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Bluesky

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Scopus Author ID: 6504636290

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Employment (4)

University of York: York, North Yorkshire, GB

2021-02-01 to present | UKRI Future Leader Fellow (Chemistry)
Employment
Source: Self-asserted source
James N Blaza

University of York: York, North Yorkshire, GB

2018-09-01 to 2021-01-31 | Lecturer (Chemistry)
Employment
Source: Self-asserted source
James N Blaza

University of Cambridge: Cambridge, Cambridgeshire, GB

2018-01-01 to 2018-08-31 | Postdoc (Biochemistry)
Employment
Source: Self-asserted source
James N Blaza

MRC Mitochondrial Biology Unit: Cambridge, Cambridgeshire, GB

2014-10 to 2017-12-31 | Career Development Fellow (MRC Mitochondrial Biology Unit)
Employment
Source: Self-asserted source
James N Blaza

Education and qualifications (3)

University of Cambridge: Cambridge, Cambridgeshire, GB

2010-10 to 2014-09 | PhD (MRC Mitochondrial Biology Unit)
Education
Source: Self-asserted source
James N Blaza

University of Leeds: Leeds, Leeds, GB

2006-09 to 2010-06 | Virology (International)
Education
Source: Self-asserted source
James N Blaza

National University of Singapore: Singapore, SG

2008-08 to 2009-05 | International Exchange Year
Education
Source: Self-asserted source
James N Blaza

Funding (3)

Probing the mechanisms that couple genome segregation to chromosome organization in Archaea

2023-04-30 to 2026-04-29 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.13249693
GRANT_NUMBER: BB/X00645X/1
Source: Self-asserted source
James N Blaza via DimensionsWizard

Understanding an ancient universal membrane effector system

2022-11-07 to 2027-11-06 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.12953496
GRANT_NUMBER: BB/X003035/1
Source: Self-asserted source
James N Blaza via DimensionsWizard

Energy metabolism and antibiotic action in the tuberculosis pathogen

2021-02-01 to 2025-01-31 | Grant
UK Research and Innovation (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.9727069
GRANT_NUMBER: MR/T040742/1
Source: Self-asserted source
James N Blaza via DimensionsWizard

Works (30)

Bioenergetic metabolism restarts alongside germinant sensing and hydration in bacterial spore germination

2025-03-15 | Preprint
DOI: 10.1101/2025.03.13.642030
Contributors: P Gupta; R Caldbeck; RC Walters; EC Wells; BL Hardman; G Christie; RJ Springett; JN Blaza
Source: check_circle
Crossref

Remission spectroscopy resolves the mode of action of bedaquiline within living mycobacteria

2024-12-05 | Preprint
DOI: 10.1101/2024.12.03.626386
Contributors: Suzanna H Harrison; Rowan C Walters; Chen-Yi Cheung; Roger J Springett; Gregory M Cook; Morwan M Osman; James N Blaza
Source: check_circle
Crossref

Structural unification of diverse membrane-bound acyltransferases reveals a conserved fold that defines the Transmembrane Acyl Transferase (TmAT) superfamily

2024-11-11 | Preprint
DOI: 10.1101/2024.11.11.622933
Contributors: Bethan E. Kinniment-Williams; Vytaute Jurgeleviciute; Reyme Herman; James N. Blaza; Marjan W. van der Woude; Gavin H. Thomas
Source: check_circle
Crossref

A promiscuous mechanism to phase separate eukaryotic carbon fixation in the green lineage

Nature Plants
2024-10-09 | Journal article
DOI: 10.1038/s41477-024-01812-x
Contributors: James Barrett; Mihris I. S. Naduthodi; Yuwei Mao; Clément Dégut; Sabina Musiał; Aidan Salter; Mark C. Leake; Michael J. Plevin; Alistair J. McCormick; James N. Blaza et al.
Source: check_circle
Crossref

Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

Nature Communications
2024-08-09 | Journal article
DOI: 10.1038/s41467-024-51135-w
Contributors: Rhianna J. Rowland; Svitlana Korolchuk; Marco Salamina; Natalie J. Tatum; James R. Ault; Sam Hart; Johan P. Turkenburg; James N. Blaza; Martin E. M. Noble; Jane A. Endicott
Source: check_circle
Crossref

A promiscuous mechanism to phase separate eukaryotic carbon fixation in the green lineage

2024-04-11 | Preprint
DOI: 10.1101/2024.04.09.588658
Contributors: James Barrett; Mihris I.S. Naduthodi; Yuwei Mao; Clément Dégut; Sabina Musiał; Aidan Salter; Mark C. Leake; Michael J. Plevin; Alistair J. McCormick; James N. Blaza et al.
Source: check_circle
Crossref

