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Malaria, Vaccines, Plasmodium, Parasitology, Infection
Portugal, United Kingdom, Netherlands

Biography

Miguel Prudêncio graduated in Biochemistry by the Faculty of Sciences of the University of Lisbon in 1993 and completed his PhD on Biochemistry by the University of East Anglia in 2000, followed by a post-doctoral period at the University of Leiden. During this period, he worked on metalloprotein characterization and protein-protein interactions. In 2004, he shifted his research focus to the field of malaria and became a post-doc in Maria Mota’s research group, initially at Instituto Gulbenkian de Ciência and later at Instituto de Medicina Molecular (iMM). In 2008 he became a Staff Scientist of iMM’s Malaria Unit, and in July 2013, he became a fully independent Group Leader at iMM, heading the Prudêncio lab. He was appointed Invited Associate Professor of the Faculdade de Medicina da Universidade de Lisboa in March 2019.

Miguel’s research interests are focused on the investigation of Plasmodium liver stages and on the exploitation of their potential for anti-malarial intervention. His research program includes the analysis of nutrient acquisition by hepatic Plasmodium parasites, the survey of novel parasite-host interactions, the study of Plasmodium-Trypanosoma co-infections, the identification of new anti-malarial compounds and the development of a new vaccination strategy against malaria, a project funded by the Bill and Melinda Gates Foundation and the Malaria Vaccine Initiative.

Miguel is the author of over 120 scientific articles in international peer-reviewed journals, having earned several scientific and innovation prizes, and is an inventor of several patents. He regularly lectures at undergraduate and graduate courses in various Faculties. He is a founding member the iMM Lisboa spin-off company RoPlaVac. He has had numerous media appearances in relation to his research work in the malaria field or to the public understanding of science.

As the COVID-19 pandemic emerged, Miguel was involved in setting up iMM’s Task Force for SARS-CoV-2 diagnostics. He has a keen interest on COVID-19 vaccination and has addressed this issue on multiple occasions in webinars and in the media.

Activities

Funding (26)

Whole-organism vaccines against P. falciparum and P. vivax malaria with enhanced efficacy and scope

2021-11-01 to 2024-10-31 | Grant
Caixa d'Estalvis i Pensions de Barcelona (Barcelona, ES)
GRANT_NUMBER:

HR21-848

Source: check_circle
CIÊNCIAVITAE

AMAZING – toxinas de serpentes da AMAZónia: INvestiGação na valorização de biorrecursos

2020-09-01 to 2024-02-29 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

CIRCNA/BRB/0281/2019

Source: check_circle
CIÊNCIAVITAE

Generation, characterization and in vivo evaluation of a novel live malaria vaccine

2019-12 to present | Contract
GSK Tres Cantos Open Lab Foundation (Madrid, ES)
GRANT_NUMBER:

TCOLF/2019

Source: check_circle
CIÊNCIAVITAE

Development and enablement of enhanced whole-sporozoite malaria vaccines

2019-03-01 to 2025-02-28 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

CEECIND/03539/2017/CP1396/CT0009

Source: check_circle
CIÊNCIAVITAE

Uma estratégia multialvo para atuar em todas as fases do ciclo de vida do Plasmodium

2018-10-01 to 2021-09-30 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/MED-QUI/30021/2017

Source: check_circle
CIÊNCIAVITAE

Enabling strategies for enhanced whole-sporozoite malaria vaccines / Estratégias para o desenvolvimento e melhoramento de vacinas de organismo inteiro contra a malária

2018-07-01 to present | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/SAU-INF/29550/2017

Source: check_circle
CIÊNCIAVITAE

A multitarget strategy to hit all stages of the Plasmodium life-cycle

2018 to 2021 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC_MED-QUI_30021_2017

Source: check_circle
CIÊNCIAVITAE

Enabling strategies for enhanced whole-sporozoite malaria vaccines

2018 to 2021 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

02/SAICT72017

Source: check_circle
CIÊNCIAVITAE

Production and maintenance of Plasmodium-infected mosquitoes

2017 to 2019 | Contract
Merck Biopharma Deutschland (Darmstadt, DE)
GRANT_NUMBER:

Pf

Source: check_circle
CIÊNCIAVITAE

A P. berghei-based vaccine against Malaria

2017 to 2018 | Contract
PATH Malaria Vaccine Initiative (Washington, US)
GRANT_NUMBER:

PbVac-II

Source: check_circle
CIÊNCIAVITAE

Improving whole organism vaccines against malaria by genetic modification / Melhoramento de vacinas de organismo inteiro contra a malária por modificação genética

2016-07-01 to 2019-12-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BBB-BMD/2695/2014

Source: check_circle
CIÊNCIAVITAE

3D hepatic cell models of Plasmodium infection

2016 to 2018 | Contract
Merck Biopharma Deutschland (Darmstadt, DE)
GRANT_NUMBER:

3DHep

Source: check_circle
CIÊNCIAVITAE

A P. berghei-based vaccine against Malaria

2015 to 2017 | Contract
PATH Malaria Vaccine Initiative (Washington, US)
GRANT_NUMBER:

PbVac

Source: check_circle
CIÊNCIAVITAE

A P. berghei-based vaccine against Malaria / Uma vacina contra a malária baseada em P. berghei

2015 to 2017 | Contract
PATH Malaria Vaccine Initiative (Washington, US)
GRANT_NUMBER:

PbVAC pre-clinical studies

Source: check_circle
CIÊNCIAVITAE

Improving whole organism vaccines against malaria by genetic modification

2014-06 to 2019 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDCMHC-CED26952014

Source: check_circle
CIÊNCIAVITAE

A new whole-organism vaccine against Malaria - Phase II / / Uma nove estratégia de vacinação contra a Malária - Fase II

2013 to 2017 | Contract
Bill & Melinda Gates Foundation (Seattle, US)
GRANT_NUMBER:

GCE OPP1025634

Source: check_circle
CIÊNCIAVITAE

Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle

2012-03 to 2015-08 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
Source: check_circle
CIÊNCIAVITAE

Utilization of host cell resources by the malaria parasite in the liver / Utilização dos recursos da célula hospedeira pelo parasita da malária no fígado

2012-01-01 to 2015-06-30 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/SAU-MIC/117060/2010

Source: check_circle
CIÊNCIAVITAE

Utilization of host cell resources by the malaria parasite in the liver

2012-01 to 2015-06 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
Source: check_circle
CIÊNCIAVITAE

Projecto Estratégico - LA 5 - 2011-2012

2011-01-01 to 2013-02-17 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PEst-OE/SAU/LA0005/2011

Source: check_circle
CIÊNCIAVITAE

New drugs for treating and eradicating malaria

2010-04 to 2013-09 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
Source: check_circle
CIÊNCIAVITAE

The influence of bile acids on malaria liver infection

2010-02-01 to 2013-07-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/SAU-MII/099118/2008

Source: check_circle
CIÊNCIAVITAE

The influence of bile acids on malaria liver infection

2010-02 to 2013-07 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
Source: check_circle
CIÊNCIAVITAE

The role of SR-BI in malaria infection

2008-03-01 to 2011-12-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BIA-BCM/71920/2006

Source: check_circle
CIÊNCIAVITAE

The role of SR-BI in malaria infection

2008-03 to 2011-12 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
Source: check_circle
CIÊNCIAVITAE

Nanodiagnostics: gold-nanoprobes for molecular recognition - application to DNA adducts detection; pathogen detection; gene expression and RNA quantification

2007-09-05 to 2011-02-28 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/SAU-BEB/66511/2006

Source: check_circle
CIÊNCIAVITAE