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http://www.med.cam.ac.uk/sinha/

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University of Cambridge: Cambridge, Cambridgeshire, GB

Professor of Cardiovascular Regenerative Medicine (Medicine)
Employment
Source: Self-asserted source
Prof Sanjay Sinha

Works (50 of 51)

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Page 1 of 2

RNA binding protein with multiple splicing (RBPMS) promotes contractile phenotype splicing in human embryonic stem cell–derived vascular smooth muscle cells

Cardiovascular Research
2024-12-14 | Journal article
DOI: 10.1093/cvr/cvae198
Contributors: Aishwarya G Jacob; Ilias Moutsopoulos; Alex Petchey; Rafael Kollyfas; Vincent R Knight-Schrijver; Irina Mohorianu; Sanjay Sinha; Christopher W J Smith
Source: check_circle
Crossref

A clinically defined and xeno-free hydrogel system for regenerative medicine

2024-06-02 | Preprint
DOI: 10.1101/2024.05.28.596179
Contributors: John Ong; George Gibbons; Lim Yee Siang; Zhou Lei; Junzhe Zhao; Alexander W. Justin; Federico Cammarata; Ravisankar Rajarethinam; Colleen Limegrover; Sanjay Sinha et al.
Source: check_circle
Crossref

Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor

2024-04-04 | Preprint
DOI: 10.21203/rs.3.rs-3970502/v1
Contributors: Anthony Davenport; Thomas Williams; Rhoda Kuc; Robyn Macrae; Sanjay Sinha; Janet Maguire; Grégory Verdon; Heather Currinn; Brian Bender; Nicolae Solcan et al.
Source: check_circle
Crossref

Three-dimensional co-culturing of stem cell-derived cardiomyocytes and cardiac fibroblasts reveals a role for both cell types in Marfan-related cardiomyopathy

Matrix Biology
2024-02 | Journal article
DOI: 10.1016/j.matbio.2024.01.003
Contributors: Jeffrey Aalders; Laurens Léger; Louis Van der Meeren; Sanjay Sinha; Andre G. Skirtach; Julie De Backer; Jolanda van Hengel
Source: check_circle
Crossref

Extracellular macrostructure anisotropy improves cardiac tissue-like construct function and phenotypic cellular maturation.

Biomaterials advances
2023-11 | Journal article
DOI: 10.1016/j.bioadv.2023.213680
PMID: 37944449
Contributors: Cyr JA; Colzani M; Bayraktar S; Köhne M; Bax DV; Graup V; Farndale R; Sinha S; Best SM; Cameron RE
Source: Self-asserted source
Prof Sanjay Sinha via Europe PubMed Central

A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target

Stem Cell Reports
2023-02 | Journal article
DOI: 10.1016/j.stemcr.2022.12.014
Contributors: Hongorzul Davaapil; Madeline McNamara; Alessandra Granata; Robyn G.C. Macrae; Mei Hirano; Martina Fitzek; J.A. Aragon-Martin; Anne Child; David M. Smith; Sanjay Sinha
Source: check_circle
Crossref

A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target

2022-04-11 | Preprint
DOI: 10.1101/2022.04.11.487841
Contributors: Hongorzul Davaapil; Madeline McNamara; Alessandra Granata; Robyn G.C. Macrae; Mei Hirano; Martina Fitzek; Jose Antonio Aragon-Martin; Anne Child; David M. Smith; Sanjay Sinha
Source: check_circle
Crossref

Regenerative and non-regenerative transcriptional states of the human epicardium: from foetus to adult and back again

2021-10-12 | Other
DOI: 10.1101/2021.10.11.462541
Contributors: Vincent R. Knight-Schrijver; Hongorzul Davaapil; Alexander Ross; Xiaoling He; Ludovic Vallier; Laure Gambardella; Sanjay Sinha
Source: check_circle
Crossref

Modulating hESC-derived cardiomyocyte and endothelial cell function with triple-helical peptides for heart tissue engineering

Biomaterials
2021-02 | Journal article
DOI: 10.1016/j.biomaterials.2020.120612
Contributors: Maria Colzani; Jean-Daniel Malcor; Emma J. Hunter; Semih Bayraktar; Murray Polkinghorne; Thomas Krieg; Ruth Cameron; Serena Best; Richard W. Farndale; Sanjay Sinha
Source: check_circle
Crossref

