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Loop profile: 1367075
Scopus Author ID: 35072539300

Keywords

Computational Structural Biology, Biophysics, Biochemistry, Biomodeling

Countries

Finland

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Employment (5)

University of Helsinki: Helsinki, FI

2022-01-01 to present | University Researcher (Physics)
Employment
Source: Self-asserted source
Giray Enkavi

University of Helsinki: Helsinki, FI

2017-05-01 to 2021-12-31 | Postdoctoral Researcher (Physics)
Employment
Source: Self-asserted source
Giray Enkavi

Tampere University of Technology: Tampere, FI

2014-08-15 to 2017-04-01 | Postdoctoral Researcher (Physics)
Employment
Source: Self-asserted source
Giray Enkavi

University of Illinois Urbana-Champaign: Urbana, Illinois, US

2014-01-01 to 2014-07-31 | Postdoctoral Researcher (Biohysics and Computational Biology)
Employment
Source: Self-asserted source
Giray Enkavi

University of Illinois Urbana-Champaign: Urbana, Illinois, US

2008-01-01 to 2013-12-31 | Research Asistant (Biohysics and Computational Biology)
Employment
Source: Self-asserted source
Giray Enkavi

Education and qualifications (3)

University of Illinois System: Urbana, IL, US

2007 to 2013 | PhD
Education
Source: Self-asserted source
Giray Enkavi

Boğaziçi Üniversitesi: Istanbul, TR

2003 to 2007 (Physics)
Education
Source: Self-asserted source
Giray Enkavi

Boğaziçi Üniversitesi: Istanbul, TR

2003 to 2007 (Molecular Biology and Genetics)
Education
Source: Self-asserted source
Giray Enkavi

Funding (1)

NPC2-Mediated Cholesterol Trafficking

Grant
Tampere University of Technology (Tampere, FI)
Source: Self-asserted source
Giray Enkavi

Works (37)

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Nature Communications
2023 | Journal article
DOI: 10.1038/s41467-023-36375-6
EID:

2-s2.0-85148358549

Part of ISSN: 20411723
Contributors: Dumesnil, C.; Vanharanta, L.; Prasanna, X.; Omrane, M.; Carpentier, M.; Bhapkar, A.; Enkavi, G.; Salo, V.T.; Vattulainen, I.; Ikonen, E. et al.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Editorial: Biomolecular function and activity modulated by membranes

Frontiers in Molecular Biosciences
2023 | Journal article
DOI: 10.3389/fmolb.2023.1133034
EID:

2-s2.0-85147449503

Part of ISSN: 2296889X
Contributors: Enkavi, G.; Li, J.; Martinez-Seara, H.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)

Cold Spring Harbor Perspectives in Biology
2023 | Journal article
DOI: 10.1101/cshperspect.a041419
EID:

2-s2.0-85173558650

Part of ISSN: 19430264
Contributors: Girych, M.; Kulig, W.; Enkavi, G.; Vattulainen, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Nature Neuroscience
2023 | Journal article
DOI: 10.1038/s41593-023-01316-5
EID:

2-s2.0-85161237972

Part of ISSN: 15461726 10976256
Contributors: Moliner, R.; Girych, M.; Brunello, C.A.; Kovaleva, V.; Biojone, C.; Enkavi, G.; Antenucci, L.; Kot, E.F.; Goncharuk, S.A.; Kaurinkoski, K. et al.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

The GET insertase exhibits conformational plasticity and induces membrane thinning

Nature Communications
2023 | Journal article
DOI: 10.1038/s41467-023-42867-2
EID:

2-s2.0-85176409595

Part of ISSN: 20411723
Contributors: McDowell, M.A.; Heimes, M.; Enkavi, G.; Farkas, Á.; Saar, D.; Wild, K.; Schwappach, B.; Vattulainen, I.; Sinning, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly

Nature Communications
2023 | Journal article
DOI: 10.1038/s41467-023-42985-x
EID:

2-s2.0-85176427483

Part of ISSN: 20411723
Contributors: Goellner, S.; Enkavi, G.; Prasad, V.; Denolly, S.; Eu, S.; Mizzon, G.; Witte, L.; Kulig, W.; Uckeley, Z.M.; Lavacca, T.M. et al.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Dimerization of the pulmonary surfactant protein C in a membrane environment

