Personal information

Emails & domains

Verified email addresses

Verified email domains

Other IDs

Scopus Author ID: 55891437900

Keywords

Cancer Biology, Signaling transduction, Kidney cancer, Hypoxia signaling, Post-translational modification

Countries

China, United States

Activities

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Employment (5)

Zhejiang University: Hangzhou, CN

2024-08 to present | Investigator, 100 Young Professor (First Affiliated Hospital, School of Medicine)
Employment
Source: Self-asserted source
Lianxin Hu

The University of Texas Southwestern Medical Center: Dallas, Texas, US

2021-08-01 to 2024-07 | Senior Research Associate (Department of Pathology)
Employment
Source: Self-asserted source
Lianxin Hu

University of Texas Southwestern Medical Center: DALLAS, TX, US

2019-10-07 to 2021-07-31 | Postdoc (Pathology)
Employment
Source: Self-asserted source
Lianxin Hu

Lineberger Comprehensive Cancer Center, UNC Chapel Hill: Chapel Hill, NC, US

2016-09-01 to 2019-10-06 | Postdoc
Employment
Source: Self-asserted source
Lianxin Hu

Shenzhen Second People's Hospital: Shenzhen, Guangdong, CN

2015-07 to 2016-07 | Postdoc
Employment
Source: Self-asserted source
Lianxin Hu

Education and qualifications (2)

Shanghai Institute of Biochemistry and Cell Biology, SIBCB, CAS: Shanghai, CN

2008-09-01 to 2015-01-17 | Ph.D.
Education
Source: Self-asserted source
Lianxin Hu

China Pharmaceutical University: Nanjing, Jiangsu, CN

2004-09-01 to 2008-06-30 | BS
Education
Source: Self-asserted source
Lianxin Hu

Works (16)

Von Hippel–Lindau protein signalling in clear cell renal cell carcinoma

Nature Reviews Urology
2024-11 | Journal article
DOI: 10.1038/s41585-024-00876-w
Contributors: Chengheng Liao; Lianxin Hu; Qing Zhang
Source: check_circle
Crossref

Mechanism of TBK1 activation in cancer cells

Cell Insight
2024-10 | Journal article
DOI: 10.1016/j.cellin.2024.100197
Contributors: Lianxin Hu; Qing Zhang
Source: check_circle
Crossref

Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.

The Journal of clinical investigation
2024-04-15 | Journal article
DOI: 10.1172/jci175703
PMID: 38618952
PMC: PMC11014668
Contributors: Zhang C; Miaomiao Yu; Hepperla AJ; Zhang Z; Raj R; Hua Zhong; Zhou J; Hu L; Jun Fang; Liu H et al.
Source: Self-asserted source
Lianxin Hu

Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.

Molecular cell
2024-01-10 | Journal article
DOI: 10.1016/j.molcel.2023.12.010
PMID: 38211588
Contributors: Hu L; Zhang Y; Guo L; Zhong H; Xie L; Zhou J; Liao C; Yao H; Jun Fang; Liu H et al.
Source: Self-asserted source
Lianxin Hu

Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

Cancer Discovery
2020-11-01 | Journal article
DOI: 10.1158/2159-8290.CD-20-0288
Contributors: Chengheng Liao; Yang Zhang; Cheng Fan; Laura E. Herring; Juan Liu; Jason W. Locasale; Mamoru Takada; Jin Zhou; Giada Zurlo; Lianxin Hu et al.
Source: check_circle
Crossref

USP37 promotes deubiquitination of HIF2α in kidney cancer

Proceedings of the National Academy of Sciences
2020-06-09 | Journal article
DOI: 10.1073/pnas.2002567117
Contributors: Kai Hong; Lianxin Hu; Xijuan Liu; Jeremy M. Simon; Travis S. Ptacek; Xingnan Zheng; Chengheng Liao; Albert S. Baldwin; Qing Zhang
Source: check_circle
Crossref

TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

Cancer Discovery
2020-03 | Journal article
DOI: 10.1158/2159-8290.cd-19-0837
Part of ISSN: 2159-8274
Part of ISSN: 2159-8290
Source: Self-asserted source
Lianxin Hu

Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.

