Personal information

epigenetics, cancer biology
Canada

Biography

My research focuses on the epigenetic determinants of cancer. In particular, I am interested in how transcriptional networks that drive the proliferation of cancer cells are established and maintained through the post-translational modification of chromatin. During my Ph.D., under the supervision of Dr. Christopher J. Nelson at the University of Victoria, I explored a noncovalent chromatin modification called proline isomerization. This research identified several novel functions for the nuclear proline isomerase FKBP25 in the maintenance of genomic stability. Recently, I have taken up a postdoctoral position at the Structural Genomics Consortium, where I will be characterizing chemical probes (ie. precision inhibitors) that target epigenetic pathways relevant to human disease.

Activities

Employment (1)

University of Toronto: Toronto, ON, CA

2017-08-01 to present | Postdoctoral Fellow (Structural Genomics Consortium)
Employment
Source: Self-asserted source
David Dilworth

Education and qualifications (2)

University of Victoria: Victoria, BC, CA

2010-09-01 to 2017-07-27 | PhD Biochemistry (Biochemistry & Microbiology)
Education
Source: Self-asserted source
David Dilworth

University of Waterloo: Waterloo, ON, CA

2004-10-01 to 2009-04-31 | BSc Science and Business: Specialization in Biochemistry (Science)
Education
Source: Self-asserted source
David Dilworth

Works (10)

Targeting protein methylation: from chemical tools to precision medicines.

Cellular and molecular life sciences : CMLS
2019-05-18 | Journal article
Source: Self-asserted source
David Dilworth

FKBP25 participates in DNA double-strand break repair 1.

Biochemistry and cell biology = Biochimie et biologie cellulaire
2019-01-08 | Journal article
Source: Self-asserted source
David Dilworth

Guiding COMPASS: Dpy-30 Positions SET1/MLL Epigenetic Signaling.

Structure (London, England : 1993)
2018-12-01 | Journal article
Source: Self-asserted source
David Dilworth

Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.

Experimental hematology
2018-10-22 | Journal article
Source: Self-asserted source
David Dilworth

The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability.

Nucleic acids research
2018-03-01 | Journal article
Source: Self-asserted source
David Dilworth

The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module.

Nucleic acids research
2017-11-01 | Journal article
Source: Self-asserted source
David Dilworth
grade
Preferred source (of 2)‎

Paternal Genome Elimination in Liposcelis Booklice (Insecta: Psocodea)

Genetics
2017-03 | Journal article
Contributors: Christina N. Hodson; Phineas T. Hamilton; Dave Dilworth; Chris J. Nelson; Caitlin I. Curtis; Steve J. Perlman
Source: Self-asserted source
David Dilworth via Crossref Metadata Search

Rapid Identification of Chemical Genetic Interactions in <em>Saccharomyces cerevisiae</em>

Journal of Visualized Experiments
2015-04-05 | Journal article
Contributors: David Dilworth; Christopher J. Nelson
Source: Self-asserted source
David Dilworth via Crossref Metadata Search

The prolyl isomerase, FKBP25, interacts with RNA-engaged nucleolin and the pre-60S ribosomal subunit

RNA
2014-05 | Journal article
Contributors: G. Gudavicius; D. Dilworth; J. J. Serpa; N. Sessler; E. V. Petrotchenko; C. H. Borchers; C. J. Nelson
Source: Self-asserted source
David Dilworth via Crossref Metadata Search

The roles of peptidyl-proline isomerases in gene regulation1This review is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.

Biochemistry and Cell Biology
2012-02 | Journal article
Part of ISSN: 0829-8211
Contributors: David Dilworth; Geoff Gudavicius; Andrew Leung; Christopher J. Nelson
Source: Self-asserted source
David Dilworth via Crossref Metadata Search