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ResearcherID: G-9844-2013
ResearcherID: G-9844-2013

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Employment (7)

Institute for Research in Biomedicine: Barcelona, Barcelona, ES

2014-06 to present | Director (Experimental Bioinformatics Laboratory)
Employment
Source: Self-asserted source
Isabelle Brun-Heath

Institute for Research in Biomedicine: Barcelona, Barcelona, ES

2012-03 to 2014-06 | Research associate
Employment
Source: Self-asserted source
Isabelle Brun-Heath

National centre of genetic analysis: Barcelona, Catalunya, ES

2010-09 to 2012-03
Employment
Source: Self-asserted source
Isabelle Brun-Heath

Université de Versailles Saint-Quentin en Yvelines UFR des Sciences: Versailles, Ile-de-France, FR

2003 to 2010 | Lecturer
Employment
Source: Self-asserted source
Isabelle Brun-Heath

Institut Curie: Paris, FR

2002-04 to 2003-06 | Post doctoral fellow (Chromatin Dynamics)
Employment
Source: Self-asserted source
Isabelle Brun-Heath

New York University: New York, New York, US

1999 to 2002-03 | Post doctoral fellow (Biology)
Employment
Source: Self-asserted source
Isabelle Brun-Heath

The Rockefeller University: New York, NY, US

1997-11 to 1999 | Post doctoral fellow (Cellular and Developmental Biology)
Employment
Source: Self-asserted source
Isabelle Brun-Heath

Education and qualifications (3)

Université Paris-Sud: Orsay, Île-de-France, FR

1993-09 to 1997-09 | Ph.D
Education
Source: Self-asserted source
Isabelle Brun-Heath

Université Paris-Sud: Orsay, Île-de-France, FR

1991-09 to 1993-09 | M.Sc. in Molecular Biology of the Cell
Education
Source: Self-asserted source
Isabelle Brun-Heath

Université Pierre et Marie Curie UFR de Biologie: Paris, Île-de-France, FR

1988-09 to 1991-06 | B.Sc in Cellular Biology
Education
Source: Self-asserted source
Isabelle Brun-Heath

Works (42)

An integrated machine-learning model to predict nucleosome architecture

Nucleic Acids Research
2024 | Journal article
DOI: 10.1093/NAR/GKAE689
WOSUID: WOS:001293708500001
Contributors: Sala, Alba; Labrador, Mireia; Buitrago, Diana; De Jorge, Pau; Battistini, Federica; Heath, Isabelle Brun; Orozco, Modesto
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Computational Biology, Bioinformatics & Artificial Intelligence Theoretical prediction of nucleosome arrays in yeast

FEBS Open Bio
2024 | Journal article
WOSUID: WOS:001287749200031
Contributors: Sala, Alba; Buitrago, Diana; Labrador, Mireia; De Jorge, Pau; Battistini, Federica; Brun Heath, Isabelle; Orozco, Modesto
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Rational optimization of a transcription factor activation domain inhibitor

Nature Structural Biology
2023 | Journal article
DOI: 10.1038/S41594-023-01159-5
WOSUID: WOS:001112830700001
Contributors: Basu, Shaon; Martinez-Cristobal, Paula; Frigole-Vivas, Marta; Pesarrodona, Mireia; Lewis, Michael; Szulc, Elzbieta; Banuelos, C. Adriana; Sanchez-Zarzalejo, Carolina; Bielskute, Stase; Zhu, Jiaqi et al.
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Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

Nature Communications
2023-08-22 | Journal article
DOI: 10.1038/s41467-023-40843-4
Contributors: Nikolaos Parisis; Pablo D. Dans; Muhammad Jbara; Balveer Singh; Diane Schausi-Tiffoche; Diego Molina-Serrano; Isabelle Brun-Heath; Denisa Hendrychová; Suman Kumar Maity; Diana Buitrago et al.
Source: check_circle
Crossref

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

Nature Communications
2023-06-12 | Journal article
DOI: 10.1038/s41467-023-39051-x
Contributors: Lorena González; Lucía Díaz; Joan Pous; Blazej Baginski; Anna Duran-Corbera; Margherita Scarpa; Isabelle Brun-Heath; Ana Igea; Pau Martin-Malpartida; Lidia Ruiz et al.
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Crossref

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides.

