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Works (28)

Harnessing droplet microfluidics and morphology-based deep learning for the label-free study of polymicrobial-phage interactions

2025-03-24 | Preprint
DOI: 10.1101/2025.03.24.644924
Contributors: Anuj Tiwari; An Mei Daniels; Robyn Manley; Fabrice Gielen
Source: check_circle
Crossref

Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2

Proceedings of the National Academy of Sciences
2023-09-26 | Journal article
DOI: 10.1073/pnas.2217612120
Contributors: Sally Rogers; Chengting Zhang; Vasilis Anagnostidis; Corin Liddle; Melissa L. Fishel; Fabrice Gielen; Steffen Scholpp
Source: check_circle
Crossref

Investigating bacteria-phage interaction dynamics using droplet-based technology

2023-07-14 | Preprint
DOI: 10.1101/2023.07.14.549014
Contributors: Nela Nikolic; Vasileios Anagnostidis; Anuj Tiwari; Remy Chait; Fabrice Gielen
Source: check_circle
Crossref

Label-free analysis of bacterial growth and lysis at the single-cell level using droplet microfluidics and object detection-oriented deep learning

2023-06-27 | Preprint
DOI: 10.1101/2023.06.27.546533
Contributors: Anuj Tiwari; Nela Nikolic; Vasileios Anagnostidis; Fabrice Gielen
Source: check_circle
Crossref

Materials and methods for droplet microfluidic device fabrication

Lab on a Chip
2022 | Journal article
DOI: 10.1039/d1lc00836f
Part of ISSN: 1473-0197
Part of ISSN: 1473-0189
Contributors: Fabrice Gielen
Source: Self-asserted source
Fabrice Gielen
grade
Preferred source (of 2)‎

High-Throughput Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform

Analytical Chemistry
2022-12-06 | Journal article
DOI: 10.1021/acs.analchem.2c03164
Contributors: Stefanie Neun; Liisa van Vliet; Florian Hollfelder; Fabrice Gielen
Source: check_circle
Crossref

Phenotyping single-cell motility in microfluidic confinement

eLife
2022-11-23 | Journal article
DOI: 10.7554/eLife.76519
Contributors: Samuel A Bentley; Hannah Laeverenz-Schlogelhofer; Vasileios Anagnostidis; Jan Cammann; Marco G Mazza; Fabrice Gielen; Kirsty Y Wan
Source: check_circle
Crossref

High throughput steady-state enzyme kinetics measured in a parallel droplet generation and absorbance detection platform

2022-07-31 | Preprint
DOI: 10.1101/2022.07.28.500969
Contributors: Stefanie Neun; Liisa van Vliet; Florian Hollfelder; Fabrice Gielen
Source: check_circle
Crossref

Multi‐Object Detector YOLOv4‐Tiny Enables High‐Throughput Combinatorial and Spatially‐Resolved Sorting of Cells in Microdroplets

Advanced Materials Technologies
2022-05 | Journal article
DOI: 10.1002/admt.202101053
Part of ISSN: 2365-709X
Part of ISSN: 2365-709X
Contributors: Fabrice Gielen
Source: Self-asserted source
Fabrice Gielen
grade
Preferred source (of 2)‎

Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats

Proceedings of the National Academy of Sciences
2021-11-16 | Journal article
DOI: 10.1073/pnas.2017708118
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Fabrice Gielen
Source: Self-asserted source
Fabrice Gielen

Functional Phenotype Flow Cytometry: On Chip Sorting of Individual Cells According to Responses to Stimuli

Advanced Biology
2021-08 | Journal article
DOI: 10.1002/adbi.202100220
Part of ISSN: 2701-0198
Part of ISSN: 2701-0198
Contributors: Fabrice Gielen
Source: Self-asserted source
Fabrice Gielen

Deep learning guided image-based droplet sorting for on-demand selection and analysis of single cells and 3D cell cultures

Lab on a Chip
2020 | Journal article
DOI: 10.1039/d0lc00055h
Part of ISSN: 1473-0197
Part of ISSN: 1473-0189
Contributors: Fabrice Gielen
Source: Self-asserted source
Fabrice Gielen
grade
Preferred source (of 2)‎

Controlled Oil/Water Partitioning of Hydrophobic Substrates Extending the Bioanalytical Applications of Droplet-Based Microfluidics

Analytical Chemistry
2019-07-10 | Journal article
DOI: 10.1021/acs.analchem.9b01839
Part of ISSN: 0003-2700
Part of ISSN: 1520-6882
Source: Self-asserted source
Fabrice Gielen
grade
Preferred source (of 2)‎

Long‐Term Perfusion Culture of Monoclonal Embryonic Stem Cells in 3D Hydrogel Beads for Continuous Optical Analysis of Differentiation

Small
2019-02 | Journal article
DOI: 10.1002/smll.201804576
Part of ISSN: 1613-6810
Part of ISSN: 1613-6829
Source: Self-asserted source
Fabrice Gielen

Ultrahigh-Throughput Screening of Single-Cell Lysates for Directed Evolution and Functional Metagenomics

Methods in Molecular Biology
2018 | Book chapter
DOI: 10.1007/978-1-4939-7366-8_18
Part of ISBN: 9781493973644
Part of ISBN: 9781493973668
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Fabrice Gielen