PLoS ONE
2022 | Journal article
DOI: 10.1371/journal.pone.0267155
EID:

2-s2.0-85128925365

Part of ISSN: 19326203
Contributors: Korolainen, H.; Lolicato, F.; Enkavi, G.; Pérez-Gil, J.; Kulig, W.; Vattulainen, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease

Computational and Structural Biotechnology Journal
2022 | Journal article
DOI: 10.1016/j.csbj.2022.06.023
EID:

2-s2.0-85133239780

Part of ISSN: 20010370
Contributors: Kaptan, S.; Girych, M.; Enkavi, G.; Kulig, W.; Sharma, V.; Vuorio, J.; Rog, T.; Vattulainen, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Cell
2021 | Journal article
DOI: 10.1016/j.cell.2021.01.034
EID:

2-s2.0-85101671832

Part of ISSN: 10974172 00928674
Contributors: Casarotto, P.C.; Girych, M.; Fred, S.M.; Kovaleva, V.; Moliner, R.; Enkavi, G.; Biojone, C.; Cannarozzo, C.; Sahu, M.P.; Kaurinkoski, K. et al.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Can di-4-ANEPPDHQ reveal the structural differences between nanodiscs and liposomes?

Biochimica et Biophysica Acta - Biomembranes
2021 | Journal article
DOI: 10.1016/j.bbamem.2021.183649
EID:

2-s2.0-85105724210

Part of ISSN: 18792642 00052736
Contributors: Chmielińska, A.; Stepien, P.; Bonarek, P.; Girych, M.; Enkavi, G.; Rog, T.; Dziedzicka-Wasylewska, M.; Polit, A.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Cholesterol-recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case of TRKB

European Journal of Neuroscience
2021 | Journal article
DOI: 10.1111/ejn.15218
EID:

2-s2.0-85104548790

Part of ISSN: 14609568 0953816X
Contributors: Cannarozzo, C.; Fred, S.M.; Girych, M.; Biojone, C.; Enkavi, G.; Róg, T.; Vattulainen, I.; Casarotto, P.C.; Castrén, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

High-content imaging and structure-based predictions reveal functional differences between Niemann-Pick C1 variants

Traffic
2020 | Journal article
DOI: 10.1111/tra.12727
EID:

2-s2.0-85083734743

Part of ISSN: 16000854 13989219
Contributors: Vanharanta, L.; Peränen, J.; Pfisterer, S.G.; Enkavi, G.; Vattulainen, I.; Ikonen, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Membrane-Dependent Binding and Entry Mechanism of Dopamine into Its Receptor

ACS Chemical Neuroscience
2020 | Journal article
DOI: 10.1021/acschemneuro.9b00656
EID:

2-s2.0-85087135930

Part of ISSN: 19487193
Contributors: Lolicato, F.; Juhola, H.; Zak, A.; Postila, P.A.; Saukko, A.; Rissanen, S.; Enkavi, G.; Vattulainen, I.; Kepczynski, M.; Róg, T.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Pulmonary Surfactant Lipid Reorganization Induced by the Adsorption of the Oligomeric Surfactant Protein B Complex

Journal of Molecular Biology
2020 | Journal article
DOI: 10.1016/j.jmb.2020.02.028
EID:

2-s2.0-85082856561

Part of ISSN: 10898638 00222836
Contributors: Liekkinen, J.; Enkavi, G.; Javanainen, M.; Olmeda, B.; Pérez-Gil, J.; Vattulainen, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Antidepressants act by binding to the transmembrane domain of trkb receptor

bioRxiv
2019 | Other
DOI: 10.1101/757989
EID:

2-s2.0-85095661702

Part of ISSN: 26928205
Contributors: Casarotto, P.C.; Girych, M.; Fred, S.M.; Moliner, R.; Enkavi, G.; Biojone, C.; Cannarozzo, C.; Brunello, C.A.; Steinzeig, A.; Winkel, F. et al.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Cholesterol recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case for TRKB

bioRxiv
2019 | Other
DOI: 10.1101/734012
EID:

2-s2.0-85103525450

Part of ISSN: 26928205
Contributors: Cannarozzo, C.; Fred, S.M.; Girych, M.; Biojone, C.; Enkavi, G.; Róg, T.; Vattulainen, I.; Casarotto, P.C.; Castrén, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Nature Communications
2019 | Journal article
DOI: 10.1038/s41467-019-13213-2
EID:

2-s2.0-85075506154

Part of ISSN: 20411723
Contributors: Kotila, T.; Wioland, H.; Enkavi, G.; Kogan, K.; Vattulainen, I.; Jégou, A.; Romet-Lemonne, G.; Lappalainen, P.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

Chemical Reviews
2019 | Journal article
DOI: 10.1021/acs.chemrev.8b00538
EID:

2-s2.0-85063142928

Part of ISSN: 15206890 00092665
Contributors: Enkavi, G.; Javanainen, M.; Kulig, W.; Róg, T.; Vattulainen, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions

PLoS Computational Biology
2019 | Journal article
DOI: 10.1371/journal.pcbi.1007033
EID:

2-s2.0-85066964975

Part of ISSN: 15537358 1553734X
Contributors: Javanainen, M.; Enkavi, G.; Guixà-Gonzaléz, R.; Kulig, W.; Martinez-Seara, H.; Levental, I.; Vattulainen, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Molecular mechanism for inhibition of twinfilin by phosphoinositides

Journal of Biological Chemistry
2018 | Journal article
DOI: 10.1074/jbc.RA117.000484
EID:

2-s2.0-85044941007

Part of ISSN: 1083351X 00219258
Contributors: Hakala, M.; Kalimeri, M.; Enkavi, G.; Vattulainen, I.; Lappalainen, P.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Structural basis of actin monomer re-charging by cyclase-Associated protein

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-04231-7
EID:

2-s2.0-85047005231

Part of ISSN: 20411723
Contributors: Kotila, T.; Kogan, K.; Enkavi, G.; Guo, S.; Vattulainen, I.; Goode, B.L.; Lappalainen, P.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin

PLoS Computational Biology
2017 | Journal article
DOI: 10.1371/journal.pcbi.1005831
EID:

2-s2.0-85032730334

Part of ISSN: 15537358 1553734X
Contributors: Enkavi, G.; Mikkolainen, H.; Güngör, B.; Ikonen, E.; Vattulainen, I.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Atomic-level characterization of transport cycle thermodynamics in the glycerol-3-phosphate:Phosphate antiporter

Nature Communications
2015 | Journal article
DOI: 10.1038/ncomms9393
EID:

2-s2.0-84942854331

Part of ISSN: 20411723
Contributors: Moradi, M.; Enkavi, G.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1409543112
EID:

2-s2.0-84923209928

Part of ISSN: 10916490 00278424
Contributors: Sharma, V.; Enkavi, G.; Vattulainen, I.; Róg, T.; Wikström, M.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

A microscopic view of the mechanisms of active transport across the cellular membrane

Annual Reports in Computational Chemistry
2014 | Book
DOI: 10.1016/B978-0-444-63378-1.00004-5
EID:

2-s2.0-84919386963
Contributors: Enkavi, G.; Li, J.; Wen, P.; Thangapandian, S.; Moradi, M.; Jiang, T.; Han, W.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Movement of NH<sub>3</sub> through the human urea transporter B: A new gas channel

American Journal of Physiology - Renal Physiology
2013 | Journal article
DOI: 10.1152/ajprenal.00609.2012
EID:

2-s2.0-84879168809
Contributors: Ryan Geyer, R.; Musa-Aziz, R.; Enkavi, G.; Mahinthichaichan, P.; Tajkhorshid, E.; Boron, W.F.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Simulation studies of the mechanism of membrane transporters

Methods in Molecular Biology
2013 | Book
DOI: 10.1007/978-1-62703-17-5_14
EID:

2-s2.0-84934444572

Part of ISSN: 10643745
Contributors: Enkavi, G.; Li, J.; Mahinthichaichan, P.; Wen, P.-C.; Huang, Z.; Shaikh, S.A.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Subangstrom resolution x-ray structure details aquaporin-water interactions

Science
2013 | Journal article
DOI: 10.1126/science.1234306
EID:

2-s2.0-84878943513

Part of ISSN: 10959203 00368075
Contributors: Eriksson, U.K.; Fischer, G.; Friemann, R.; Enkavi, G.; Tajkhorshid, E.; Neutze, R.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Transient formation of water-conducting states in membrane transporters

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
DOI: 10.1073/pnas.1218986110
EID:

2-s2.0-84877317987

Part of ISSN: 00278424 10916490
Contributors: Li, J.; Shaikh, S.A.; Enkavi, G.; Wen, P.-C.; Huang, Z.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Visualizing functional motions of membrane transporters with molecular dynamics simulations

Biochemistry
2013 | Journal article
DOI: 10.1021/bi301086x
EID:

2-s2.0-84873845174

Part of ISSN: 15204995 00062960
Contributors: Shaikh, S.A.; Li, J.; Enkavi, G.; Wen, P.-C.; Huang, Z.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Simulation studies of the mechanism of membrane transporters.

Methods in molecular biology (Clifton, N.J.)
2013-01 | Journal article
DOI: 10.1007/978-1-62703-017-5_14
PMID: 23034756
Contributors: Enkavi G; Li J; Mahinthichaichan P; Wen PC; Huang Z; Shaikh SA; Tajkhorshid E
Source: Self-asserted source
Giray Enkavi via Europe PubMed Central

Structure and permeation mechanism of a mammalian urea transporter

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
DOI: 10.1073/pnas.1207362109
EID:

2-s2.0-84863944898

Part of ISSN: 00278424 10916490
Contributors: Levin, E.J.; Cao, Y.; Enkavi, G.; Quick, M.; Pan, Y.; Tajkhorshid, E.; Zhou, M.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Membrane transporters: Molecular machines coupling cellular energy to vectorial transport across the membrane

Molecular Machines
2011 | Book
Part of DOI: 10.1142/9789814343466_0009
EID:

2-s2.0-84973412341
Contributors: Huang, Z.; Shaikh, S.A.; Wen, P.-C.; Enkavi, G.; Li, J.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Capturing functional motions of membrane channels and transporters with molecular dynamics simulation

Journal of Computational and Theoretical Nanoscience
2010 | Journal article
DOI: 10.1166/jctn.2010.1636
EID:

2-s2.0-79955430070

Part of ISSN: 15461955
Contributors: Shaikh, S.A.; Wen, P.-C.; Enkavi, G.; Huang, Z.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Simulation of spontaneous substrate binding revealing the binding pathway and mechanism and initial conformational response of GlpT

Biochemistry
2010 | Journal article
DOI: 10.1021/bi901412a
EID:

2-s2.0-76749163994

Part of ISSN: 00062960 15204995
Contributors: Enkavi, G.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria

American Journal of Physiology - Cell Physiology
2010 | Journal article
DOI: 10.1152/ajpcell.00310.2009
EID:

2-s2.0-77749254712

Part of ISSN: 03636143 15221563
Contributors: Feng, J.; Lucchinetti, E.; Enkavi, G.; Wang, Y.; Gehrig, P.; Roschitzki, B.; Schaub, M.C.; Tajkhorshid, E.; Zaugg, K.; Zaugg, M.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Structural basis of substrate selectivity in the glycerol-3-phosphate: Phosphate antiporter GlpT

Biophysical Journal
2009 | Journal article
DOI: 10.1016/j.bpj.2009.06.026
EID:

2-s2.0-70349588813

Part of ISSN: 15420086 00063495
Contributors: Law, C.J.; Enkavi, G.; Wang, D.-N.; Tajkhorshid, E.
Source: Self-asserted source
Giray Enkavi via Scopus - Elsevier

Peer review (18 reviews for 10 publications/grants)

Review activity for Biochemistry. (1)
Review activity for Biomacromolecules. (1)
Review activity for Brain disorders. (3)
Review activity for Communications biology. (1)
Review activity for Computational and Structural Biotechnology Journal (1)
Review activity for Computational biology and chemistry. (5)
Review activity for Molecular pharmaceutics. (1)
Review activity for PloS one. (1)
Review activity for Structure. (3)
Review activity for The journal of physical chemistry. (1)
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