Nucleic acids research
2023-04-26 | Journal article
DOI: 10.1093/nar/gkad309
PMID: 37099382
Contributors: Vito Genna; Iglesias-Fernández J; Reyes-Fraile L; Villegas N; Guckian K; Seth P; Wan B; Cabrero C; Terrazas M; Brun-Heath I et al.
Source: Self-asserted source
Isabelle Brun-Heath

MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution.

Nature structural & molecular biology
2022-10-11 | Journal article | Author
DOI: 10.1038/s41594-022-00839-y
PMID: 36220894
PMC: PMC9627188
Contributors: Maria Victoria Neguembor; Juan Pablo Arcon; Diana Buitrago Ospina; Lema R; Walther J; Garate X; Laura Martin; Pablo Romero-Marimon; Jumana AlHaj Abed; Marta Gut et al.
Source: Self-asserted source
Isabelle Brun-Heath

A method for multiplexed full-length single-molecule sequencing of the human mitochondrial genome

Nature Communications
2022-10-06 | Journal article
DOI: 10.1038/s41467-022-33530-3
Contributors: Ieva Keraite; Philipp Becker; Davide Canevazzi; Cristina Frias-López; Marc Dabad; Raúl Tonda-Hernandez; Ida Paramonov; Matthew John Ingham; Isabelle Brun-Heath; Jordi Leno et al.
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Crossref

Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2.

Chem catalysis
2022-04-19 | Journal article
DOI: 10.1016/j.checat.2022.03.019
PMID: 35465139
PMC: PMC9016896
Contributors: Aranda J; Wieczór M; Montserrat Terrazas; Brun-Heath I; Orozco M
Source: Self-asserted source
Isabelle Brun-Heath

Novel method for multiplexed full-length single-molecule sequencing of the human mitochondrial genome

2022-02-08 | Preprint
DOI: 10.1101/2022.02.08.479581
Contributors: Ieva Keraite; Philipp Becker; Davide Canevazzi; Maria C. Frias-López; Marc Dabad; Raúl Tonda-Hernandez; Ida Paramonov; Matthew John Ingham; Isabelle Brun-Heath; Jordi Leno et al.
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Crossref

Molecular basis of Arginine and Lysine DNA sequence-dependent thermo-stability modulation

PLOS Computational Biology
2022-01-10 | Journal article
DOI: 10.1371/journal.pcbi.1009749
Contributors: Benjamin Martin; Anna R. Panchenko; Pablo D. Dans; Milosz Wieczór; Nuria Villegas; Isabelle Brun-Heath; Federica Battistini; Montserrat Terrazas; Modesto Orozco
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Crossref

Impact of DNA methylation on 3D genome structure

Nature Communications
2021-12 | Journal article
DOI: 10.1038/s41467-021-23142-8
Part of ISSN: 2041-1723
Source: Self-asserted source
Isabelle Brun-Heath

The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function

PLOS Computational Biology
2021-11-08 | Journal article
DOI: 10.1371/journal.pcbi.1009547
Contributors: Federica Battistini; Shi-Jie Chen; Pablo D. Dans; Montserrat Terrazas; Chiara L. Castellazzi; Guillem Portella; Mireia Labrador; Núria Villegas; Isabelle Brun-Heath; Carlos González et al.
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Crossref

Bioactivity descriptors for uncharacterized chemical compounds.