A new family of bacterial ribosome hibernation factors

Nature
2024-02-29 | Journal article
DOI: 10.1038/s41586-024-07041-8
Contributors: Karla Helena-Bueno; Mariia Yu. Rybak; Chinenye L. Ekemezie; Rudi Sullivan; Charlotte R. Brown; Charlotte Dingwall; Arnaud Baslé; Claudia Schneider; James P. R. Connolly; James N. Blaza et al.
Source: check_circle
Crossref

Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase fromRhizobium leguminosarum

2023-03-14 | Preprint
DOI: 10.1101/2023.03.13.532361
Contributors: Jinling Li; Mahima Sharma; Richard Meek; Amani Alhifthi; Zachary Armstrong; Niccolay Madiedo Soler; Mihwa Lee; Ethan D. Goddard-Borger; James N. Blaza; Gideon J. Davies et al.
Source: check_circle
Crossref

Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism

Structure
2023-02 | Journal article
DOI: 10.1016/j.str.2023.01.010
Part of ISSN: 0969-2126
Contributors: Alexander J.D. Snow; Mahima Sharma; Palika Abayakoon; Spencer J. Williams; James N. Blaza; Gideon J. Davies
Source: Self-asserted source
James N Blaza

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides

Science
2023-01-27 | Journal article
DOI: 10.1126/science.ade3332
Contributors: Hannah R. Bridges; James N. Blaza; Zhan Yin; Injae Chung; Michael N. Pollak; Judy Hirst
Source: check_circle
Crossref

A bacterial ribosome hibernation factor with evolutionary connections to eukaryotic protein synthesis

2022-11-24 | Preprint
DOI: 10.1101/2022.11.24.517861
Contributors: Karla Helena-Bueno; Chinenye L. Ekemezie; Charlotte R. Brown; Arnaud Baslé; James N. Blaza; Chris H. Hill; Sergey V. Melnikov
Source: check_circle
Crossref

Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Structure
2022-10 | Journal article
DOI: 10.1016/j.str.2022.07.001
Part of ISSN: 0969-2126
Contributors: Zachary Armstrong; Richard W. Meek; Liang Wu; James N. Blaza; Gideon J. Davies
Source: Self-asserted source
James N Blaza

Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase

eLife
2022-08-26 | Journal article
DOI: 10.7554/eLife.79361
Contributors: Chris Furlan; Nipa Chongdar; Pooja Gupta; Wolfgang Lubitz; Hideaki Ogata; James N Blaza; James A Birrell
Source: check_circle
Crossref

Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

2022-08-09 | Preprint
DOI: 10.1101/2022.08.09.503333
Contributors: Hannah R. Bridges; James N. Blaza; Zhan Yin; Injae Chung; Michael N. Pollak; Judy Hirst
Source: check_circle
Crossref

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

Journal of Biological Chemistry
2022-03 | Journal article
DOI: 10.1016/j.jbc.2022.101602
Contributors: Daniel N. Grba; James N. Blaza; Hannah R. Bridges; Ahmed-Noor A. Agip; Zhan Yin; Masatoshi Murai; Hideto Miyoshi; Judy Hirst
Source: check_circle
Crossref

Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase

2021-12-03 | Other
DOI: 10.21203/rs.3.rs-1116484/v1
Contributors: James Birrell; Chris Furlan; Nipa Chongdar; Pooja Gupta; Wolfgang Lubitz; Hideaki Ogata; James Blaza
Source: check_circle
Crossref

Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT

Nature Communications
2021-11-11 | Journal article
DOI: 10.1038/s41467-021-26796-6
Contributors: Richard W. Meek; James N. Blaza; Jil A. Busmann; Matthew G. Alteen; David J. Vocadlo; Gideon J. Davies
Source: check_circle
Crossref

Structure of inhibitor-bound mammalian complex I

Nature Communications
2020-10-16 | Journal article
DOI: 10.1038/s41467-020-18950-3
Contributors: Hannah R. Bridges; Justin G. Fedor; James N. Blaza; Andrea Di Luca; Alexander Jussupow; Owen D. Jarman; John J. Wright; Ahmed-Noor A. Agip; Ana P. Gamiz-Hernandez; Maxie M. Roessler et al.
Source: check_circle
Crossref

Understanding How the Rate of C-H Bond Cleavage Affects Formate Oxidation Catalysis by a Mo-Dependent Formate Dehydrogenase.

