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Education and qualifications (3)

Wellcome Sanger Institute: Cambridge, GB

2019-10 to present | Ph.D.
Education
Source: Self-asserted source
Matthew Neville

University of Cambridge: Cambridge, GB

2018-10 to 2019-09 | MPhil (Genetics)
Education
Source: Self-asserted source
Matthew Neville

Queen's University: Kingston, ON, CA

2013-09 to 2017-06 | B.Sc.
Education
Source: Self-asserted source
Matthew Neville

Works (9)

Cohort-level analysis of humande novomutations points to drivers of clonal expansion in spermatogonia

2025-01-05 | Preprint
DOI: 10.1101/2025.01.03.25319979
Contributors: Vladimir Seplyarskiy; Mikhail A Moldovan; Evan Koch; Prathitha Kar; Matthew DC Neville; Raheleh Rahbari; Shamil Sunyaev
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Sperm sequencing reveals extensive positive selection in the male germline

2024-11-01 | Preprint
DOI: 10.1101/2024.10.30.24316414
Contributors: Matthew DC Neville; Andrew RJ Lawson; Rashesh Sanghvi; Federico Abascal; My H Pham; Alex Cagan; Pantelis A Nicola; Tetyana Bayzetinova; Adrian Baez-Ortega; Kirsty Roberts et al.
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Complex de novo structural variants are an underestimated cause of rare disorders

2024-08-07 | Preprint
DOI: 10.21203/rs.3.rs-4197130/v1
Contributors: Raheleh Rahbari; Hyunchul Jung; Tsun-Po Yang; Susan Walker; Petr Danecek; Omar Garcia-Salinas; Matthew D C Neville; Isidro Cortés-Ciriano; Helen Firth; Aylwyn Scally et al.
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Heritability of de novo germline mutation reveals a contribution from paternal but not maternal genetic factors

2022-12-17 | Preprint
DOI: 10.1101/2022.12.17.520885
Contributors: Seongwon Hwang; Matthew D. C. Neville; Felix R. Day; Aylwyn Scally
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Genetic and chemotherapeutic influences on germline hypermutation

Nature
2022-05-19 | Journal article
DOI: 10.1038/s41586-022-04712-2
Contributors: Joanna Kaplanis; Benjamin Ide; Rashesh Sanghvi; Matthew Neville; Petr Danecek; Tim Coorens; Elena Prigmore; Patrick Short; Giuseppe Gallone; Jeremy McRae et al.
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Reduced reproductive success is associated with selective constraint on human genes

Nature
2022-03-31 | Journal article
DOI: 10.1038/s41586-022-04549-9
Contributors: Eugene J. Gardner; Matthew D. C. Neville; Kaitlin E. Samocha; Kieron Barclay; Martin Kolk; Mari E. K. Niemi; George Kirov; Hilary C. Martin; Matthew E. Hurles
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The mutational landscape of human somatic and germline cells

Nature
2021-09-16 | Journal article
DOI: 10.1038/s41586-021-03822-7
Contributors: Luiza Moore; Alex Cagan; Tim H. H. Coorens; Matthew D. C. Neville; Rashesh Sanghvi; Mathijs A. Sanders; Thomas R. W. Oliver; Daniel Leongamornlert; Peter Ellis; Ayesha Noorani et al.
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Extensive phylogenies of human development inferred from somatic mutations

Nature
2021-08-25 | Journal article
DOI: 10.1038/s41586-021-03790-y
DOI: 10.1101/2020.11.25.397828
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Matthew Neville
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The contribution of X-linked coding variation to severe developmental disorders

Nature Communications
2021-01-27 | Journal article
DOI: 10.1038/s41467-020-20852-3
Contributors: Hilary C. Martin; Eugene J. Gardner; Kaitlin E. Samocha; Joanna Kaplanis; Nadia Akawi; Alejandro Sifrim; Ruth Y. Eberhardt; Ana Lisa Taylor Tavares; Matthew D. C. Neville; Mari E. K. Niemi et al.
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