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Employment (6)

NMD Pharma: Aarhus, Denmark, DK

2019-04-01 to 2023 | CDO & Head NonClinical Safety (Drug Development)
Employment
Source: Self-asserted source
Eva Chin

Cytokinetics (United States): South San Francisco, CA, US

2016-01-25 to 2019-03-31 | Senior Director (Pharmacology & NonClinical Safety)
Employment
Source: Self-asserted source
Eva Chin

University of Maryland, College Park: College Park, US

2008-08-25 to 2016-06-30 | Assistant Professor (Kinesiology)
Employment
Source: Self-asserted source
Eva Chin

Pfizer: Groton, CT, US

2006-04-01 to 2008-08-22 | Associate Director (Project Management - Drug Development)
Employment
Source: Self-asserted source
Eva Chin

Pfizer: La Jolla Research Labs, CA, US

2004-01-24 to 2006-03-31 | Principal Scientist (Research Pharmacology)
Employment
Source: Self-asserted source
Eva Chin

Pfizer: Groton, CT, US

1999-12-15 to 2004-01-21 | Senior Research Scientist (Drug Discovery (CVMD))
Employment
Source: Self-asserted source
Eva Chin

Works (49)

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

Journal of medicinal chemistry
2021 | Journal article
DOI: 10.1021/acs.jmedchem.1c01290
Part of ISSN: 0022-2623
Contributors: Chuang, Chihyuan; Collibee, Scott; Ashcraft, Luke; Wang, Wenyue; Vander Wal, Mark; Wang, Xiaolin; Hwee, Darren T; Wu, Yangsong; Wang, Jingying; Chin, Eva R et al.
Source: Self-asserted source
Eva Chin

Defects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease

Skeletal muscle
2019 | Journal article
DOI: 10.1186/s13395-018-0187-5
Part of ISSN: 2044-5040
Contributors: Michailowsky, V; Li, H; Mittra, B; Iyer, SR; Mazála, DAG; Corrotte, M; Wang, Y; Chin, ER; Lovering, RM; Andrews, NW
Source: Self-asserted source
Eva Chin

Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis

Acta neuropathologica communications
2017 | Journal article
DOI: 10.1186/s40478-017-0427-7
Part of ISSN: 2051-5960
Contributors: Amici, David R; Pinal-Fernandez, Iago; Mázala, Davi A G; Lloyd, Thomas E; Corse, Andrea M; Christopher-Stine, Lisa; Mammen, Andrew L; Chin, Eva R
Source: Self-asserted source
Eva Chin

Investigating the extremes of the continuum of paracrine functions in CD34-/CD31+ CACs across diverse populations

American journal of physiology. Heart and circulatory physiology
2017 | Journal article
DOI: 10.1152/ajpheart.00342.2016
Part of ISSN: 0363-6135
Contributors: Landers-Ramos, Rian Q; Sapp, Ryan M; VandeWater, Emily; Macko, Jennifer; Robinson, Shawn; Wang, Yan; Chin, Eva R; Spangenburg, Espen E; Prior, Steven J; Hagberg, James M
Source: Self-asserted source
Eva Chin

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

Science translational medicine
2016 | Journal article
DOI: 10.1126/scitranslmed.aaf5504
Part of ISSN: 1946-6234
Contributors: Ryu, Dongryeol; Zhang, Hongbo; Ropelle, Eduardo R; Sorrentino, Vincenzo; Mázala, Davi A G; Mouchiroud, Laurent; Marshall, Philip L; Campbell, Matthew D; Ali, Amir Safi; Knowels, Gary M et al.
Source: Self-asserted source
Eva Chin

Response to Comment on Prior et al. Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining. Diabetes 2015;64:3386-3395

Diabetes
2016 | Journal article
DOI: 10.2337/dbi15-0038
Part of ISSN: 0012-1797
Contributors: Prior, Steven J; Goldberg, Andrew P; Ortmeyer, Heidi K; Chin, Eva R; Chen, Dapeng; Blumenthal, Jacob B; Ryan, Alice S
Source: Self-asserted source
Eva Chin

