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Loop profile: 558740
Scopus Author ID: 36006806600

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Employment (4)

University of Veterinary Medicine Hannover, Foundation: Hanover, DE

2019-01-01 to present | Senior Research Scientist & Project lead (Research Centre for Emerging infections and Zoonoses)
Employment
Source: Self-asserted source
Chittappen K Prajeeth

Medizinische Hochschule Hannover: Hannover, Niedersachsen, DE

2011-04 to 2018-12-31 | Postdoc (Neurology)
Employment
Source: Self-asserted source
Chittappen K Prajeeth

Universitätsklinikum Erlangen: Erlangen, Bayern, DE

2008-11-01 to 2011-03-31 | Postdoc (Institute for Clinical Microbiology, Immunology and Hygiene)
Employment
Source: Self-asserted source
Chittappen K Prajeeth

Centre for Cellular and Molecular Biology CSIR: Hyderabad, Telangana, IN

2003-09 to 2004-07 | Junior Research fellow
Employment
Source: Self-asserted source
Chittappen K Prajeeth

Education and qualifications (3)

Medizinische Hochschule Hannover: Hannover, Niedersachsen, DE

2004-10-01 to 2008-06-06 | Ph.D (Clinical Immunology)
Education
Source: Self-asserted source
Chittappen K Prajeeth

Madurai Kamaraj University: Madurai, Tamil Nadu, IN

2001-08-01 to 2003-07-01 | M.Sc (School of Biotechnology)
Education
Source: Self-asserted source
Chittappen K Prajeeth

Osmania University: Hyderabad, Telangana, IN

1997-07 to 2000-05 | B.Sc (Microbiology)
Education
Source: Self-asserted source
Chittappen K Prajeeth

Works (32)

Impact of Tick-Borne Orthoflaviviruses Infection on Compact Human Brain Endothelial Barrier

International Journal of Molecular Sciences
2025-03-06 | Journal article
DOI: 10.3390/ijms26052342
Contributors: Felix Schweitzer; Tamás Letoha; Albert Osterhaus; Chittappen Kandiyil Prajeeth
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Crossref
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Immune correlates of protection of the four-segmented Rift Valley fever virus candidate vaccine in mice

Emerging Microbes & Infections
2024-12-31 | Journal article
DOI: 10.1080/22221751.2024.2373313
Contributors: Chittappen K. Prajeeth; Isabel Zdora; Giulietta Saletti; Julia Friese; Thomas Gerlach; Lucas Wilken; Jana Beicht; Mareike Kubinski; Christina Puff; Wolfgang Baumgärtner et al.
Source: check_circle
Crossref

Immunity to Tick-Borne Encephalitis Virus NS3 Protein Induced with a Recombinant Modified Vaccinia Virus Ankara Fails to Afford Mice Protection against TBEV Infection

Vaccines
2024-01-20 | Journal article
DOI: 10.3390/vaccines12010105
Contributors: Mareike Kubinski; Jana Beicht; Thomas Gerlach; Amare Aregay; Albert D. M. E. Osterhaus; Alina Tscherne; Gerd Sutter; Chittappen Kandiyil Prajeeth; Guus F. Rimmelzwaan
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Crossref
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Rift Valley Fever Virus—Infection, Pathogenesis and Host Immune Responses

Pathogens
2023-09-19 | Journal article
DOI: 10.3390/pathogens12091174
Contributors: Niranjana Nair; Albert D. M. E. Osterhaus; Guus F. Rimmelzwaan; Chittappen Kandiyil Prajeeth
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Crossref
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Recombinant Modified Vaccinia Virus Ankara Expressing a Glycosylation Mutant of Dengue Virus NS1 Induces Specific Antibody and T-Cell Responses in Mice

Vaccines
2023-03-23 | Journal article
DOI: 10.3390/vaccines11040714
Contributors: Lucas Wilken; Sonja Stelz; Ayse Agac; Gerd Sutter; Chittappen Kandiyil Prajeeth; Guus F. Rimmelzwaan
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Crossref
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Transient Blockade of Type I Interferon Signalling Promotes Replication of Dengue Virus Strain D2Y98P in Adult Wild-Type Mice

Viruses
2023-03-23 | Journal article
DOI: 10.3390/v15040814
Contributors: Lucas Wilken; Sonja Stelz; Chittappen Kandiyil Prajeeth; Guus F. Rimmelzwaan
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Crossref
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Cross-reactive antibodies against Langat virus protect mice from lethal tick-borne encephalitis virus infection

Frontiers in Immunology
2023-02-28 | Journal article
DOI: 10.3389/fimmu.2023.1134371
Part of ISSN: 1664-3224
Contributors: Mareike Kubinski; Jana Beicht; Isabel Zdora; Giulietta Saletti; Magdalena Kircher; Monique Petry-Gusmag; Imke Steffen; Christina Puff; Klaus Jung; Wolfgang Baumgärtner et al.
Source: Self-asserted source
Chittappen K Prajeeth

