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Gestational diabetes, Insulin, Thyroid hormones, Thyroid hormones transporters, deiodinases, Machine Learning
Chile

Activities

Employment (1)

Universidad de Concepción: Concepcion, Bio Bio, CL

2018-07-23 to present (Bioquímica Clínica e Inmunología)
Employment
Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Education and qualifications (5)

Universidad de Sevilla Facultad de Farmacia: Sevilla, Andalucía, ES

2012-08 to 2014-08 | PhD in Molecular Biology and Biomedicine (Fisiologia)
Education
Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Pontificia Universidad Católica de Chile Facultad de Ciencias Biológicas: Santiago, CL

2010-03 to 2014-01 | PhD in Biological Sciences m/ Physiological Sciences (Fisiologia)
Education
Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Pontificia Universidad Católica de Chile Facultad de Ciencias Biológicas: Santiago, CL

2010-03 to 2011-07 | MSc in Physiology (Fisiología)
Education
Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Universidad de Concepcion Facultad de Farmacia: Concepcion, CL

2008-03 to 2010-05 | MSc in Clinical Biochemistry and Immunology (Bioquimica Clinica)
Education
Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Universidad de Concepcion Facultad de Medicina: Concepcion, CL

2003-03-01 to 2007-12-20 | Medical Technologist
Education
Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Funding (3)

Fortalecimiento de la red de cooperación para el estudio de alteraciones vasculares asociados a trastornos del embarazo en Latinoamérica

2018-01 to 2019-12 | Award
Comisión Nacional de Investigación Científica y Tecnológica (Santiago, Santiago, CL)
GRANT_NUMBER:

REDI170287

Source: Self-asserted source
Enrique Guzmán-Gutiérrez

EXPRESIÓN DE ISOFORMAS DEL RECEPTOR DE INSULINA Y SU ASOCIACIÓN CON NEOPLASIAS MAMARIAS CANINAS EN LA REGIÓN DEL BIOBIO

2018-01 to 2018-12 | Grant
COMITE PRODUCTIVO REGIONAL DEL BIOBIO (Concepcion, Bio Bio, CL)
GRANT_NUMBER:

17CTEBI-83482

Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Maternal Thyroid Profile characterization during pregnancy: Association with gestational diabetes, altered metabolism thyroid in placenta and neonatal thyroid profile

2017-11 to 2020-10 | Award
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, Santiago, CL)
GRANT_NUMBER:

11170710

Source: Self-asserted source
Enrique Guzmán-Gutiérrez

Works (31)

Simple and Fast Prediction of Gestational Diabetes Mellitus Based on Machine Learning and Near-Infrared Spectra of Serum: A Proof of Concept Study at Different Stages of Pregnancy

Biomedicines
2024-05-21 | Journal article
Contributors: Daniela Mennickent; Lucas Romero-Albornoz; Sebastián Gutiérrez-Vega; Claudio Aguayo; Federico Marini; Enrique Guzmán-Gutiérrez; Juan Araya
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The expression of deiodinase 2 and deiodinase 3 are reduced by insulin and D-glucose respectively, in human placental explant cultures

2023-10-16 | Preprint
Contributors: Nestor Herrera-Chavez; Javiera Appel-Rubio; Daniela Rojas; Daniela Mennickent; Jorge Buchert; Katherine Roble; Andrea Sanchez; Claudio Aguayo; Marcelo Gonzalez; Enrique Guzmán-Gutiérrez
Source: check_circle
Crossref

Evaluation of first and second trimester maternal thyroid profile on the prediction of gestational diabetes mellitus and post load glycemia

PLOS ONE
2023-01-13 | Journal article
Contributors: Daniela Mennickent; Surangi Nilanka Jayakody Mudiyanselage; Bernel Ortega-Contreras; Sebastián Gutiérrez-Vega; Erica Castro; Andrés Rodríguez; Juan Araya; Enrique Guzmán-Gutiérrez
Source: check_circle
Crossref

Loxin Reduced the Inflammatory Response in the Liver and the Aortic Fatty Streak Formation in Mice Fed with a High-Fat Diet

International Journal of Molecular Sciences
2022-06 | Journal article | Author
Contributors: Camila Reyes; Estefania Nova-Lamperti; Daniel Duran-Sandoval; Daniela Rojas; Jorge Gajardo; Enrique Guzmán-Gutiérrez; Camila Bustos-Ruiz; Valeska Alejandra Ormazábal Valladares; Felipe A. Zuniga; Carlos Escudero et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Maternal thyroid profile in first and second trimester of pregnancy is correlated with gestational diabetes mellitus through machine learning

