT Mesra), Mesra campus, Jharkhand, India, 2019. In Masters, he worked in the field of antimicrobial drug design and development under the supervision of Prof. Swastika Ganguly, Professor, Ex. Head, Department of Pharmaceutical Sciences, BIT, Mesra, Ranchi, India. He joined Ph.D. programme at BITS Pilani, Pilani Campus, under the supervision of Prof. Hemant R. Jadhav, Professor, Department of Pharmacy, BITS Pilani, Pilani Campus in the year 2019. His research interest includes the use of molecular modeling tools in the design of analogs, and synthetic medicinal chemistry for the treatment of neurodegeneration. He has published articles in peer-reviewed journals.
My expertise in medicinal chemistry science and technology empowers me to create new paradigms in pursuit of breakthrough treatments to enhance the lives of those affected by debilitating conditions.
Research Areas-
-Neurodegenerative disease (Exploration on BACE-1 and AChE)
- Antimicrobial drug discovery emphasis on AMR
-Drug design & discovery
- Synthetic medicinal chemistry (targeted small molecule synthesis using organic/green chemistry approach)
- Hit-to-Lead Optimization, Structure-activity relationship (SAR)
- New method development, Process Optimization
-Computer-aided drug design
-Expertise in molecular modeling: Molecular Docking (Glide) and Molecular Dynamics Simulation via Schrödinger (Desmond), Pharmacophore modeling/mapping, Homology Modeling, QSAR, SBDD/LBDD/Denovo, High throughput Virtual Screening, Site Map Analysis (binding site prediction), MMGBSA/MMPBSA Calculations, Molegro Virtual Docker (MVD), Pyrex, SeeSAR, Qik Prop, Swiss ADME, Protox, DruLiTo, OSIRIS Data Warrior, UCSF Chimera 1.10.2, Discovery Studio Visualizer, VMD 1.9.2, PyMOL 3.0, Autodock, and Autodock Vina MGL tools
- In-vitro studies: In-vitro culture of primary and secondary human and mouse cell lines and biological evaluation of various cells using techniques such as cytotoxicity, apoptosis, cellular uptake assay using multicolor flow cytometry, confocal, and fluorescence microscopy, and In-vitro enzyme inhibition assays.
- Track record of high-impact peer-reviewed scientific publications, awards, and fellowships.