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Loop profile: 2398346

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United Kingdom, India

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Employment (2)

University College London: London, London, GB

2018-07-02 to present | Research Associate (Institute of structural and molecular biology)
Employment
Source: Self-asserted source
Vaibhav Kumar Shukla

Center for Excellence in Basic Sciences: Mumbai, Maharashtra, IN

2015-04-15 to 2018-06-10 | DST-SERB-NPDF (CHEMISTRY)
Employment
Source: Self-asserted source
Vaibhav Kumar Shukla

Education and qualifications (3)

CSIR-CENTRAL DRUG RESEARCH INSTITUTE: LUCKNOW, UTTARPRADESH, IN

2009-11-13 to 2015-07-21 | PhD (MOLECULAR AND STRUCTURAL BIOLOGY)
Education
Source: Self-asserted source
Vaibhav Kumar Shukla

Banaras Hindu University: Varanasi, Uttar Pradesh, IN

2007-07-01 to 2009-04-30 | M.Sc. (BIOCHEMISTRY)
Education
Source: Self-asserted source
Vaibhav Kumar Shukla

RML AVADH UNIVERSITY: FAIZABAD, UTTARPRADESH, IN

2002-07-01 to 2005-05-31 | B.Sc.
Education
Source: Self-asserted source
Vaibhav Kumar Shukla

Funding (1)

Structural, dynamics and biophysical characterization of MED28/Magicin/EG-1 for inhibitor screening: Therapeutic and prognosis target of epithelial derived Cancer

2016-07 to 2018-06 | Grant
Department of Science and Technology, Ministry of Science and Technology (DELHI, IN)
Source: Self-asserted source
Vaibhav Kumar Shukla

Works (28)

A combined NMR and Deep Neural Network approach for enhancing the spectral resolution of aromatic side chains in proteins

Science Advances
2024-12-20 | Journal article | Author
DOI: 10.1126/sciadv.adr2155
Contributors: Pramodh Vallurupalli; Dennis Flemming Hansen; Vaibhav Kumar Shukla; Gogulan Karunanithy
Source: check_circle
AAAS - Science
grade
Preferred source (of 2)‎

Solution-state methyl NMR spectroscopy of large non-deuterated proteins enabled by deep neural networks

Nature Communications
2024-06-13 | Journal article
DOI: 10.1038/s41467-024-49378-8
Contributors: Gogulan Karunanithy; Vaibhav Kumar Shukla; D. Flemming Hansen
Source: check_circle
Crossref

An integrative characterisation of prolinecisandtransconformers in a disordered peptide

2024-05-15 | Preprint
DOI: 10.1101/2024.05.14.594077
Contributors: Alice J. Pettitt; Vaibhav Kumar Shukla; Angelo Miguel Figueiredo; Lydia S. Newton; Stephen McCarthy; Alethea B. Tabor; Gabriella T. Heller; Christian D. Lorenz; D. Flemming Hansen
Source: check_circle
Crossref

Characterising Aromatic Side Chains in Proteins through the Synergistic Development of NMR Experiments and Deep Neural Networks

2024-04-02 | Preprint
DOI: 10.1101/2024.04.01.587635
Contributors: Vaibhav Kumar Shukla; Gogulan Karunanithy; Pramodh Vallurupalli; D Flemming Hansen
Source: check_circle
Crossref

Picosecond Dynamics of a Small Molecule in Its Bound State with an Intrinsically Disordered Protein

Journal of the American Chemical Society
2024-01-31 | Journal article
DOI: 10.1021/jacs.3c11614
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Contributors: Gabriella T Heller; Vaibhav Kumar Shukla; Angelo Miguel Figueiredo; Dennis Flemming Hansen
Source: Self-asserted source
Vaibhav Kumar Shukla

Biomolecular NMR spectroscopy in the era of artificial intelligence

Structure
2023-11 | Journal article
DOI: 10.1016/j.str.2023.09.011
Part of ISSN: 0969-2126
Contributors: Vaibhav Kumar Shukla; Gabriella T Heller; Dennis Flemming Hansen
Source: Self-asserted source
Vaibhav Kumar Shukla

Intrinsic structural dynamics dictate enzymatic activity and inhibition

Proceedings of the National Academy of Sciences
2023-10-10 | Journal article
DOI: 10.1073/pnas.2310910120
Contributors: Vaibhav Kumar Shukla; Lucas Siemons; D. Flemming Hansen
Source: check_circle
Crossref

Solution State Methyl NMR Spectroscopy of Large Non-Deuterated Proteins Enabled by Deep Neural Networks

2023-09-17 | Preprint
DOI: 10.1101/2023.09.15.557823
Contributors: Gogulan Karunanithy; Vaibhav Kumar Shukla; D. Flemming Hansen
Source: check_circle
Crossref

Small-molecule binding to an intrinsically disordered protein revealed by experimental NMR19F transverse spin-relaxation

2023-05-04 | Preprint
DOI: 10.1101/2023.05.03.539297
Contributors: Gabriella T. Heller; Vaibhav Kumar Shukla; Angelo M. Figueiredo; D. Flemming Hansen
Source: check_circle
Crossref

Implications of critical node-dependent unidirectional cross-talk of Plasmodium SUMO pathway proteins

Biophysical Journal
2022-04 | Journal article
DOI: 10.1016/j.bpj.2022.03.022
Part of ISSN: 0006-3495
Source: Self-asserted source
Vaibhav Kumar Shukla

Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8

Chemical Science
2021 | Journal article
DOI: 10.1039/D1SC01929E
Contributors: Vaibhav Kumar Shukla; Lucas Siemons; Francesco L. Gervasio; D. Flemming Hansen
Source: check_circle
Crossref

