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Funding (8)

NEURODIET - Molecular Mechanisms of Dietary Intervention on Neurodegeneration (PT001)

2023-09-01 to 2026-08-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

JPND/0001/2022

Source: check_circle
CIÊNCIAVITAE

Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3

2023-03-01 to 2024-08-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

2022.06127.PTDC

Source: check_circle
CIÊNCIAVITAE

Overcoming the major roadblocks for successful AAV-based gene therapy in the CNS

2021-01-01 to 2024-12-31 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

2020.09668.BD

Source: check_circle
CIÊNCIAVITAE

Validação expedita e Fabrico em larga escala de um dispositivo de sopro para colheita com inativação de amostras para deteção do SARS-CoV-2

2020-06 to 2020-08 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

269_596884125

Source: check_circle
CIÊNCIAVITAE

A Therapeutic Strategy in Machado-Joseph Disease

2019-12 to 2020-01 | Contract
Blade Therapeutics (South San Francisco, US)
GRANT_NUMBER:

CPD0020A01

Source: check_circle
CIÊNCIAVITAE

Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA

2019-02 to 2019-09 | Contract
uniQure NV (Amsterdam, NL)
GRANT_NUMBER:

NA

Source: check_circle
CIÊNCIAVITAE

BrainHealth 2020: Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias

2018-05 to present | Grant
N/A (N/A, PT)
GRANT_NUMBER:

SAICT 000008 BrainHealth 2020

Source: check_circle
CIÊNCIAVITAE

Gene repair and repression strategies to alleviate Machado-Joseph disease

2016-04-01 to 2019-12-31 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/NEU-NMC/0084/2014

Source: check_circle
CIÊNCIAVITAE

Works (38)

A systematic screening assay identifies efficient small guide RNAs for CRISPR activation

Frontiers in Bioengineering and Biotechnology
2025-01-23 | Journal article
SOURCE-WORK-ID:

cv-prod-id-4499676

Part of ISSN: 2296-4185
Contributors: Arvidsson, Elin; Lobo, Diana Duarte; Sabarese, Ermelinda; Duarte, Fabio; Nobre, Rui Jorge; Quintino, Luis; Lundberg, Cecilia
Source: check_circle
CIÊNCIAVITAE

Allele-specific silencing for Spinocerebellar Ataxia Type 3 via AAV9 polycistronic microRNA-based therapy

Annual Meeting of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB day)
2024-05 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387526

Contributors: Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, Miguel M; Pereira, Dina; Duarte, Sónia P; et al.
Source: check_circle
CIÊNCIAVITAE

Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol

Journal of Visualized Experiments
2024-04-05 | Journal article
SOURCE-WORK-ID:

cv-prod-id-4499677

Part of ISSN: 1940-087X
Contributors: Lopes, Miguel M.; Lopes, Sara M.; Baganha, Rafael; Henriques, Carina; Silva, Ana C.; Lobo, Diana Duarte; Cortes, Luísa; de Almeida, Luís Pereira; Nobre, Rui Jorge
Source: check_circle
CIÊNCIAVITAE

Viral-based animal models in polyglutamine disorders

Brain
2024-04-04 | Journal article
SOURCE-WORK-ID:

cv-prod-id-4499675

Contributors: Carina Henriques; Miguel M Lopes; Ana C Silva; Diana D Lobo; Romina Aron Badin; Philippe Hantraye; Luís Pereira de Almeida; Rui Jorge Nobre
Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Allele-specific silencing of mutant ATXN3 rescues motor deficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration

ESGCT 30th Congress
2023-10 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387523

Contributors: Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, Miguel Monteiro; Pereira, Dina; Duarte, Sónia; et al.
Source: check_circle
CIÊNCIAVITAE

Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)

ESGCT 30th Congress
2023-10 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387518

Contributors: Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al.
Source: check_circle
CIÊNCIAVITAE

CRISPR activation as a therapeutic tool for Spinocerebellar ataxia type 3 (SCA3)

ESGCT/SFTCG/NVGCT Collaborative Congress (Brussels, Belgium) 24-27October 2023
2023-10-24 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4035064

Contributors: Lobo, Diana Duarte; Luís Quintino; Ana Carolina Silva; Carina Henriques; Ribeiro, Rodrigo; Lopes, Sara M. ; Pedro Perdigão; et al. Corresponding author: Pereira de Almeida, Luis Fernando Morgado.
Source: check_circle
CIÊNCIAVITAE

Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Machado-Joseph Disease/Spinocerebellar Ataxia Type 3

30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium
2023-10-24 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387515

Contributors: Leandro, Kevin; Rufino-Ramos, David; Lopes, Sara M. ; Pasqua, C; Santos, P; Silva, Ana Carolina; Lobo, Diana Duarte; et al. Corresponding author: Pereira de Almeida, Luis .
Source: check_circle
CIÊNCIAVITAE

The Guardians of Balance: Mesenchymal Stem Cells as a Promising Strategy to Restore Blood-brain Barrier Integrity in Spinocerebellar Ataxia Type 3.

