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https://www.rockefeller.edu/our-scientists/heads-of-laboratories/1163-jeffrey-m-friedman/

Keywords

leptin obesity

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United States

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Works (38)

On the causes of obesity and its treatment: The end of the beginning

Cell Metabolism
2025-03 | Journal article
DOI: 10.1016/j.cmet.2025.01.026
Contributors: Jeffrey M. Friedman
Source: check_circle
Crossref

A subcortical feeding circuit linking an interoceptive node to jaw movement

Nature
2024-12-05 | Journal article
DOI: 10.1038/s41586-024-08098-1
Contributors: Christin Kosse; Jessica Ivanov; Zachary Knight; Kyle Pellegrino; Jeffrey Friedman
Source: check_circle
Crossref

The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity

Proceedings of the National Academy of Sciences
2024-09-24 | Journal article
DOI: 10.1073/pnas.2415550121
Contributors: Jeffrey M. Friedman
Source: check_circle
Crossref

Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Science
2024-04-19 | Journal article
DOI: 10.1126/science.adk6742
Contributors: Bowen Tan; Caleb J. Browne; Tobias Nöbauer; Alipasha Vaziri; Jeffrey M. Friedman; Eric J. Nestler
Source: check_circle
Crossref

Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake

2024-01-26 | Preprint
DOI: 10.1101/2024.01.25.577315
Contributors: Han Tan; Luping Yin; Yuqi Tan; Jessica Ivanov; Kaja Plucinska; Anoj Ilanges; Brian R. Herb; Putianqi Wang; Christin Kosse; Paul Cohen et al.
Source: Self-asserted source
Jeffrey M. Friedman

Seeking satiety: From signals to solutions.

Science translational medicine
2023-11-22 | Journal article | Author
DOI: 10.1126/scitranslmed.adh4453
PMID: 37992155
Contributors: Matthias Tschoep; Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman
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A Simple Subcortical Feeding Circuit Linking Interoceptive Inputs to Consummatory Behavior

2023-10-11 | Preprint
DOI: 10.1101/2023.10.11.561735
Contributors: Christin Kosse; Jessica Ivanov; Zachary Knight; Kyle Pellegrino; Jeffrey Friedman
Source: Self-asserted source
Jeffrey M. Friedman

Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

2023-09-05 | Preprint
DOI: 10.1101/2023.09.03.556059
Contributors: Bowen Tan; Caleb Browne; Tobias Nöbauer; Alipasha Vaziri; Jeffrey M. Friedman; Eric J. Nestler
Source: Self-asserted source
Jeffrey M. Friedman

Cellular and molecular basis of leptin resistance

2023-08-26 | Preprint
DOI: 10.1101/2023.08.24.554526
Contributors: Bowen Tan; Kristina Hedbacker; Leah Kelly; Zhaoyue Zhang; Ji-Dung Luo; Joshua D. Rabinowitz; Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman

Magnetogenetic cell activation using endogenous ferritin

2023-06-20 | Preprint
DOI: 10.1101/2023.06.20.545120
Contributors: Lisa Pomeranz; Rosemary Li; Xiaofei Yu; Leah Kelly; Gholamreza Hassanzadeh; Henrik Molina; Daniel Gross; Matthew Brier; George Vaisey; Putianqi Wang et al.
Source: Self-asserted source
Jeffrey M. Friedman

FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system.

Cell metabolism
2023-03-01 | Journal article
DOI: 10.1016/j.cmet.2023.02.005
PMID: 36889282
PMC: PMC10009780
Contributors: Choi M; Schneeberger M; Fan W; Bugde A; Gautron L; Kevin Vale; Hammer RE; Zhang Y; Friedman JM; Mangelsdorf DJ et al.
Source: Self-asserted source
Jeffrey M. Friedman

Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction.

Nature metabolism
2022-11-21 | Journal article | Author
DOI: 10.1038/s42255-022-00677-8
PMID: 36411386
PMC: PMC9684079
Contributors: Schneeberger M; Brice NL; Pellegrino K; Parolari L; Shaked JT; Page KJ; Marchildon F; Barrows DW; Carroll TS; Topilko T et al.
Source: Self-asserted source
Jeffrey M. Friedman

Dynamic processing of hunger and thirst by common mesolimbic neural ensembles.

Proceedings of the National Academy of Sciences of the United States of America
2022-10-17 | Journal article | Author
DOI: 10.1073/pnas.2211688119
PMID: 36252036
PMC: PMC9618039
Contributors: Bowen Tan; Tobias Nöbauer; Browne CJ; Nestler EJ; Vaziri A; Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman
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Brainstem ADCYAP1<sup>+</sup> neurons control multiple aspects of sickness behaviour.

