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Employment (1)

Northwestern University - Chicago: Chicago, IL, US

2017-01-01 to present | Assistant Professor (Biochemistry and Molecular Genetics)
Employment
Source: Self-asserted source
Issam Ben-Sahra

Funding (1)

Developing PROMIS: The blueprint of human proteome-metabolome interactions in cancers

2023-07-01 to 2025-06-30 | Grant
American Cancer Society (Atlanta, US)
DOI: 10.53354/ACS.DBG-23-1039959-01-TBE.pc.gr.168086
GRANT_NUMBER:

DBG-23-1039959-01-TBE
Source: check_circle
American Cancer Society - ProposalCentral

Works (18)

Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases

Journal of Clinical Investigation
2025-02-17 | Journal article
DOI: 10.1172/JCI188507
Contributors: Ali Shilatifard; Issam Ben-Sahra
Source: check_circle
Crossref

Brain-penetrating molecule might offer a route to treat glioblastoma tumours

Nature
2024-12-12 | Journal article
DOI: 10.1038/d41586-024-03556-2
Contributors: Mushtaq A. Nengroo; Issam Ben-Sahra
Source: check_circle
Crossref

Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life

JCI Insight
2024-06-10 | Journal article
DOI: 10.1172/jci.insight.181901
Contributors: Konrad T. Sawicki; Hongyan Ning; Norrina B. Allen; Mercedes R. Carnethon; Amisha Wallia; James D. Otvos; Issam Ben-Sahra; Elizabeth M. McNally; Janet K. Snell-Bergeon; John T. Wilkins
Source: check_circle
Crossref

Regulation of nucleotide metabolism in cancers and immune disorders

Trends in Cell Biology
2023-11 | Journal article
DOI: 10.1016/j.tcb.2023.03.003
Contributors: Eunus S. Ali; Issam Ben-Sahra
Source: check_circle
Crossref

Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life

JCI Insight
2023-04-24 | Journal article
DOI: 10.1172/jci.insight.166956
Contributors: Konrad T. Sawicki; Hongyan Ning; Norrina B. Allen; Mercedes R. Carnethon; Amisha Wallia; James D. Otvos; Issam Ben-Sahra; Elizabeth M. McNally; Janet K. Snell-Bergeon; John T. Wilkins
Source: check_circle
Crossref

The cell cycle loops UTP around CAD

Nature Metabolism
2023-02-06 | Journal article
DOI: 10.1038/s42255-023-00737-7
Contributors: Umakant Sahu; Issam Ben-Sahra
Source: check_circle
Crossref

GATOR2 rings GATOR1 to speak to mTORC1

Molecular Cell
2023-01 | Journal article
DOI: 10.1016/j.molcel.2022.12.011
Contributors: Umakant Sahu; Issam Ben-Sahra
Source: check_circle
Crossref

Purine synthesis suppression reduces development and progression of pulmonary hypertension in rodent models

2023-01-18 | Other
DOI: 10.1093/eurheartj/ehad044
Contributors: Yuqing Huo; Zheng Dong; Issam Ben-Sahra
Source: check_circle
Crossref

ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice

Journal of Clinical Investigation
2022-05-16 | Journal article
DOI: 10.1172/JCI154491
Contributors: Hidemichi Kouzu; Yuki Tatekoshi; Hsiang-Chun Chang; Jason S. Shapiro; Warren A. McGee; Adam De Jesus; Issam Ben-Sahra; Zoltan Arany; Jonathan Leor; Chunlei Chen et al.
Source: check_circle
Crossref

SGLT2 Inhibition on Cardiac Mitochondrial Function: Searching for a Sweet Spot

Journal of the American Heart Association
2021-07-06 | Journal article
DOI: 10.1161/JAHA.121.021949
Contributors: Konrad Teodor Sawicki; Issam Ben‐Sahra; Elizabeth M. McNally
Source: check_circle
Crossref

ASS1igning purine dependency to cancer

Nature Cancer
2020-09-03 | Journal article
DOI: 10.1038/s43018-020-00117-0
Contributors: Elodie Villa; Issam Ben-Sahra
Source: check_circle
Crossref

A spoonful of DHAP keeps mTORC1 running on sugars

Nature Metabolism
2020-07-27 | Journal article
DOI: 10.1038/s42255-020-0246-1
Contributors: Gerta Hoxhaj; Jason W. Locasale; Issam Ben-Sahra
Source: check_circle
Crossref

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

Molecular cell
2020-06-01 | Journal article
DOI: 10.1016/j.molcel.2020.05.001
PMID: 32485148
Source: Self-asserted source
Issam Ben-Sahra

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

Cancers
2019-05-17 | Journal article
DOI: 10.3390/cancers11050688
Contributors: Elodie Villa; Eunus Ali; Umakant Sahu; Issam Ben-Sahra
Source: check_circle
Crossref

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase.

Science (New York, N.Y.)
2019-03-01 | Journal article
DOI: 10.1126/science.aau3903
PMID: 30846598
PMC: PMC7261235
Source: Self-asserted source
Issam Ben-Sahra

mTORC1 signaling and the metabolic control of cell growth.

Current opinion in cell biology
2017-04-12 | Journal article
DOI: 10.1016/j.ceb.2017.02.012
PMID: 28411448
PMC: PMC5545101
Source: Self-asserted source
Issam Ben-Sahra

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Science (New York, N.Y.)
2016-02-01 | Journal article
DOI: 10.1126/science.aad0489
PMID: 26912861
PMC: PMC4786372
Source: Self-asserted source
Issam Ben-Sahra

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

Science (New York, N.Y.)
2013-02-21 | Journal article
DOI: 10.1126/science.1228792
PMID: 23429703
PMC: PMC3753690
Source: Self-asserted source
Issam Ben-Sahra

Peer review (68 reviews for 18 publications/grants)

Review activity for Cancer & metabolism. (3)
Review activity for Cell death discovery. (1)
Review activity for Cell metabolism. (2)
Review activity for Cell reports medicine. (1)
Review activity for Cell reports. (4)
Review activity for Cell. (4)
Review activity for Current opinion in biotechnology. (1)
Review activity for Molecular cell. (14)
Review activity for Nature (8)
Review activity for Nature cancer. (4)
Review activity for Nature cell biology (2)
Review activity for Nature chemical biology. (1)
Review activity for Nature communications (11)
Review activity for Nature immunology. (1)
Review activity for Nature metabolism. (8)
Review activity for Nature reviews. (1)
Review activity for Review Commons (1)
Review activity for Science. (1)
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