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Colombia, Belgium, United States

Activities

Employment (1)

National Center for Advancing Translational Sciences: Rockville, Maryland, US

2023-05-01 to present | Fellow
Employment
Source: Self-asserted source
Alexander Rodríguez-López

Education and qualifications (2)

Pontificia Universidad Javeriana: Bogota, CO

2014-01-19 to 2018-10-23 | PhD in Biological Sciences
Education
Source: Self-asserted source
Alexander Rodríguez-López

Universiteit Gent Faculteit Wetenschappen: Gent, BE

2014-01-19 to 2018-07-04 | PhD Biochemistry and Biotechnology
Education
Source: Self-asserted source
Alexander Rodríguez-López

Works (50)

Generation of induced pluripotent stem cell lines TRNDi037-A and TRNDi038-A from two patients with Alagille syndrome carrying heterozygous JAG1 mutations.

Stem cell research
2024-12-17 | Journal article
Contributors: Evans EF; Chen G; Pavlinov I; Huang X; Linask K; Liu C; Alexander Rodríguez-López; Gilbert MA; Spinner NB; Rodemse S et al.
Source: Self-asserted source
Alexander Rodríguez-López

Generation of an induced pluripotent stem cell line (TRNDi042-A) from a Mucopolysaccharidosis type IIIB patient with homozygous p. R626X (c. 1876C > T) mutation in the NAGLU gene.

Stem cell research
2024-11-16 | Journal article
Contributors: Rodriguez-Lopez A; Huang X; Chen C; Zou J; Zheng W; Chen G
Source: Self-asserted source
Alexander Rodríguez-López

Identification of Orthosteric and Allosteric Pharmacological Chaperones for Mucopolysaccharidosis Type IIIB

ChemBioChem
2024-08 | Journal article
Contributors: Juan Camilo Losada; Heidy Triana; Egdda Vanegas; Angela Caro; Alexander Rodríguez‐López; Angela Johana Espejo‐Mojica; Carlos Javier Alméciga‐Diaz
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Novel human recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in a glyco-engineered <i>Escherichia coli</i> strain.

Heliyon
2024-06-08 | Journal article
Contributors: Pimentel-Vera LN; Rodríguez-López A; Angela Johana Espejo-Mojica; Ramírez AM; Cardona C; Luis H. Reyes; Tomatsu S; Jaroentomeechai T; Matthew DeLisa; Sánchez OF et al.
Source: Self-asserted source
Alexander Rodríguez-López

Identifying major histocompatibility complex class II-DR molecules in bovine and swine peripheral blood monocyte-derived macrophages using mAb-L243

Vaccine
2024-05 | Journal article
Contributors: Carmen Celis-Giraldo; Diego Ordoñez; Diana Díaz-Arévalo; Michel D. Bohórquez; Nieves Ibarrola; Carlos F. Suárez; Kewin Rodríguez; Yoelis Yepes; Alexander Rodríguez; Catalina Avendaño et al.
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Crossref

Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome

Heliyon
2022-09 | Journal article
Part of ISSN: 2405-8440
Contributors: Angie Marcela Calvo Barbosa; Stefany Casallas Cortes; Ninna Pulido-Ochoa; Martha Yaneth Parra; Alexander Rodríguez-López; Guevara-Morales, Johana M; Olga Yaneth Echeverri-Peña
Source: Self-asserted source
Alexander Rodríguez-López via Crossref Metadata Search

Engineering a heterologously expressed fructosyltransferase from Aspergillus oryzae N74 in Komagataella phaffii (Pichia pastoris) for kestose production

New Biotechnology
2022-07 | Journal article
Part of ISSN: 1871-6784
Contributors: Manuela Alvarado-Obando; Nicolás Contreras; Diana León; Lina Botero; Laura Beltran; Dennis Díaz; Alexander Rodríguez-López; Luis H. Reyes; Carlos J. Alméciga-Díaz; Oscar F. Sánchez
Source: Self-asserted source
Alexander Rodríguez-López via Crossref Metadata Search

Effect of two preservation methods on the viability and enzyme production of a recombinant Komagataella phaffii (Pichia pastoris) strain

Cryobiology
2022-04 | Journal article
Part of ISSN: 0011-2240
Contributors: Angela María Alvarado-Fernández; Edwin Alexander Rodríguez-López; Angela Johana Espejo-Mojica; Angela Rocío Mosquera-Arévalo; Carlos Javier Alméciga-Díaz; Alba Alicia Trespalacios-Rangel
Source: Self-asserted source
Alexander Rodríguez-López via Crossref Metadata Search