The SH3 and cysteine-rich domain 3 (Stac3) gene is important to growth, fiber composition, and calcium release from the sarcoplasmic reticulum in postnatal skeletal muscle

Skeletal muscle
2016 | Journal article
DOI: 10.1186/s13395-016-0088-4
Part of ISSN: 2044-5040
Contributors: Cong, Xiaofei; Doering, Jonathan; Mazala, Davi A G; Chin, Eva R; Grange, Robert W; Jiang, Honglin
Source: Self-asserted source
Eva Chin

Activation of the endoplasmic reticulum stress response in skeletal muscle of G93A*SOD1 amyotrophic lateral sclerosis mice

Frontiers in cellular neuroscience
2015 | Journal article
DOI: 10.3389/fncel.2015.00170
Part of ISSN: 1662-5102
Contributors: Chen, Dapeng; Wang, Yan; Chin, Eva R
Source: Self-asserted source
Eva Chin

Chronic endurance exercise affects paracrine action of CD31+ and CD34+ cells on endothelial tube formation

American journal of physiology. Heart and circulatory physiology
2015 | Journal article
DOI: 10.1152/ajpheart.00123.2015
Part of ISSN: 0363-6135
Contributors: Landers-Ramos, Rian Q; Sapp, Ryan M; Jenkins, Nathan T; Murphy, Anna E; Cancre, Lucile; Chin, Eva R; Spangenburg, Espen E; Hagberg, James M
Source: Self-asserted source
Eva Chin

Direct growth inhibition assay of total airborne fungi with application of biocide-treated malt extract agar

MethodsX
2015 | Journal article
DOI: 10.1016/j.mex.2015.07.002
Part of ISSN: 2215-0161
Contributors: Er, Chin Ming; Sunar, NM; Leman, AM; Othman, N
Source: Self-asserted source
Eva Chin

Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining

Diabetes
2015 | Journal article
DOI: 10.2337/db14-1771
Part of ISSN: 0012-1797
Contributors: Prior, Steven J; Goldberg, Andrew P; Ortmeyer, Heidi K; Chin, Eva R; Chen, Dapeng; Blumenthal, Jacob B; Ryan, Alice S
Source: Self-asserted source
Eva Chin

SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models

American journal of physiology. Cell physiology
2015 | Journal article
DOI: 10.1152/ajpcell.00341.2014
Part of ISSN: 0363-6143
Contributors: Mázala, Davi A G; Pratt, Stephen J P; Chen, Dapeng; Molkentin, Jeffery D; Lovering, Richard M; Chin, Eva R
Source: Self-asserted source
Eva Chin

The role of proteases in excitation-contraction coupling failure in muscular dystrophy

American journal of physiology. Cell physiology
2015 | Journal article
DOI: 10.1152/ajpcell.00267.2013
Part of ISSN: 0363-6143
Contributors: Mázala, Davi A G; Grange, Robert W; Chin, Eva R
Source: Self-asserted source
Eva Chin

Exercise biology and medicine: innovative research to improve global health

Mayo Clinic proceedings
2014 | Journal article
DOI: 10.1016/j.mayocp.2013.11.013
Part of ISSN: 0025-6196
Contributors: Bamman, Marcas M; Cooper, Dan M; Booth, Frank W; Chin, Eva R; Neufer, P Darrell; Trappe, Scott; Lightfoot, J Timothy; Kraus, William E; Joyner, Michael J
Source: Self-asserted source
Eva Chin

Perturbations in intracellular Ca2+ handling in skeletal muscle in the G93A*SOD1 mouse model of amyotrophic lateral sclerosis

American journal of physiology. Cell physiology
2014 | Journal article
DOI: 10.1152/ajpcell.00237.2013
Part of ISSN: 0363-6143
Contributors: Chin, Eva R; Chen, Dapeng; Bobyk, Kostyantyn D; Mázala, Davi A G
Source: Self-asserted source
Eva Chin

Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers

The journals of gerontology. Series A, Biological sciences and medical sciences
2014 | Journal article
DOI: 10.1093/gerona/glt211
Part of ISSN: 1079-5006
Contributors: Ludlow, Andrew T; Spangenburg, Espen E; Chin, Eva R; Cheng, Wen-Hsing; Roth, Stephen M
Source: Self-asserted source
Eva Chin