Protein Labeling and Structure Determination by NMR Spectroscopy

Biophysical and Computational Tools in Drug Discovery
2021 | Book chapter
DOI: 10.1007/7355_2021_133
Part of ISBN: 9783030852801
Part of ISBN: 9783030852818
Part of ISSN: 1862-2461
Part of ISSN: 1862-247X
Source: Self-asserted source
Vaibhav Kumar Shukla

Methodological advancements for characterising protein side chains by NMR spectroscopy

Current Opinion in Structural Biology
2021-10 | Journal article
DOI: 10.1016/j.sbi.2021.04.002
Part of ISSN: 0959-440X
Source: Self-asserted source
Vaibhav Kumar Shukla

A distal regulatory region of a class I human histone deacetylase

Nature Communications
2020-07-31 | Journal article
DOI: 10.1038/s41467-020-17610-w
Contributors: Nicolas D. Werbeck; Vaibhav Kumar Shukla; Micha B. A. Kunze; Havva Yalinca; Ruth B. Pritchard; Lucas Siemons; Somnath Mondal; Simon O. R. Greenwood; John Kirkpatrick; Charles M. Marson et al.
Source: check_circle
Crossref

Intra-residue methyl-methyl correlations for valine and leucine residues in large proteins from a 3D-HMBC-HMQC experiment.

Journal of biomolecular NMR
2019-11-12 | Journal article
DOI: 10.1007/s10858-019-00287-9
PMID: 31720925
Source: Self-asserted source
Vaibhav Kumar Shukla

Backbone and side-chain resonance assignments of centromeric protein Scm3 from Saccharomyces cerevisiae.

Biomolecular NMR assignments
2019-04-01 | Journal article
DOI: 10.1007/s12104-019-09889-8
PMID: 30937734
Source: Self-asserted source
Vaibhav Kumar Shukla

An efficient combination of BEST and NUS methods in multidimensional NMR spectroscopy for high throughput analysis of proteins

2018 | Journal article
DOI: 10.1039/c8ra00527c
Part of ISSN: 2046-2069
Source: Self-asserted source
Vaibhav Kumar Shukla

Solution structure and dynamics of glia maturation factor from Caenorhabditis elegans.

Biochimica et biophysica acta. Proteins and proteomics
2018-07-06 | Journal article
DOI: 10.1016/j.bbapap.2018.06.007
PMID: 29981887
Source: Self-asserted source
Vaibhav Kumar Shukla

Structure, dynamics, and biochemical characterization of ADF/cofilin Twinstar from Drosophilamelanogaster.

Biochimica et biophysica acta. Proteins and proteomics
2018-04-30 | Journal article
DOI: 10.1016/j.bbapap.2018.04.010
PMID: 29709602
Source: Self-asserted source
Vaibhav Kumar Shukla

Unfolding of CPR3 Gets Initiated at the Active Site and Proceeds via Two Intermediates.

Biophysical journal
2017-02-01 | Journal article
DOI: 10.1016/j.bpj.2016.12.020
PMID: 28256221
PMC: PMC5340121
Source: Self-asserted source
Vaibhav Kumar Shukla

Measurement of 1H NMR relaxation times in complex organic chemical systems: application of PSYCHE

2016 | Journal article
DOI: 10.1039/c6ra20047h
Part of ISSN: 2046-2069
Source: Self-asserted source
Vaibhav Kumar Shukla

A comparative study of fibrillation kinetics of two homologous proteins under identical solution condition.

Biochimie
2016-11-05 | Journal article
DOI: 10.1016/j.biochi.2016.11.002
PMID: 27825804
Source: Self-asserted source
Vaibhav Kumar Shukla

Backbone and side-chain resonance assignments of Plasmodium falciparum SUMO.

Biomolecular NMR assignments
2016-10-03 | Journal article
DOI: 10.1007/s12104-016-9712-9
PMID: 27699617
Source: Self-asserted source
Vaibhav Kumar Shukla

NMR assignments of mitochondrial cyclophilin Cpr3 from Saccharomyces cerevisiae.

Biomolecular NMR assignments
2016-02-20 | Journal article
DOI: 10.1007/s12104-016-9667-x
PMID: 26897529
Source: Self-asserted source
Vaibhav Kumar Shukla

Solution structures and dynamics of ADF/cofilins UNC-60A and UNC-60B from Caenorhabditis elegans.

The Biochemical journal
2015-01-01 | Journal article
DOI: 10.1042/BJ20140923
PMID: 25279657
PMC: PMC4325984
Source: Self-asserted source
Vaibhav Kumar Shukla

NMR assignments of actin depolymerizing factor (ADF) like UNC-60A and cofilin like UNC-60B proteins of Caenorhabditis elegans.

Biomolecular NMR assignments
2014-12-11 | Journal article
DOI: 10.1007/s12104-014-9588-5
PMID: 25503290
PMC: PMC4465417
Source: Self-asserted source
Vaibhav Kumar Shukla

Pseudo 5D HN(C)N experiment to facilitate the assignment of backbone resonances in proteins exhibiting high backbone shift degeneracy

2014-09 | Journal article
DOI: 10.1016/j.chemphys.2014.07.018
Part of ISSN: 0301-0104
Source: Self-asserted source
Vaibhav Kumar Shukla

Solution structure and dynamics of ADF from Toxoplasma gondii.

Journal of structural biology
2011-07-26 | Journal article
DOI: 10.1016/j.jsb.2011.07.011
PMID: 21820516
PMC: PMC3703439
Source: Self-asserted source
Vaibhav Kumar Shukla
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