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Nanosafety, High-content screening, Inflammation, Toxicology
Italy, Austria, Bosnia and Herzegovina, Sweden

Biography

Andi Alijagic is a researcher in toxicology at Örebro University. His research interests focus on the understanding of cellular toxicity and modes-of-action underlying health impacts of particle and chemical pollutants, with an emphasis on micro and nanoplastics and plastic-associated chemicals (Alijagic et al. 2024a, Environ Int). In addition to research, he is actively involved in teaching and supervision of students.

In his research, Andi employs cell-based models, high-content imaging (Cell Painting), and multi-omics, focusing on the cellular and molecular mechanisms regulating cell health and function, inflammatory responses, genotoxicity, and endocrine disruption in response to particle and chemical exposure. He has a strong interest in the use of New Approach Methodologies (NAMs), and together with ORU team, he has initiated the application of Cell Painting for non-target toxicological screening of emerging pollutants (Alijagic et al. 2023, Cells; Alijagic et al. 2024b, Environ Int; Alijagic et al. 2024c, Environ Int; Le Du-Carrée et al. 2024, J Haz Mat; Alijagic et al. 2025, Environ Res). With this approach he aims at contributing to a healthy and zero-pollution environment by performing research at the forefront of human and environmental toxicology.

In the NanoSafety2 project (Synergi22; included at the Royal Swedish Academy of Engineering Sciences (IVA) 100-List for 2024) he is coordinating the research on toxicity and health effects of (nano)particles and chemicals found in additive manufacturing or industrial 3D printing. Via ongoing projects, Andi works closely with a number of Swedish and international leading companies and academic partners. Andi is also part of the COST action PRIORITY (Plastics monitoRIng detectiOn RemedIaTion recovery) as Management Committee Member for Sweden and member of WG1 Impacts and risks on human health and environment related to nano- and microplastics and WG4 Nanoplastics.

In addition, he is serving as the editorial board member in the journals Discover Toxicology (Springer Nature), Frontiers in Toxicology (section: Nanotoxicology), and Frontiers in Environmental Science (section: Toxicology, Pollution and the Environment). He is actively involved in the communication of science both to the public at large and the research community.

Activities

Employment (4)

Örebro Universitet: Örebro, Sweden, SE

2023-01-01 to present | Researcher (School of Science and Technology)
Employment
Source: Self-asserted source
Andi Alijagic

Örebro University: Örebro, SE

2021-02-04 to 2022-12-31 | Postdoctoral researcher (School of Science and Technology)
Employment
Source: Self-asserted source
Andi Alijagic

Institute of biomedical research and innovaton: Palermo, IT

2019-06-01 to 2019-09-30 | Doctoral researcher
Employment
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Andi Alijagic

Institute for Biomedicine and Molecular Immunology: Palermo, IT

2016-10-01 to 2019-05-31 | Doctoral researcher
Employment
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Andi Alijagic

Education and qualifications (1)

University of Salzburg : Salzburg, Austria, AT

2017-03-21 to 2020-09-11 | PhD (Molecular biology)
Education
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Andi Alijagic

Professional activities (3)

SweNanoSafe: Stockholm, SE

Membership
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Andi Alijagic

Swedish Society of Toxicology: Stockholm, SE

Membership
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Andi Alijagic

SWACCS: Stockholm, SE

Membership
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Andi Alijagic

Funding (3)

NANOSIGN - Identifying cellular and molecular signatures of nanoparticle exposure in additive manufacturing

2023-12 to 2025 | Grant
KK-Stiftelsen (Stockholm, SE)
Source: Self-asserted source
Andi Alijagic

Primary monocyte derived macrophages as a model to study chronic low-grade inflammation

2022-02 to 2023 | Grant
X-HiDE, KK-Stiftelsen (Örebro, SE)
Source: Self-asserted source
Andi Alijagic

Early Stage Researcher PhD fellowship in the Marie Skłodowska-Curie ITN European Training Network PANDORA

Grant
Horizon 2020 Framework Programme (Bruxelles, BE)
Source: Self-asserted source
Andi Alijagic

Works (30)

Deciphering the phenotypic, inflammatory, and endocrine disrupting impacts of e-waste plastic-associated chemicals

Environmental Research
2025 | Journal article
Contributors: Alijagic, Andi; Seilitz, Fredric Sodergren; Bredberg, Anna; Hakonen, Aron; Larsson, Maria; Selin, Erica; Sjoberg, Viktor; Kotlyar, Oleksandr; Scherbak, Nikolai; Repsilber, Dirk et al.
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Sea urchin immune cells and associated microbiota co-exposed to iron oxide nanoparticles activate cellular and molecular reprogramming that promotes physiological adaptation

Journal of Hazardous Materials
2025 | Journal article
Contributors: Alijagic, Andi; Russo, Roberta; Scuderi, Viviana; Ussia, Martina; Scalese, Silvia; Taverna, Simona; Engwall, Magnus; Pinsino, Annalisa
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Assessing chromium toxicity across aquatic and terrestrial environments: a cross-species review

Drug and Chemical Toxicology
2024 | Journal article
Contributors: Suljevic, Damir; Focak, Muhamed; Alijagic, Andi
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Can evolutionary immunology decode micro and nanoplastic challenges?