Iduronate-2-sulfatase interactome: validation by yeast two-hybrid assay

Heliyon
2022-03 | Journal article
Part of ISSN: 2405-8440
Contributors: Eliana Benincore-Flórez; Jorge El-Azaz Ciudad; Gabriela Alejandra Solarte; Alexander Rodríguez; Luis H. Reyes; Carlos Javier Alméciga-Díaz; Carolina Cardona-Ramírez
Source: Self-asserted source
Alexander Rodríguez-López via Crossref Metadata Search

The prevalence of Chlamydia psittaci in confiscated Psittacidae in Colombia

Preventive Veterinary Medicine
2022-03 | Journal article
Part of ISSN: 0167-5877
Contributors: Alejandra Ruiz-Laiton; Norela Molano-Ayala; Sebastián García-Castiblanco; Angie Melissa Puentes-Orozco; Ana Carolina Falla; Milena Camargo; Leonardo Roa; Alexander Rodríguez-López; Patarroyo Manuel A.; Catalina Avendaño
Source: Self-asserted source
Alexander Rodríguez-López via Crossref Metadata Search

1H-Nuclear Magnetic Resonance Analysis of Urine as Diagnostic Tool for Organic Acidemias and Aminoacidopathies

Metabolites
2021-12-20 | Journal article
Contributors: Ninna Pulido; Johana M. Guevara-Morales; Alexander Rodriguez-López; Álvaro Pulido; Jhon Díaz; Ru Angelie Edrada-Ebel; Olga Y. Echeverri-Peña
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Crossref
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Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach

Heliyon
2021-07 | Journal article
Part of ISSN: 2405-8440
Contributors: Olga Y. Echeverri-Peña; Diego A. Salazar-Barreto; Alexander Rodríguez-Lopez; Janneth González; Carlos J. Alméciga-Díaz; Cristian H. Verano-Guevara; Luis A. Barrera
Source: Self-asserted source
Alexander Rodríguez-López via Crossref Metadata Search

Human recombinant lysosomal β‐Hexosaminidases produced in Pichia pastoris efficiently reduced lipid accumulation in Tay‐Sachs fibroblasts

American Journal of Medical Genetics Part C: Seminars in Medical Genetics
2020-12 | Journal article
Contributors: Angela J. Espejo‐Mojica; Alexander Rodríguez‐López; Rong Li; Wei Zheng; Carlos J. Alméciga‐Díaz; Cindy Dulcey‐Sepúlveda; Germán Combariza; Luis A. Barrera
Source: check_circle
Crossref

Bromocriptine as a Novel Pharmacological Chaperone for Mucopolysaccharidosis IV A

ACS Medicinal Chemistry Letters
2020-07-09 | Journal article
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Source: Self-asserted source
Alexander Rodríguez-López

Characterization of Human Recombinant N-Acetylgalactosamine-6-Sulfate Sulfatase Produced in Pichia pastoris as Potential Enzyme for Mucopolysaccharidosis IVA Treatment

Journal of Pharmaceutical Sciences
2019 | Journal article
EID:

2-s2.0-85064674654

Contributors: Rodríguez-López, A.; Pimentel-Vera, L.N.; Espejo-Mojica, A.J.; Van Hecke, A.; Tiels, P.; Tomatsu, S.; Callewaert, N.; Alméciga-Díaz, C.J.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Identification of Ezetimibe and Pranlukast as Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA

Journal of Medicinal Chemistry
2019 | Journal article
EID:

2-s2.0-85068375848

Contributors: Alméciga-Diaz, C.J.; Hidalgo, O.A.; Olarte-Avellaneda, S.; Rodríguez-López, A.; Guzman, E.; Garzón, R.; Pimentel-Vera, L.N.; Puentes-Tellez, M.A.; Rojas-Rodriguez, A.F.; Gorshkov, K. et al.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Identification of the iduronate-2-sulfatase proteome in wild-type mouse brain

Heliyon
2019 | Journal article
EID:

2-s2.0-85065393343

Contributors: Cardona, C.; Benincore, E.; Pimentel, N.; Reyes, L.H.; Patarroyo, C.; Rodríguez-López, A.; Rufián, M.M.; Barrera, L.A.; Alméciga-Díaz, C.J.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Advances in the Development of Pharmacological Chaperones for the Mucopolysaccharidoses