Nature communications
2021-06-24 | Journal article | Author
DOI: 10.1038/s41467-021-24150-4
PMID: 34168145
PMC: PMC8225676
Contributors: Martino Bertoni; Miquel Duran-Frigola; Pau Badia-i-Mompel; Eduardo Pauls; Orozco-Ruiz M; Guitart-Pla O; Alcalde V; Víctor Manuel Díaz; Antoni Berenguer-LLergo; Isabelle Brun-Heath et al.
Source: Self-asserted source
Isabelle Brun-Heath
grade
Preferred source (of 2)‎

Bioactivity Profile Similarities to Expand the Repertoire of COVID-19 Drugs.

Journal of chemical information and modeling
2020-07 | Journal article
DOI: 10.1021/acs.jcim.0c00420
PMID: 32672454
Contributors: Duran-Frigola M; Bertoni M; Blanco R; Martínez V; Pauls E; Alcalde V; Turon G; Villegas N; Fernández-Torras A; Pons C et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

A multifunctional toolkit for target-directed cancer therapy

Chemical Communications
2019 | Journal article
DOI: 10.1039/C8CC08823C
WOSUID: WOS:000457300200011
Contributors: Terrazas, Montserrat; Sanchez, Dani; Battistini, Federica; Villegas, Nuria; Brun-Heath, Isabelle; Orozco, Modesto
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Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

Nature Communications
2019 | Journal article
DOI: 10.1038/S41467-019-11594-Y
WOSUID: WOS:000479188700005
Contributors: Eftekharzadeh, Bahareh; Banduseela, Varuna C.; Chiesa, Giulio; Martinez-Cristobal, Paula; Rauch, Jennifer N.; Nath, Samir R.; Schwarz, Daniel M. C.; Shao, Hao; Marin-Argany, Marta; Di Sanza, Claudio et al.
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Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor (vol 10, 3562, 2019)

Nature Communications
2019 | Journal article
DOI: 10.1038/S41467-019-12578-8
WOSUID: WOS:000489014800001
Contributors: Eftekharzadeh, Bahareh; Banduseela, Varuna C.; Chiesa, Giulio; Martinez-Cristobal, Paula; Rauch, Jennifer N.; Nath, Samir R.; Schwarz, Daniel M. C.; Shao, Hao; Marin-Argany, Marta; Di Sanza, Claudio et al.
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Web of Science Researcher Profile Sync

Nucleosome Dynamics: a new tool for the dynamic analysis of nucleosome positioning

Nucleic Acids Research
2019 | Journal article
DOI: 10.1093/NAR/GKZ759
WOSUID: WOS:000491241400015
Contributors: Buitrago, Diana; Codo, Laia; Illa, Ricard; de Jorge, Pau; Battistini, Federica; Flores, Oscar; Bayarri, Genis; Royo, Romina; Del Pino, Marc; Heath, Simon et al.
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Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope

Proceedings of the National Academy of Sciences
2019 | Journal article
DOI: 10.1073/PNAS.1821442116
WOSUID: WOS:000467804000052
Contributors: Orellana, Laura; Thorne, Amy H.; Lema, Rafael; Gustavsson, Johan; Parisian, Alison D.; Hospital, Adam; Cordeiro, Tiago N.; Bernado, Pau; Scott, Andrew M.; Brun-Heath, Isabelle et al.
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The Origins and the Biological Consequences of the Pur/Pyr DNA•RNA Asymmetry

Chem
2019 | Journal article
DOI: 10.1016/J.CHEMPR.2019.04.002
WOSUID: WOS:000476610100020
Contributors: Terrazas, Montserrat; Genna, Vito; Portella, Guillem; Villegas, Nuria; Sanchez, Dani; Arnan, Carme; Pulido-Quetglas, Carlos; Johnson, Rory; Guigo, Roderic; Brun-Heath, Isabelle et al.
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MuGVRE. A virtual research environment for 3D/4D genomics

2019-04 | Preprint
DOI: 10.1101/602474
PPR: PPR75813
Contributors: Codó L; Bayarri G; Cid-Fuentes JA; Conejero J; Royo R; Repchevsky D; Pasi M; Meletiou A; McDowall MD; Reham F et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators

Structure
2018 | Journal article
DOI: 10.1016/J.STR.2017.11.007
WOSUID: WOS:000419101700017
Contributors: De Mol, Eva; Szulc, Elzbieta; Di Sanza, Claudio; Martinez-Cristobal, Paula; Bertoncini, Carlos W.; Bryn Fenwick, R.; Frigole-Vivas, Marta; Masin, Marianela; Hunter, Irene; Buzon, Victor et al.
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Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells.