Nature
2022-09-07 | Journal article | Author
DOI: 10.1038/s41586-022-05161-7
PMID: 36071158
PMC: PMC9492535
Contributors: Ilanges A; Shiao R; Jordan Shaked; Ji-Dung Luo; Xiaofei Yu; Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman
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FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons

2022-08-11 | Preprint
DOI: 10.1101/2022.08.09.502667
Contributors: Mihwa Choi; Marc Schneeberger; Wei Fan; Abhijit Bugde; Laurent Gautron; Kevin Vale; Yuan Zhang; Jeffrey M. Friedman; David J. Mangelsdorf; Steven A. Kliewer
Source: check_circle
Crossref

Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure.

The Journal of clinical investigation
2021-12-01 | Journal article
DOI: 10.1172/jci151976
PMID: 34673574
PMC: PMC8670849
Contributors: Ortuño MJ; Schneeberger M; Ilanges A; Francois Marchildon; Kyle Pellegrino; Friedman JM; Patricia Ducy
Source: Self-asserted source
Jeffrey M. Friedman

How the discovery of microbial opsins led to the development of optogenetics.

Cell
2021-09-24 | Journal article
DOI: 10.1016/j.cell.2021.08.022
PMID: 34562360
Contributors: Friedman JM
Source: Self-asserted source
Jeffrey M. Friedman

The genetic structure of the Turkish population reveals high levels of variation and admixture.

Proceedings of the National Academy of Sciences of the United States of America
2021-09-01 | Journal article | Author
DOI: 10.1073/pnas.2026076118
PMID: 34426522
PMC: PMC8433500
Contributors: Meltem Ece Kars; Ayşe Nazlı Başak; onat oe; Bilguvar K; Jungmin Choi; Itan Y; caner caglar; Palvadeau R; Jean-Laurent Casanova; David N. Cooper et al.
Source: Self-asserted source
Jeffrey M. Friedman

Higher-Order Inputs Involved in Appetite Control.

Biological psychiatry
2021-07-24 | Journal article | Author
DOI: 10.1016/j.biopsych.2021.07.015
PMID: 34593204
PMC: PMC9704062
Contributors: Azevedo EP; Violet J Ivan; Jeffrey M. Friedman; Sarah Stern
Source: Self-asserted source
Jeffrey M. Friedman
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Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice.

Molecular psychiatry
2021-06-07 | Journal article | Author
DOI: 10.1038/s41380-021-01162-6
PMID: 34099874
Contributors: Luca Parolari; Marc Schneeberger Pane; Nathaniel Heintz; Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman
grade
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Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.

Genes & development
2021-04-22 | Journal article
DOI: 10.1101/gad.346791.120
PMID: 33888560
PMC: PMC8091968
Contributors: Ito K; Schneeberger M; Alan Gerber; Jishage M; Francois Marchildon; Maganti AV; Cohen P; Friedman JM; Roeder RG
Source: Self-asserted source
Jeffrey M. Friedman

Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons.

Cell metabolism
2021-03-23 | Journal article
DOI: 10.1016/j.cmet.2021.03.001
PMID: 33761312
PMC: PMC8628615
Contributors: Stern SA; Azevedo EP; Pomeranz LE; Doerig KR; Violet J Ivan; Friedman JM
Source: Self-asserted source
Jeffrey M. Friedman

Restriction of food intake by PPP1R17-expressing neurons in the DMH.

Proceedings of the National Academy of Sciences of the United States of America
2021-03-01 | Journal article | Author
DOI: 10.1073/pnas.2100194118
PMID: 33753517
PMC: PMC8020659
Contributors: caner caglar; Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman
grade
Preferred source (of 2)‎

Gut-to-brain signals in feeding control.

American journal of physiology. Endocrinology and metabolism
2020-12-07 | Journal article
DOI: 10.1152/ajpendo.00388.2020
PMID: 33284086
PMC: PMC8260365
Contributors: Moura-Assis, A or Assis, AM; Friedman JM; Velloso LA
Source: Self-asserted source
Jeffrey M. Friedman

A limbic circuit selectively links active escape to food suppression.

eLife
2020-09-07 | Journal article | Author
DOI: 10.7554/elife.58894
PMID: 32894221
PMC: PMC7476759
Contributors: Estefania Azevedo; Bowen Tan; Pomeranz LE; Violet J Ivan; Fetcho R; Schneeberger M; Doerig KR; Liston C; Jeffrey M. Friedman; Sarah Stern
Source: Self-asserted source
Jeffrey M. Friedman
grade
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Uncovering a possible role of reactive oxygen species in magnetogenetics.

Scientific reports
2020-08-04 | Journal article
DOI: 10.1038/s41598-020-70067-1
PMID: 32753716
PMC: PMC7403421
Contributors: Brier MI; Mundell JW; Yu X; Su L; Holmann A; Squeri J; Zhang B; Stanley SA; Friedman JM; Dordick JS
Source: Self-asserted source
Jeffrey M. Friedman

A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue.

Nature
2020-07-22 | Journal article
DOI: 10.1038/s41586-020-2527-y
PMID: 32699414
Contributors: Wang P; Ken H. Loh; Michelle Wu; Donald Morgan; Schneeberger M; Xiaofei Yu; Jingyi Chi; Christin Kosse; Kim D; Kamal Rahmouni et al.
Source: Self-asserted source
Jeffrey M. Friedman

Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2020-07-01 | Journal article
DOI: 10.1002/advs.202000818
PMID: 32832353
PMC: PMC7435230
Contributors: Tao P; Kuang Y; Li Y; Li W; Gao Z; Liu L; Qiang M; Zha Z; Fan K; peixiang ma et al.
Source: Self-asserted source
Jeffrey M. Friedman

Limitation of adipose tissue by the number of embryonic progenitor cells.

eLife
2020-05-26 | Journal article | Author
DOI: 10.7554/elife.53074
PMID: 32452759
PMC: PMC7253174
Contributors: Kristina Hedbacker; Lu YH; Olof Dallner; Zhiying Li; Fayzikhodjaeva G; Kivanc Birsoy; Han C; Yang C; Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman
grade
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Leptin and the endocrine control of energy balance.

Nature metabolism
2019-08-12 | Journal article | Author
DOI: 10.1038/s42255-019-0095-y
PMID: 32694767
Contributors: Jeffrey M. Friedman
Source: Self-asserted source
Jeffrey M. Friedman
grade
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Regulation of Energy Expenditure by Brainstem GABA Neurons.

Cell
2019-06-27 | Journal article
DOI: 10.1016/j.cell.2019.05.048
PMID: 31257028
PMC: PMC7481042
Contributors: Schneeberger M; Parolari L; Das Banerjee T; Varun Bhave; Wang P; Patel B; Thomas TOPILKO; Zhuhao Wu; Chan Hee J. Choi; Xiaofei Yu et al.
Source: Self-asserted source
Jeffrey M. Friedman

Electromagnetic Regulation of Cell Activity.

Cold Spring Harbor perspectives in medicine
2019-05-01 | Journal article
DOI: 10.1101/cshperspect.a034322
PMID: 30249601
PMC: PMC6496334
Contributors: Stanley SA; Friedman JM
Source: Self-asserted source
Jeffrey M. Friedman

A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake.

Neuron
2019-03-28 | Journal article
DOI: 10.1016/j.neuron.2019.03.011
PMID: 30930044
Contributors: Azevedo EP; Pomeranz L; Cheng J; Schneeberger M; Vaughan R; Sarah Stern; Bowen Tan; Katherine Doerig; Greengard P; Friedman JM
Source: Self-asserted source
Jeffrey M. Friedman

Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal.

Proceedings of the National Academy of Sciences of the United States of America
2018-07-02 | Journal article
DOI: 10.1073/pnas.1806123115
PMID: 29967172
PMC: PMC6055192
Contributors: Inna Tabansky; Liang Y; Maya Frankfurt; Daniels MA; Harrigan M; Stern S; Milner TA; Leshan R; Rama R; Moll T et al.
Source: Self-asserted source
Jeffrey M. Friedman

A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass.

Proceedings of the National Academy of Sciences of the United States of America
2018-06-11 | Journal article
DOI: 10.1073/pnas.1806366115
PMID: 29891714
PMC: PMC6042069
Contributors: Yinxin Zhang; Dallner OS; Nakadai T; Fayzikhodjaeva G; Lu YH; Mitchell Lazar; Roeder RG; Friedman JM
Source: Self-asserted source
Jeffrey M. Friedman
grade
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Control of non-homeostatic feeding in sated mice using associative learning of contextual food cues.

Molecular psychiatry
2018-06-06 | Journal article
DOI: 10.1038/s41380-018-0072-y
PMID: 29875477
PMC: PMC6281813
Contributors: Sarah Stern; Katherine Doerig; Azevedo EP; Stoffel E; Friedman JM
Source: Self-asserted source
Jeffrey M. Friedman

Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus.

The European journal of neuroscience
2018-05-23 | Journal article
DOI: 10.1111/ejn.13966
PMID: 29791746
PMC: PMC6251769
Contributors: Cali Calarco; Li Z; Taylor SR; Somin Lee; Wenliang Zhou; Friedman JM; Mineur YS; Cecilia Gotti; Marina Picciotto
Source: Self-asserted source
Jeffrey M. Friedman

Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons.

Molecular metabolism
2018-05-08 | Journal article
DOI: 10.1016/j.molmet.2018.05.001
PMID: 29843980
PMC: PMC6026325
Contributors: Schneeberger M; Tan K; Alexander Nectow; Parolari L; caner caglar; Azevedo E; Li Z; Ana I Domingos; Friedman JM
Source: Self-asserted source
Jeffrey M. Friedman

Peer review (4 reviews for 3 publications/grants)

Review activity for Molecular psychiatry. (2)
Review activity for Nature (1)
Review activity for Science. (1)
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