International Journal of Molecular Sciences
2019-12-29 | Journal article
Contributors: Juan Camilo Losada Díaz; Jacobo Cepeda del Castillo; Edwin Alexander Rodriguez-López; Carlos J. Alméciga-Díaz
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Crossref
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Media improvement for 10 L bioreactor production of rPOXA 1B laccase by P. pastoris

3 Biotech
2019-11-11 | Journal article
Part of ISSN: 2190-5738
Contributors: Leidy D. Ardila-Leal; Diego A. Albarracín-Pardo; Claudia M. Rivera-Hoyos; Edwin D. Morales-Álvarez; Poutou-Piñales, R.A.; Angela M. Cardozo-Bernal; Balkys E. Quevedo-Hidalgo; Aura M. Pedroza-Rodríguez; Dennis J. Díaz-Rincón; Alexander Rodríguez-López et al.
Source: Self-asserted source
Alexander Rodríguez-López via Crossref Metadata Search

ACPT Control de concentración de ox́ıgeno disuelto en un bioreactor mediante ganancia programable

IEEE Latin America Transactions
2018 | Journal article
Source: Self-asserted source
Alexander Rodríguez-López

Gain-Scheduled Oxygen Concentration Control System for a Bioreactor

IEEE Latin America Transactions
2018 | Journal article
EID:

2-s2.0-85071010068

Contributors: Arevalo, H.; Sanchez, F.; Ruiz, F.; Guerrero, D.; Patino, D.; Almeciga-Diaz, C.J.; Rodriguez-Lopez, A.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease.

Orphanet journal of rare diseases
2018-09 | Journal article
Contributors: Vu M; Li R; Baskfield A; Lu B; Farkhondeh A; Gorshkov K; Motabar O; Beers J; Chen G; Zou J et al.
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

Research, diagnosis and education in inborn errors of metabolism in Colombia: 20 years' experience from a reference center.

Orphanet journal of rare diseases
2018-08 | Journal article
Contributors: Echeverri OY; Guevara JM; Espejo-Mojica ÁJ; Ardila A; Pulido N; Reyes M; Rodriguez-Lopez A; Alméciga-Díaz CJ; Barrera LA
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

Production and characterization of a human lysosomal recombinant iduronate-2-sulfatase produced in Pichia pastoris.

Biotechnology and applied biochemistry
2018-04 | Journal article
Contributors: Pimentel N; Rodríguez-Lopez A; Díaz S; Losada JC; Díaz-Rincón DJ; Cardona C; Espejo-Mojica ÁJ; Ramírez AM; Ruiz F; Landázuri P et al.
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

Understanding the metabolic consequences of human Arylsulfatase a deficiency through a computational systems biology study

Central Nervous System Agents in Medicinal Chemistry
2017 | Journal article
EID:

2-s2.0-85013792738

Contributors: Echeverri Olga, P.Y.; Diego, S.A.; Rodríguez-Lopez, A.; Janneth, G.; Alméciga-Díaz Carlos, J.; Luis, B.A.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Anaerobic sulfatase maturase AslB from Escherichia coli activates human recombinant iduronate-2-sulfate sulfatase (IDS) and N-acetylgalactosamine-6-sulfate sulfatase (GALNS).

Gene
2017-09 | Journal article
Contributors: Alméciga-Díaz CJ; Tolosa-Díaz AD; Pimentel LN; Bonilla YA; Rodríguez-López A; Espejo-Mojica AJ; Patiño JD; Sánchez OF; Gonzalez-Santos J
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

Production of Recombinant Trichoderma reesei Cellobiohydrolase II in a New Expression System Based on Wickerhamomyces anomalus.

Enzyme research
2017-08 | Journal article
Contributors: Díaz-Rincón DJ; Duque I; Osorio E; Rodríguez-López A; Espejo-Mojica A; Parra-Giraldo CM; Poutou-Piñales RA; Alméciga-Díaz CJ; Quevedo-Hidalgo B
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

Production of human recombinant phenylalanine hydroxylase in Lactobacillus plantarum for gastrointestinal delivery.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2017-07 | Journal article
Contributors: Ramírez AM; Rodriguez-López A; Ardila A; Beltran L; Patarroyo CA; Melendez ADP; Sánchez OF; Alméciga-Díaz CJ
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

Improvement in the production of the human recombinant enzyme N-acetylgalactosamine-6-sulfatase (rhGALNS) in Escherichia coli using synthetic biology approaches

Scientific Reports
2017-07-19 | Journal article
Contributors: Luis H. Reyes; Carolina Cardona; Luisa Pimentel; Alexander Rodríguez-López; Carlos J. Alméciga-Díaz
Source: check_circle
Crossref

Plackett-Burman Design for rGILCC1 Laccase Activity Enhancement in Pichia pastoris: Concentrated Enzyme Kinetic Characterization.