2017-03 | Journal article
DOI: 10.1039/c6cc10287e
PMID: 28218319
Contributors: Gandioso A; Massaguer A; Villegas N; Salvans C; Sánchez D; Brun-Heath I; Marchán V; Orozco M; Terrazas M
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expression.

2016-05 | Journal article
DOI: 10.1093/nar/gkw169
PMID: 26975656
PMC: PMC4872095
Contributors: Terrazas M; Ivani I; Villegas N; Paris C; Salvans C; Brun-Heath I; Orozco M
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells.

2013-09 | Journal article
DOI: 10.1016/j.stem.2013.06.002
PMID: 23850244
Contributors: Habibi E; Brinkman AB; Arand J; Kroeze LI; Kerstens HH; Matarese F; Lepikhov K; Gut M; Brun-Heath I; Hubner NC et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

2012-11 | Journal article
DOI: 10.1038/ng.2443
PMID: 23064414
Contributors: Kulis M; Heath S; Bibikova M; Queirós AC; Navarro A; Clot G; Martínez-Trillos A; Castellano G; Brun-Heath I; Pinyol M et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Hyperphosphatasia With Seizures, Neurologic Deficit, and Characteristic Facial Features: Five New Patients With Mabry Syndrome (vol 152A, pg 1661, 2010)

American Journal of Medical Genetics Part A
2011 | Journal article
DOI: 10.1002/AJMG.A.33680
WOSUID: WOS:000290716700044
Contributors: Thompson, Miles D.; Nezarati, Marjan M.; Gillessen-Kaesbach, Gabriele; Meinecke, Peter; Mendoza-Londono, Roberto; Mornet, Etienne; Brun-Heath, Isabelle; Squarcioni, Catherine Prost; Legeai-Mallet, Laurence; Munnich, Arnold et al.
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Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues.

2011-03 | Journal article
DOI: 10.1007/s00441-010-1111-4
PMID: 21191615
Contributors: Brun-Heath I; Ermonval M; Chabrol E; Xiao J; Palkovits M; Lyck R; Miller F; Couraud PO; Mornet E; Fonta C
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

A sequence variation in the promoter of the placental alkaline phosphatase gene (ALPP) is associated with allele-specific expression in human term placenta.

2010-09 | Journal article
DOI: 10.1016/j.placenta.2010.06.012
PMID: 20663553
Contributors: Bellazi L; Germond S; Dupont C; Brun-Heath I; Taillandier A; De Mazancourt P; Dieudonné MN; Mornet E
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Hyperphosphatasia with seizures, neurologic deficit, and characteristic facial features: Five new patients with Mabry syndrome.

2010-07 | Journal article
DOI: 10.1002/ajmg.a.33438
PMID: 20578257
Contributors: Thompson MD; Nezarati MM; Gillessen-Kaesbach G; Meinecke P; Mendoza-Londono R; Mornet E; Brun-Heath I; Squarcioni CP; Legeai-Mallet L; Munnich A et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Mild forms of hypophosphatasia mostly result from dominant negative effect of severe alleles or from compound heterozygosity for severe and moderate alleles.

2009 | Journal article
DOI: 10.1186/1471-2350-10-51
PMID: 19500388
PMC: PMC2702372
Contributors: Fauvert D; Brun-Heath I; Lia-Baldini AS; Bellazi L; Taillandier A; Serre JL; de Mazancourt P; Mornet E
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Infantile hypophosphatasia due to a new compound heterozygous TNSALP mutation - functional evidence for a hydrophobic side-chain?