Densified Collagen Tubular Grafts for Human Tissue Replacement and Disease Modelling Applications

2021-02-07 | Other
DOI: 10.1101/2021.02.05.429744
Contributors: Alexander W. Justin; Sebastian Burgess; Silas R. Estevez; Agavi Stavropoulou-Tatla; John Ong; Aishwarya G. Jacob; Kourosh Saeb-Parsy; Sanjay Sinha; Athina E. Markaki
Source: check_circle
Crossref

Cell cycle regulators control mesoderm specification in human pluripotent stem cells

2019-05-09 | Other
DOI: 10.1101/632307
Contributors: Loukia Yiangou; Rodrigo A. Grandy; Sanjay Sinha; Ludovic Vallier
Source: check_circle
Crossref

A novel human pluripotent stem cell-derived neural crest model of Treacher Collins Syndrome shows defects in cell death and migration.

Stem Cells Dev
2018 | Journal article
DOI: 10.1089/scd.2017.0234
Source: Self-asserted source
Prof Sanjay Sinha

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling.

Am J Respir Crit Care Med
2018 | Journal article
DOI: 10.1164/rccm.201801-0049LE
Source: Self-asserted source
Prof Sanjay Sinha

Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF.

Biomaterials
2018 | Journal article
DOI: 10.1016/j.biomaterials.2018.07.050
Source: Self-asserted source
Prof Sanjay Sinha

Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics.

Stem Cell Reports
2018 | Journal article
DOI: 10.1016/j.stemcr.2018.11.020
Source: Self-asserted source
Prof Sanjay Sinha

New models to study vascular mural cell embryonic origin: implications in vascular diseases.

Cardiovasc Res
2018 | Journal article
DOI: 10.1093/cvr/cvy005
Source: Self-asserted source
Prof Sanjay Sinha

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death.

Nat Genet
2017 | Journal article
DOI: 10.1038/ng.3723
Source: Self-asserted source
Prof Sanjay Sinha
grade
Preferred source (of 2)‎

Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.

Stem Cells Transl Med
2017 | Journal article
DOI: 10.1002/sctm.17-0004
Source: Self-asserted source
Prof Sanjay Sinha

Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals.

Stem Cells Transl Med
2017 | Journal article
DOI: 10.5966/sctm.2016-0129
Source: Self-asserted source
Prof Sanjay Sinha

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Nat Med
2017 | Journal article
DOI: 10.1038/nm.4360
Source: Self-asserted source
Prof Sanjay Sinha
grade
Preferred source (of 2)‎

Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation.

Stem Cells Transl Med
2016 | Journal article
DOI: 10.5966/sctm.2015-0282
Source: Self-asserted source
Prof Sanjay Sinha

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.

Development
2016 | Journal article
DOI: 10.1242/dev.138081
Source: Self-asserted source
Prof Sanjay Sinha

Vascular Smooth Muscle Cells in Atherosclerosis.

Circ Res
2016 | Journal article
DOI: 10.1161/CIRCRESAHA.115.306361
Source: Self-asserted source
Prof Sanjay Sinha

Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.

Arterioscler Thromb Vasc Biol
2015 | Journal article
DOI: 10.1161/ATVBAHA.114.305218
Source: Self-asserted source
Prof Sanjay Sinha

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.

Development
2015 | Journal article
DOI: 10.1242/dev.119271
Source: Self-asserted source
Prof Sanjay Sinha

Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3.

Stem Cells Dev
2015 | Journal article
DOI: 10.1089/scd.2014.0520
Source: Self-asserted source
Prof Sanjay Sinha

Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells.

Nat Protoc
2014 | Journal article
DOI: 10.1038/nprot.2014.059
Source: Self-asserted source
Prof Sanjay Sinha

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application.

Cell Mol Life Sci
2014 | Journal article
DOI: 10.1007/s00018-013-1554-3
Source: Self-asserted source
Prof Sanjay Sinha

Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity.

Arterioscler Thromb Vasc Biol
2013 | Journal article
DOI: 10.1161/ATVBAHA.112.300539
Source: Self-asserted source
Prof Sanjay Sinha

Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-β.

Arterioscler Thromb Vasc Biol
2013 | Journal article
DOI: 10.1161/ATVBAHA.112.301000
Source: Self-asserted source
Prof Sanjay Sinha

Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.

Nat Biotechnol
2012 | Journal article
DOI: 10.1038/nbt.2107
Source: Self-asserted source
Prof Sanjay Sinha

Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.

PLoS One
2012 | Journal article
DOI: 10.1371/journal.pone.0044052
Source: Self-asserted source
Prof Sanjay Sinha

Vascular disease in a dish: all the right ingredients?

Circulation
2012 | Journal article
DOI: 10.1161/CIRCULATIONAHA.112.134387
Source: Self-asserted source
Prof Sanjay Sinha

11 Generation of developmental origin-specific vascular smooth muscle cells from human embryonic stem cells.

Heart
2011 | Journal article
DOI: 10.1136/heartjnl-2011-300920b.11
Source: Self-asserted source
Prof Sanjay Sinha

Human embryonic stem cell-derived vascular smooth muscle cells in therapeutic neovascularisation.

J Mol Cell Cardiol
2011 | Journal article
DOI: 10.1016/j.yjmcc.2011.07.014
Source: Self-asserted source
Prof Sanjay Sinha

Derivation of contractile smooth muscle cells from embryonic stem cells.

Methods Mol Biol
2009 | Journal article
DOI: 10.1007/978-1-59745-060-7_22
Source: Self-asserted source
Prof Sanjay Sinha

Conditional mouse models to study developmental and pathophysiological gene function in muscle.

Handb Exp Pharmacol
2007 | Journal article
DOI: 10.1007/978-3-540-35109-2_18
Source: Self-asserted source
Prof Sanjay Sinha

Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells.

Stem Cells
2006 | Journal article
DOI: 10.1634/stemcells.2006-0002
Source: Self-asserted source
Prof Sanjay Sinha

5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo.

J Clin Invest
2005 | Journal article
DOI: 10.1172/JCI22648
Source: Self-asserted source
Prof Sanjay Sinha

ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development.

Am J Physiol Heart Circ Physiol
2005 | Journal article
DOI: 10.1152/ajpheart.00620.2004
Source: Self-asserted source
Prof Sanjay Sinha

Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression.

J Biol Chem
2005 | Journal article
DOI: 10.1074/jbc.M412862200
Source: Self-asserted source
Prof Sanjay Sinha

A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.

Circ Res
2004 | Journal article
DOI: 10.1161/01.RES.0000147961.09840.fb
Source: Self-asserted source
Prof Sanjay Sinha

L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism.

Circ Res
2004 | Journal article
DOI: 10.1161/01.RES.0000138582.36921.9e
Source: Self-asserted source
Prof Sanjay Sinha

Transforming growth factor-β1 signaling contributes to development of smooth muscle cells from embryonic stem cells

American Journal of Physiology - Cell Physiology
2004 | Journal article
DOI: 10.1152/ajpcell.00221.2004
Source: Self-asserted source
Prof Sanjay Sinha
grade
Preferred source (of 2)‎

A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression.

J Biol Chem
2003 | Journal article
DOI: 10.1074/jbc.M301902200
Source: Self-asserted source
Prof Sanjay Sinha

Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty.

Circulation
2003 | Journal article
DOI: 10.1161/01.CIR.0000097068.49080.A0
Source: Self-asserted source
Prof Sanjay Sinha

Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes.

Circ Res
2003 | Journal article
DOI: 10.1161/01.RES.0000068405.49081.09
Source: Self-asserted source
Prof Sanjay Sinha

Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury.

Cardiovasc Res
2002 | Journal article
Source: Self-asserted source
Prof Sanjay Sinha

Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition.

Circulation
2001 | Journal article
Source: Self-asserted source
Prof Sanjay Sinha

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis.

Int J Exp Pathol
2001 | Journal article
Source: Self-asserted source
Prof Sanjay Sinha
Items per page:
Page 1 of 2

Peer review (4 reviews for 2 publications/grants)

Review activity for Nature biomedical engineering. (1)
Review activity for Nature cardiovascular research. (3)
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