Enzyme research
2017-03 | Journal article
Contributors: Morales-Álvarez ED; Rivera-Hoyos CM; Cardozo-Bernal ÁM; Poutou-Piñales RA; Pedroza-Rodríguez AM; Díaz-Rincón DJ; Rodríguez-López A; Alméciga-Díaz CJ; Cuervo-Patiño CL
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

Characterization of recombinant human lysosomal beta-hexosaminidases produced in the methylotrophic yeast Pichia pastoris

Universitas Scientiarum
2016 | Journal article
EID:

2-s2.0-85011887534

Source: Self-asserted source
Alexander Rodríguez-López
grade
Preferred source (of 2)‎

Recombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in the methylotrophic yeast Pichia pastoris

Scientific Reports
2016 | Journal article
EID:

2-s2.0-84977268453

Contributors: Rodríguez-López, A.; Alméciga-Diáz, C.J.; Sánchez, J.; Moreno, J.; Beltran, L.; Diáz, D.; Pardo, A.; Ramírez, A.M.; Espejo-Mojica, A.J.; Pimentel, L. et al.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Systems biology study of mucopolysaccharidosis using a human metabolic reconstruction network

Molecular Genetics and Metabolism
2016 | Journal article
EID:

2-s2.0-84957849334

Contributors: Salazar, D.A.; Rodríguez-López, A.; Herreño, A.; Barbosa, H.; Herrera, J.; Ardila, A.; Barreto, G.E.; González, J.; Alméciga-Díaz, C.J.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Understanding the Metabolic Consequences of Human Arylsulfatase A Deficiency through a Computational Systems Biology Study.

Central nervous system agents in medicinal chemistry
2016-05 | Journal article
Contributors: Echeverri Olga Y; Salazar Diego A; Rodriguez-Lopez A; Janneth G; Almeciga-Diaz Carlos J; Barrera Luis A
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

In Silico Analysis of the Structure of Fungal Fructooligosaccharides-Synthesizing Enzymes.

Interdisciplinary sciences, computational life sciences
2016-02 | Journal article
Contributors: Olarte-Avellaneda S; Rodríguez-López A; Patiño JD; Alméciga-Díaz CJ; Sánchez OF
Source: Self-asserted source
Alexander Rodríguez-López via Europe PubMed Central

A set membership approach to oxygen transport modeling with unmodeled dynamics

2015 IEEE 2nd Colombian Conference on Automatic Control, CCAC 2015 - Conference Proceedings
2015 | Conference paper
EID:

2-s2.0-84960408899

Contributors: Ruiz, F.; Sanchez, F.; Arevalo, H.; Almeciga-Diaz, J.; Rodriguez-Lopez, A.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Human recombinant lysosomal enzymes produced in microorganisms

Molecular Genetics and Metabolism
2015 | Journal article
EID:

2-s2.0-84940900300

Contributors: Espejo-Mojica, T.J.; Alméciga-Díaz, C.J.; Rodríguez, A.; Mosquera, Á.; Díaz, D.; Beltrán, L.; Díaz, S.; Pimentel, N.; Moreno, J.; Sánchez, J. et al.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with morquio a syndrome

Drug Design, Development and Therapy
2015 | Journal article
EID:

2-s2.0-84929147162

Contributors: Tomatsu, S.; Sawamoto, K.; Alméciga-Díaz, C.J.; Shimada, T.; Bober, M.B.; Chinen, Y.; Yabe, H.; Montaño, A.M.; Giugliani, R.; Kubaski, F. et al.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Characterization of a new bacteriocin from Lactobacillus plantarum LE5 and LE27 isolated from ensiled corn

Applied Biochemistry and Biotechnology
2014 | Journal article
EID:

2-s2.0-84899441986

Contributors: Amortegui, J.; Rodríguez-López, A.; Rodríguez, D.; Carrascal, A.K.; Alméciga-Díaz, C.J.; Melendez, A.D.P.; Sánchez, O.F.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Computational analysis of human N-acetylgalactosamine-6-sulfate sulfatase enzyme: an update in genotype–phenotype correlation for Morquio A

Molecular Biology Reports
2014 | Journal article
EID:

2-s2.0-84917738716

Contributors: Olarte-Avellaneda, S.; Rodríguez-López, A.; Alméciga-Díaz, C.J.; Barrera, L.A.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

In-silico analysis of the active cavity of N-acetylgalactosamine-6-sulfate sulfatase in eight species

Advances in Intelligent Systems and Computing
2014 | Book
EID:

2-s2.0-84894731079

Contributors: Olarte-Avellaneda, S.; Rodríguez-López, A.; Alméciga-Díaz, C.J.
Source: Self-asserted source
Alexander Rodríguez-López via Scopus - Elsevier

Effect of culture conditions and signal peptide on production of human recombinant N-acetylgalactosamine-6-sulfate sulfatase in Escherichia coli BL21

J Microbiol Biotechnol
2013 | Journal article
WOSUID:

WOS:000319712400014

Contributors: Hernández, A.; Velásquez, O.; Leonardi, F.; Soto, C.; Rodríguez, A.; Lizaraso, L.; Mosquera, Á; Bohórquez, J.; Coronado, A.; Espejo, Á et al.
Source: Self-asserted source
Alexander Rodríguez-López via ResearcherID

Production of Trametes pubescens laccase under submerged and semi-solid culture conditions on agro-industrial wastes

PLoS One
2013 | Journal article
Contributors: Gonzalez, J. C.; Medina, S. C.; Rodriguez, A.; Osma, J. F.; Alméciga-Díaz, C. J.; Sánchez, O. F.
Source: Self-asserted source
Alexander Rodríguez-López via ResearcherID

Characterization of a recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in E. coli for enzyme replacement therapy of Morquio A disease

Process Biochemistry
2012 | Journal article
WOSUID:

WOS:000313851700051

Contributors: Mosquera, Angela; Rodríguez, Alexander; Soto, Carlos; Leonardi, Felice; Espejo, Angela; Sánchez, Oscar F.; Alméciga-Díaz, Carlos J.; Barrera, Luis A.
Source: Self-asserted source
Alexander Rodríguez-López via ResearcherID

INTERACCIÓN DE LA GLUTAMINA SINTETASA (GS) Y EL PÉPTIDO B -AMILOIDE COMO UNA ESTRATEGIA DE PURIFICACIÓN

Revista Colombiana de Qúımica
2012 | Journal article
Source: Self-asserted source
Alexander Rodríguez-López

Computational analysis of the fructosyltransferase enzymes in plants, fungi and bacteria

Gene
2011 | Journal article
Contributors: Alméciga-Díaz, C. J.; Gutierrez, A. M.; Bahamon, I.; Rodríguez, A.; Rodríguez, M. A.; Sánchez, O. F.
Source: Self-asserted source
Alexander Rodríguez-López via ResearcherID

Development of a sandwich enzyme linked immunosorbent assay (ELISA) for the quantification of iduronate-2-sulfate sulfatase

J Immunol Methods
2011 | Journal article
Contributors: Sosa, A. C.; Espejo, A. J.; Rodriguez, E. A.; Lizaraso, L. M.; Rojas, A.; Guevara, J.; Echeverri, O. Y.; Barrera, L. A.
Source: Self-asserted source
Alexander Rodríguez-López via ResearcherID

Evaluation of toxicity and degradation of a chlorophenol mixture by the laccase produced by Trametes pubescens

Bioresour Technol
2011 | Journal article
Contributors: Gaitan, I. J.; Medina, S. C.; González, J. C.; Rodríguez, A.; Espejo, A. J.; Osma, J. F.; Sarria, V.; Alméciga-Díaz, C. J.; Sánchez, O. F.
Source: Self-asserted source
Alexander Rodríguez-López via ResearcherID

Enzyme replacement therapy for Morquio A: an active recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in Escherichia coli BL21

J Ind Microbiol Biotechnol
2010 | Journal article
Contributors: Rodríguez, A.; Espejo, A. J.; Hernández, A.; Velásquez, O. L.; Lizaraso, L. M.; Cordoba, H. A.; Sánchez, O. F.; Alméciga-Díaz, C. J.; Barrera, L. A.
Source: Self-asserted source
Alexander Rodríguez-López via ResearcherID

Recent patents in diagnosis and treatment for inborn errors of metabolism

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
2009 | Journal article
Source: Self-asserted source
Alexander Rodríguez-López

Peer review (2 reviews for 1 publication/grant)

Review activity for BMC biotechnology (2)