Frontiers in Immunology
2024 | Journal article
Contributors: Alijagic, Andi; Sarndahl, Eva
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Characteristics and health risks of the inhalable fraction of metal additive manufacturing powders

Nano Select
2024 | Journal article
Contributors: Alijagic, Andi; Wang, Xuying; Vallabani, Naga Vera Srikanth; Melin, Pelle; Sarndahl, Eva; Karlsson, Hanna L.; Odnevall, Inger
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Cocktail effects of tire wear particles leachates on diverse biological models: A multilevel analysis

Journal of Hazardous Materials
2024 | Journal article
Contributors: Le Du-Carree, Jessy; Palacios, Clara Kempkens; Rotander, Anna; Larsson, Maria; Alijagic, Andi; Kotlyar, Oleksandr; Engwall, Magnus; Sjoberg, Viktor; Keiter, Steffen H.; Almeda, Rodrigo
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Comprehensive chemical and toxicological screening of e-waste plastic chemicals

Toxicology Letters
2024 | Journal article
Contributors: Alijagic, A.; Seilitz, F. Sodergren; Bredberg, A.; Hakonen, A.; Larsson, M.; Sjoberg, V.; Kotlyar, O.; Persson, A.; Scherbak, N.; Repsilber, D. et al.
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Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals

Environment International
2024 | Journal article
Contributors: Alijagic, Andi; Kotlyar, Oleksandr; Larsson, Maria; Salihovic, Samira; Hedbrant, Alexander; Eriksson, Ulrika; Karlsson, Patrik; Persson, Alexander; Scherbak, Nikolai; Farnlund, Kim et al.
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Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models

Environment International
2024 | Journal article
Contributors: Alijagic, Andi; Sinisalu, Lisanna; Duberg, Daniel; Kotlyar, Oleksandr; Scherbak, Nikolai; Engwall, Magnus; Oresic, Matej; Hyotylainen, Tuulia
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Results of an international interlaboratory study on dioxin-like activities in drinking-, river surface- and wastewater using DR CALUX bioassay

Science of the Total Environment
2024 | Journal article
Contributors: Behnisch, Peter; Besselink, Harrie; Suzuki, Go; Buchinger, Sebastian; Reifferscheid, Georg; Lukas, Marcus; Wollenweber, Marc; Wollenweber, Simone; Hollert, Henner; Kunisue, Tatsuya et al.
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The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective

Environment International
2024 | Journal article
Contributors: Alijagic, Andi; Suljevic, Damir; Focak, Muhamed; Sulejmanovic, Jasmina; Sehovic, Elma; Sarndahl, Eva; Engwall, Magnus
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A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles

Cells
2023 | Journal article
Contributors: Alijagic, Andi; Scherbak, Nikolai; Kotlyar, Oleksandr; Karlsson, Patrik; Wang, Xuying; Odnevall, Inger; Benada, Oldrich; Amiryousefi, Ali; Andersson, Lena; Persson, Alexander et al.
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Low-dose and repeated exposure to nickel leads to bioaccumulation and cellular and metabolic alterations in quails

Environmental Pollution
2023 | Journal article
Contributors: Suljevic, Damir; Focak, Muhamed; Sulejmanovic, Jasmina; Sehovic, Elma; Alijagic, Andi
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NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity

Frontiers in Immunology
2023 | Journal article
Contributors: Alijagic, Andi; Hedbrant, Alexander; Persson, Alexander; Larsson, Maria; Engwall, Magnus; Sarndahl, Eva
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Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing

Toxicology Letters
2022 | Journal article
Contributors: Alijagic, A.; Scherbak, N.; Kotlyar, O.; Karlsson, P.; Persson, A.; Hedbrant, A.; Norinder, U.; Larsson, M.; Felth, J.; Andersson, L. et al.
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Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing

Frontiers in Toxicology
2022 | Journal article
Contributors: Alijagic, Andi; Engwall, Magnus; Saerndahl, Eva; Karlsson, Helen; Hedbrant, Alexander; Andersson, Lena; Karlsson, Patrik; Dalemo, Magnus; Scherbak, Nikolai; Faernlund, Kim et al.
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Toxicity evaluation of particles formed during 3D-printing: Cytotoxic, genotoxic, and inflammatory response in lung and macrophage models

Toxicology
2022 | Journal article
Contributors: Vallabani, N. V. Srikanth; Alijagic, Andi; Persson, Alexander; Odnevall, Inger; Sarndahl, Eva; Karlsson, Hanna L.
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Assessing hexavalent chromium tissue-specific accumulation patterns and induced physiological responses to probe chromium toxicity in Coturnix japonica quail