Intact Type I Interferon Receptor Signaling Prevents Hepatocellular Necrosis but Not Encephalitis in a Dose-Dependent Manner in Rift Valley Fever Virus Infected Mice

International Journal of Molecular Sciences
2022-10 | Journal article | Author
DOI: 10.3390/ijms232012492
Contributors: Lukas Mathias Michaely; Lukas Schuwerk; Lisa Allnoch; Kathleen Schön; Inken Waltl; Pia-Katharina Larsen; Andreas Pavlou; Chittappen K Prajeeth; Guus Rimmelzwaan; Stefanie C. Becker et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Sequential MAVS and MyD88/TRIF signaling triggers anti‐viral responses of tick‐borne encephalitis virus‐infected murine astrocytes

Journal of Neuroscience Research
2021-10 | Journal article
DOI: 10.1002/jnr.24923
Part of ISSN: 0360-4012
Part of ISSN: 1097-4547
Contributors: Chittappen K Prajeeth; Luca Ghita; Veronika Breitkopf; Felix Mulenge; Andreas Pavlou; Olivia Luise Gern; Verónica Durán; Chittappen Kandiyil Prajeeth; Moritz Kohls; Klaus Jung et al.
Source: Self-asserted source
Chittappen K Prajeeth

Immunity to TBEV Related Flaviviruses with Reduced Pathogenicity Protects Mice from Disease but Not from TBEV Entry into the CNS

Vaccines
2021-02 | Journal article | Author
DOI: 10.3390/vaccines9030196
Contributors: Monique Petry-Gusmag; Martin Palus; Eva Leitzen; Johanna Gracia Mitterreiter; Bei Huang; Andrea Kröger; Verjans G.M.G.M.; Wolfgang Baumgärtner; Guus Rimmelzwaan; Daniel Ruzek et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Polarized microglia do not influence oligodendrocyte lineage cells via astrocytes

International Journal of Developmental Neuroscience
2019-10 | Journal article
DOI: 10.1016/j.ijdevneu.2019.01.006
Part of ISSN: 0736-5748
Source: Self-asserted source
Chittappen K Prajeeth

Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes

Brain Sciences
2019-09-19 | Journal article
DOI: 10.3390/brainsci9090241
Part of ISSN: 2076-3425
Source: Self-asserted source
Chittappen K Prajeeth

Fumaric Acids Directly Influence Gene Expression of Neuroprotective Factors in Rodent Microglia

International Journal of Molecular Sciences
2019-01-15 | Journal article
DOI: 10.3390/ijms20020325
Part of ISSN: 1422-0067
Source: Self-asserted source
Chittappen K Prajeeth

Regulation of neuroinflammatory properties of glial cells by T cell effector molecules

Neural Regeneration Research
2018 | Journal article
DOI: 10.4103/1673-5374.226385
EID:

2-s2.0-85051870949
Contributors: Prajeeth, C.K.; Huehn, J.; Stangel, M.
Source: Self-asserted source
Chittappen K Prajeeth via Scopus - Elsevier

Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

Cell Reports
2018 | Journal article
DOI: 10.1016/j.celrep.2018.09.003
EID:

2-s2.0-85053902255
Contributors: Chhatbar, C.; Detje, C.N.; Grabski, E.; Borst, K.; Spanier, J.; Ghita, L.; Elliott, D.A.; Jordão, M.J.C.; Mueller, N.; Sutton, J. et al.
Source: Self-asserted source
Chittappen K Prajeeth via Scopus - Elsevier

IFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes

Frontiers in Cellular Neuroscience
2018-10-10 | Journal article
DOI: 10.3389/fncel.2018.00352
Part of ISSN: 1662-5102
Contributors: Chittappen K Prajeeth; Chittappen K. Prajeeth; Oliver Dittrich-Breiholz; Steven R. Talbot; Philippe A. Robert; Jochen Huehn; Martin Stangel
Source: Self-asserted source
Chittappen K Prajeeth

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

Journal of Neuroinflammation
2017 | Journal article
DOI: 10.1186/s12974-017-0978-3
EID:

2-s2.0-85031502518
Contributors: Prajeeth, C.K.; Kronisch, J.; Khorooshi, R.; Knier, B.; Toft-Hansen, H.; Gudi, V.; Floess, S.; Huehn, J.; Owens, T.; Korn, T. et al.
Source: Self-asserted source
Chittappen K Prajeeth via Scopus - Elsevier

Astrocytes Enhance Streptococcus suis-Glial Cell Interaction in Primary Astrocyte-Microglial Cell Co-Cultures.