Using a novel coculture model to dissect the role of intramuscular lipid load on skeletal muscle insulin responsiveness under reduced estrogen conditions

American journal of physiology. Endocrinology and metabolism
2013 | Journal article
DOI: 10.1152/ajpendo.00617.2012
Part of ISSN: 0193-1849
Contributors: Wohlers, Lindsay M; Powers, Brittany L; Chin, Eva R; Spangenburg, Espen E
Source: Self-asserted source
Eva Chin

Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development

Physiological genomics
2011 | Journal article
DOI: 10.1152/physiolgenomics.00049.2011
Part of ISSN: 1094-8341
Contributors: Sheppard, Ryan L; Spangenburg, Espen E; Chin, Eva R; Roth, Stephen M
Source: Self-asserted source
Eva Chin

Intracellular Ca2+ signaling in skeletal muscle: decoding a complex message

Exercise and sport sciences reviews
2010 | Journal article
DOI: 10.1097/jes.0b013e3181d495d2
Part of ISSN: 0091-6331
Contributors: Chin, Eva R
Source: Self-asserted source
Eva Chin

Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
2007 | Journal article
DOI: 10.1139/h07-093
Part of ISSN: 1715-5312
Contributors: Michel, Robin N; Chin, Eva R; Chakkalakal, Joe V; Eibl, Joe K; Jasmin, Bernard J
Source: Self-asserted source
Eva Chin

Stimulation pulse characteristics and electrode configuration determine site of excitation in isolated mammalian skeletal muscle: implications for fatigue

Journal of applied physiology (Bethesda, Md. : 1985)
2007 | Journal article
DOI: 10.1152/japplphysiol.01267.2006
Part of ISSN: 8750-7587
Contributors: Cairns, Simeon P; Chin, Eva R; Renaud, Jean-Marc
Source: Self-asserted source
Eva Chin

Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle

Human molecular genetics
2006 | Journal article
DOI: 10.1093/hmg/ddl065
Part of ISSN: 0964-6906
Contributors: Chakkalakal, Joe V; Michel, Stephanie A; Chin, Eva R; Michel, Robin N; Jasmin, Bernard J
Source: Self-asserted source
Eva Chin

Aging does not alter the mechanosensitivity of the p38, p70S6k, and JNK2 signaling pathways in skeletal muscle

Journal of applied physiology (Bethesda, Md. : 1985)
2005 | Journal article
DOI: 10.1152/japplphysiol.00870.2004
Part of ISSN: 8750-7587
Contributors: Hornberger, Troy A; Mateja, RD; Chin, ER; Andrews, JL; Esser, KA
Source: Self-asserted source
Eva Chin

Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction.

American journal of physiology. Cell physiology
2005 | Journal article
DOI: 10.1152/ajpcell.00196.2005
Part of ISSN: 0363-6143
Contributors: Angus, Lindsay M; Chakkalakal, Joe V; Méjat, Alexandre; Eibl, Joe K; Bélanger, Guy; Megeney, Lynn A; Chin, Eva R; Schaeffer, Laurent; Michel, Robin N; Jasmin, Bernard J
Source: Self-asserted source
Eva Chin

Comparison of the re-usable LMA Classic and two single-use laryngeal masks (LMA Unique and SoftSeal) in airway management by novice personnel

Anaesthesia and intensive care
2005 | Journal article
DOI: 10.1177/0310057x0503300606
Part of ISSN: 0310-057X
Contributors: Tan, M G E; Chin, E R C; Kong, CS; Chan, YH; Ip-Yam, PC
Source: Self-asserted source
Eva Chin

Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity

Journal of applied physiology (Bethesda, Md. : 1985)
2005 | Journal article
DOI: 10.1152/japplphysiol.00015.2005
Part of ISSN: 8750-7587
Contributors: Chin, Eva R
Source: Self-asserted source
Eva Chin

Calcineurin and skeletal muscle growth

The Proceedings of the Nutrition Society
2004 | Journal article
DOI: 10.1079/pns2004362
Part of ISSN: 0029-6651
Contributors: Michel, Robin N; Dunn, Shannon E; Chin, Eva R
Source: Self-asserted source
Eva Chin

Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism

The Biochemical journal
2004 | Journal article
DOI: 10.1042/bj20040274
Part of ISSN: 0264-6021
Contributors: Hornberger, Troy A; Stuppard, Rudy; Conley, Kevin E; Fedele, Mark J; Fiorotto, Marta L; Chin, Eva R; Esser, Karyn A
Source: Self-asserted source
Eva Chin

The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis

The Proceedings of the Nutrition Society
2004 | Journal article
DOI: 10.1079/pns2004335
Part of ISSN: 0029-6651
Contributors: Chin, Eva R
Source: Self-asserted source
Eva Chin

Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin

The Journal of physiology
2003 | Journal article
DOI: 10.1113/jphysiol.2002.024760
Part of ISSN: 0022-3751
Contributors: Chin, Eva R; Grange, Robert W; Viau, Francois; Simard, Alain R; Humphries, Caroline; Shelton, John; Bassel-Duby, Rhonda; Williams, R Sanders; Michel, Robin N
Source: Self-asserted source
Eva Chin

Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling

Proceedings of the National Academy of Sciences of the United States of America
2003 | Journal article
DOI: 10.1073/pnas.0932671100
Part of ISSN: 0027-8424
Contributors: Chakkalakal, Joe V; Stocksley, Mark A; Harrison, Mary-Ann; Angus, Lindsay M; Deschenes-Furry, Julie; St-Pierre, Simon; Megeney, Lynn A; Chin, Eva R; Michel, Robin N; Jasmin, Bernard J
Source: Self-asserted source
Eva Chin

Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle

Journal of applied physiology (Bethesda, Md. : 1985)
2000 | Journal article
DOI: 10.1152/jappl.2000.88.3.1134
Part of ISSN: 8750-7587
Contributors: Ordway, GA; Neufer, PD; Chin, ER; DeMartino, GN
Source: Self-asserted source
Eva Chin

Matching of calcineurin activity to upstream effectors is critical for skeletal muscle fiber growth

The Journal of cell biology
2000 | Journal article
DOI: 10.1083/jcb.151.3.663
Part of ISSN: 0021-9525
Contributors: Dunn, SE; Chin, ER; Michel, RN
Source: Self-asserted source
Eva Chin

MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type

The EMBO journal
2000 | Journal article
DOI: 10.1093/emboj/19.9.1963
Part of ISSN: 0261-4189
Contributors: Wu, H; Naya, FJ; McKinsey, TA; Mercer, B; Shelton, JM; Chin, ER; Simard, AR; Michel, RN; Bassel-Duby, R; Olson, EN et al.
Source: Self-asserted source
Eva Chin

A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type

Genes & development
1998 | Journal article
DOI: 10.1101/gad.12.16.2499
Part of ISSN: 0890-9369
Contributors: Chin, ER; Olson, EN; Richardson, JA; Yang, Q; Humphries, C; Shelton, JM; Wu, H; Zhu, W; Bassel-Duby, R; Williams, RS
Source: Self-asserted source
Eva Chin

Mice without myoglobin

Nature
1998 | Journal article
DOI: 10.1038/27681
Part of ISSN: 0028-0836
Contributors: Garry, DJ; Ordway, GA; Lorenz, JN; Radford, NB; Chin, ER; Grange, RW; Bassel-Duby, R; Williams, RS
Source: Self-asserted source
Eva Chin

The contribution of pH-dependent mechanisms to fatigue at different intensities in mammalian single muscle fibres

The Journal of physiology
1998 | Journal article
DOI: 10.1111/j.1469-7793.1998.831bd.x
Part of ISSN: 0022-3751
Contributors: Chin, ER; Allen, DG
Source: Self-asserted source
Eva Chin

Distribution of lactate and other ions in inactive skeletal muscle: influence of hyperkalemic lactacidosis

Canadian journal of physiology and pharmacology
1997 | Journal article
DOI: 10.1139/cjpp-75-12-1375
Part of ISSN: 0008-4212
Contributors: Chin, ER; Lindinger, MI; Heigenhauser, GJ
Source: Self-asserted source
Eva Chin

