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Technion Israel Institute of Technology: Haifa, Haifa, IL

Professor (Schulich Faculty of Chemistry )
Education
Source: Self-asserted source
Ashraf Brik

Works (50 of 57)

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Page 1 of 2

Chemical approaches to explore ubiquitin-like proteins

RSC Chemical Biology
2025 | Journal article
DOI: 10.1039/D4CB00220B
Contributors: Reem Mousa; Dana Shkolnik; Yam Alalouf; Ashraf Brik
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Chemical protein synthesis combined with protein cell delivery reveals new insights on the maturation process of SUMO2

Chemical Science
2025 | Journal article
DOI: 10.1039/D4SC06254J
Contributors: Dana Shkolnik; Subhasis Dey; Mahdi Hasan; Michael J. Matunis; Ashraf Brik
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Wash-free Imaging in Live Cells

ACS Central Science
2025-01-22 | Journal article
DOI: 10.1021/acscentsci.4c02083
Contributors: Mahdi Hasan; Ashraf Brik
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Suspension Bead Loading (SBL): An Economical Protein Delivery Platform to Study URM1’s Behavior in Live Cells

Angewandte Chemie
2024-11-25 | Journal article
DOI: 10.1002/ange.202410135
Contributors: Abhishek Saha; Reem Mousa; Yam Alalouf; Pradeep Sadhu; Mahdi Hasan; Shaswati Mandal; Guy Mann; Ashraf Brik
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Suspension Bead Loading (SBL): An Economical Protein Delivery Platform to Study URM1’s Behavior in Live Cells

Angewandte Chemie International Edition
2024-11-25 | Journal article
DOI: 10.1002/anie.202410135
Contributors: Abhishek Saha; Reem Mousa; Yam Alalouf; Pradeep Sadhu; Mahdi Hasan; Shaswati Mandal; Guy Mann; Ashraf Brik
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Exocyclic and Linker Editing of Lys63‐linked Ubiquitin Chains Modulators Specifically Inhibits Non‐homologous End‐joining Repair

Angewandte Chemie
2024-10-24 | Journal article
DOI: 10.1002/ange.202409012
Contributors: Abhishek Saha; Laila A. Bishara; Yakop Saed; Ganga B. Vamisetti; Shaswati Mandal; Hiroaki Suga; Nabieh Ayoub; Ashraf Brik
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Exocyclic and Linker Editing of Lys63‐linked Ubiquitin Chains Modulators Specifically Inhibits Non‐homologous End‐joining Repair

Angewandte Chemie International Edition
2024-10-24 | Journal article
DOI: 10.1002/anie.202409012
Contributors: Abhishek Saha; Laila A. Bishara; Yakop Saed; Ganga B. Vamisetti; Shaswati Mandal; Hiroaki Suga; Nabieh Ayoub; Ashraf Brik
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De novo Semi‐Synthetic Platform for Monitoring Protein degradation in Live Cells

ChemBioChem
2024-02 | Journal article
DOI: 10.1002/cbic.202300731
Contributors: Mahdi Hasan; Deepanjan Panda; Guy Mann; Ashraf Brik
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Synthesis of ubiquitinated proteins for biochemical and functional analysis

Chemical Science
2023 | Journal article
DOI: 10.1039/D3SC03664B
Contributors: Julia Kriegesmann; Ashraf Brik
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Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation

Nature Communications
2023-11-08 | Journal article
DOI: 10.1038/s41467-023-43025-4
Contributors: Betsegaw Lemma; Di Zhang; Ganga B. Vamisetti; Bryan G. Wentz; Hiroaki Suga; Ashraf Brik; Jacek Lubkowski; David Fushman
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Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes

Accounts of Chemical Research
2023-07-18 | Journal article
DOI: 10.1021/acs.accounts.3c00178
Contributors: Abhishek Saha; Hiroaki Suga; Ashraf Brik
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Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails

Marine Drugs
2023-06-09 | Journal article
DOI: 10.3390/md21060356
Contributors: Yazid Mohamed Souf; Gonxhe Lokaj; Veeresh Kuruva; Yakop Saed; Delphine Raviglione; Ashraf Brik; Annette Nicke; Nicolas Inguimbert; Sébastien Dutertre
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Probing the cell delivery of synthetic diubiquitin chains