2016 | Journal article
DOI: 10.3390/pathogens5020043
PMID: 27304968
PMC: PMC4931394
Contributors: Seele J; Nau R; Prajeeth CK; Stangel M; Valentin-Weigand P; Seitz M
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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In vitro evaluation of physiologically relevant concentrations of teriflunomide on activation and proliferation of primary rodent microglia

Journal of Neuroinflammation
2016 | Journal article
DOI: 10.1186/s12974-016-0715-3
EID:

2-s2.0-84995545944
Contributors: Wostradowski, T.; Prajeeth, C.K.; Gudi, V.; Kronenberg, J.; Witte, S.; Brieskorn, M.; Stangel, M.
Source: Self-asserted source
Chittappen K Prajeeth via Scopus - Elsevier

The antiviral drug ganciclovir does not inhibit microglial proliferation and activation.

2015 | Journal article
DOI: 10.1038/srep14935
PMID: 26447351
PMC: PMC4597339
Contributors: Skripuletz T; Salinas Tejedor L; Prajeeth CK; Hansmann F; Chhatbar C; Kucman V; Zhang N; Raddatz BB; Detje CN; Sühs KW et al.
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
grade
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Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system.

2015-11 | Journal article
DOI: 10.1016/j.bbi.2015.06.024
PMID: 26140734
Contributors: Salinas Tejedor L; Berner G; Jacobsen K; Gudi V; Jungwirth N; Hansmann F; Gingele S; Prajeeth CK; Baumgärtner W; Hoffmann A et al.
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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Effect of FTY720-phosphate on the expression of inflammation-associated molecules in astrocytes in vitro.

2015-10 | Journal article
DOI: 10.3892/mmr.2015.4120
PMID: 26239526
Contributors: Janssen S; Schlegel C; Gudi V; Prajeeth CK; Skripuletz T; Trebst C; Stangel M
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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Upon intranasal vesicular stomatitis virus infection, astrocytes in the olfactory bulb are important interferon Beta producers that protect from lethal encephalitis.

2015-03 | Journal article
DOI: 10.1128/jvi.02044-14
PMID: 25540366
PMC: PMC4325722
Contributors: Detje CN; Lienenklaus S; Chhatbar C; Spanier J; Prajeeth CK; Soldner C; Tovey MG; Schlüter D; Weiss S; Stangel M et al.
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.

2014 | Journal article
DOI: 10.1186/s12974-014-0180-9
PMID: 25391297
PMC: PMC4236492
Contributors: Prajeeth CK; Beineke A; Iskandar CD; Gudi V; Herder V; Gerhauser I; Haist V; Teich R; Huehn J; Baumgärtner W et al.
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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A pivotal role of nonmuscle myosin II during microglial activation.

2014-11 | Journal article
DOI: 10.1016/j.expneurol.2014.08.010
PMID: 25150163
Contributors: Janßen S; Gudi V; Prajeeth CK; Singh V; Stahl K; Heckers S; Skripuletz T; Pul R; Trebst C; Tsiavaliaris G et al.
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
grade
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Long-term impact of neonatal inflammation on demyelination and remyelination in the central nervous system.

2014-10 | Journal article
DOI: 10.1002/glia.22706
PMID: 24909143
Contributors: Bénardais K; Gudi V; Gai L; Neßler J; Singh V; Prajeeth CK; Skripuletz T; Stangel M
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia.

2014-03 | Journal article
DOI: 10.1016/j.bbi.2014.01.001
PMID: 24412213
Contributors: Prajeeth CK; Löhr K; Floess S; Zimmermann J; Ulrich R; Gudi V; Beineke A; Baumgärtner W; Müller M; Huehn J et al.
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
grade
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Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination.

2013 | Journal article
DOI: 10.1371/journal.pone.0069795
PMID: 23922802
PMC: PMC3724887
Contributors: Nessler J; Bénardais K; Gudi V; Hoffmann A; Salinas Tejedor L; Janßen S; Prajeeth CK; Baumgärtner W; Kavelaars A; Heijnen CJ et al.
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
grade
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Quantification of microglial phagocytosis by a flow cytometer-based assay

Microglia
2013 | Book chapter
Part of DOI: doi: 10.1007/978-1-62703-520-0_14.
Source: Self-asserted source
Chittappen K Prajeeth

2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells.

2013-08 | Journal article
DOI: 10.1111/cei.12109
PMID: 23607690
Contributors: Singh V; Prajeeth CK; Gudi V; Bénardais K; Voss EV; Stangel M
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity.

2011-07 | Journal article
DOI: 10.1128/iai.00079-11
PMID: 21518784
PMC: PMC3191990
Contributors: Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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The synthetic TLR2 agonist BPPcysMPEG leads to efficient cross-priming against co-administered and linked antigens.

2010-05 | Journal article
DOI: 10.1002/eji.200939790
PMID: 20213735
Contributors: Prajeeth CK; Jirmo AC; Krishnaswamy JK; Ebensen T; Guzman CA; Weiss S; Constabel H; Schmidt RE; Behrens GM
Source: Self-asserted source
Chittappen K Prajeeth via Europe PubMed Central
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Peer review (3 reviews for 2 publications/grants)

Review activity for Journal of virological methods. (2)
Review activity for One health outlook. (1)
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