Placenta
2021 | Journal article
EID:

2-s2.0-85093668880

Part of ISSN: 15323102 01434004
Contributors: Araya, J.; Rodriguez, A.; Lagos-SanMartin, K.; Mennickent, D.; Gutiérrez-Vega, S.; Ortega-Contreras, B.; Valderrama-Gutiérrez, B.; Gonzalez, M.; Farías-Jofré, M.; Guzmán-Gutiérrez, E.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus

PLoS ONE
2020 | Journal article
EID:

2-s2.0-85096818822

Part of ISSN: 19326203
Contributors: Gutierrez-Vega, S.; Armella, A.; Mennickent, D.; Loyola, M.; Covarrubias, A.; Ortega-Contreras, B.; Escudero, C.; Gonzalez, M.; Alcala, M.; Del Pilar Ramos, M. et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

Role of proteases in dysfunctional placental vascular remodelling in preeclampsia

Biochimica et Biophysica Acta - Molecular Basis of Disease
2020 | Journal article
EID:

2-s2.0-85064317790

Part of ISSN: 1879260X 09254439
Contributors: Gutiérrez, J.A.; Gómez, I.; Chiarello, D.I.; Salsoso, R.; Klein, A.D.; Guzmán-Gutiérrez, E.; Toledo, F.; Sobrevia, L.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein

Nitric Oxide - Biology and Chemistry
2020 | Journal article
EID:

2-s2.0-85081644873

Part of ISSN: 10898611 10898603
Contributors: Rojas, S.; Basualto, E.; Valdivia, L.; Vallejos, N.; Ceballos, K.; Peña, E.; Rivas, C.; Nualart, F.; Guzmán-Gutiérrez, E.; Escudero, C. et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

Antioxidants and oxidative stress: Focus in obese pregnancies

Frontiers in Physiology
2018 | Journal article
EID:

2-s2.0-85056259942

Part of ISSN: 1664042X
Contributors: Alcala, M.; Gutierrez-Vega, S.; Castro, E.; Guzman-Gutiérrez, E.; Ramos-Álvarez, M.P.; Viana, M.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

Slight pH Fluctuations in the Gold Nanoparticle Synthesis Process Influence the Performance of the Citrate Reduction Method

Sensors
2018-07 | Journal article
Source: check_circle
Multidisciplinary Digital Publishing Institute

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

Molecular Aspects of Medicine
2017 | Journal article
EID:

2-s2.0-85011546033

Part of ISSN: 18729452 00982997
Contributors: Leiva, A.; Guzmán-Gutiérrez, E.; Contreras-Duarte, S.; Fuenzalida, B.; Cantin, C.; Carvajal, L.; Salsoso, R.; Gutiérrez, J.; Pardo, F.; Sobrevia, L.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1

PLoS ONE
2017 | Journal article
EID:

2-s2.0-85027678197

Part of ISSN: 19326203
Contributors: Troncoso, F.; Acurio, J.; Herlitz, K.; Aguayo, C.; Bertoglia, P.; Guzman-Gutierrez, E.; Loyola, M.; Gonzalez, M.; Rezgaoui, M.; Desoye, G. et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

Insulin requires A1 adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium.

2016-03 | Journal article
Contributors: Guzmán-Gutiérrez E; Armella A; Toledo F; Pardo F; Leiva A; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Effect of Systemic Inflammation on the Function of Insulin and Glucose Metabolism in Rheumatoid Arthritis.

2015 | Journal article
Contributors: Herlitz-Cifuentes HS; Garces PC; Fernandez LI; Guzman-Gutierrez EA
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Insulin reverses D-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells.

2015 | Journal article
Contributors: González M; Rojas S; Avila P; Cabrera L; Villalobos R; Palma C; Aguayo C; Peña E; Gallardo V; Guzmán-Gutiérrez E et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia.

2015-03 | Journal article
Contributors: Salsoso R; Guzmán-Gutiérrez E; Sáez T; Bugueño K; Ramírez MA; Farías M; Pardo F; Leiva A; Sanhueza C; Mate A et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium.

2015-01 | Journal article
Contributors: Westermeier F; Salomón C; Farías M; Arroyo P; Fuenzalida B; Sáez T; Salsoso R; Sanhueza C; Guzmán-Gutiérrez E; Pardo F et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Is a low level of free thyroxine in the maternal circulation associated with altered endothelial function in gestational diabetes?

