Yuhui Sun (0000-0001-5720-9620)

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Prof. Yuhui Sun obtained his B.S. degree from Jiangxi Agricultural University majoring in genetics, and completed his M.S. and Ph.D. studies under the supervision of Prof. Zixin Deng at Huazhong Agricultural University and Shanghai Jiao Tong University, respectively. Since then, he started the research on Streptomyces genetics and secondary metabolite biosynthesis, mainly studied on the polyether nanchangmycin and avermectin-like macrolide meilingmycin biosynthetic mechanism during pursuing his degree of biochemistry and molecular biology. He then carried out postdoctoral research in Prof. Peter F. Leadlay’s group at University of Cambridge and mainly focused on investigation of mechanism of tetronate and polyketide natural products. Then, he was appointed as a Professor at Wuhan University in 2010, and currently the head of the Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and the vice dean of the School of Pharmaceutical Sciences. His research interests include: (1) Exploration and improvement of biosynthetic mechanism of microbial natural products with pharmaceutical value. (2) Establishment and development of molecular tools or approaches for genome editing.

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Wuhan University: Wuhan, Hubei, CN

2010-05 to present | Professor (School of Pharmaceutical Sciences)

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Yuhui Sun

https://orcid.org/0000-0001-5720-9620

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Employment (2)

Wuhan University: Wuhan, Hubei, CN

University of Cambridge: Cambridge, Cambridgeshire, GB

Education and qualifications (3)

Shanghai Jiao Tong University: Shanghai, CN

Huazhong Agriculture University: Wuhan, Hubei, CN

Jiangxi Agricultural University: Nanchang, Jiangxi, CN

Professional activities (9)

The Chinese Society of Microbiology: Beijing, CN

The Royal Society of Chemistry: London, GB

Faculty of 1000: London, GB

The Globe Industrial Microbiology Society (GIM): Wuhan, CN

Science and Technology Society of Hubei Province: Wuhan, CN

State Council of the People's Republic of China: Beijing, CN

Education Department of Jiangxi Province: Nanchang, CN

Jiangxi Provincial Government: Nanchang, CN

Shanghai Municipal Government: Shanghai, CN

Funding (7)

Study on the modular skipping mechanism of polyketide synthase in microbial natural product hangtaimycin biosynthesis

Study on the non-colinear catalytic mechanism of enoylreductase domain of polyketide synthase in azalomycin F biosynthesis

Elucidation of synthetic pathways and heterologous expression of natural products with anti-tumor and anti infective activities

Biosynthetic mechanism of complex gentamicins and rational reconstitution of monocomponent biosynthesis

Study on the impacts on off-target of Streptococcus pyogenes CRISPR/Cas9 and mechanism of targeting specificity

Coupling biosynthetic mechanism of gentamicin and sisomicin in Micromonospora echinospora ATCC15835

Comparative studies on azalomycin F biosynthetic mechanism and their structural diversities

Works (50 of 65)

Engineering of Peptide‐Inserted Base Editors with Enhanced Accuracy and Security

Genome-Based Mining of Carpatamides I–M and Their Candidate Biosynthetic Gene Cluster

Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

Direct asymmetric synthesis of β-branched aromatic α-amino acids using engineered phenylalanine ammonia lyases

Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis

Engineered cytosine base editor enabling broad-scope and high-fidelity gene editing in Streptomyces

Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

Design and Engineering of Light‐Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity

Methylation in hangtaimycin biosynthesis and its antibacterial activities

Dissection of 3D chromosome organization in Streptomyces coelicolor A3(2) leads to biosynthetic gene cluster overexpression

Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition

Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites

Two new streptovaricin derivatives from mutants of Streptomyces spectabilis CCTCC M2017417

Antibacterial natural products lobophorin L and M from the marine-derived Streptomyces sp. 4506

Mechanistic insights into dideoxygenation in gentamicin biosynthesis

The mechanism of dehydrating bimodules in acyltransferase polyketide biosynthesis: a showcase study on hepatoprotective hangtaimycin

Improving the precision of base editing by bubble hairpin single guide RNA

A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species

Skin microbiota analysis-inspired development of novel anti-infectives

Cross‐module enoylreduction in the azalomycin F polyketide synthase

Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis

Ansavaricin J, a new heterocyclic ring‐fused streptovaricin from gene stvP5‐deleted mutant of Streptomyces spectabilis CCTCC M2017417

Exploration of hygromycin B biosynthesis utilizing CRISPR-Cas9-associated base editing

Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis

In vitro packaging mediated one-step targeted cloning of natural poduct pathway

Base editing in Streptomyces with Cas9-deaminase fusions

A protein biosynthesis machinery strategy for identifying P53PTC-rescuing compounds as synergic anti-tumor drugs

Direct genetic and enzymatic evidence for oxidative cyclization in hygromycin B biosynthesis

CRISPR/Cas9-based editing of Streptomyces for discovery, characterization, and production of natural products

Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin

Methyltransferases of gentamicin biosynthesis

Structural basis of the selectivity of GenN, an aminoglycoside N-methyltransferase involved in gentamicin biosynthesis

Functional analysis of cytochrome P450s involved in streptovaricin biosynthesis and generation of anti-MRSA analogues

An iterative module in the azalomycin F polyketide synthase contains a switchable enoylreductase domain

The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase

Chemical probing of thiotetronate bio-assembly

Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase

Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation cycle associated with tandem reduction and sequential hydroxylation

An insight into the protospacer adjacent motif of Streptococcus pyogenes Cas9 with artificially stimulated RNA-guided-Cas9 DNA cleavage flexibility

A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis

Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system

In vitro CRISPR/Cas9 system for efficient targeted DNA editing

Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex