Personal information

Websites & social links

https://www.researchgate.net/profile/Jakub-Jakowiecki-2

Keywords

GPCRs, G Protein Coupled Receptors, CB1, MD simulations, molecular dynamics

Countries

Poland

Activities

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Education and qualifications (2)

University of Warsaw: Warsaw, PL

2012-10-01 to 2023-04-27 | Ph.D. (Chemistry)
Education
Source: Self-asserted source
Jakub Jakowiecki

University of Warsaw: Warsaw, PL

2002-10-01 to 2008-06-27 | Master of Science (Chemistry)
Education
Source: Self-asserted source
Jakub Jakowiecki

Professional activities (1)

Vanderbilt University: Nashville, Tennessee, US

2006-07-11 to 2006-11-15 | Visiting sudent (Chemistry)
Invited position
Source: Self-asserted source
Jakub Jakowiecki

Funding (1)

Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

2017-07 to 2019-08 | Grant
Narodowe Centrum Nauki (Kraków, PL)
GRANT_NUMBER:

2016/23/N/NZ1/02960
Source: Self-asserted source
Jakub Jakowiecki

Works (13)

Conformational Changes and Unfolding of β-Amyloid Substrates in the Active Site of γ-Secretase

International Journal of Molecular Sciences
2024-02-22 | Journal article
DOI: 10.3390/ijms25052564
Contributors: Jakub Jakowiecki; Urszula Orzeł; Przemysław Miszta; Krzysztof Młynarczyk; Sławomir Filipek
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Crossref
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GS-SMD server for steered molecular dynamics of peptide substrates in the active site of the γ-secretase complex.

Nucleic acids research
2023-07 | Journal article
DOI: 10.1093/nar/gkad409
PMID: 37207343
PMC: PMC10320170
Contributors: Orzeł U; Pasznik P; Miszta P; Lorkowski M; Niewieczerzał S; Jakowiecki J; Filipek S
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central

Specificities of Protein Homology Modeling for Allosteric Drug Design.

Methods in molecular biology (Clifton, N.J.)
2023-01 | Journal article
DOI: 10.1007/978-1-0716-2974-1_19
PMID: 36959457
Contributors: Jakowiecki J; Orzeł U; Gliździnska A; Możajew M; Filipek S
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central

GPCRsignal: webserver for analysis of the interface between G-protein-coupled receptors and their effector proteins by dynamics and mutations.

Nucleic acids research
2021-07 | Journal article
DOI: 10.1093/nar/gkab434
PMID: 34060630
PMC: PMC8262697
Contributors: Miszta P; Pasznik P; Niewieczerzał S; Jakowiecki J; Filipek S
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central

The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex

Biomolecules
2021-06-24 | Journal article
DOI: 10.3390/biom11070935
Contributors: Urszula Orzeł; Jakub Jakowiecki; Krzysztof Młynarczyk; Sławomir Filipek
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Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

Molecules
2021-04-23 | Journal article
DOI: 10.3390/molecules26092456
Contributors: Jakub Jakowiecki; Renata Abel; Urszula Orzeł; Paweł Pasznik; Robert Preissner; Sławomir Filipek
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The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations

Molecules
2020-04-21 | Journal article
DOI: 10.3390/molecules25081930
Contributors: Jakub Jakowiecki; Urszula Orzeł; Sathapana Chawananon; Przemysław Miszta; Sławomir Filipek
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GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models.

Nucleic acids research
2018-07 | Journal article
DOI: 10.1093/nar/gky429
PMID: 29788177
PMC: PMC6030973
Contributors: Miszta P; Pasznik P; Jakowiecki J; Sztyler A; Latek D; Filipek S
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central

Aquaporin–graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

Interface Focus
2018-06-06 | Journal article
DOI: 10.1098/rsfs.2017.0066
Contributors: Jakub Jakowiecki; Agnieszka Sztyler; Slawomir Filipek; Pingzuo Li; Karthik Raman; Natarajan Barathiraja; Seeram Ramakrishna; Jairam R. Eswara; Ali Altaee; Adel O. Sharif et al.
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Crossref

Approaches for Differentiation and Interconverting GPCR Agonists and Antagonists.

Methods in molecular biology (Clifton, N.J.)
2018-01 | Journal article
DOI: 10.1007/978-1-4939-7465-8_12
PMID: 29188567
Contributors: Miszta P; Jakowiecki J; Rutkowska E; Turant M; Latek D; Filipek S
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

Journal of molecular graphics & modelling
2017-08 | Journal article
DOI: 10.1016/j.jmgm.2017.08.008
PMID: 28826032
Contributors: Jarmuła A; Wilk P; Maj P; Ludwiczak J; Dowierciał A; Banaszak K; Rypniewski W; Cieśla J; Dąbrowska M; Frączyk T et al.
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central

Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor.

Journal of chemical information and modeling
2016-12 | Journal article
DOI: 10.1021/acs.jcim.6b00499
PMID: 27966915
Contributors: Jakowiecki J; Filipek S
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central

Synthesis of alpha-trifluoromethyl-beta-lactams and esters of beta-amino acids via 1,3-dipolar cycloaddition of nitrones to fluoroalkenes.

The Journal of organic chemistry
2008-06 | Journal article
DOI: 10.1021/jo800721w
PMID: 18558769
Contributors: Jakowiecki J; Loska R; Makosza M
Source: Self-asserted source
Jakub Jakowiecki via Europe PubMed Central
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