Chemosphere
2021 | Journal article
Contributors: Suljevic, Damir; Sulejmanovic, Jasmina; Focak, Muhamed; Halilovic, Erna; Pupalovic, Dzemila; Hasic, Azra; Alijagic, Andi
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Cross-Species Comparisons of Nanoparticle Interactions with Innate Immune Systems: A Methodological Review

Nanomaterials
2021 | Journal article
Contributors: Swartzwelter, Benjamin J.; Mayall, Craig; Alijagic, Andi; Barbero, Francesco; Ferrari, Eleonora; Hernadi, Szabolcs; Michelini, Sara; Pacheco, Natividad Isabel Navarro; Prinelli, Alessandra; Swart, Elmer et al.
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Gold nanoparticles coated with polyvinylpyrrolidone and sea urchin extracellular molecules induce transient immune activation

Journal of Hazardous Materials
2021 | Journal article
Contributors: Alijagic, Andi; Barbero, Francesco; Gaglio, Daniela; Napodano, Elisabetta; Benada, Oldrich; Kofronova, Olga; Puntes, Victor F.; Bastus, Neus G.; Pinsino, Annalisa
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Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells

Nanomaterials
2021 | Journal article
Contributors: Alijagic, Andi; Bonura, Angela; Barbero, Francesco; Puntes, Victor F.; Gervasi, Francesco; Pinsino, Annalisa
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Lead Exposure Influences Serum Biomarkers, Hepatocyte Survival, Bone Marrow Hematopoiesis, and the Reproductive Cycle in Japanese Quails

Biological Trace Element Research
2021 | Journal article
Contributors: Suljevic, Damir; Handzic, Nejira; Focak, Muhamed; Lasic, Ivan; Sipovic, Faris; Sulejmanovic, Jasmina; Begic, Sabina; Alijagic, Andi
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Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

Small
2020 | Journal article
Contributors: Boraschi, Diana; Alijagic, Andi; Auguste, Manon; Barbero, Francesco; Ferrari, Eleonora; Hernadi, Szabolcs; Mayall, Craig; Michelini, Sara; Navarro Pacheco, Natividad I.; Prinelli, Alessandra et al.
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Safety Evaluation of TiO<sub>2</sub> Nanoparticle-Based Sunscreen UV Filters on the Development and the Immunological State of the Sea Urchin <i>Paracentrotus lividus</i>

Nanomaterials
2020 | Journal article
Contributors: Catalano, Riccardo; Labille, Jerome; Gaglio, Daniela; Alijagic, Andi; Napodano, Elisabetta; Slomberg, Danielle; Campos, Andrea; Pinsino, Annalisa
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Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity

Journal of Hazardous Materials
2020 | Journal article
Contributors: Alijagic, Andi; Gaglio, Daniela; Napodano, Elisabetta; Russo, Roberta; Costa, Caterina; Benada, Oldrich; Kofronova, Olga; Pinsino, Annalisa
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First person - Annalisa Pinsino and Andi Alijagic

Biology Open
2019 | Journal article
Contributors: Pinsino, Annalisa; Alijagic, Andi
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Impairments of bone marrow hematopoietic cells followed by the sever erythrocyte damage and necrotic liver as the outcome of chronic in vivo exposure to cadmium: novel insights from quails

Environmental Toxicology and Pharmacology
2019 | Journal article
Contributors: Suljevic, Damir; Corbic, Anida; Islamagic, Erna; Focak, Muhamed; Filipic, Filip; Alijagic, Andi
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Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior

Frontiers in Immunology
2019 | Journal article
Contributors: Alijagic, Andi; Benada, Oldrich; Kofronova, Olga; Cigna, Diego; Pinsino, Annalisa
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Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions

Biology Open
2019 | Journal article
Contributors: Pinsino, Annalisa; Alijagic, Andi
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Probing safety of nanoparticles by outlining sea urchin sensing and signaling cascades

Ecotoxicology and Environmental Safety
2017 | Journal article
Contributors: Alijagic, Andi; Pinsino, Annalisa
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Peer review (21 reviews for 17 publications/grants)

Review activity for Aquatic toxicology. (1)
Review activity for Cosmetics. (2)
Review activity for Environment international. (2)
Review activity for Environmental science & technology. (1)
Review activity for Environmental science and pollution research international (1)
Review activity for Gels. (1)
Review activity for International journal of molecular sciences. (2)
Review activity for Journal of Environmental Science. (1)
Review activity for Life. (1)
Review activity for Marine environmental research. (1)
Review activity for Marine pollution bulletin. (2)
Review activity for Molecules. (1)
Review activity for NanoImpact. (1)
Review activity for Pharmaceutics. (1)
Review activity for Science of the total environment. (1)
Review activity for Sustainability. (1)
Review activity for Toxicology in vitro. (1)