30th Annual Meeting of the European Society of Gene & Cell Therapy
2023-10-24 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387514

Contributors: Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Lopes, Sara; Martins, Inês; Pereira de Almeida, L; Miranda, Catarina; Corresponding author: Miranda, Catarina.
Source: check_circle
CIÊNCIAVITAE

Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Spinocerebellar Ataxia Type 3/Machado-Joseph Disease

CAG Triplet Repeat Disorders GRC
2023-06 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387522

Contributors: Leandro, Kevin; Rufino-Ramos, David; Lopes, Sara Monteiro; Pasqua, C; Santos P; Silva, Ana Carolina; Lobo, Diana Duarte; et al.
Source: check_circle
CIÊNCIAVITAE

Extracellular Vesicle-Based Delivery of Silencing Sequences for the Treatment of Machado-Joseph Disease

American Society of Gene Therapy (ASGCT) 26th Annual
2023-05 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387521

Contributors: Rufino-Ramos, David; Leandro, Kevin; Vitor, Carmona; Martins, Ines Morgado; Albuquerque, Patrícia Rosado; Fernandes, Ana Rita; Henriques, Carina; et al.
Source: check_circle
CIÊNCIAVITAE

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3

Molecular Therapy
2023-05 | Journal article
SOURCE-WORK-ID:

cv-prod-id-3436885

Part of ISSN: 1525-0016
Contributors: Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al.
Source: check_circle
CIÊNCIAVITAE

Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease

FENS Regional Meeting 2023 (FRM)
2023-05-04 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387517

Contributors: Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina; Corresponding author: Miranda, Catarina.
Source: check_circle
CIÊNCIAVITAE

Mesenchymal Stromal Cells Uptake Mutant Aatxin-3 and Alleviate Late Autophagy and Mitophagy impairments in Spinocerebellar ataxia type-3 (In Vitro and In Vivo) Models.

Congresso Anual SPDMov 2023
2023-03-18 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387513

Contributors: Silva, António; Barros, Inês; Lobo, Diana Duarte; Gonzaga, Daniela; Pereira de Almeida, Luis ; Miranda, Catarina
Source: check_circle
CIÊNCIAVITAE

Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.

26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH)
2022-11-17 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387519

Contributors: Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira
Source: check_circle
CIÊNCIAVITAE

Mesenchymal Stromal Cells therapy rescues mitophagy in Machado-Joseph Disease models.

26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH)
2022-11-17 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387512

Contributors: Silva, António; Barros, Inês; Lobo, Diana Duarte; Gonzaga, Daniela; Pereira de Almeida, Luis ; Miranda, Catarina; Corresponding author: Miranda, Catarina.
Source: check_circle
CIÊNCIAVITAE

Importin-8 silencing reduces ataxin-3 aggregation, alleviates neuropathology and delays progression of Spinocerebellar Ataxia Type 3 (SCA3)

ICAR2022 - International Congress for Ataxia Research
2022-11-01 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387508

Contributors: Inês Morgado Martins; Sowa, Anna Sergeevna; Rufino-Ramos, David; Lobo, Diana Duarte; et al.
Source: check_circle
CIÊNCIAVITAE

1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal

ESGCT 29th Congress
2022-10 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387509

Contributors: Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado
Source: check_circle
CIÊNCIAVITAE

Extracellular vesicles-based delivery of silencing seqeunces for the treatment of Machado-Joseph disease (MJD)/ Spinocerebellar Ataxia type-3 (SCA3)

ESGCT 29th Congress
2022-10 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387510

Contributors: David Rufino-Ramos; Leandro, Kevin; Albuquerque, Patrícia Rosado; Carmona, Vitor; Martins, Ines Morgado; Faro, Rosário; Henriques, Carina; et al.
Source: check_circle
CIÊNCIAVITAE

Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Machado-Joseph Disease

29th Congress of the European Society for Gene and Cell Therapy (ESGCT) in collaboration with BSGCT; Edinburgh, Scotland, United Kingdom
2022-10 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387524

Contributors: Leandro, Kevin; Rufino-Ramos, David; D'Amelio, T.; Salgueiro, Margarida A.; Lopes, Sara M. ; Pereira, Dina; Martins, M. I.; et al. Corresponding author: Pereira de Almeida, Luis .
Source: check_circle
CIÊNCIAVITAE

Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice

29th Congress of the European Society for Gene and Cell Therapy (ESGCT) in collaboration with BSGCT; Edinburgh, Scotland, United Kingdom
2022-10 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387516

Contributors: Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, M. I.; Sara M. Lopes; Duarte, Sonia, P. ; Wagner, E.; Nobre, Rui Jorge; Pereira de Almeida, Luis
Source: check_circle
CIÊNCIAVITAE

miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3

Nucleic Acid Therapeutics
2022-06-01 | Journal article
Contributors: Rui Jorge Nobre; Diana D. Lobo; Carina Henriques; Sonia P. Duarte; Sara M. Lopes; Ana C. Silva; Miguel M. Lopes; Fanny Mariet; Lukas K. Schwarz; M.S. Baatje et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease

12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
2022-03-10 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387520

