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Biography

My research career started as a research assistant in IPMB and learned basic molecular biology techniques (1986). My PhD work is focused on regulatory sequences for two classes of potato sucrose synthase genes finding the important regulatory roles of their long leader introns (1995). I started to work on plant ubiquitin proteasome field as a postdoc and started to functionally annotate all proteasome subunits and identified the first binding site on RPN10 for the ubiquitinated proteasome substrates (1998). After joining IPMB, I continued to work on and complete the functional annotation of all proteasome subunits. I then started to map subunit interactions of the 26S proteasome and to characterize major ubiquitin receptors biochemically and functionally and extend my studies to the recently identified OTU deubiquitinases focusing on OTU5 and a K11 linkage-specific E2 UBC22.

Activities

Employment (4)

Academia Sinica: Taipei, Taipei, TW

2002-10 to 2022 | Associate Research Fellow (Institute of Plant and Microbial Biology)
Employment
Source: Self-asserted source
Hongyong Fu

Academia Sinica: Taipei, TW

2019-10 to 2021-09 | Deputy Director (Institute of Plant and Microbial Biology)
Employment
Source: Self-asserted source
Hongyong Fu

Academia Sinica: Taipei, TW

1998-07 to 2002-10 | Assistant Research Fellow (Institute of Plant and Microbial Biology)
Employment
Source: Self-asserted source
Hongyong Fu

University of Wisconsin-Madison: Madison, Wisconsin, US

1996-01 to 1998-07 | Postdoctoral Research
Employment
Source: Self-asserted source
Hongyong Fu

Education and qualifications (2)

Texas A&M University: College Station, TX, US

1988-09 to 1995-05 | PhD (Biology)
Education
Source: Self-asserted source
Hongyong Fu

National Taiwan University: Taipei, TW

1981-09 to 1984-06 | BSc (Agronomy)
Education
Source: Self-asserted source
Hongyong Fu

Professional activities (1)

Academia Sinica: Taipei, TW

2019-10 to 2021-09 | Deputy Director (Institute of Plant and Microbial Biology)
Service
Source: Self-asserted source
Hongyong Fu

Works (37)

The Structural Role of RPN10 in the 26S Proteasome and an RPN2-Binding Residue on RPN13 Are Functionally Important in Arabidopsis

International Journal of Molecular Sciences
2024-10 | Journal article | Author
Contributors: Shih-Yun Lin; Ya-Ling Lin; Raju Usharani; Ramalingam Radjacommare; Hongyong Fu
Source: check_circle
Multidisciplinary Digital Publishing Institute

Stabilization of HSA32, an aggregation-prone protein, by the protein disaggregase HSP101 plays a critical role in maintaining acquired thermotolerance in Arabidopsis

2024-10-17 | Preprint
Contributors: Suma Mitra; Shih-Jiun Yu; Nai-Yu Liu; Chuan-Chih Hsu; Hong-Yi Li; Akankshita Borah; Yu-Yen Shen; Shang-hao Wu; Yang-Hsin Hsu; Hongyong Fu et al.
Source: check_circle
Crossref

The Arabidopsis Deubiquitylase OTU5 Suppresses Flowering by Histone Modification-Mediated Activation of the Major Flowering Repressors <i>FLC</i>, <i>MAF4</i>, and <i>MAF5</i>

International Journal of Molecular Sciences
2023-03 | Journal article | Author
Contributors: Ramalingam Radjacommare; Shih-Yun Lin; Raju Usharani; Wen-Dar Lin; Guang-Yuh Jauh; Wolfgang Schmidt; Hongyong Fu
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

The Deubiquitinase OTU5 Regulates Root Responses to Phosphate Starvation

Plant Physiology
2018-03 | Journal article
Part of ISSN: 0032-0889
Part of ISSN: 1532-2548
Source: Self-asserted source
Hongyong Fu

Deubiquitinating Enzyme OTU5 Contributes to DNA Methylation Patterns and Is Critical for Phosphate Nutrition Signals

Plant Physiology
2017-12 | Journal article
Part of ISSN: 0032-0889
Part of ISSN: 1532-2548
Source: Self-asserted source
Hongyong Fu