Exploring sequence space in search of functional enzymes using microfluidic droplets

Current Opinion in Chemical Biology
2017 | Journal article
DOI: 10.1016/j.cbpa.2017.02.018
WOSUID:

WOS:000401782100020
Contributors: Mair, P.; Gielen, F.; Hollfelder, F.
Source: Self-asserted source
Fabrice Gielen via ResearcherID
grade
Preferred source (of 2)‎

Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets

Analytical Chemistry
2017 | Journal article
DOI: 10.1021/acs.analchem.6b02528
WOSUID:

WOS:000392458100012
Contributors: Gielen, F.; Butz, M.; Rees, E. J.; Erdelyi, M.; Moschetti, T.; Hyvonen, M.; Edel, J. B.; Kaminski, C. F.; Hollfelder, F.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)

Proceedings of the National Academy of Sciences
2016 | Journal article
DOI: 10.1073/pnas.1606927113
WOSUID:

WOS:000388830700007
Contributors: Gielen, Fabrice; Hours, Raphaelle; Emond, Stephane; Fischlechner, Martin; Schell, Ursula; Hollfelder, Florian
Source: Self-asserted source
Fabrice Gielen via ResearcherID

A Method to Quantify FRET Stoichiometry with Phasor Plot Analysis and Acceptor Lifetime Ingrowth

Biophysical Journal
2015 | Journal article
DOI: 10.1016/j.bpj.2015.01.012
WOSUID:

WOS:000350969000002
Contributors: Chen, W. Y.; Avezov, E.; Schlachter, S. C.; Gielen, F.; Laine, R. F.; Harding, H. P.; Hollfelder, F.; Ron, D.; Kaminski, C. F.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Interfacing Microwells with Nanoliter Compartments: A Sampler Generating High-Resolution Concentration Gradients for Quantitative Biochemical Analyses in Droplets

Analytical Chemistry
2015 | Journal article
DOI: 10.1021/ac503336g
WOSUID:

WOS:000347590400064
Contributors: Gielen, F.; Buryska, T.; Van Vliet, L.; Butz, M.; Damborsky, J.; Prokop, Z.; Hollfelder, F.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics

Nature Communications
2015 | Journal article
DOI: 10.1038/ncomms10008
WOSUID:

WOS:000367567100003
Contributors: Colin, P. Y.; Kintses, B.; Gielen, F.; Miton, C. M.; Fischer, G.; Mohamed, M. F.; Hyvonen, M.; Morgavi, D. P.; Janssen, D. B.; Hollfelder, F.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

A Fully Unsupervised Compartment-on-Demand Platform for Precise Nanoliter Assays of Time-Dependent Steady-State Enzyme Kinetics and Inhibition

Analytical Chemistry
2013 | Journal article
DOI: 10.1021/ac400480z
WOSUID:

WOS:000318756100077
Contributors: Gielen, F.; van Vliet, L.; Koprowski, B. T.; Devenish, S. R. A.; Fischlechner, M.; Edel, J. B.; Niu, X. Z.; deMello, A. J.; Hollfelder, F.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Controlled one dimensional oscillation of the Belousov-Zhabotinsky reaction confined within microchannels

Rsc Advances
2012 | Journal article
DOI: 10.1039/c2ra21019c
WOSUID:

WOS:000306415100007
Contributors: Hassan, S. U.; Gielen, F.; Niu, X. Z.; Edel, J. B.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Dielectric Cell Response in Highly Conductive Buffers

Analytical Chemistry
2012 | Journal article
DOI: 10.1021/ac2022103
WOSUID:

WOS:000300470800009
Contributors: Gielen, F.; Demello, A. J.; Edel, J. B.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

A Microdroplet Dilutor for High-Throughput Screening

Nature Chemistry
2011 | Journal article
DOI: 10.1038/nchem.1046
WOSUID:

WOS:000290846300009
Contributors: Niu, X. Z.; Gielen, F.; Edel, J. B.; deMello, A. J.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

High-Resolution Local Imaging of Temperature in Dielectrophoretic Platforms

Analytical Chemistry
2010 | Journal article
DOI: 10.1021/ac101557g
WOSUID:

WOS:000281306000064
Contributors: Gielen, F.; Pereira, F.; deMello, A. J.; Edel, J. B.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Electro-Coalescence of Digitally Controlled Droplets

Analytical Chemistry
2009 | Journal article
DOI: 10.1021/ac901188n
WOSUID:

WOS:000269312000029
Contributors: Niu, X. Z.; Gielen, F.; deMello, A. J.; Edel, J. B.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Increasing the Trapping Efficiency of Particles in Microfluidic Planar Platforms by Means of Negative Dielectrophoresis

Journal of Physical Chemistry B
2009 | Journal article
DOI: 10.1021/jp808897g
WOSUID:

WOS:000262902600033
Contributors: Gielen, F.; deMello, A. J.; Cass, T.; Edel, J. B.
Source: Self-asserted source
Fabrice Gielen via ResearcherID

Peer review (5 reviews for 4 publications/grants)

Review activity for ACS sensors. (1)
Review activity for Analytical chemistry. (2)
Review activity for Communications biology. (1)
Review activity for Nature nanotechnology (1)
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