Molecular cell
2020-02-04 | Journal article
DOI: 10.1016/j.molcel.2020.01.009
PMID: 32023483
PMC: PMC7093231
Contributors: Liu X; Simon JM; Xie H; Hu L; jun wang; Zurlo G; Fan C; Ptacek TS; Herring L; Tan X et al.
Source: Self-asserted source
Lianxin Hu

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma

Science
2018 | Journal article
DOI: 10.1126/science.aap8411
EID:

2-s2.0-85050514864
Contributors: Zhang, J.; Wu, T.; Simon, J.; Takada, M.; Saito, R.; Fan, C.; Liu, X.-D.; Jonasch, E.; Xie, L.; Chen, X. et al.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

FBW7 loss promotes chromosomal instability and tumorigenesis via cyclin E1/CDK2–mediated phosphorylation of CENP-A

Cancer Research
2017 | Journal article
DOI: 10.1158/0008-5472.CAN-17-1240
EID:

2-s2.0-85031423269
Contributors: Takada, M.; Zhang, W.; Suzuki, A.; Kuroda, T.S.; Yu, Z.; Inuzuka, H.; Gao, D.; Wan, L.; Zhuang, M.; Hu, L. et al.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded

Cell Discovery
2016 | Journal article
DOI: 10.1038/celldisc.2015.47
EID:

2-s2.0-85016243270
Contributors: Hu, L.; Xu, J.; Yin, M.-X.; Lu, Y.; Wu, W.; Xue, Z.; Ho, M.S.; Gao, G.; Zhao, Y.; Zhang, L. et al.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

Importin α1 mediates yorkie nuclear import via an N-terminal non-canonical nuclear localization signal

Journal of Biological Chemistry
2016 | Journal article
DOI: 10.1074/jbc.M115.700823
EID:

2-s2.0-84964686317
Contributors: Wang, S.; Lu, Y.; Yin, M.-X.; Wang, C.; Wu, W.; Li, J.; Wu, W.; Ge, L.; Hu, L.; Zhao, Y. et al.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis

Nature Communications
2015 | Journal article
DOI: 10.1038/ncomms7607
EID:

2-s2.0-84925637156
Contributors: Wang, C.; Zhang, W.; Yin, M.-X.; Hu, L.; Li, P.; Xu, J.; Huang, H.; Wang, S.; Lu, Y.; Wu, W. et al.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling

Developmental Biology
2014 | Journal article
DOI: 10.1016/j.ydbio.2013.11.008
EID:

2-s2.0-84891627773
Contributors: Huang, H.; Li, J.; Hu, L.; Ge, L.; Ji, H.; Zhao, Y.; Zhang, L.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

Drosophila casein kinase 2 (CK2) promotes warts protein to suppress yorkie protein activity for growth control

Journal of Biological Chemistry
2014 | Journal article
DOI: 10.1074/jbc.M114.580456
EID:

2-s2.0-84912100451
Contributors: Hu, L.; Huang, H.; Li, J.; Yin, M.-X.; Lu, Y.; Wu, W.; Zeng, R.; Jiang, J.; Zhao, Y.; Zhang, L.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by hippo signaling

eLife
2013 | Journal article
DOI: 10.7554/eLife.00999.001
EID:

2-s2.0-84885897697
Contributors: Jin, Y.; Xu, J.; Yin, M.-X.; Lu, Y.; Hu, L.; Li, P.; Zhang, P.; Yuan, Z.; Ho, M.S.; Zhao, Y. et al.
Source: Self-asserted source
Lianxin Hu via Scopus - Elsevier

Peer review (4 reviews for 3 publications/grants)

Review activity for Biochimica et biophysica acta. Molecular cell research (1)
Review activity for Heliyon. (2)
Review activity for The American journal of pathology. (1)
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