Personal information

Keywords

CRISPR/Cas9, Genome Editing, Chromatin, Non-coding RNA

Countries

United Kingdom

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Employment (1)

Wellcome Trust Sanger Institute: Cambridge, Cambridgeshire, GB

2016-05-02 to present | Head of Research (Cellular Operations) (Cellular Operations)
Employment
Source: Self-asserted source
Andrew Bassett

Works (46)

Optimisation of Xenium automated in situ sequencing for PAXgene-fixed tissue samples

2025-02-12 | Preprint
DOI: 10.1101/2025.02.11.637091
Contributors: Kenny Roberts; Andrew R. Bassett
Source: check_circle
Crossref

ONE-STEP tagging: a versatile method for rapid site-specific integration by simultaneous reagent delivery

2024-08-29 | Preprint
DOI: 10.1101/2024.08.29.610246
Contributors: Valentina Migliori; Michaela B. Bruntraeger; Ivan S. Guylev; Thomas Burgold; Florence Lichou; Andrew L. Trinh; Sam J. Washer; Carla P Jones; Gosia Trynka; Andrew R. Bassett
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Crossref

Dynein and dynactin move long-range but are delivered separately to the axon tip

Journal of Cell Biology
2024-05-06 | Journal article
DOI: 10.1083/jcb.202309084
Contributors: Alexander D. Fellows; Michaela Bruntraeger; Thomas Burgold; Andrew R. Bassett; Andrew P. Carter
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Crossref

scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics

Genome Biology
2024-01-15 | Journal article
DOI: 10.1186/s13059-024-03169-y
Contributors: Sarah E. Cooper; Matthew A. Coelho; Magdalena E. Strauss; Aleksander M. Gontarczyk; Qianxin Wu; Mathew J. Garnett; John C. Marioni; Andrew R. Bassett
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Crossref

An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial function

2023-11-06 | Preprint
DOI: 10.1101/2023.11.04.565613
Contributors: Erica Bello; Kathleen Long; Sho Iwama; Juliette Steer; Sarah Cooper; Kaur Alasoo; Natsuhiko Kumasaka; Jeremy Schwartzentruber; Nikolaos I Panousis; Andrew Bassett
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Crossref

Screening for functional regulatory variants in open chromatin using GenIE-ATAC

Nucleic Acids Research
2023-06-23 | Journal article
DOI: 10.1093/nar/gkad332
Contributors: Sarah Cooper; Jeremy Schwartzentruber; Eve L Coomber; Qianxin Wu; Andrew Bassett
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Crossref

High-throughput phenotyping of single nucleotide variants by linking transcriptomes to genotypes in single cells

2023-05-24 | Preprint
DOI: 10.1101/2023.05.22.541777
Contributors: Sarah E. Cooper; Matthew A. Coelho; Magdalena E. Strauss; Aleksander M. Gontarczyk; Qianxin Wu; Mathew J. Garnett; John C. Marioni; Andrew R. Bassett
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Crossref

DNA methylation can alter CRISPR/Cas9 editing frequency and DNA repair outcome in a target‐specific manner

New Phytologist
2022-09 | Journal article
DOI: 10.1111/nph.18212
Contributors: Adéla Přibylová; Lukáš Fischer; Douglas E. Pyott; Andrew Bassett; Attila Molnar
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Crossref

Screening for functional regulatory variants in open chromatin using GenIE-ATAC

2022-02-10 | Preprint
DOI: 10.1101/2022.02.09.479775
Contributors: Sarah Cooper; Jeremy Schwartzentruber; Eve L Coomber; Qianxin Wu; Andrew Bassett
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Crossref

The RAD51 recombinase protects mitotic chromatin in human cells

Nature Communications
2021-09-10 | Journal article
DOI: 10.1038/s41467-021-25643-y
Contributors: Isabel E. Wassing; Emily Graham; Xanita Saayman; Lucia Rampazzo; Christine Ralf; Andrew Bassett; Fumiko Esashi
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Crossref

Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells

International Journal of Molecular Sciences
2021-02-20 | Journal article
DOI: 10.3390/ijms22042092
Contributors: Ana Artero-Castro; Kathleen Long; Andrew Bassett; Almudena Ávila-Fernandez; Marta Cortón; Antonio Vidal-Puig; Pavla Jendelova; Francisco Rodriguez-Jimenez; Eleonora Clemente; Carmen Ayuso et al.
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Crossref
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INSIGHT: A population-scale COVID-19 testing strategy combining point-of-care diagnosis with centralized high-throughput sequencing

Science Advances
2021-02-12 | Journal article
DOI: 10.1126/sciadv.abe5054
Contributors: Qianxin Wu; Chenqu Suo; Tom Brown; Tengyao Wang; Sarah A. Teichmann; Andrew R. Bassett
Source: check_circle
Crossref