Journal of the American Chemical Society
2020-07-06 | Journal article
DOI: 10.1021/jacs.0c03574
PMID: 32551568
Source: Self-asserted source
James N Blaza

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

Nature Structural & Molecular Biology
2018-07-18 | Journal article
DOI: 10.1038/s41594-018-0073-1
Contributors: Ahmed-Noor A. Agip; James N. Blaza; Hannah R. Bridges; Carlo Viscomi; Shaun Rawson; Stephen P. Muench; Judy Hirst
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Crossref
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Deleting the IF 1 -like ζ subunit from Paracoccus denitrificans ATP synthase is not sufficient to activate ATP hydrolysis

Open Biology
2018-01 | Journal article
DOI: 10.1098/rsob.170206
Part of ISSN: 2046-2441
Contributors: Febin Varghese; James N. Blaza; Andrew J. Y. Jones; Owen D. Jarman; Judy Hirst
Source: Self-asserted source
James N Blaza via Crossref Metadata Search
grade
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Respiratory complex i in bos taurus and paracoccus denitrificans pumps four protons across the membrane for every NADH oxidized

Journal of Biological Chemistry
2017 | Journal article
DOI: 10.1074/jbc.M116.771899
EID:

2-s2.0-85016260244
Contributors: Jones, A.J.Y.; Blaza, J.N.; Varghese, F.; Hirst, J.
Source: Self-asserted source
James N Blaza via Scopus - Elsevier

Structure of the deactive state of mammalian respiratory complex I

2017-07-19 | Preprint
DOI: 10.1101/165753
Contributors: James N. Blaza; Kutti R. Vinothkumar; Judy Hirst
Source: check_circle
Crossref

Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump

Nature Microbiology
2017-05-15 | Journal article
DOI: 10.1038/nmicrobiol.2017.70
Contributors: Anthony W. P. Fitzpatrick; Salomé Llabrés; Arthur Neuberger; James N. Blaza; Xiao-Chen Bai; Ui Okada; Satoshi Murakami; Hendrik W. van Veen; Ulrich Zachariae; Sjors H. W. Scheres et al.
Source: check_circle
Crossref
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The Enigma of the Respiratory Chain Supercomplex.

2017-04 | Journal article
DOI: 10.1016/j.cmet.2017.03.009
PMID: 28380371
Contributors: Milenkovic D; Blaza JN; Larsson NG; Hirst J
Source: Self-asserted source
James N Blaza via Europe PubMed Central
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An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

eLife
2017-03-29 | Journal article
DOI: 10.7554/eLife.24905
Contributors: Zhao Wang; Guizhen Fan; Corey F Hryc; James N Blaza; Irina I Serysheva; Michael F Schmid; Wah Chiu; Ben F Luisi; Dijun Du
Source: check_circle
Crossref
grade
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Respiratory complex I in Bos taurus and Paracoccus denitrificans pumps four protons across the membrane for every NADH oxidized.

2017-02 | Journal article
PMID: 28174301
Contributors: Jones AJ; Blaza JN; Varghese F; Hirst J
Source: Self-asserted source
James N Blaza via Europe PubMed Central

The mechanism of catalysis by type-II NADH:quinone oxidoreductases.

2017-01 | Journal article
DOI: 10.1038/srep40165
PMID: 28067272
PMC: PMC5220320
Contributors: Blaza JN; Bridges HR; Aragão D; Dunn EA; Heikal A; Cook GM; Nakatani Y; Hirst J
Source: Self-asserted source
James N Blaza via Europe PubMed Central
grade
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A Self-Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone-10 Cycling between Complex I and the Alternative Oxidase.

2016-01 | Journal article
DOI: 10.1002/anie.201507332
PMID: 26592861
PMC: PMC4954055
Contributors: Jones AJ; Blaza JN; Bridges HR; May B; Moore AL; Hirst J
Source: Self-asserted source
James N Blaza via Europe PubMed Central
grade
Preferred source (of 2)‎

Kinetic evidence against partitioning of the ubiquinone pool and the catalytic relevance of respiratory-chain supercomplexes.

2014-11 | Journal article
DOI: 10.1073/pnas.1413855111
PMID: 25331896
PMC: PMC4226120
Contributors: Blaza JN; Serreli R; Jones AJ; Mohammed K; Hirst J
Source: Self-asserted source
James N Blaza via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (13 reviews for 9 publications/grants)

Review activity for ACS synthetic biology. (1)
Review activity for Advanced materials. (1)
Review activity for Cell reports. (1)
Review activity for Communications biology. (1)
Review activity for eLife (1)
Review activity for JoVE. (1)
Review activity for Nature communications (1)
Review activity for Structure. (4)
Review activity for UK Research and Innovation (2)
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