Chemical Communications
2022 | Journal article
DOI: 10.1039/D2CC02476D
Contributors: Shaswati Mandal; Ashraf Brik
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Structure–Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell‐Penetrating Peptides for Live‐Cell Delivery of Synthetic Proteins

Angewandte Chemie International Edition
2022-11-21 | Journal article
DOI: 10.1002/anie.202207551
Contributors: Abhishek Saha; Shaswati Mandal; Jan Vincent V. Arafiles; Jacobo Gómez‐González; Christian P. R. Hackenberger; Ashraf Brik
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Struktur‐Wirkungsbeziehung von an zyklische Zell‐penetrierende Peptide gebundenen DABCYL‐Derivaten für den Transport von synthetischen Proteinen in lebende Zellen

Angewandte Chemie
2022-11-21 | Journal article
DOI: 10.1002/ange.202207551
Contributors: Abhishek Saha; Shaswati Mandal; Jan Vincent V. Arafiles; Jacobo Gómez‐González; Christian P. R. Hackenberger; Ashraf Brik
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Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair

Nature Communications
2022-10-18 | Journal article
DOI: 10.1038/s41467-022-33808-6
Contributors: Ganga B. Vamisetti; Abhishek Saha; Yichao J. Huang; Rajeshwer Vanjari; Guy Mann; Julia Gutbrod; Nabieh Ayoub; Hiroaki Suga; Ashraf Brik
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Synthetic Proteins behind the Plasma Barrier: Molecular Spies

Accounts of Chemical Research
2022-08-02 | Journal article
DOI: 10.1021/acs.accounts.2c00236
Contributors: Guy Mann; Pradeep Sadhu; Ashraf Brik
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Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1

Molecules
2022-07-29 | Journal article
DOI: 10.3390/molecules27154867
Contributors: Guy Mann; Prasad Sulkshane; Pradeep Sadhu; Tamar Ziv; Michael H. Glickman; Ashraf Brik
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Front Cover: Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of Their Localization and Function in Live Cells (ChemBioChem 11/2022)

ChemBioChem
2022-06-03 | Journal article
DOI: 10.1002/cbic.202200150
Contributors: Guy Mann; Pradeep Sadhu; Ashraf Brik
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Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of Their Localization and Function in Live Cells

ChemBioChem
2022-06-03 | Journal article
DOI: 10.1002/cbic.202200122
Contributors: Guy Mann; Pradeep Sadhu; Ashraf Brik
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Gold(I)-Mediated Rapid Cyclization of Propargylated Peptides via Imine Formation

Journal of the American Chemical Society
2022-03-23 | Journal article
DOI: 10.1021/jacs.1c12906
Contributors: Rajeshwer Vanjari; Deepanjan Panda; Shaswati Mandal; Ganga B. Vamisetti; Ashraf Brik
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Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins

Chemical Society Reviews
2021 | Journal article
DOI: 10.1039/D0CS01156H
Contributors: Shay Laps; Gandhesiri Satish; Ashraf Brik
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Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy

Chemical Communications
2021 | Journal article
DOI: 10.1039/D1CC04045F
Contributors: Guy Mann; Gandhesiri Satish; Prasad Sulkshane; Shaswati Mandal; Michael H. Glickman; Ashraf Brik
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Highly Efficient Cyclization Approach of Propargylated Peptides via Gold(I)-Mediated Sequential C–N, C–O, and C–C Bond Formation

ACS Central Science
2021-12-22 | Journal article
DOI: 10.1021/acscentsci.1c00969
Contributors: Rajeshwer Vanjari; Emad Eid; Ganga B. Vamisetti; Shaswati Mandal; Ashraf Brik
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Insight on the Order of Regioselective Ultrafast Formation of Disulfide Bonds in (Antimicrobial) Peptides and Miniproteins

Angewandte Chemie
2021-11-02 | Journal article
DOI: 10.1002/ange.202107861
Contributors: Shay Laps; Fatima Atamleh; Guy Kamnesky; Shaked Uzi; Michael M. Meijler; Ashraf Brik
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Insight on the Order of Regioselective Ultrafast Formation of Disulfide Bonds in (Antimicrobial) Peptides and Miniproteins