Screening for functional transcriptional and splicing regulatory variants with GenIE

Nucleic Acids Research
2020-12-16 | Journal article
DOI: 10.1093/nar/gkaa960
Contributors: Sarah E Cooper; Jeremy Schwartzentruber; Erica Bello; Eve L Coomber; Andrew R Bassett
Source: check_circle
Crossref

Single-Cell Transcriptomics of Parkinson’s Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses

Cell Reports
2020-10 | Journal article
DOI: 10.1016/j.celrep.2020.108263
Contributors: Hugo J.R. Fernandes; Nikolaos Patikas; Stefanie Foskolou; Sarah F. Field; Jong-Eun Park; Meg L. Byrne; Andrew R. Bassett; Emmanouil Metzakopian
Source: check_circle
Crossref

INSIGHT: a population scale COVID-19 testing strategy combining point-of-care diagnosis with centralised high-throughput sequencing

2020-06-02 | Preprint
DOI: 10.1101/2020.06.01.127019
Contributors: Qianxin Wu; Chenqu Suo; Tom Brown; Tengyao Wang; Sarah A. Teichmann; Andrew R. Bassett
Source: check_circle
Crossref

The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

PLOS Genetics
2019-12-27 | Journal article
DOI: 10.1371/journal.pgen.1008501
Contributors: Elizabeth A. Coe; Hans Widlund; Jennifer Y. Tan; Michael Shapiro; Pakavarin Louphrasitthiphol; Andrew R. Bassett; Ana C. Marques; Colin R. Goding; Keith W. Vance
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Crossref

The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons

Human Molecular Genetics
2019-02-15 | Journal article
DOI: 10.1093/hmg/ddy370
Contributors: Mattéa J Finelli; Davide Aprile; Enrico Castroflorio; Alexander Jeans; Matteo Moschetta; Lauren Chessum; Matteo T Degiacomi; Julia Grasegger; Alexis Lupien-Meilleur; Andrew Bassett et al.
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Crossref

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

Nature communications
2017-12 | Journal article
DOI: 10.1038/s41467-017-00686-2
PMID: 29235467
PMC: PMC5727397
Contributors: Wu Q; Ferry QRV; Baeumler TA; Michaels YS; Vitsios DM; Habib O; Arnold R; Jiang X; Maio S; Steinkraus BR et al.
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.

Human molecular genetics
2017-11 | Journal article
DOI: 10.1093/hmg/ddx331
PMID: 28973645
Contributors: Heman-Ackah SM; Manzano R; Hoozemans JJM; Scheper W; Flynn R; Haerty W; Cowley SA; Bassett AR; Wood MJA
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Epigenetic and Genetic Contributions to Adaptation in Chlamydomonas.

Molecular biology and evolution
2017-09 | Journal article
DOI: 10.1093/molbev/msx166
PMID: 28535256
Contributors: Kronholm I; Bassett A; Baulcombe D; Collins S
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Editing the genome of hiPSC with CRISPR/Cas9: disease models.

Mammalian genome : official journal of the International Mammalian Genome Society
2017-08 | Journal article
DOI: 10.1007/s00335-017-9684-9
PMID: 28303292
PMC: PMC5569153
Contributors: Bassett AR
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.

Development (Cambridge, England)
2017-08 | Journal article
DOI: 10.1242/dev.150227
PMID: 28694258
Contributors: Hachem A; Godwin J; Ruas M; Lee HC; Ferrer Buitrago M; Ardestani G; Bassett A; Fox S; Navarrete F; de Sutter P et al.
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons.

2016 | Journal article
PMID: 27341390
PMC: PMC4920027
Contributors: Heman-Ackah SM; Bassett AR; Wood MJ
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

Nature communications
2016-11 | Journal article
DOI: 10.1038/ncomms13661
PMID: 27892467
PMC: PMC5133711
Contributors: Cooper S; Grijzenhout A; Underwood E; Ancelin K; Zhang T; Nesterova TB; Anil-Kirmizitas B; Bassett A; Kooistra SM; Agger K et al.
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Most microRNAs in the single-cell alga Chlamydomonas reinhardtii are produced by Dicer-like 3-mediated cleavage of introns and untranslated regions of coding RNAs.

2016-04 | Journal article
PMID: 26968199
PMC: PMC4817775
Contributors: Valli AA; Santos BA; Hnatova S; Bassett AR; Molnar A; Chung BY; Baulcombe DC
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

A genome-wide CRISPR library for high-throughput genetic screening in Drosophila cells.