Contributors: Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira; Corresponding author: Miranda, Catarina Oliveira.
Source: check_circle
CIÊNCIAVITAE

Antinsense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph Disease

XVII Meeting of the Portuguese Society for Neuroscience
2021-12-02 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387505

Contributors: Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Ines M; Lopes, Sara Monteiro; Duarte, Sonia P; Wagner, Elizabeth; Nobre, Rui Jorge; Pereira de Almeida, Luis
Source: check_circle
CIÊNCIAVITAE

Antisense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph disease

XVII Meeting of the Portuguese Society for Neuroscience
2021-12-02 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387506

Contributors: Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Inês M; Lopes, Sara M. ; Duarte, Sónia P; Wagner, Elizabeth; Nobre, Rui Jorge; Pereira de Almeida, Luis
Source: check_circle
CIÊNCIAVITAE

miRNA mediated knockdown of ATXN3 alleviates molecular disease hallmarks in a mouse model for Spinocerebellar ataxia type 3

Nucleic Acid Therapeutics
2021-10 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2699536

Contributors: Nobre, Rui Jorge; Lobo, Diana Duarte; Henriques, Carina; Pereira de Almeida, Luis Fernando Morgado; Corresponding author: Pereira de Almeida, Luis Fernando Morgado.
Source: check_circle
CIÊNCIAVITAE

Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics

1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal
2021-07 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387525

Contributors: Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia Patrícia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado
Source: check_circle
CIÊNCIAVITAE

ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease

Molecular Therapy
2021-07 | Journal article
SOURCE-WORK-ID:

cv-prod-id-2699083

Contributors: Vasconcelos-Ferreira, Ana; Martins, Inês Morgado; Lobo, Diana; Pereira, Dina; Lopes, Miguel M.; Faro, Rosário; Lopes, Sara M.; et al.
Source: check_circle
CIÊNCIAVITAE

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Acta Neuropathologica Communications
2020-08-11 | Journal article
SOURCE-WORK-ID:

cv-prod-id-1743562

Contributors: Duarte Lobo, Diana; Nobre, Rui Jorge; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís
Source: check_circle
CIÊNCIAVITAE

Uma viagem rara

Público
2020-02-28 | Newspaper article
SOURCE-WORK-ID:

cv-prod-id-1395863

Contributors: Lobo, Diana Duarte; Vinhas, Ana Catarina; Ferreira, Ana Cristina; Henriques, Carina S.; Silva, Carolina; Oliveira Miranda, Catarina; Henriques, Daniel; et al.
Source: check_circle
CIÊNCIAVITAE

Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: results from human and mouse samples

XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
2019 | Conference paper
SOURCE-WORK-ID:

cv-prod-id-4387511

Contributors: Lobo, Diana; Nobre, Rui Jorge; Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Castelo-Branco, Miguel; et al.
Source: check_circle
CIÊNCIAVITAE

Holy CIBB

2019-12 | Other
SOURCE-WORK-ID:

cv-prod-id-1395807

Contributors: Lobo, Diana Duarte
Source: check_circle
CIÊNCIAVITAE

Extracellular vesicles-associated AAVs as new gene delivery vectors for the treatment of brain disorders

3rd BEB Day
2019-12-09 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1402103

Contributors: Henriques, Carina S.; Lopes, M. M.; Albuquerque, PR; Rufino-Ramos, David; Gaspar, Laetitia; Lobo, Diana Duarte; Duarte, Sónia; et al.
Source: check_circle
CIÊNCIAVITAE

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders

Brain
2019-11-18 | Journal article
SOURCE-WORK-ID:

cv-prod-id-526882

Contributors: Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis
Source: check_circle
CIÊNCIAVITAE

Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph Disease

2019 International Machado-Joseph Research Disease Conference. Washington, DC. USA
2019-11-15 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4387507

Contributors: Vasconcelos-Ferreira, Ana; Inês Morgado Martins; Lobo, Diana Duarte; Pereira, Dina; et al.
Source: check_circle
CIÊNCIAVITAE

Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases

5th GEIVEX Symposium
2019-11-06 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-1402183

Contributors: Henriques, Carina S.; Lopes, M. M.; Albuquerque, PR; Rufino-Ramos, David; Gaspar, Laetitia; Lobo, Diana Duarte; Duarte, Sónia; et al.
Source: check_circle
CIÊNCIAVITAE

Blood-brain barrier dysfunction in spinocerebellar ataxia type 3 (Machado-Joseph disease): Results from mouse and human brain tissues

Society for Neuroscience Meeting 2019
2019-10-23 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-806546

Contributors: Rui Jorge Nobre; Lobo, Diana Duarte; Catarina Oliveira Miranda; Dina Pereira; João Castelhano; José Sereno; Miguel Castelo-Branco; Luís Pereira de Almeida
Source: check_circle
CIÊNCIAVITAE

Cerebrovascular and Blood-Brain Barrier Impairments in Machado-Joseph Disease

2017 | Dissertation or Thesis
SOURCE-WORK-ID:

cv-prod-id-455964

Contributors: Lobo, Diana Filipa Duarte
Source: check_circle
CIÊNCIAVITAE