Personal information

United States

Biography

My goal as a future physician-scientist is to develop computational methods and software focused on extracting clinically actionable information from data sources ranging from high throughput multi-omic experiments to clinical exam medical records. As an undergraduate researcher studying organic synthesis, I never produced enough data to warrant a deep dive into rigorous computational analysis; however, as a post-baccalaureate researcher at the NIH, I found that the application of high-throughput proteomic analysis to a bacterial disease models could produce a significant amount of complex data. Under Dr. Harlan Caldwell’s guidance, I established foundational knowledge of human-microbial interactions through the study Chlamydia trachomatis pathogenesis while gaining deep understanding of how to perform wet lab omic analyses using mass spectrometry. During my three years at the NIH, I first-authored two publications describing a novel C. trachomatis immune avoidance mechanism and performed experiments resulting in the highest proteomic coverage of the organism to date. After departing the NIH, I began my first year as a MD/PhD student at the University of Alabama at Birmingham (UAB) with a desire to learn the informatic expertise required to analyze more complex omic datasets in human disease studies. By the end of my first year of medical school, I realized that my previous experience with high-throughput proteomics at the NIH was pulling me closer to a pursuit of bioinformatics and software development. As a current graduate student, I committed myself to the pursuit of a PhD in biomedical science and informatics. With the mentorship of Dr. William Byrd and Dr. Matthew Might, I am developing a skill-set in programming, data mining and clinical decision support software development at the UAB Precision Medicine Institute.

Activities

Employment (3)

University of Alabama at Birmingham: Birmingham, AL, US

2017-06-01 to present | MD/PhD Candidate (Hugh Kaul Precision Medicine Institute)
Employment
Source: Self-asserted source
Michael Patton

National Institutes of Health: Bethesda, MD, US

2014-06-18 to 2017-05-17 | Post-Baccalaureate Researcher (National Institutes of Health Intramural Training Research Award (IRTA) Researcher)
Employment
Source: Self-asserted source
Michael Patton

United States-India Educational Foundation: Chennai , Tamil Nadu, IN

2013-06-10 to 2014-04-30 | Fulbright Scholar (Fulbright Association)
Employment
Source: Self-asserted source
Michael Patton

Education and qualifications (2)

University of Alabama School of Medicine: Birmingham, AL, US

2017-06-10 to present | MD-PhD, (MSTP 2nd Year) (Medicine)
Education
Source: Self-asserted source
Michael Patton

Occidental College: Los Angeles, CA, US

2009-08-01 to 2013-05-17 | BA, Cum Laude, Honors in Chemistry (Chemistry Major)
Education
Source: Self-asserted source
Michael Patton

Works (8)

Circulating SARS-CoV-2+ Megakaryocytes Associate with Severe Viral Infection in COVID-19.

Blood Advances
2023-03 | Journal article
Contributors: Fortmann, Seth D; Patton, Michael; Frey, Blake F; Tipper, Jennifer L; Reddy, Sivani B; Vieira, Cristiano P; Hanumanthu, Vidya Sagar; Sterrett, Sarah; Floyd, Jason L; Prasad, Ram et al.
Source: Self-asserted source
Michael Patton

COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation.

Critical Care
2023-01 | Journal article
Part of ISSN: 1364-8535
Contributors: Patton, Michael John; Orihuela, Carlos J; Harrod, Kevin S; Bhuiyan, Mohammad A N; Dominic, Paari; Kevil, Christopher G; Fort, Daniel; Liu, Vincent X; Farhat, Maha; Koff, Jonathan L et al.
Source: Self-asserted source
Michael Patton

The precision medicine process for treating rare disease using the artificial intelligence tool mediKanren.

Frontiers in Artificial Intelligence
2022-09 | Journal article
Part of ISSN: 2624-8212
Contributors: Foksinska, Aleks; ra; Crowder, Camerron M; Crouse, Andrew B; Henrikson, Jeff; Byrd, William E; Rosenblatt, Gregory; Patton, Michael J; He, Kaiwen; Tran-Nguyen, Thi K et al.
Source: Self-asserted source
Michael Patton

Plasma Microbiome in COVID-19 Subjects: An Indicator of Gut Barrier Defects and Dysbiosis.

International Journal of Molecular Sciences
2022-08 | Journal article
Contributors: Prasad, Ram; Patton, Michael John; Floyd, Jason Levi; Fortmann, Seth; DuPont, Mariana; Harbour, Angela; Wright, Justin; Lamendella, Regina; Stevens, Bruce R; Oudit, Gavin Y et al.
Source: Self-asserted source
Michael Patton

Chlamydia trachomatis Lipopolysaccharide Evades the Canonical and Noncanonical Inflammatory Pathways To Subvert Innate Immunity

mBio
2019-04-23 | Journal article
Part of ISSN: 2150-7511
Source: Self-asserted source
Michael Patton

Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive Chlamydia trachomatis Biovars.

mBio
2018-01 | Journal article
Contributors: Patton MJ; Chen CY; Yang C; McCorrister S; Grant C; Westmacott G; Yuan XY; Ochoa E; Fariss R; Whitmire WM et al.
Source: Self-asserted source
Michael Patton via Europe PubMed Central

Chlamydia trachomatis ChxR is a transcriptional regulator of virulence factors that function in in vivo host-pathogen interactions.

Pathogens and disease
2017-04 | Journal article
Contributors: Yang C; Kari L; Sturdevant GL; Song L; Patton MJ; Couch CE; Ilgenfritz JM; Southern TR; Whitmire WM; Briones M et al.
Source: Self-asserted source
Michael Patton via Europe PubMed Central

Chlamydial Protease-Like Activity Factor and Type III Secreted Effectors Cooperate in Inhibition of p65 Nuclear Translocation.

mBio
2016-09 | Journal article
Contributors: Patton MJ; McCorrister S; Grant C; Westmacott G; Fariss R; Hu P; Zhao K; Blake M; Whitmire B; Yang C et al.
Source: Self-asserted source
Michael Patton via Europe PubMed Central