2014 | Journal article
Contributors: Guzmán-Gutiérrez E; Veas C; Leiva A; Escudero C; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Reduced L-carnitine transport in aortic endothelial cells from spontaneously hypertensive rats.

2014 | Journal article
Contributors: Salsoso R; Guzmán-Gutiérrez E; Arroyo P; Salomón C; Zambrano S; Ruiz-Armenta MV; Blanca AJ; Pardo F; Leiva A; Mate A et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Role of insulin and adenosine in the human placenta microvascular and macrovascular endothelial cell dysfunction in gestational diabetes mellitus.

2014-01 | Journal article
Contributors: Guzmán-Gutiérrez E; Arroyo P; Salsoso R; Fuenzalida B; Sáez T; Leiva A; Pardo F; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Role of equilibrative adenosine transporters and adenosine receptors as modulators of the human placental endothelium in gestational diabetes mellitus.

2013-12 | Journal article
Contributors: Pardo F; Arroyo P; Salomón C; Westermeier F; Salsoso R; Sáez T; Guzmán-Gutiérrez E; Leiva A; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Maternal hypercholesterolemia in pregnancy associates with umbilical vein endothelial dysfunction: role of endothelial nitric oxide synthase and arginase II.

2013-10 | Journal article
Contributors: Leiva A; de Medina CD; Salsoso R; Sáez T; San Martín S; Abarzúa F; Farías M; Guzmán-Gutiérrez E; Pardo F; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Gestational diabetes reduces adenosine transport in human placental microvascular endothelium, an effect reversed by insulin.

2012 | Journal article
Contributors: Salomón C; Westermeier F; Puebla C; Arroyo P; Guzmán-Gutiérrez E; Pardo F; Leiva A; Casanello P; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Insulin-increased L-arginine transport requires A(2A) adenosine receptors activation in human umbilical vein endothelium.

2012 | Journal article
Contributors: Guzmán-Gutiérrez E; Westermeier F; Salomón C; González M; Pardo F; Leiva A; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.

2012 | Journal article
Contributors: Aravena C; Beltrán AR; Cornejo M; Torres V; Díaz ES; Guzmán-Gutiérrez E; Pardo F; Leiva A; Sobrevia L; Ramírez MA
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Maternal and fetal metabolic dysfunction in pregnancy diseases associated with vascular oxidative and nitrative stress

The Molecular Basis for the Link between Maternal Health and the Origin of Fetal Congenital Abnormalities: An Overview of Association with Oxidative Stress
2011 | Book chapter
EID:

2-s2.0-84882595947

Contributors: González, M.; Muñoz, E.; Puebla, C.; Guzmán-Gutiérrez, E.; Cifuentes, F.; Nien, J.K.; Abarzúa, F.; Leiva, A.; Casanello, P.; Sobrevia, L.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Scopus - Elsevier

Functional link between adenosine and insulin: a hypothesis for fetoplacental vascular endothelial dysfunction in gestational diabetes.

2011-11 | Journal article
Contributors: Guzmán-Gutiérrez E; Abarzúa F; Belmar C; Nien JK; Ramírez MA; Arroyo P; Salomón C; Westermeier F; Puebla C; Leiva A et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation.

2011-11 | Journal article
Contributors: González M; Gallardo V; Rodríguez N; Salomón C; Westermeier F; Guzmán-Gutiérrez E; Abarzúa F; Leiva A; Casanello P; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium.

2011-06 | Journal article
Contributors: Westermeier F; Salomón C; González M; Puebla C; Guzmán-Gutiérrez E; Cifuentes F; Leiva A; Casanello P; Sobrevia L
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes.

2011-03 | Journal article
Contributors: Sobrevia L; Abarzúa F; Nien JK; Salomón C; Westermeier F; Puebla C; Cifuentes F; Guzmán-Gutiérrez E; Leiva A; Casanello P
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Differential expression of functional nucleoside transporters in non-differentiated and differentiated human endothelial progenitor cells.

2010-10 | Journal article
Contributors: Guzmán-Gutiérrez E; Sandoval C; Nova E; Castillo JL; Vera JC; Lamperti L; Krause B; Salomón C; Sepúlveda C; Aguayo C et al.
Source: Self-asserted source
Enrique Guzmán-Gutiérrez via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for Biological Research. (1)