Personal information

Activities

Employment (1)

Pfizer Global Research and Development: Groton, CT, US

2000 to present (Design and Synthesis Sciences)
Employment
Source: Self-asserted source
Gilles Goetz

Works (41)

Updating the portfolio of physicochemical descriptors related to permeability in the beyond the rule of 5 chemical space

European Journal of Pharmaceutical Sciences
2020 | Journal article
EID:

2-s2.0-85081325743

Part of ISBN:

18790720 09280987

Contributors: Ermondi, G.; Vallaro, M.; Goetz, G.; Shalaeva, M.; Caron, G.
Source: Self-asserted source
Gilles Goetz via Scopus - Elsevier

Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography

International Journal of Pharmaceutics
2019 | Journal article
EID:

2-s2.0-85061837981

Part of ISBN:

18733476 03785173

Contributors: Russo, G.; Barbato, F.; Grumetto, L.; Philippe, L.; Lynen, F.; Goetz, G.H.
Source: Self-asserted source
Gilles Goetz via Scopus - Elsevier

Experimental lipophilicity for beyond Rule of 5 compounds

Future Drug Discovery
2019 | Journal article
Source: Self-asserted source
Gilles Goetz

Preface

Methods in Molecular Biology
2019 | Book
EID:

2-s2.0-85066284903

Part of ISBN:

19406029 10643745

Contributors: Goetz, G.
Source: Self-asserted source
Gilles Goetz via Scopus - Elsevier

Determining molecular properties with differential mobility spectrometry and machine learning

Nature Communications
2018 | Journal article
EID:

2-s2.0-85057600898

Part of ISBN:

20411723

Contributors: Walker, S.W.C.; Anwar, A.; Psutka, J.M.; Crouse, J.; Liu, C.; Le Blanc, J.C.Y.; Montgomery, J.; Goetz, G.H.; Janiszewski, J.S.; Campbell, J.L. et al.
Source: Self-asserted source
Gilles Goetz via Scopus - Elsevier

Leveraging chromatography based physicochemical properties for efficient drug design

ADMET and DMPK
2018 | Journal article
EID:

2-s2.0-85048667190

Part of ISBN:

18487718

Contributors: Goetz, G.H.; Shalaeva, M.
Source: Self-asserted source
Gilles Goetz via Scopus - Elsevier

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

Organic and Biomolecular Chemistry
2017 | Journal article
EID:

2-s2.0-85016242366

Part of ISBN:

14770520

Contributors: Price, D.A.; Eng, H.; Farley, K.A.; Goetz, G.H.; Huang, Y.; Jiao, Z.; Kalgutkar, A.S.; Kablaoui, N.M.; Khunte, B.; Liras, S. et al.
Source: Self-asserted source
Gilles Goetz via Scopus - Elsevier

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators

Journal of Medicinal Chemistry
2017 | Journal article
EID:

2-s2.0-85038376847

Part of ISBN:

15204804 00222623

Contributors: Boehm, M.; Beaumont, K.; Jones, R.; Kalgutkar, A.S.; Zhang, L.; Atkinson, K.; Bai, G.; Brown, J.A.; Eng, H.; Goetz, G.H. et al.
Source: Self-asserted source
Gilles Goetz via Scopus - Elsevier

Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity

Scientific Reports
2016 | Journal article
Contributors: Qingzhou Zhang; Fan Jiang; Bingchuan Zhao; Huacan Lin; Yuan Tian; Mingsheng Xie; Guoyun Bai; Adam M. Gilbert; Gilles H. Goetz; Spiros Liras et al.
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Relationship between Passive Permeability and Molecular Polarity Using Block Relevance Analysis

Molecular Pharmaceutics
2016 | Journal article
Contributors: Gilles H. Goetz; Marina Shalaeva; Giulia Caron; Giuseppe Ermondi; Laurence Philippe
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network

Bioorganic & Medicinal Chemistry
2016-08 | Journal article
Contributors: Simone Sciabola; Gilles H. Goetz; Guoyun Bai; Bruce N. Rogers; David L. Gray; Allen Duplantier; Kari R. Fonseca; Michelle A. Vanase-Frawley; Natasha M. Kablaoui
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

