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Works (13)

Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis

ACS Central Science
2024-05-22 | Journal article
DOI: 10.1021/acscentsci.4c00125
Contributors: Vishav Sharma; Dmytro Fedoseyenko; Sumedh Joshi; Sameh Abdelwahed; Tadhg P. Begley
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Alkylcysteine Sulfoxide C–S Monooxygenase Uses a Flavin-Dependent Pummerer Rearrangement

Journal of the American Chemical Society
2023-06-07 | Journal article
DOI: 10.1021/jacs.3c03545
Contributors: Sohan Hazra; Tadhg P. Begley
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Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in Candida albicans

Journal of the American Chemical Society
2023-03-01 | Journal article
DOI: 10.1021/jacs.2c08560
Contributors: Anushree Mondal; Rung-Yi Lai; Dmytro Fedoseyenko; Nitai Giri; Tadhg P. Begley
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Mechanistic Studies on the Single-Turnover Yeast Thiamin Pyrimidine Synthase: Characterization of the Inactive Enzyme

Journal of the American Chemical Society
2022-06-22 | Journal article
DOI: 10.1021/jacs.2c03322
Contributors: Rung-Yi Lai; Anushree Mondal; Dmytro Fedoseyenko; Tadhg P. Begley
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Cysteine Dealkylation in Bacillus subtilis by a Novel Flavin-Dependent Monooxygenase

Biochemistry
2022-06-07 | Journal article
DOI: 10.1021/acs.biochem.2c00020
Contributors: Sohan Hazra; Dhananjay M. Bhandari; Kalyanaraman Krishnamoorthy; Agnieszka Sekowska; Antoine Danchin; Tadhg P. Begley
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Menaquinone Biosynthesis: The Mechanism of 5,8-Dihydroxy-2-naphthoate Synthase (MqnD)

Biochemistry
2021-06-29 | Journal article
DOI: 10.1021/acs.biochem.1c00257
Contributors: Hannah R. Manion-Sommerhalter; Dmytro Fedoseyenko; Sumedh Joshi; Tadhg P. Begley
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Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction

Biochemistry
2021-06-01 | Journal article
DOI: 10.1021/acs.biochem.1c00181
Contributors: Sumedh Joshi; Dmytro Fedoseyenko; Vishav Sharma; Mark A. Nesbit; R. David Britt; Tadhg P. Begley
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Radical SAM Enzyme HydE Generates Adenosylated Fe(I) Intermediates En Route to the [FeFe]-Hydrogenase Catalytic H-Cluster

Journal of the American Chemical Society
2020-06-17 | Journal article
DOI: 10.1021/jacs.0c03802
Contributors: Lizhi Tao; Scott A. Pattenaude; Sumedh Joshi; Tadhg P. Begley; Thomas B. Rauchfuss; R. David Britt
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Mechanistic Studies on CysS – A Vitamin B12-Dependent Radical SAM Methyltransferase Involved in the Biosynthesis of the tert-Butyl Group of Cystobactamid

Journal of the American Chemical Society
2020-06-03 | Journal article
DOI: 10.1021/jacs.9b06454
Contributors: Yuanyou Wang; Tadhg P. Begley
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Trapping and Electron Paramagnetic Resonance Characterization of the 5′dAdo• Radical in a Radical S-Adenosyl Methionine Enzyme Reaction with a Non-Native Substrate

ACS Central Science
2019-11-27 | Journal article
DOI: 10.1021/acscentsci.9b00706
Contributors: Richard I. Sayler; Troy A. Stich; Sumedh Joshi; Nicole Cooper; Jared T. Shaw; Tadhg P. Begley; Dean J. Tantillo; R. David Britt
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Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase

Biochemistry
2019-04-09 | Journal article
DOI: 10.1021/acs.biochem.9b00105
Contributors: Nilkamal Mahanta; Katherine A. Hicks; Saad Naseem; Yang Zhang; Dmytro Fedoseyenko; Steven E. Ealick; Tadhg P. Begley
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Novel enzymology in futalosine-dependent menaquinone biosynthesis

Current Opinion in Chemical Biology
2018-12 | Journal article
DOI: 10.1016/j.cbpa.2018.09.015
Contributors: Sumedh Joshi; Dmytro Fedoseyenko; Nilkamal Mahanta; Hannah Manion; Saad Naseem; Tohru Dairi; Tadhg P Begley
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Tryptophan Lyase (NosL): A Cornucopia of 5′-Deoxyadenosyl Radical Mediated Transformations

Journal of the American Chemical Society
2016-12-21 | Journal article
DOI: 10.1021/jacs.6b06139
Contributors: Dhananjay M. Bhandari; Dmytro Fedoseyenko; Tadhg P. Begley
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Peer review (37 reviews for 5 publications/grants)

Review activity for ACS catalysis. (1)
Review activity for Biochemistry. (9)
Review activity for Journal of natural products. (1)
Review activity for Journal of the American Chemical Society. (21)
Review activity for Organic letters. (5)
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