2009-01 | Journal article
DOI: 10.1055/s-2008-1073157
PMID: 18523927
Contributors: Utsch B; Brun-Heath I; Staatz G; Gravou-Apostolatou C; Karle S; Jacobs U; Ludwig M; Zenker M; Dörr HG; Rascher W et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Hypophosphatasia: molecular testing of 19 prenatal cases and discussion about genetic counseling.

2008-11 | Journal article
DOI: 10.1002/pd.2088
PMID: 18925618
Contributors: Simon-Bouy B; Taillandier A; Fauvert D; Brun-Heath I; Serre JL; Armengod CG; Bialer MG; Mathieu M; Cousin J; Chitayat D et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

A new mechanism of dominance in hypophosphatasia: the mutated protein can disturb the cell localization of the wild-type protein.

2008-05 | Journal article
DOI: 10.1007/s00439-008-0480-1
PMID: 18340466
Contributors: Lia-Baldini AS; Brun-Heath I; Carrion C; Simon-Bouy B; Serre JL; Nunes ME; Mornet E
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

A case of lethal hypophosphatasia providing new insights into the perinatal benign form of hypophosphatasia and expression of the ALPL gene.

2008-03 | Journal article
DOI: 10.1111/j.1399-0004.2007.00902.x
PMID: 17922851
Contributors: Brun-Heath I; Chabrol E; Fox M; Drexler K; Petit C; Taillandier A; De Mazancourt P; Serre JL; Mornet E
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Delayed transport of tissue-nonspecific alkaline phosphatase with missense mutations causing hypophosphatasia.

2007 | Journal article
DOI: 10.1016/j.ejmg.2007.06.005
PMID: 17719863
Contributors: Brun-Heath I; Lia-Baldini AS; Maillard S; Taillandier A; Utsch B; Nunes ME; Serre JL; Mornet E
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Characterization of missense mutations and large deletions in the ALPL gene by sequencing and quantitative multiplex PCR of short fragments.

2006 | Journal article
DOI: 10.1089/gte.2006.10.252
PMID: 17253930
Contributors: Spentchian M; Brun-Heath I; Taillandier A; Fauvert D; Serre JL; Simon-Bouy B; Carvalho F; Grochova I; Mehta SG; Müller G et al.
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Childhood hypophosphatasia due to a de novo missense mutation in the tissue-nonspecific alkaline phosphatase gene.

2005-04 | Journal article
DOI: 10.1210/jc.2004-1456
PMID: 15671102
Contributors: Taillandier A; Sallinen SL; Brun-Heath I; De Mazancourt P; Serre JL; Mornet E
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Characterization of 11 novel mutations in the tissue non-specific alkaline phosphatase gene responsible for hypophosphatasia and genotype-phenotype correlations.

2005-03 | Journal article
DOI: 10.1016/j.ymgme.2004.11.003
PMID: 15694177
Contributors: Brun-Heath I; Taillandier A; Serre JL; Mornet E
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Dual role of the C34 subunit of RNA polymerase III in transcription initiation.

1997-09 | Journal article
DOI: 10.1093/emboj/16.18.5730
PMID: 9312031
PMC: PMC1170204
Contributors: Brun I; Sentenac A; Werner M
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Mutations in the alpha-amanitin conserved domain of the largest subunit of yeast RNA polymerase III affect pausing, RNA cleavage and transcriptional transitions.

1996-02 | Journal article
PMID: 8599945
PMC: PMC449980
Contributors: Thuillier V; Brun I; Sentenac A; Werner M
Source: Self-asserted source
Isabelle Brun-Heath via Europe PubMed Central

Peer review (2 reviews for 2 publications/grants)

Review activity for International journal of molecular sciences. (1)
Review activity for PloS one. (1)
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