A Fast Chromatographic Method for Estimating Lipophilicity and Ionization in Nonpolar Membrane-Like Environment

Molecular Pharmaceutics
2016-03-07 | Journal article
Contributors: Giulia Caron; Maura Vallaro; Giuseppe Ermondi; Gilles H. Goetz; Yuriy A. Abramov; Laurence Philippe; Marina Shalaeva
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides

Organic Letters
2015-06 | Journal article
Contributors: Joshua Schwochert; Rushia Turner; Melissa Thang; Ray F Berkeley; Alexandra R Ponkey; Kelsie M. Rodriguez; Siegfried S F Leung; Bhagyashree Khunte; Gilles Goetz; Chris Limberakis et al.
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Desorption electrospray ionization (DESI) with atmospheric pressure ion mobility spectrometry for drug detection

The Analyst
2014 | Journal article
Contributors: Kristyn M. Roscioli; Jessica A. Tufariello; Xing Zhang; Shelly X. Li; Gilles H. Goetz; Guilong Cheng; William F. Siems; Herbert H. Hill
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides

ACS Medicinal Chemistry Letters
2014-10-09 | Journal article
Contributors: Gilles H. Goetz; Laurence Philippe; Michael J. Shapiro
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2

ChemMedChem
2014-04-11 | Journal article
Contributors: Florian Wakenhut; Thien Duc Tran; Chris Pickford; Stephen Shaw; Mike Westby; Caroline Smith-Burchnell; Lesa Watson; Michael Paradowski; Jared Milbank; David Stonehouse et al.
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

High Throughput Method for the Indirect Detection of Intramolecular Hydrogen Bonding

Journal of Medicinal Chemistry
2014-04-10 | Journal article
Contributors: Gilles H. Goetz; William Farrell; Marina Shalaeva; Simone Sciabola; Dennis Anderson; Jiangli Yan; Laurence Philippe; Michael J. Shapiro
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool

Journal of Medicinal Chemistry
2013-06 | Journal article
Contributors: Marina Shalaeva; Giulia Caron; Yuriy A. Abramov; Thomas N. O’Connell; Mark S. Plummer; Geeta Yalamanchi; Kathleen A. Farley; Gilles H. Goetz; Laurence Philippe; Michael J. Shapiro
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Synthesis of 12-membered macrocyclic templates and library analogs for PPI

Tetrahedron Letters
2013-06 | Journal article
Contributors: Jinshan Chen; Frank Rong; Bo Shan; Yuanwei Chen; Yingfu Li; Hua Yu; Li Chen; Tongtao Kuang; Shai Li; Youpei Chen et al.
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Real time pharmaceutical reaction monitoring by electrospray ion mobility-mass spectrometry

International Journal of Mass Spectrometry
2013-02 | Journal article
Contributors: Kristyn M. Roscioli; Xing Zhang; Shelly X. Li; Gilles H. Goetz; Guilong Cheng; Zhongli Zhang; William F. Siems; Herbert H. Hill
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1 H-[1, 2, 3] triazolo [4, 5-b] pyrazin-6-yl)-1 H-pyrazol-1-yl) ethanol (PF-04217903) for the Treatment of Cancer

Journal of medicinal chemistry
2012 | Journal article
Source: Self-asserted source
Gilles Goetz

Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation

Journal of Chemical Information and Modeling
2012-04 | Journal article
Contributors: Cristiano R. W. Guimarães; Alan M. Mathiowetz; Marina Shalaeva; Gilles Goetz; Spiros Liras
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

On-Column Solvent Exchange for Purified Preparative Fractions

Journal of Laboratory Automation
2011-10 | Journal article
Contributors: Gilles H. Goetz; Emily Beck; Peter W. Tidswell
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Terpenes and flavonoids from an Egyptian collection ofCleome droserifolia

Natural Product Research
2010-04 | Journal article
Contributors: Mohamed I. Aboushoer; Hoda M. Fathy; Maged S. Abdel-Kader; Gilles Goetz; Abdallah A. Omar
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Dolabellane diterpenes from Cleome droserifolia

Natural Product Communications
2008 | Journal article
Source: Self-asserted source
Gilles Goetz