Reversible ubiquitylation in plant biology

Frontiers in Plant Science
2014-12-10 | Other
Part of ISSN: 1664-462X
Source: Self-asserted source
Hongyong Fu

Distinct phylogenetic relationships and biochemical properties of Arabidopsis ovarian tumor-related deubiquitinases support their functional differentiation

Frontiers in Plant Science
2014-03-12 | Journal article
Part of ISSN: 1664-462X
Source: Self-asserted source
Hongyong Fu

IRT1 DEGRADATION FACTOR1, a RING E3 Ubiquitin Ligase, Regulates the Degradation of IRON-REGULATED TRANSPORTER1 in <i>Arabidopsis</i>

The Plant Cell
2013-08 | Journal article
Part of ISSN: 1040-4651
Part of ISSN: 1532-298X
Source: Self-asserted source
Hongyong Fu

In vivo relevance of substrate recognition function of major Arabidopsis ubiquitin receptors

Plant Signaling &amp; Behavior
2012-07 | Journal article
Part of ISSN: 1559-2324
Source: Self-asserted source
Hongyong Fu

The Defective Proteasome but Not Substrate Recognition Function Is Responsible for the Null Phenotypes of the <i>Arabidopsis</i> Proteasome Subunit RPN10

The Plant Cell
2011-07 | Journal article
Part of ISSN: 1040-4651
Part of ISSN: 1532-298X
Source: Self-asserted source
Hongyong Fu

Proteasomal recognition of ubiquitylated substrates

Trends in Plant Science
2010-07 | Review
Part of ISSN: 1360-1385
Source: Self-asserted source
Hongyong Fu

The RAD23 Family Provides an Essential Connection between the 26S Proteasome and Ubiquitylated Proteins in<i>Arabidopsis</i> 

The Plant Cell
2010-03-03 | Journal article
Part of ISSN: 1532-298X
Part of ISSN: 1040-4651
Source: Self-asserted source
Hongyong Fu

Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis

FEBS Journal
2010-02 | Journal article
Part of ISSN: 1742-464X
Source: Self-asserted source
Hongyong Fu

Pollen-Specific SKP1-Like Proteins are Components of Functional SCF Complexes and Essential for Lily Pollen Tube Elongation

Plant and Cell Physiology
2009-08 | Journal article
Part of ISSN: 1471-9053
Part of ISSN: 0032-0781
Source: Self-asserted source
Hongyong Fu

Generation and analyses of the transgenic potatoes expressing heterologous thermostable β-amylase

Plant Science
2008-06 | Journal article
Part of ISSN: 0168-9452
Source: Self-asserted source
Hongyong Fu

Abscisic acid-inducible nuclear proteins bind to bipartite promoter elements required for ABA response and embryo-regulated expression of the carrot Dc3 gene

Planta
2005-01 | Journal article
Part of ISSN: 0032-0935
Part of ISSN: 1432-2048
Source: Self-asserted source
Hongyong Fu

Purification of the Arabidopsis 26 S Proteasome

Journal of Biological Chemistry
2004-02 | Journal article
Part of ISSN: 0021-9258
Source: Self-asserted source
Hongyong Fu

Monomeric NarB Is a Dual-Affinity Nitrate Reductase, and Its Activity Is Regulated Differently from That of Nitrate Uptake in the Unicellular Diazotrophic Cyanobacterium <i>Synechococcus</i> sp. Strain RF-1

Journal of Bacteriology
2003-10 | Journal article
Part of ISSN: 0021-9193
Part of ISSN: 1098-5530
Source: Self-asserted source
Hongyong Fu

Molecular cloning of the carboxylesterase gene and biochemical characterization of the encoded protein from Pseudomonas citronellolis ATCC 13674

Research in Microbiology
2003-09 | Journal article
Part of ISSN: 0923-2508
Source: Self-asserted source
Hongyong Fu

Construction and characterization of thermo-inducible vectors derived from heat-sensitivelacI genes in combination with the T7 A1 promoter

Biotechnology and Bioengineering
2002-07-05 | Journal article
Part of ISSN: 0006-3592
Part of ISSN: 1097-0290
Source: Self-asserted source
Hongyong Fu

Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome

The EMBO Journal
2001-12-17 | Journal article
Part of ISSN: 1460-2075
Source: Self-asserted source
Hongyong Fu

Potato and Tomato Forever Young Genes Contain class-I Patatin promoter-like Sequences

Botanical Bulletin of Academia Sinica
2001-10-01 | Journal article
Source: Self-asserted source
Hongyong Fu

Overproduction of d -hydantoinase and carbamoylase in a soluble form in Escherichia coli

Applied Microbiology and Biotechnology
2000-09-15 | Journal article
Part of ISSN: 0175-7598
Part of ISSN: 1432-0614
Source: Self-asserted source
Hongyong Fu

Functional Analysis of the Proteasome Regulatory Particle

Molecular Biology Reports
1999 | Review
Part of ISSN: 0301-4851
Source: Self-asserted source
Hongyong Fu

Structure and function analyses of 26 S proteasome subunits from Arabidopsis

Molecular Biology Reports
1999 | Review
Part of ISSN: 0301-4851
Source: Self-asserted source
Hongyong Fu

One-Step Production of D-p-Hydroxyphenylglycine by Recombinant Escherichia coli Strains

Biotechnology Progress
1999-12-03 | Journal article
Part of ISSN: 8756-7938
Source: Self-asserted source
Hongyong Fu

Multiubiquitin Chain Binding Subunit MCB1 (RPN10) of the 26S Proteasome Is Essential for Developmental Progression in <i>Physcomitrella patens</i>

The Plant Cell
1999-08 | Journal article
Part of ISSN: 1040-4651
Part of ISSN: 1532-298X
Source: Self-asserted source
Hongyong Fu

Structural and functional analysis of the six regulatory particle triple-A ATPase subunits from the Arabidopsis 26S proteasome

The Plant Journal
1999-06 | Journal article
Part of ISSN: 0960-7412
Part of ISSN: 1365-313X
Source: Self-asserted source
Hongyong Fu

Use of alternate splice sites in granule-bound starch synthase mRNA from low-amylose rice varieties

Plant Molecular Biology
1998 | Journal article
Part of ISSN: 0167-4412
Source: Self-asserted source
Hongyong Fu

Anchor probes for comparative mapping of grass genera

Theoretical and Applied Genetics
1998-08 | Journal article
Part of ISSN: 0040-5752
Part of ISSN: 1432-2242
Source: Self-asserted source
Hongyong Fu

Molecular Organization of the 20S Proteasome Gene Family from Arabidopsis thaliana

Genetics
1998-06-01 | Journal article
Part of ISSN: 1943-2631
Source: Self-asserted source
Hongyong Fu

Multiubiquitin Chain Binding and Protein Degradation Are Mediated by Distinct Domains within the 26 S Proteasome Subunit Mcb1

Journal of Biological Chemistry
1998-01 | Journal article
Part of ISSN: 0021-9258
Source: Self-asserted source
Hongyong Fu

ATPase and ubiquitin-binding proteins of the yeast proteasome

Molecular Biology Reports
1997 | Review
Part of ISSN: 0301-4851
Source: Self-asserted source
Hongyong Fu

The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover

Molecular and Cellular Biology
1996-11 | Journal article
Part of ISSN: 0270-7306
Part of ISSN: 1098-5549
Source: Self-asserted source
Hongyong Fu

A potato Sus3 sucrose synthase gene contains a context-dependent 3' element and a leader intron with both positive and negative tissue-specific effects.

The Plant Cell
1995-09 | Journal article
Part of ISSN: 1040-4651
Part of ISSN: 1532-298X
Source: Self-asserted source
Hongyong Fu

High-level tuber expression and sucrose inducibility of a potato Sus4 sucrose synthase gene require 5' and 3' flanking sequences and the leader intron.

The Plant Cell
1995-09 | Journal article
Part of ISSN: 1040-4651
Part of ISSN: 1532-298X
Source: Self-asserted source
Hongyong Fu

Sink- and vascular-associated sucrose synthase functions are encoded by different gene classes in potato.

The Plant Cell
1995-09 | Journal article
Part of ISSN: 1040-4651
Part of ISSN: 1532-298X
Source: Self-asserted source
Hongyong Fu