Effects of reduced muscle glycogen concentration on force, Ca2+ release and contractile protein function in intact mouse skeletal muscle

The Journal of physiology
1997 | Journal article
DOI: 10.1113/jphysiol.1997.sp021838
Part of ISSN: 0022-3751
Contributors: Chin, ER; Allen, DG
Source: Self-asserted source
Eva Chin

Role of intracellular calcium and metabolites in low-frequency fatigue of mouse skeletal muscle

The American journal of physiology
1997 | Journal article
DOI: 10.1152/ajpcell.1997.272.2.c550
Part of ISSN: 0002-9513
Contributors: Chin, ER; Balnave, CD; Allen, DG
Source: Self-asserted source
Eva Chin

Effects of tissue fractionation on exercise-induced alterations in SR function in rat gastrocnemius muscle

Journal of applied physiology (Bethesda, Md. : 1985)
1996 | Journal article
DOI: 10.1152/jappl.1996.80.3.940
Part of ISSN: 8750-7587
Contributors: Chin, ER; Green, HJ
Source: Self-asserted source
Eva Chin

The role of elevations in intracellular [Ca2+] in the development of low frequency fatigue in mouse single muscle fibres

The Journal of physiology
1996 | Journal article
DOI: 10.1113/jphysiol.1996.sp021259
Part of ISSN: 0022-3751
Contributors: Chin, ER; Allen, DG
Source: Self-asserted source
Eva Chin

Effects of prolonged low frequency stimulation on skeletal muscle sarcoplasmic reticulum

Canadian journal of physiology and pharmacology
1995 | Journal article
DOI: 10.1139/y95-165
Part of ISSN: 0008-4212
Contributors: Chin, ER; Green, HJ; Grange, F; Dossett-Mercer, J; O'Brien, PJ
Source: Self-asserted source
Eva Chin

Failure of short term stimulation to reduce sarcoplasmic reticulum Ca(2+)-ATPase function in homogenates of rat gastrocnemius

Molecular and cellular biochemistry
1995 | Journal article
DOI: 10.1007/bf00926877
Part of ISSN: 0300-8177
Contributors: Dossett-Mercer, J; Green, H; Chin, ER; Grange, F
Source: Self-asserted source
Eva Chin

Technical considerations for assessing alterations in skeletal muscle sarcoplasmic reticulum Ca(++)-sequestration function in vitro

Molecular and cellular biochemistry
1994 | Journal article
DOI: 10.1007/bf00944202
Part of ISSN: 0300-8177
Contributors: Chin, ER; Green, HJ; Grange, F; Mercer, JD; O'Brien, PJ
Source: Self-asserted source
Eva Chin

Increases in human skeletal muscle Na(+)-K(+)-ATPase concentration with short-term training

The American journal of physiology
1993 | Journal article
DOI: 10.1152/ajpcell.1993.264.6.c1538
Part of ISSN: 0002-9513
Contributors: Green, HJ; Chin, ER; Ball-Burnett, M; Ranney, D
Source: Self-asserted source
Eva Chin

Na(+)-K+ ATPase concentration in different adult rat skeletal muscles is related to oxidative potential

Canadian journal of physiology and pharmacology
1993 | Journal article
DOI: 10.1139/y93-087
Part of ISSN: 0008-4212
Contributors: Chin, ER; Green, HJ
Source: Self-asserted source
Eva Chin

Time-dependent increases in Na+,K(+)-ATPase content of low-frequency-stimulated rabbit muscle

FEBS letters
1992 | Journal article
DOI: 10.1016/0014-5793(92)81312-a
Part of ISSN: 0014-5793
Contributors: Green, HJ; Ball-Burnett, M; Chin, ER; Dux, L; Pette, D
Source: Self-asserted source
Eva Chin

Lactate metabolism in inactive skeletal muscle during lactacidosis

The American journal of physiology
1991 | Journal article
DOI: 10.1152/ajpregu.1991.261.1.r98
Part of ISSN: 0002-9513
Contributors: Chin, ER; Lindinger, MI; Heigenhauser, GJ
Source: Self-asserted source
Eva Chin
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