Chemical and Biological Integrity in Natural Products Screening

Combinatorial Chemistry & High Throughput Screening
2005-09-01 | Journal article
Contributors: Bentham Science Publisher George G. Harrigan; Bentham Science Publisher Gilles H. Goetz
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Editorial

Combinatorial Chemistry & High Throughput Screening
2005-09-01 | Journal article
Contributors: Bentham Science Publisher Gilles H. Goetz
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Meet The Guest Editor

Combinatorial Chemistry & High Throughput Screening
2005-09-01 | Journal article
Contributors: Bentham Science Publisher Gilles H. Goetz
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Symbiotic and dietary marine microalgae as a source of bioactive molecules--experience from natural products research

Journal of Applied Phycology
2002 | Journal article
Source: Self-asserted source
Gilles Goetz

The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares

Current Medicinal Chemistry
2002-10-01 | Journal article
Contributors: H. Luesch; G. Harrigan; G. Goetz; F. Horgen
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Kulokekahilide-1, a Cytotoxic Depsipeptide from the Cephalaspidean Mollusk Philinopsis speciosa

The Journal of Organic Chemistry
2002-03 | Journal article
Contributors: Junji Kimura; Yuuki Takada; Tomoko Inayoshi; Yoichi Nakao; Gilles Goetz; Wesley Y. Yoshida; Paul J. Scheuer
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Chemical defenses of the sacoglossan mollusk Elysia rufescens and its host alga Bryopsis sp.

Journal of Chemical ecology
2001 | Journal article
Source: Self-asserted source
Gilles Goetz

Ugibohlin:  A New Dibromo-seco-isophakellin from Axinella carteri †

Journal of Natural Products
2001 | Journal article
Contributors: Gilles H. Goetz; George G. Harrigan; John Likos
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Furodysin Lactone and Pyrodysinoic Acid, New Sesquiterpenes from a Philippines Dysidea Species

Journal of Natural Products
2001-11 | Journal article
Contributors: Gilles H. Goetz; George G. Harrigan; John Likos
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Dysideaprolines A−F and Barbaleucamides A−B, Novel Polychlorinated Compounds from a Dysidea Species

Journal of Natural Products
2001-09 | Journal article
Contributors: George G. Harrigan; Gilles H. Goetz; Hendrik Luesch; Shengtian Yang; John Likos
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

‘Upenamide:  An Unprecedented Macrocyclic Alkaloid from the Indonesian Sponge Echinochalina sp.

The Journal of Organic Chemistry
2000 | Journal article
Contributors: Jorge I. Jiménez; Gilles Goetz; Christina M. S. Mau; Wesley Y. Yoshida; Paul J. Scheuer; R. Thomas Williamson; Michelle Kelly
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

A New Depsipeptide from the Sacoglossan MolluskElysiaornataand the Green AlgaBryopsisSpecies1

Journal of Natural Products
2000-01 | Journal article
Contributors: F. David Horgen; Derrick B. delos Santos; Gilles Goetz; Bryan Sakamoto; Yukiko Kan; Hiroshi Nagai; Paul J. Scheuer
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Resistance factors to grey mould in grape berries: identification of some phenolics inhibitors of Botrytis cinerea stilbene oxidase

Phytochemistry
1999-11 | Journal article
Contributors: Gilles Goetz; Abdellatif Fkyerat; Nadine Métais; Manuela Kunz; Raffaele Tabacchi; Roger Pezet; Vincent Pont
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

The absolute stereochemistry of Kahalalide F

Tetrahedron
1999-06 | Journal article
Contributors: Gilles Goetz; Wesley Y Yoshida; Paul J Scheuer
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Synthesis of a water-soluble analog of 6-methyl-3-N-alkyl catechol labeled with carbon 13: NMR approach to the reactivity of poison ivy/oak sensitizers toward proteins

Bioorganic & Medicinal Chemistry Letters
1999-04 | Journal article
Contributors: Gilles Goetz; Emmanuel Meschkat; Jean-Pierre Lepoittevin
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search

Two Acyclic Kahalalides from the Sacoglossan Mollusk Elysia rufescens 1

Journal of Natural Products
1997-06 | Journal article
Contributors: Gilles Goetz; Yoichi Nakao; Paul J. Scheuer
Source: Self-asserted source
Gilles Goetz via Crossref Metadata Search