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Loop profile: 1051612

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Works (12)

HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly

Nature Communications
2024-09-13 | Journal article
DOI: 10.1038/s41467-024-51971-w
Contributors: Alex Kleinpeter; Donna L. Mallery; Nadine Renner; Anna Albecka; J. Ole Klarhof; Eric O. Freed; Leo C. James
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Crossref

The Effect of Inositol Hexakisphosphate on HIV-1 Particle Production and Infectivity can be Modulated by Mutations that Affect the Stability of the Immature Gag Lattice.

Journal of molecular biology
2023-06-16 | Journal article
DOI: 10.1016/j.jmb.2023.168037
PMID: 37330292
PMC: PMC10544863
Contributors: Kleinpeter AB; Zhu Y; Mallery DL; Ablan SD; Chen L; Hardenbrook N; Adolfo Saiardi; James LC; Zhang P; Freed EO
Source: Self-asserted source
Alex Kleinpeter

HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly

Nature Structural & Molecular Biology
2023-03 | Journal article
DOI: 10.1038/s41594-022-00887-4
Contributors: Nadine Renner; Alex Kleinpeter; Donna L. Mallery; Anna Albecka; K. M. Rifat Faysal; Till Böcking; Adolfo Saiardi; Eric O. Freed; Leo C. James
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Structural basis of HIV-1 maturation inhibitor binding and activity

Nature Communications
2023-03-04 | Journal article
DOI: 10.1038/s41467-023-36569-y
Contributors: Sucharita Sarkar; Kaneil K. Zadrozny; Roman Zadorozhnyi; Ryan W. Russell; Caitlin M. Quinn; Alex Kleinpeter; Sherimay Ablan; Hamed Meshkin; Juan R. Perilla; Eric O. Freed et al.
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Crossref

CryoET structures of immature HIV Gag reveal six-helix bundle

Communications Biology
2021-04-16 | Journal article
DOI: 10.1038/s42003-021-01999-1
Contributors: Luiza Mendonça; Dapeng Sun; Jiying Ning; Jiwei Liu; Abhay Kotecha; Mateusz Olek; Thomas Frosio; Xiaofeng Fu; Benjamin A. Himes; Alex B. Kleinpeter et al.
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Crossref

A stable immature lattice packages IP 6 for HIV capsid maturation

Science Advances
2021-03-12 | Journal article
DOI: 10.1126/sciadv.abe4716
Contributors: Donna L. Mallery; Alex B. Kleinpeter; Nadine Renner; K. M. Rifat Faysal; Mariia Novikova; Leo Kiss; Miranda S. C. Wilson; Bilal Ahsan; Zunlong Ke; John A. G. Briggs et al.
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Crossref

How to package the RNA of HIV-1

eLife
2020-11-17 | Journal article
DOI: 10.7554/eLife.63585
Contributors: Alex Kleinpeter; Eric O Freed
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Crossref

HIV-1 Maturation: Lessons Learned from Inhibitors.

Viruses
2020-08-26 | Journal article
DOI: 10.3390/v12090940
PMID: 32858867
PMC: PMC7552077
Source: Self-asserted source
Alex Kleinpeter

The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.

The Journal of biological chemistry
2019-12-16 | Journal article
DOI: 10.1074/jbc.ra119.011410
PMID: 31843969
PMC: PMC6983837
Source: Self-asserted source
Alex Kleinpeter

Cellular IP<sub>6</sub> Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP<sub>6</sub> Are Attenuated for Infection and Replication.

Cell reports
2019-12-01 | Journal article
DOI: 10.1016/j.celrep.2019.11.050
PMID: 31851928
PMC: PMC6931105
Source: Self-asserted source
Alex Kleinpeter

Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds.

The Journal of biological chemistry
2018-08-03 | Journal article
DOI: 10.1074/jbc.ra118.004012
PMID: 30076219
PMC: PMC6153301
Source: Self-asserted source
Alex Kleinpeter

Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.

Structure (London, England : 1993)
2015-09-10 | Journal article
DOI: 10.1016/j.str.2015.08.007
PMID: 26365801
PMC: PMC4635043
Source: Self-asserted source
Alex Kleinpeter

Peer review (13 reviews for 10 publications/grants)

Review activity for ACS chemical biology. (2)
Review activity for Biochemistry. (1)
Review activity for Biomolecules. (2)
Review activity for Journal of general virology. (1)
Review activity for Journal of Molecular Biology. (1)
Review activity for Nature communications (1)
Review activity for Nature immunology. (1)
Review activity for PLOS pathogens : (2)
Review activity for Retrovirology. (1)
Review activity for Viruses. (1)
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