2015-06 | Journal article
PMID: 26165496
PMC: PMC4508376
Contributors: Bassett AR; Kong L; Liu JL
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Considerations when investigating lncRNA function in vivo.

2014 | Journal article
PMID: 25124674
PMC: PMC4132285
Contributors: Bassett AR; Akhtar A; Barlow DP; Bird AP; Brockdorff N; Duboule D; Ephrussi A; Ferguson-Smith AC; Gingeras TR; Haerty W et al.
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9.

2014 | Journal article
PMID: 24326186
PMC: PMC3892159
Contributors: Bassett AR; Tibbit C; Ponting CP; Liu JL
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.

2014 | Journal article
PMID: 25135198
PMC: PMC4143950
Contributors: Bassett AR; Azzam G; Wheatley L; Tibbit C; Rajakumar T; McGowan S; Stanger N; Ewels PA; Taylor S; Ponting CP et al.
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

CRISPR/Cas9 mediated genome engineering in Drosophila

Methods
2014-09 | Journal article
DOI: 10.1016/j.ymeth.2014.02.019
Source: check_circle
Crossref

CRISPR/Cas9 mediated genome engineering in Drosophila.

2014-09 | Journal article
PMID: 24576617
Contributors: Bassett A; Liu JL
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System.

Cell reports
2014-03 | Journal article
DOI: 10.1016/j.celrep.2014.03.017
PMID: 28898684
PMC: PMC5638937
Contributors: Bassett AR; Tibbit C; Ponting CP; Liu JL
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

CRISPR/Cas9 and genome editing in Drosophila.

2014-01 | Journal article
PMID: 24480743
Contributors: Bassett AR; Liu JL
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system.

2013-07 | Journal article
PMID: 23827738
PMC: PMC3714591
Contributors: Bassett AR; Tibbit C; Ponting CP; Liu JL
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome.

2012 | Journal article
PMID: 22403033
PMC: PMC3342871
Contributors: Young RS; Marques AC; Tibbit C; Haerty W; Bassett AR; Liu JL; Ponting CP
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Extraordinary transgressive phenotypes of hybrid tomato are influenced by epigenetics and small silencing RNAs.

2012-01 | Journal article
PMID: 22179699
PMC: PMC3261569
Contributors: Shivaprasad PV; Dunn RM; Santos BA; Bassett A; Baulcombe DC
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Mobile 24 nt small RNAs direct transcriptional gene silencing in the root meristems of Arabidopsis thaliana.

2011-10 | Journal article
PMID: 21962713
Contributors: Melnyk CW; Molnar A; Bassett A; Baulcombe DC
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD.

2010-11 | Journal article
PMID: 20733004
PMC: PMC2953047
Contributors: Reddy BA; Bajpe PK; Bassett A; Moshkin YM; Kozhevnikova E; Bezstarosti K; Demmers JA; Travers AA; Verrijzer CP
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Small silencing RNAs in plants are mobile and direct epigenetic modification in recipient cells.

2010-05 | Journal article
PMID: 20413459
Contributors: Molnar A; Melnyk CW; Bassett A; Hardcastle TJ; Dunn R; Baulcombe DC
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Highly specific gene silencing by artificial microRNAs in the unicellular alga Chlamydomonas reinhardtii.

2009-04 | Journal article
PMID: 19054357
Contributors: Molnar A; Bassett A; Thuenemann E; Schwach F; Karkare S; Ossowski S; Weigel D; Baulcombe D
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

The folding and unfolding of eukaryotic chromatin.

2009-04 | Journal article
PMID: 19346124
Contributors: Bassett A; Cooper S; Wu C; Travers A
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

The chromatin remodelling factor dATRX is involved in heterochromatin formation.

2008 | Journal article
PMID: 18461125
PMC: PMC2324200
Contributors: Bassett AR; Cooper SE; Ragab A; Travers AA
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack.

2008-03 | Journal article
PMID: 18160715
PMC: PMC2258761
Contributors: Bajpe PK; van der Knaap JA; Demmers JA; Bezstarosti K; Bassett A; van Beusekom HM; Travers AA; Verrijzer CP
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

A variable topology for the 30-nm chromatin fibre.

2007-12 | Journal article
PMID: 18059311
PMC: PMC2267236
Contributors: Wu C; Bassett A; Travers A
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation.

2004-08 | Journal article
PMID: 15306652
Contributors: Dallman JE; Allopenna J; Bassett A; Travers A; Mandel G
Source: Self-asserted source
Andrew Bassett via Europe PubMed Central

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes.

Journal article
DOI: 10.1038/s41588-020-00776-w
PMID: 33589840
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EMBL-EBI

Peer review (2 reviews for 1 publication/grant)

Review activity for PLoS biology. (2)
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