Angewandte Chemie International Edition
2021-11-02 | Journal article
DOI: 10.1002/anie.202107861
Contributors: Shay Laps; Fatima Atamleh; Guy Kamnesky; Shaked Uzi; Michael M. Meijler; Ashraf Brik
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Synthesis and Evaluation of Ubiquitin–Dioxetane Conjugate as a Chemiluminescent Probe for Monitoring Deubiquitinase Activity

Bioconjugate Chemistry
2021-10-20 | Journal article
DOI: 10.1021/acs.bioconjchem.1c00413
Contributors: Sara Gutkin; Satish Gandhesiri; Ashraf Brik; Doron Shabat
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Enhanced Live‐Cell Delivery of Synthetic Proteins Assisted by Cell‐Penetrating Peptides Fused to DABCYL

Angewandte Chemie
2021-03-22 | Journal article
DOI: 10.1002/ange.202016208
Contributors: Shaswati Mandal; Guy Mann; Gandhesiri Satish; Ashraf Brik
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Enhanced Live‐Cell Delivery of Synthetic Proteins Assisted by Cell‐Penetrating Peptides Fused to DABCYL

Angewandte Chemie International Edition
2021-03-22 | Journal article
DOI: 10.1002/anie.202016208
Contributors: Shaswati Mandal; Guy Mann; Gandhesiri Satish; Ashraf Brik
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The Development of a Fluorescence‐Based Competitive Assay Enabled the Discovery of Dimeric Cyclic Peptide Modulators of Ubiquitin Chains

Angewandte Chemie International Edition
2021-03-22 | Journal article
DOI: 10.1002/anie.202013392
Contributors: Ganga B. Vamisetti; Roman Meledin; Mickal Nawatha; Hiroaki Suga; Ashraf Brik
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The Development of a Fluorescence‐Based Competitive Assay Enabled the Discovery of Dimeric Cyclic Peptide Modulators of Ubiquitin Chains

Angewandte Chemie
2021-03-22 | Journal article
DOI: 10.1002/ange.202013392
Contributors: Ganga B. Vamisetti; Roman Meledin; Mickal Nawatha; Hiroaki Suga; Ashraf Brik
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General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

Nature Communications
2021-02-08 | Journal article
DOI: 10.1038/s41467-021-21209-0
Contributors: Shay Laps; Fatima Atamleh; Guy Kamnesky; Hao Sun; Ashraf Brik
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Examining the role of phosphorylation of p19INK4d in its stability and ubiquitination using chemical protein synthesis

Chemical Science
2020 | Journal article
DOI: 10.1039/C9SC06300E
Contributors: Muna Msallam; Hao Sun; Roman Meledin; Pauline Franz; Ashraf Brik
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On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins

Journal of the American Chemical Society
2020-11-18 | Journal article
DOI: 10.1021/jacs.0c07663
Contributors: Ganga B. Vamisetti; Gandhesiri Satish; Prasad Sulkshane; Guy Mann; Michael H. Glickman; Ashraf Brik
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De Novo Synthetic Design for Ultrafast Formation of Disulfide Bonds in Peptides and Proteins .pdf

2020-10-08 | Other
DOI: 10.26434/chemrxiv.13065278.v1
Contributors: Shay Laps; Fatima Atamleh; Guy Kamnesky; Hao Sun; ashraf brik
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On-Demand Detachment of Maleimide Derivatives on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins

2020-07-16 | Other
DOI: 10.26434/chemrxiv.12661502.v1
Contributors: Ganga B. Vamisetti; satish gandhesiri; Prasad Sulkshane; Guy Mann; Michael H. Glickman; ashraf brik
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Examining Several Strategies for the Chemical Synthesis of Phosphorylated Histone H3 Reveals the Effectiveness of the Convergent Approach

European Journal of Organic Chemistry
2020-06-08 | Journal article
DOI: 10.1002/ejoc.201900257
Contributors: Muhammad Jbara; Suman Kumar Maity; Ashraf Brik
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Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation

Journal of the American Chemical Society
2020-05-06 | Journal article
DOI: 10.1021/jacs.9b13216
Contributors: Muhammad Jbara; Emad Eid; Ashraf Brik
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Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions

Bioconjugate Chemistry
2020-03-18 | Journal article
DOI: 10.1021/acs.bioconjchem.0c00026
Contributors: Emad Eid; Gábor N. Boross; Hao Sun; Muna Msallam; Sumeet K. Singh; Ashraf Brik
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The Journey for the Total Chemical Synthesis of a 53 kDa Protein

Accounts of Chemical Research
2019-12-17 | Journal article
DOI: 10.1021/acs.accounts.9b00372
Contributors: Hao Sun; Ashraf Brik
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Palladium‐Mediated Cleavage of Proteins with Thiazolidine‐Modified Backbone in Live Cells

Angewandte Chemie International Edition
2019-09-16 | Journal article
DOI: 10.1002/anie.201906545
Contributors: Guy Mann; Gandhesiri Satish; Roman Meledin; Ganga B. Vamisetti; Ashraf Brik
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Palladium‐Mediated Cleavage of Proteins with Thiazolidine‐Modified Backbone in Live Cells

Angewandte Chemie
2019-09-16 | Journal article
DOI: 10.1002/ange.201906545
Contributors: Guy Mann; Gandhesiri Satish; Roman Meledin; Ganga B. Vamisetti; Ashraf Brik
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Palladium‐Mediated Direct Disulfide Bond Formation in Proteins Containing S‐Acetamidomethyl‐cysteine under Aqueous Conditions

Angewandte Chemie International Edition
2019-04-16 | Journal article
DOI: 10.1002/anie.201900988
Contributors: Shay Laps; Hao Sun; Guy Kamnesky; Ashraf Brik
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Palladium‐Mediated Direct Disulfide Bond Formation in Proteins Containing S‐Acetamidomethyl‐cysteine under Aqueous Conditions

Angewandte Chemie
2019-04-16 | Journal article
DOI: 10.1002/ange.201900988
Contributors: Shay Laps; Hao Sun; Guy Kamnesky; Ashraf Brik
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Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7

ChemBioChem
2019-01-18 | Journal article
DOI: 10.1002/cbic.201800612
Contributors: Ganga B. Vamisetti; Roman Meledin; Pushparathinam Gopinath; Ashraf Brik
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Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

Organic & Biomolecular Chemistry
2018 | Journal article
DOI: 10.1039/C8OB00890F
Contributors: Muhammad Jbara; Emad Eid; Ashraf Brik
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Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases

Chemical Science
2018 | Journal article
DOI: 10.1039/C7SC04518B
Contributors: Hao Sun; Roman Meledin; Sachitanand M. Mali; Ashraf Brik
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Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins

Nature Communications
2018-08-08 | Journal article
DOI: 10.1038/s41467-018-05628-0
Contributors: Muhammad Jbara; Shay Laps; Michael Morgan; Guy Kamnesky; Guy Mann; Cynthia Wolberger; Ashraf Brik
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Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Angewandte Chemie
2018-05-14 | Journal article
DOI: 10.1002/ange.201800032
Contributors: Roman Meledin; Sachitanand M. Mali; Oded Kleifeld; Ashraf Brik
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Activity‐Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α‐Globin‐Modulating Deubiquitinase

Angewandte Chemie International Edition
2018-05-14 | Journal article
DOI: 10.1002/anie.201800032
Contributors: Roman Meledin; Sachitanand M. Mali; Oded Kleifeld; Ashraf Brik
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Peer review (123 reviews for 16 publications/grants)

Review activity for Accounts of chemical research. (3)
Review activity for ACS central science. (4)
Review activity for ACS chemical biology. (3)
Review activity for ACS chemical neuroscience. (1)
Review activity for Angewandte Chemie. (30)
Review activity for Biochemistry. (1)
Review activity for Bioconjugate chemistry. (6)
Review activity for Chemical reviews. (1)
Review activity for Chemistry. (1)
Review activity for European journal of organic chemistry. (1)
Review activity for Israel journal of chemistry. (2)
Review activity for Journal of organic chemistry. (3)
Review activity for Journal of the American Chemical Society. (47)
Review activity for Nature chemistry. (1)
Review activity for Nature reviews. (1)
Review activity for Organic letters. (18)
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