Personal information

malaria, genomic epidemiology, genomics, antimicrobial resistance
United Kingdom

Biography

I am an academic clinician specialising in infectious diseases and medical microbiology. I am interested in microbial evolutionary genetics, pathogen transmission dynamics, and antimicrobial resistance (AMR). I aim to investigate fundamental processes in microbial genetics alongside translational applications to infectious disease control.

Activities

Employment (5)

University of Cambridge: Cambridge, GB

2022-02-02 to present | Clinical Lecturer in Medical Microbiology (Department of Medicine)
Employment
Source: Self-asserted source
William L. Hamilton

Cambridge University Hospitals NHS Foundation Trust: Cambridge, Cambridgeshire, GB

2020-08 to present | Specialist registrar in infectious diseases and medical microbiology (Infectious diseases and microbiology)
Employment
Source: Self-asserted source
William L. Hamilton

Wellcome Sanger Institute: Cambridge, GB

2021-08 to 2024-10 | Senior Staff Scientist
Employment
Source: Self-asserted source
William L. Hamilton

Cambridge University Hospitals NHS Foundation Trust: Cambridge, Cambridgeshire, GB

2018-08-01 to 2021-07-31 | Academic Clinical Fellow (CMT; Infectious Diseases and Microbiology)
Employment
Source: Self-asserted source
William L. Hamilton

Brighton and Sussex University Hospitals NHS Trust: Brighton, GB

2016-08-01 to 2018-07-31 | Academic Foundation Programme
Employment
Source: Self-asserted source
William L. Hamilton

Education and qualifications (5)

University of Glasgow: Glasgow, GB

2022-09-01 to 2023-06-15 | Diploma in Tropical Medicine and Hygiene (DTM&H)
Education
Source: Self-asserted source
William L. Hamilton

Royal College of Physicians: London, London, GB

2017-06-01 to 2019-03-28 | Member of the Royal College of Physicians (MRCP)
Qualification
Source: Self-asserted source
William L. Hamilton

University of Cambridge School of Clinical Medicine: Cambridge, Cambridgeshire, GB

2010-09 to 2016-07 | Medicine
Education
Source: Self-asserted source
William L. Hamilton

Wellcome Trust Sanger Institute: Cambridge, Cambridgeshire, GB

2011-08 to 2015-10 | PhD (Malaria Programme)
Education
Source: Self-asserted source
William L. Hamilton

University of Cambridge: Cambridge, Cambridgeshire, GB

2007-10 to 2010-06 | Biological and Biomedical Science
Education
Source: Self-asserted source
William L. Hamilton

Professional activities (2)

Fellow of the Royal College of Pathologists (FRCPath): London, GB

2024-06 to present
Membership
Source: Self-asserted source
William L. Hamilton

Royal College of Physicians: London, London, GB

2019-03-28 to present
Membership
Source: Self-asserted source
William L. Hamilton

Works (29)

Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis

The Lancet Microbe
2024-11 | Journal article
Part of ISSN: 2666-5247
Contributors: Olivo Miotto; Alfred Amambua-Ngwa; Lucas N Amenga-Etego; Muzamil M Abdel Hamid; Ishag Adam; Enoch Aninagyei; Tobias Apinjoh; Gordon A Awandare; Philip Bejon; Gwladys I Bertin et al.
Source: Self-asserted source
William L. Hamilton

Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana

Nature Microbiology
2023-11-23 | Journal article | Author
Part of ISSN: 2058-5276
Contributors: Sophia T. Girgis; Edem Adika; Felix E. Nenyewodey; Dodzi K. Senoo Jnr; Joyce Ngoi; Kukua Bandoh; Oliver Lorenz; Guus van de Steeg; Alexandria Harrott; Sebastian Nsoh et al.
Source: Self-asserted source
William L. Hamilton

Nanopore sequencing for malaria molecular surveillance: opportunities and challenges

Trends in Parasitology
2023-11-08 | Journal article | Author
Part of ISSN: 1471-4922
Contributors: William L. Hamilton; Deus Ishengoma; Jonathan B. Parr; Daniel Bridges; Alyssa Barry
Source: Self-asserted source
William L. Hamilton

The clinical, genomic, and microbiological profile of invasive multi-drug resistant Escherichia coli in a major teaching hospital in the United Kingdom

Microbial Genomics
2023-10-30 | Journal article | Author
Part of ISSN: 2057-5858
Contributors: William L. Hamilton; Suny Coscione; Mailis Maes; Ben Warne; Lindsay J. Pike; Fahad A. Khokhar; Beth Blane; Nicholas M. Brown; Theodore Gouliouris; Gordon Dougan et al.
Source: Self-asserted source
William L. Hamilton

Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers

Scientific Reports
2022-07 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
William L. Hamilton

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Nature Communications
2022-02 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
William L. Hamilton

A2B-COVID: A tool for rapidly evaluating potential SARS-CoV-2 transmission events

Molecular Biology and Evolution
2022-02-02 | Journal article
Part of ISSN: 0737-4038
Part of ISSN: 1537-1719
Source: Self-asserted source
William L. Hamilton

The role of viral genomics in understanding COVID-19 outbreaks in long-term care facilities

The Lancet Microbe
2021-09 | Journal article
Part of ISSN: 2666-5247
Source: Self-asserted source
William L. Hamilton

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Nature
2021-09-06 | Journal article
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
William L. Hamilton

Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections

eLife
2021-08-24 | Journal article
Source: Self-asserted source
William L. Hamilton
grade
Preferred source (of 2)‎

Patterns of within-host genetic diversity in SARS-CoV-2

eLife
2021-08-13 | Journal article
Source: Self-asserted source
William L. Hamilton

Applying prospective genomic surveillance to support investigation of hospital-onset COVID-19

The Lancet Infectious Diseases
2021-07 | Journal article
Part of ISSN: 1473-3099
Source: Self-asserted source
William L. Hamilton

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

2021-07-13 | Journal article
Part of ISSN: 2398-502X
Source: Self-asserted source
William L. Hamilton

Genomic epidemiology of COVID-19 in care homes in the East of England.

eLife
2021-03-02 | Journal article
Source: Self-asserted source
William L. Hamilton
grade
Preferred source (of 2)‎

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.

Nature communications
2020-12-14 | Journal article
Source: Self-asserted source
William L. Hamilton

Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study.

The Lancet. Infectious diseases
2020-07-14 | Journal article
Source: Self-asserted source
William L. Hamilton

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.

eLife
2020-05-11 | Journal article
Source: Self-asserted source
William L. Hamilton

The impact of diagnostic microbiology on de-escalation of antimicrobial therapy in hospitalised adults.

BMC infectious diseases
2020-02-03 | Journal article
Source: Self-asserted source
William L. Hamilton

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

The Lancet Infectious Diseases
2019-09 | Journal article
Part of ISSN: 1473-3099
Source: Self-asserted source
William L. Hamilton

Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

The Lancet Infectious Diseases
2019-09 | Journal article
Part of ISSN: 1473-3099
Source: Self-asserted source
William L. Hamilton

Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres

Wellcome Open Research
2018-05-03 | Journal article
Part of ISSN: 2398-502X
Source: Self-asserted source
William L. Hamilton

Imported gnathostomiasis manifesting as cutaneous larva migrans and Löffler’s syndrome

BMJ Case Reports
2018-02-02 | Journal article
Part of ISSN: 1757-790X
Source: Self-asserted source
William L. Hamilton

Public health interventions to protect against falsified medicines: a systematic review of international, national and local policies

Health Policy and Planning
2016-12 | Journal article
Part of ISSN: 0268-1080
Part of ISSN: 1460-2237
Source: Self-asserted source
William L. Hamilton

Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification

Malaria Journal
2016-12 | Journal article
Part of ISSN: 1475-2875
Source: Self-asserted source
William L. Hamilton

Extreme mutation bias and high AT content inPlasmodium falciparum

Nucleic Acids Research
2016-12-19 | Journal article
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
William L. Hamilton

Shiga Toxin–ProducingEscherichia coliInfection, Antibiotics, and Risk of Developing Hemolytic Uremic Syndrome: A Meta-analysis

Clinical Infectious Diseases
2016-05-15 | Journal article
Part of ISSN: 1058-4838
Part of ISSN: 1537-6591
Source: Self-asserted source
William L. Hamilton

Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.

2014-12 | Journal article
Contributors: Claessens A; Hamilton WL; Kekre M; Otto TD; Faizullabhoy A; Rayner JC; Kwiatkowski D
Source: Self-asserted source
William L. Hamilton via Europe PubMed Central

Optimized Whole-Genome Amplification Strategy for Extremely AT-Biased Template

DNA Research
2014-12-01 | Journal article
Part of ISSN: 1340-2838
Part of ISSN: 1756-1663
Source: Self-asserted source
William L. Hamilton
grade
Preferred source (of 2)‎

TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.

2014-09 | Journal article
Contributors: Uchil PD; Pawliczek T; Reynolds TD; Ding S; Hinz A; Munro JB; Huang F; Floyd RW; Yang H; Hamilton WL et al.
Source: Self-asserted source
William L. Hamilton via Europe PubMed Central

Peer review (2 reviews for 1 publication/grant)

Review activity for PLoS neglected tropical diseases (2)